MATERIALS AND METHODS UTILIZING BIOTIN PRODUCING MUTANT HOSTS FOR THE PRODUCTION OF 7-CARBON CHEMICALS
    8.
    发明申请
    MATERIALS AND METHODS UTILIZING BIOTIN PRODUCING MUTANT HOSTS FOR THE PRODUCTION OF 7-CARBON CHEMICALS 审中-公开
    利用生物素生产突变体生产7-碳化合物的材料和方法

    公开(公告)号:WO2018022595A1

    公开(公告)日:2018-02-01

    申请号:PCT/US2017/043682

    申请日:2017-07-25

    Abstract: Disclosed are methods for regulating biosynthesis of at least one of pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine, 7-arninoheiptanol and 1,7-heptanediol (C7 building blocks) using a pathway having a pimeloyl-ACP intermediate, the method including the step of downregulating the activity of BioF. Also disclosed are recombinant hosts by fermentation in which the above methods are performed. Further disclosed are recombinant hosts for producing pimeloyl-ACP, the recombinant host including a deletion of a bioF gene.

    Abstract translation: 公开了用于调节庚二酸,7-氨基庚酸,7-羟基庚酸,七亚甲基二胺,7-氨基海帕醇和1,7-庚二醇(C7结构单元)中的至少一种的生物合成的方法, 该途径具有庚二酰-ACP中间体,该方法包括下调BioF活性的步骤。 还公开了通过发酵进行上述方法的重组宿主。 还公开了用于产生庚二酰基-ACP的重组宿主,该重组宿主包括bioF基因的缺失。

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