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    New applications of amino acid antispasmodics
    2.
    发明专利
    New applications of amino acid antispasmodics 有权

    公开(公告)号：JP4307068B2

    公开(公告)日：2009-08-05

    申请号：JP2002520843

    申请日：2001-08-24

    Applicant: リサーチ コーポレイション テクノロジーズ,インコーポレイテッドResearch Corporation Technologies, Inc.

    Inventor： ロバート エイチ． ハリス、

    IPC: A61K31/16 ,  A61K38/00 ,  A61K31/165 ,  A61K31/195 ,  A61P25/04 ,  A61P25/06 ,  A61P29/00 ,  C07K5/10

    CPC classification number: A61K38/05 ,  A61K31/16 ,  A61K31/165 ,  A61K31/195 ,  A61K31/40 ,  A61K31/44 ,  A61K38/04

    Abstract: The present invention describes the use of a compound of the following formula (I) for the manufacture of a medicament effective in the treatment or prevention of bipolar disease of a mammal: wherein R is hydrogen or lower alkyl, lower alkenyl, lower alkynyl, aryl, aryl lower alkyl, heterocyclic, heterocyclic lower alkyl, lower alkyl heterocyclic, lower cycloalkyl, lower cycloalkyl lower alkyl, each optionally substituted with at least one electron withdrawing or electron donating group; R1  is hydrogen or lower alkyl, lower alkenyl, lower alkynyl, aryl lower alkyl, aryl, heterocyclic lower alkyl, heterocyclic, lower alkyl heterocyclic, lower cycloalkyl, lower cycloalkyl lower alkyl, each optionally substituted with an electron donating or an electron withdrawing group; R2 and R3   are independently hydrogen, lower alkyl, lower alkenyl, lower alkynyl, aryl lower alkyl, aryl, halogen, heterocyclic, heterocyclic lower alkyl, lower alkyl heterocyclic, lower cycloalkyl, lower cycloalkyl lower alkyl, or Z-Y; R2 and R3 are optionally substituted with at least one electron withdrawing or electron donating group; Z is O, S, S(O)a, NR4 or PR4; Y is hydrogen, lower alkyl, aryl, aryl lower alkyl, lower alkenyl, lower alkynyl, heterocyclic, heterocyclic lower alkyl, and Y is optionally substituted with an electron donating or electron withdrawing group, or ZY  taken together is NR4NR5R7, NR4OR5, ONR4R7, OPR4R5, PR4OR5, SNR4R7, NR4SR7, SPR4R5, PR4SR7, NR4PR5R6, PR4NR5R7, NR4C(=O)R5, S(C=O)R5, NR4C(=O)OR5, or S(C=O)OR5, R4, R5 and R6   are independently hydrogen or lower alkyl, aryl, aryl lower alkyl, lower alkenyl, or lower alkynyl, each optionally substituted with an electron withdrawing or an electron donating group; R7  is COOR8, COR8, hydrogen or lower alkyl, aryl, aryl lower alkyl, lower alkenyl or lower alkynyl, each optionally substituted with an electron withdrawing or electron donating group; R8  is hydrogen, lower alkyl or aryl lower alkyl, the aryl or alkyl group is optionally substituted with an electron withdrawing or an electron donating group; n is 1-4; and a is 1-3.

    New applications of amino acid antispasmodics
    4.
    发明专利
    New applications of amino acid antispasmodics 有权

    公开(公告)号：JP2004506692A

    公开(公告)日：2004-03-04

    申请号：JP2002520843

    申请日：2001-08-24

    Applicant: リサーチ コーポレイション テクノロジーズ,インコーポレイテッドResearch Corporation Technologies, Inc.

    Inventor： ハリス、　ロバート　エイチ．

    IPC: A61K38/00 ,  A61K31/16 ,  A61K31/165 ,  A61K31/195 ,  A61P25/04 ,  A61P25/06 ,  A61P29/00 ,  C07K5/10

    CPC classification number: A61K38/05 ,  A61K31/16 ,  A61K31/165 ,  A61K31/195 ,  A61K31/40 ,  A61K31/44 ,  A61K38/04

