公开(公告)号：FR2863458B1

公开(公告)日：2006-06-02

申请号：FR0314768

申请日：2003-12-16

Applicant: TOURNIER PASCAL GERARD

Inventor： TOURNIER PASCAL GERARD

IPC: A43B13/04 ,  A43B7/24 ,  A43B13/12 ,  A43B13/18 ,  A43B13/22 ,  A43B13/24 ,  A43B21/26 ,  B29D35/12 ,  B29D35/14

公开(公告)号：FR2863458A1

公开(公告)日：2005-06-17

申请号：FR0314768

申请日：2003-12-16

Applicant: TOURNIER PASCAL GERARD

Inventor： TOURNIER PASCAL GERARD

IPC: A43B7/24 ,  A43B13/12 ,  A43B13/18 ,  A43B13/22 ,  A43B21/26 ,  B29D35/12 ,  B29D35/14 ,  A43B13/04 ,  A43B13/24 ,  B29D31/515

Abstract: The footwear sole and heel consists of a layer (11) of a flexible material such as a compact or cellular elastomer containing reinforcing elements (8, 15) that are slender in shape, i.e. with crosssections inferior to their length, and extend to a height equivalent to at least half the thickness of the sole. The reinforcing elements, which are made from an optionally reinforced or expanded elastomer material and enlarged at the base (7, 16), are embedded in the flexible material of the sole and are angled at 30 - 150 degrees to its outer surface. They are also shaped to promote deformation by flexion. An independent claim is included for a manufacturing method of the inventive shoe soles comprising attaching the reinforcing material to the sole.

公开(公告)号：FR3026860B1

公开(公告)日：2017-12-08

申请号：FR1459513

申请日：2014-10-03

Applicant: MILON PASCAL GERARD

Inventor： MILON PASCAL GERARD

IPC: G06F1/16

Abstract: La présente invention concerne un dispositif (1) comprenant un premier étui (2) apte à recevoir un support graphique (4), le premier étui (2) comprenant une première fenêtre (5) destinée à permettre l'observation du support graphique (4), et un deuxième étui (3) permettant de recevoir un appareil électronique intégrant un afficheur électronique (6), le deuxième étui comprenant une deuxième fenêtre (7) permettant d'observer tout ou partie de l'afficheur électronique (6), les premier et deuxième étuis (2, 3) étant reliés l'un à l'autre. La première fenêtre (5) permet d'observer le support graphique (4), ce qui permet de personnaliser le dispositif (1).

公开(公告)号：FR2776244B1

公开(公告)日：2000-06-16

申请号：FR9803710

申请日：1998-03-20

Applicant: TOURNIER PASCAL GERARD

Inventor： TOURNIER PASCAL GERARD

IPC: B60K5/12 ,  B62D21/15

公开(公告)号：FR2731202A1

公开(公告)日：1996-09-06

申请号：FR9502671

申请日：1995-03-02

Applicant: PASCAL GERARD

IPC: B64D17/02 ,  B64D17/34

Abstract: The parachute sail double surface wing span is reduced by folding, in flight, one or more cavities onto themselves by a system of halyards (1) and internal pulleys (2). The halyards and pulleys are fastened on the inter-cavity partitions (3) to form a reduction zone and bring closer together these partitions when the halyards are pulled. The halyards are joined in a single cavity partition (4) in order to allow simultaneous pulling and locking by the parachutist. The anchoring point of one partition has an eyelet for fixing the halyard ends which then pass through holes in reduction zone partitions to join on to the pulleys

公开(公告)号：FR3026860A1

公开(公告)日：2016-04-08

申请号：FR1459513

申请日：2014-10-03

Applicant: MILON PASCAL GERARD

Inventor： MILON PASCAL GERARD

IPC: G06F1/16

Abstract: La présente invention concerne un dispositif (1) comprenant un premier étui (2) apte à recevoir un support graphique (4), le premier étui (2) comprenant une première fenêtre (5) destinée à permettre l'observation du support graphique (4), et un deuxième étui (3) permettant de recevoir un appareil électronique intégrant un afficheur électronique (6), le deuxième étui comprenant une deuxième fenêtre (7) permettant d'observer tout ou partie de l'afficheur électronique (6), les premier et deuxième étuis (2, 3) étant reliés l'un à l'autre. La première fenêtre (5) permet d'observer le support graphique (4), ce qui permet de personnaliser le dispositif (1).

