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公开(公告)号：SG11202107268WA
公开(公告)日：2021-08-30
申请号：SG11202107268W
申请日：2020-01-31
Applicant: LABCYTE INC
Inventor： ELLSON RICHARD N , STEARNS RICHARD G , HADIMIOGLU BABUR
Abstract: Systems and methods described herein employ focused acoustic energy applied to a reservoir containing a fluid to eject a fluid sample from the fluid sample reservoir, e.g. to an inlet of an analytical device. In many embodiments, the ejected fluid sample traverses an air gap separating the inlet of the analytical device from an upper surface of the fluid in the fluid sample reservoir. In many embodiments, the ejected fluid sample comprises one or more droplets ejected from the fluid sample reservoir, which can contain particles suspended in the fluid sample.
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公开(公告)号：ES2873324T3
公开(公告)日：2021-11-03
申请号：ES15850361
申请日：2015-10-19
Applicant: LABCYTE INC
Inventor： ELLSON RICHARD N , STEARNS RICHARD G , OLECHNO JOSEPH D , SINCLAIR IAN , WINGFIELD JONATHAN
Abstract: Un método para determinar la concentración de un analito en una muestra de fluido que además comprende una sal tampón para mantener el pH o la fuerza iónica, comprendiendo el método volatilizar e ionizar la muestra de fluido e introducir la muestra ionizada y volatilizada en un dispositivo de detección de analito iónico que proporciona una señal proporcional en intensidad a la cantidad de analito ionizado detectado, en donde el método comprende: emplear un sal tampón que: (a) (i) es más volátil que el analito, o (ii) tras volatilizar la muestra de fluido, sufre una reacción para producir al menos un producto de reacción que es más volátil que el analito; y (b) da como resultado un aumento en la intensidad de la señal y/o una relación señal/ruido mayor que la intensidad de la señal o la relación señal/ruido obtenida en presencia de un sal tampón menos volátil, en donde el método comprende además generar gotitas del tamaño de nanolitros de muestra de fluido antes de la volatilización e ionización, de modo que la muestra de fluido se introduce en el dispositivo de detección de analito iónico en forma de gotitas del tamaño de nanolitros que tienen un área superficial eficaz para facilitar la extracción en fase gaseosa de la sal tampón de las gotitas tras la volatilización de las gotitas.
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公开(公告)号：AU2019245278A1
公开(公告)日：2020-10-22
申请号：AU2019245278
申请日：2019-03-29
Applicant: LABCYTE INC
Inventor： HADIMIOGLU BABUR , DAULTON JAY , ELLSON RICHARD N
Abstract: A fluid impermeable transducer includes an assembly of a transducer head and a casing, and an actuator disposed in the casing rearward of the back of the transducer head and operable to transmit acoustic energy through the transducer head. The transducer head and casing define a working portion of the transducer that is fluid impermeable.
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公开(公告)号：AU2019370221A1
公开(公告)日：2021-06-10
申请号：AU2019370221
申请日：2019-10-29
Applicant: LABCYTE INC
Inventor： DATWANI SAMMY S , RICHE CARSON T , BLAUWKAMP MARSHA N , BLONIGAN JUSTIN
Abstract: Methods of ejecting droplets containing a non-Newtonian fluid by an acoustic droplet ejector can include applying a tone burst of focused acoustic energy to a fluid reservoir containing a non-Newtonian fluid at sufficient amplitude to effect droplet ejection according to a tone burst pattern. The tone burst pattern may include three discrete tone burst segments, the first tone burst segment having greater duration than the second and third segments, and third segment having greater duration than the second segment. The exact durations and amplitudes of the tone burst segments can be tuned to influence the ejection properties.
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公开(公告)号：CA3117800A1
公开(公告)日：2020-05-07
申请号：CA3117800
申请日：2019-10-29
Applicant: LABCYTE INC
Inventor： DATWANI SAMMY S , RICHE CARSON T , BLAUWKAMP MARSHA N , BLONIGAN JUSTIN
Abstract: Methods of ejecting droplets containing a non-Newtonian fluid by an acoustic droplet ejector can include applying a tone burst of focused acoustic energy to a fluid reservoir containing a non-Newtonian fluid at sufficient amplitude to effect droplet ejection according to a tone burst pattern. The tone burst pattern may include three discrete tone burst segments, the first tone burst segment having greater duration than the second and third segments, and third segment having greater duration than the second segment. The exact durations and amplitudes of the tone burst segments can be tuned to influence the ejection properties.
