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公开(公告)号：AU2016353229B2
公开(公告)日：2021-05-06
申请号：AU2016353229
申请日：2016-11-11
Applicant: MICROOPTX INC
Inventor： MARTIN ROY CHRISTIAN , PULLING CHRISTOPHER CLARK , MARTIN CHRISTOPHER THOMAS , BROWN J DAVID
IPC: A61B3/12 , A61B5/1455 , A61B5/1459
Abstract: A method for monitoring glucose concentration in aqueous humor can include inserting an implantable device into an eye and determining glucose concentration as a function of glucose sensed at the implantable device. The method can optionally include optically detecting glucose concentration as a function of polarimetry and/or fluorescence. A system for monitoring glucose concentration can include devices described herein.
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公开(公告)号：AU2015374033A1
公开(公告)日：2017-07-13
申请号：AU2015374033
申请日：2015-12-30
Applicant: MICROOPTX INC
Inventor： BROWN J DAVID
Abstract: Devices can be implanted in an eye to treat glaucoma. The devices described herein include a body defining a lumen and having first and second ends and external and lumenal surfaces. The body has a length sufficient to provide fluid communication between the anterior chamber and tear film of the eye through the lumen when the device is implanted in the sclera. By the strategic selection of particular materials of construction, and/or by controlling the configuration and size of the lumen, in some embodiments, the device is a filterless construct. In some embodiments, a filter is included. The glaucoma treatment devices as provided herein are designed to prevent bacterial ingress and to provide the required level of outflow resistance to achieve a desired intraocular pressure. Methods of treating glaucoma wherein the device is implanted in the sclera of an afflicted eye are also described.
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公开(公告)号：WO2019118231A1
公开(公告)日：2019-06-20
申请号：PCT/US2018/063796
申请日：2018-12-04
Applicant: MICROOPTX INC.
Inventor： COHEN, Edward Aaron , MARTIN, Roy Christian
IPC: G01N27/327 , A61B5/145 , A61B5/00
Abstract: Monitoring glucose concentration in aqueous humor can include inserting an implantable device into an eye and determining glucose concentration as a function of glucose sensed at the implantable device. In some implantable device embodiments, the device includes a polymer layer comprising a material that changes volume in response to varying glucose concentrations of the aqueous humor. A pressure sensor in the device can detect the changes in volume. In some implantable device embodiments, the device includes electrodes for determining the glucose concentration.
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公开(公告)号：WO2018009556A1
公开(公告)日：2018-01-11
申请号：PCT/US2017/040738
申请日：2017-07-05
Applicant: MICROOPTX INC. , BROWN, J. David , PULLING, Christopher Clark , MARTIN, Roy Christian , COHEN, Edward Aaron
Inventor： BROWN, J. David , PULLING, Christopher Clark , MARTIN, Roy Christian , COHEN, Edward Aaron
Abstract: Devices can be implanted in an eye to treat glaucoma and/or dry eye. The devices described herein include a body defining a lumen and having first and second ends and external and lumenal surfaces. The body has a length sufficient to provide fluid communication between the anterior chamber and tear film of the eye through the lumen when the device is implanted in the sclera. The body can include a radiused distal edge. A distal end portion of the body can be laterally flared. The body can include a mid-body portion that is laterally narrower than distal and proximal end portions of the body. Methods of treating glaucoma and/or dry eye, wherein the device is implanted in the sclera of an afflicted eye, are also described.
Abstract translation: 可将装置植入眼内以治疗青光眼和/或干眼症。 这里描述的装置包括限定内腔并具有第一和第二端以及外部和内腔表面的主体。 当器械植入巩膜时，身体的长度足以提供前房和眼睛泪膜之间的流体连通。 身体可以包括一个圆角的远端边缘。 主体的远端部分可以横向展开。 主体可以包括横向比主体的远端部分和近端部分更窄的中间主体部分。 还描述了治疗青光眼和/或干眼症的方法，其中该装置被植入患病眼睛的巩膜中。
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公开(公告)号：WO2018027009A1
公开(公告)日：2018-02-08
申请号：PCT/US2017/045259
申请日：2017-08-03
Applicant: MICROOPTX INC.
Inventor： PAN, Tingrui , COHEN, Aaron , BAZOR, Ben , YANG, Gaomai
IPC: C08F287/00 , C08F291/00 , C08F265/04 , C08F265/02 , C08F265/00 , C08F293/00 , C08J7/18 , C08J7/12 , C08J7/06 , C08J7/04 , C08J7/16
Abstract: Some polymeric devices, as described herein, can be made of a first layer and a second layer bonded together with one or more microfluidic channels defined internal to the device. The first layer and the second layer may each include a substrate and a polymer bonded to the substrate. The two layers may be bonded through a polymer network that interpenetrates the polymers in the first and second layers. This disclosure also describes methods of bonding together polymeric articles. The methods include diffusing polymerizable monomers and radical forming initiators into the surfaces of one or both of the polymers, putting the surfaces into contact, and initiating polymerization to create a polymer network that interpenetrates the polymers.