公开(公告)号：FR2731202B1

公开(公告)日：1997-06-27

申请号：FR9502671

申请日：1995-03-02

Applicant: PASCAL GERARD

IPC: B64D17/02 ,  B64D17/34

公开(公告)号：FR2776244A1

公开(公告)日：1999-09-24

申请号：FR9803710

申请日：1998-03-20

Applicant: TOURNIER PASCAL GERARD

Inventor： TOURNIER PASCAL GERARD

IPC: B60K5/12 ,  B62D21/15

Abstract: Mounting has rigid struts (14,20,26,30) extending longitudinally from an attachment zone with one point attached to chassis and a spaced longitudinal point attached to the engine, which is lower than the first attachment zone.- DETAILED DESCRIPTION - In event of a front impact, the strut pivots at attachment zones about axis extending transversely from the vehicle where impact is transmitted along strut to guide the engine rearwards and down. One strut attachment zone is non-pivotal prior to the impact and the other has a vibration damper

公开(公告)号：WO2005108949A2

公开(公告)日：2005-11-17

申请号：PCT/EP2005/052186

申请日：2005-05-12

Applicant: GALAPAGOS GENOMICS N.V. ,  LAENEN, Wendy ,  SPITTAELS, Koenraad, Frederik, Florentina ,  HOFFMANN, Marcel ,  MERCHIERS, Pascal, Gerard

Inventor： SPITTAELS, Koenraad, Frederik, Florentina ,  HOFFMANN, Marcel ,  MERCHIERS, Pascal, Gerard

IPC: G01N

CPC classification number: C12Q1/37 ,  A61K48/00 ,  C12Q1/25 ,  C12Q1/485 ,  G01N33/6896 ,  G01N33/74 ,  G01N2333/4709 ,  G01N2333/726 ,  G01N2333/9015 ,  G01N2500/00 ,  G01N2500/02 ,  G01N2500/04 ,  G01N2800/2821

Abstract: A method for identifying compounds that inhibit amyloid-beta precursor protein processing in cells, comprising contacting a test compound with a PROTEASE polypeptide, or fragment thereof, and measuring a compound-PROTEASE property related to the production of amyloid-beta peptide. Cellular assays of the method measure indicators including cleaved protease substrate and/or amyloid beta peptide levels. Therapeutic methods, and pharmaceutical compositions including effective amyloid-beta precursor processing-inhibiting amounts of PROTEASE expression inhibitors, are useful for treating conditions involving cognitive impairment such as Alzheimer's disease.

Abstract translation: 用于鉴定抑制细胞中淀粉样蛋白β前体蛋白加工的化合物的方法，包括使测试化合物与PROTEASE多肽或其片段接触，并测量与淀粉状蛋白-β肽的产生相关的化合物-TETEASE性质。 所述方法的细胞测定测量指标，包括切割的蛋白酶底物和/或淀粉样蛋白β肽水平。 包括有效淀粉样蛋白β前体加工抑制量的PROTEASE表达抑制剂的治疗方法和药物组合物可用于治疗涉及认知障碍的症状如阿尔茨海默病。

公开(公告)号：WO2005103713A2

公开(公告)日：2005-11-03

申请号：PCT/EP2005/004325

申请日：2005-04-20

Applicant: GALAPAGOS GENOMICS N.V. ,  MERCHIERS, Pascal, Gerard ,  SPITTAELS, Koenraad, Frederik, Florentina ,  HOFFMANN, Marcel

Inventor： MERCHIERS, Pascal, Gerard ,  SPITTAELS, Koenraad, Frederik, Florentina ,  HOFFMANN, Marcel

IPC: G01N33/68

CPC classification number: C12Q1/37 ,  G01N33/566 ,  G01N33/6896 ,  G01N2333/4709 ,  G01N2333/726 ,  G01N2500/00 ,  G01N2800/2821

Abstract: A method for identifying compounds that inhibit amyloid-beta precursor protein processing in cells, comprising contacting a test compound with a GPCR polypeptide, or fragment thereof, and measuring a compound-GPCR property related to the production of amyloid-beta peptide. Cellular assays of the method measure indicators including second messenger and/or amyloid beta peptide levels. Therapeutic methods, and pharmaceutical compositions including effective amyloid-beta precursor processing-inhibiting amounts of GPCR expression inhibitors, are useful for treating conditions involving cognitive impairment such as Alzheimers Disease.

Abstract translation: 鉴定抑制细胞中淀粉样-β前体蛋白质加工的化合物的方法，包括将测试化合物与GPCR多肽或其片段接触，并测量与产生下列化合物相关的化合物-GPCR性质： 淀粉状蛋白-β肽。 该方法的细胞分析测量包括第二信使和/或淀粉状蛋白β肽水平的指标。 治疗方法和包括有效抑制淀粉样蛋白β前体加工量的GPCR表达抑制剂的药物组合物可用于治疗涉及认知障碍的病症，例如阿尔茨海默氏病。