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Patent Agency Ranking
公开(公告)号：CA3095144A1
公开(公告)日：2019-10-03
申请号：CA3095144
申请日：2019-03-29
Applicant: LABCYTE INC
Inventor： HADIMIOGLU BABUR , DAULTON JAY , ELLSON RICHARD N
Abstract: A fluid impermeable transducer includes an assembly of a transducer head and a casing, and an actuator disposed in the casing rearward of the back of the transducer head and operable to transmit acoustic energy through the transducer head. The transducer head and casing define a working portion of the transducer that is fluid impermeable.
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7.发明申请
公开(公告)号：WO2019173238A1
公开(公告)日：2019-09-12
申请号：PCT/US2019/020596
申请日：2019-03-04
Applicant: LABCYTE, INC.
Inventor： OLECHNO, Joseph D. , ELLSON, Richard N.
Abstract: A method and system are provided for extracting a target analyte from a sample using acoustic ejection technology. The method involves applying focused acoustic energy to a fluid reservoir housing a fluid composition that contains a target analyte and comprises an upper region and a lower region, where the concentration of the target analyte in the upper region differs from that in the lower region. The focused acoustic energy is applied in a manner that is effective to result in the ejection of a fluid droplet from from the fluid composition into a droplet receiver, wherein the concentration of the analyte in the droplet corresponds to either the concentration of the analyte in the upper region or the concentration of the analyte in the lower region, and wherein the concentration of the analyte is substantially uniform throughout the droplet. The fluid composition may comprise an ionic liquid, used in the extraction of ionic target analytes. Related methods and an acoustic extraction system are also provided.
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公开(公告)号：WO2015108807A9
公开(公告)日：2016-06-09
申请号：PCT/US2015010980
申请日：2015-01-12
Applicant: LABCYTE INC
Inventor： MAJLOF LARS , ELLSON RICHARD N
CPC classification number: B01L3/50 , B01L3/54 , B01L3/5453 , B01L2300/021 , G01N2035/00752 , G06K19/06028 , G06K19/06037 , G09F7/165
Abstract: A container may include a tubular sidewall defining interior and exterior surfaces of the container, and including first and second regions disposed relative to one another along a major axis of the tubular sidewall. An identification mark may be embedded within the tubular sidewall at sectors about the tubular sidewall within the first region. Each sector may have a width, and the identification mark is machine readable by a reader viewing any arbitrary one or more of the sectors. Also provided herein is generally tubular container, preferably including a plurality of reservoirs defined therein. The container can be adapted for acoustic ejection of a fluid disposed within at least one of the reservoirs of the plurality of reservoirs. Alternatively, the container can be adapted for extraction of a fluid disposed within at least one of the reservoirs of the plurality of reservoirs using a non-acoustic liquid handling method.
Abstract translation: 容器可以包括限定容器的内部和外部表面的管状侧壁，并且包括沿着管状侧壁的长轴线相对于彼此设置的第一和第二区域。 识别标记可以在管状侧壁内围绕第一区域内的管状侧壁的扇区嵌入。 每个扇区可以具有宽度，并且识别标记由阅读器观看任意一个或多个扇区的机器可读取。 本文还提供了通常为管状容器，优选地包括限定在其中的多个储存器。 容器可以适于声音喷射设置在多个储存器的至少一个储存器中的流体。 或者，容器可以适于使用非声学液体处理方法来提取设置在多个储存器的至少一个储存器内的流体。
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公开(公告)号：DK3207374T3
公开(公告)日：2021-05-25
申请号：DK15850361
申请日：2015-10-19
Applicant: LABCYTE INC
Inventor： ELLSON RICHARD N , STEARNS RICHARD G , OLECHNO JOSEPH D , SINCLAIR IAN , WINGFIELD JONATHAN
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公开(公告)号：CA3127492A1
公开(公告)日：2020-08-06
申请号：CA3127492
申请日：2020-01-31
Applicant: LABCYTE INC
Inventor： ELLSON RICHARD N , STEARNS RICHARD G , HADIMIOGLU BABUR
Abstract: Systems and methods described herein employ focused acoustic energy applied to a reservoir containing a fluid to eject a fluid sample from the fluid sample reservoir, e.g. to an inlet of an analytical device. In many embodiments, the ejected fluid sample traverses an air gap separating the inlet of the analytical device from an upper surface of the fluid in the fluid sample reservoir. In many embodiments, the ejected fluid sample comprises one or more droplets ejected from the fluid sample reservoir, which can contain particles suspended in the fluid sample.
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