Abstract translation: 如本文所述的一些聚合物装置可以由与设备内部限定的一个或多个微流体通道结合在一起的第一层和第二层制成。 第一层和第二层可以各自包括基底和结合到基底的聚合物。 两层可以通过使第一层和第二层中的聚合物相互渗透的聚合物网络结合。 本公开还描述了将聚合物制品粘合在一起的方法。 该方法包括将可聚合单体和形成自由基的引发剂扩散到一种或两种聚合物的表面中，使表面接触，并引发聚合反应以形成贯穿聚合物的聚合物网络。
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Patent Agency Ranking
公开(公告)号：CA3033064A1
公开(公告)日：2018-02-08
申请号：CA3033064
申请日：2017-08-03
Applicant: MICROOPTX INC
Inventor： PAN TINGRUI , COHEN EDWARD AARON , BAZOR BEN , YANG GAOMAI
IPC: C08F287/00 , C08F265/00 , C08F265/02 , C08F265/04 , C08F291/00 , C08F293/00 , C08J7/04 , C08J7/06 , C08J7/12 , C08J7/16 , C08J7/18
Abstract: Some polymeric devices, as described herein, can be made of a first layer and a second layer bonded together with one or more microfluidic channels defined internal to the device. The first layer and the second layer may each include a substrate and a polymer bonded to the substrate. The two layers may be bonded through a polymer network that interpenetrates the polymers in the first and second layers. This disclosure also describes methods of bonding together polymeric articles. The methods include diffusing polymerizable monomers and radical forming initiators into the surfaces of one or both of the polymers, putting the surfaces into contact, and initiating polymerization to create a polymer network that interpenetrates the polymers.
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公开(公告)号：CA3000402A1
公开(公告)日：2017-04-06
申请号：CA3000402
申请日：2016-09-30
Applicant: MICROOPTX INC
Inventor： BROWN J DAVID
Abstract: Devices can be implanted in an eye to treat a dry eye condition. The devices include a body defining a lumen and having first and second ends and external and lumenal surfaces. The body has a length sufficient to provide fluid communication between the anterior chamber and tear film of the eye through the lumen when the device is implanted in the sclera. In some embodiments, the device is filterless. In some embodiments, a filter is included. The dry eye treatment devices provided herein prevent bacterial ingress, provide outflow resistance to retain a normal intraocular pressure, and provide moisture (e.g., aqueous humor) to an otherwise dry eye. Methods of treating a dry eye condition wherein the device is implanted in the sclera of an afflicted eye are also described.
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公开(公告)号：WO2020191318A1
公开(公告)日：2020-09-24
申请号：PCT/US2020/023919
申请日：2020-03-20
Applicant: MICROOPTX INC.
Inventor： COHEN, Edward Aaron , VOCE, Daniel Charles
Abstract: An implantable ocular drug delivery system can include inserting an implantable device into an eye, where the device contains therapeutics intended to be released for local or systemic effects. In some implantable device embodiments, the device includes a microchannel intended to reduce intraocular pressure. In some implantable device embodiments, the device includes a microchannel intended to treat dry eye.
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公开(公告)号：AU2016331925B2
公开(公告)日：2021-04-22
申请号：AU2016331925
申请日：2016-09-30
Applicant: MICROOPTX INC
Inventor： BROWN J DAVID
Abstract: Devices can be implanted in an eye to treat a dry eye condition. The devices include a body defining a lumen and having first and second ends and external and lumenal surfaces. The body has a length sufficient to provide fluid communication between the anterior chamber and tear film of the eye through the lumen when the device is implanted in the sclera. In some embodiments, the device is filterless. In some embodiments, a filter is included. The dry eye treatment devices provided herein prevent bacterial ingress, provide outflow resistance to retain a normal intraocular pressure, and provide moisture (e.g., aqueous humor) to an otherwise dry eye. Methods of treating a dry eye condition wherein the device is implanted in the sclera of an afflicted eye are also described.
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公开(公告)号：AU2017305431A1
公开(公告)日：2019-02-28
申请号：AU2017305431
申请日：2017-08-03
Applicant: MICROOPTX INC
Inventor： PAN TINGRUI , COHEN EDWARD AARON , BAZOR BEN , YANG GAOMAI
IPC: C08F287/00 , C08F265/00 , C08F265/02 , C08F265/04 , C08F291/00 , C08F293/00 , C08J7/04 , C08J7/06 , C08J7/12 , C08J7/16 , C08J7/18
Abstract: Some polymeric devices, as described herein, can be made of a first layer and a second layer bonded together with one or more microfluidic channels defined internal to the device. The first layer and the second layer may each include a substrate and a polymer bonded to the substrate. The two layers may be bonded through a polymer network that interpenetrates the polymers in the first and second layers. This disclosure also describes methods of bonding together polymeric articles. The methods include diffusing polymerizable monomers and radical forming initiators into the surfaces of one or both of the polymers, putting the surfaces into contact, and initiating polymerization to create a polymer network that interpenetrates the polymers.
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