    Abstract: The present invention describes the use of a compound of the following formula (I) for the manufacture of a medicament effective in the treatment or prevention of bipolar disease of a mammal: wherein R is hydrogen or lower alkyl, lower alkenyl, lower alkynyl, aryl, aryl lower alkyl, heterocyclic, heterocyclic lower alkyl, lower alkyl heterocyclic, lower cycloalkyl, lower cycloalkyl lower alkyl, each optionally substituted with at least one electron withdrawing or electron donating group; R1  is hydrogen or lower alkyl, lower alkenyl, lower alkynyl, aryl lower alkyl, aryl, heterocyclic lower alkyl, heterocyclic, lower alkyl heterocyclic, lower cycloalkyl, lower cycloalkyl lower alkyl, each optionally substituted with an electron donating or an electron withdrawing group; R2 and R3   are independently hydrogen, lower alkyl, lower alkenyl, lower alkynyl, aryl lower alkyl, aryl, halogen, heterocyclic, heterocyclic lower alkyl, lower alkyl heterocyclic, lower cycloalkyl, lower cycloalkyl lower alkyl, or Z-Y; R2 and R3 are optionally substituted with at least one electron withdrawing or electron donating group; Z is O, S, S(O)a, NR4 or PR4; Y is hydrogen, lower alkyl, aryl, aryl lower alkyl, lower alkenyl, lower alkynyl, heterocyclic, heterocyclic lower alkyl, and Y is optionally substituted with an electron donating or electron withdrawing group, or ZY  taken together is NR4NR5R7, NR4OR5, ONR4R7, OPR4R5, PR4OR5, SNR4R7, NR4SR7, SPR4R5, PR4SR7, NR4PR5R6, PR4NR5R7, NR4C(=O)R5, S(C=O)R5, NR4C(=O)OR5, or S(C=O)OR5, R4, R5 and R6   are independently hydrogen or lower alkyl, aryl, aryl lower alkyl, lower alkenyl, or lower alkynyl, each optionally substituted with an electron withdrawing or an electron donating group; R7  is COOR8, COR8, hydrogen or lower alkyl, aryl, aryl lower alkyl, lower alkenyl or lower alkynyl, each optionally substituted with an electron withdrawing or electron donating group; R8  is hydrogen, lower alkyl or aryl lower alkyl, the aryl or alkyl group is optionally substituted with an electron withdrawing or an electron donating group; n is 1-4; and a is 1-3.

    New applications of amino acid antispasmodics
    8.
    发明专利
    New applications of amino acid antispasmodics 有权

    公开(公告)号：JP5190334B2

    公开(公告)日：2013-04-24

    申请号：JP2008304255

    申请日：2008-11-28

    Applicant: リサーチ コーポレイション テクノロジーズ,インコーポレイテッドResearch Corporation Technologies, Inc.

    Inventor： ロバート エイチ． ハリス、

    IPC: A61K31/165 ,  A61K38/00 ,  A61K31/16 ,  A61K31/195 ,  A61P25/04 ,  A61P25/06 ,  A61P29/00 ,  C07K5/10

    CPC classification number: A61K38/05 ,  A61K31/16 ,  A61K31/165 ,  A61K31/195 ,  A61K31/40 ,  A61K31/44 ,  A61K38/04

    Abstract: The present invention describes the use of a compound of the following formula (I) for the manufacture of a medicament effective in the treatment or prevention of bipolar disease of a mammal: wherein R is hydrogen or lower alkyl, lower alkenyl, lower alkynyl, aryl, aryl lower alkyl, heterocyclic, heterocyclic lower alkyl, lower alkyl heterocyclic, lower cycloalkyl, lower cycloalkyl lower alkyl, each optionally substituted with at least one electron withdrawing or electron donating group; R1  is hydrogen or lower alkyl, lower alkenyl, lower alkynyl, aryl lower alkyl, aryl, heterocyclic lower alkyl, heterocyclic, lower alkyl heterocyclic, lower cycloalkyl, lower cycloalkyl lower alkyl, each optionally substituted with an electron donating or an electron withdrawing group; R2 and R3   are independently hydrogen, lower alkyl, lower alkenyl, lower alkynyl, aryl lower alkyl, aryl, halogen, heterocyclic, heterocyclic lower alkyl, lower alkyl heterocyclic, lower cycloalkyl, lower cycloalkyl lower alkyl, or Z-Y; R2 and R3 are optionally substituted with at least one electron withdrawing or electron donating group; Z is O, S, S(O)a, NR4 or PR4; Y is hydrogen, lower alkyl, aryl, aryl lower alkyl, lower alkenyl, lower alkynyl, heterocyclic, heterocyclic lower alkyl, and Y is optionally substituted with an electron donating or electron withdrawing group, or ZY  taken together is NR4NR5R7, NR4OR5, ONR4R7, OPR4R5, PR4OR5, SNR4R7, NR4SR7, SPR4R5, PR4SR7, NR4PR5R6, PR4NR5R7, NR4C(=O)R5, S(C=O)R5, NR4C(=O)OR5, or S(C=O)OR5, R4, R5 and R6   are independently hydrogen or lower alkyl, aryl, aryl lower alkyl, lower alkenyl, or lower alkynyl, each optionally substituted with an electron withdrawing or an electron donating group; R7  is COOR8, COR8, hydrogen or lower alkyl, aryl, aryl lower alkyl, lower alkenyl or lower alkynyl, each optionally substituted with an electron withdrawing or electron donating group; R8  is hydrogen, lower alkyl or aryl lower alkyl, the aryl or alkyl group is optionally substituted with an electron withdrawing or an electron donating group; n is 1-4; and a is 1-3.

    Method of treating endometriosis
    10.
    发明专利
    Method of treating endometriosis 审中-公开
    治疗子宫内膜异位症的方法

    公开(公告)号：JP2004224793A

    公开(公告)日：2004-08-12

    申请号：JP2004008412

    申请日：2004-01-15

    Applicant: Research Corp Technologies Inc ,  リサーチ コーポレイション テクノロジーズ,インコーポレイテッドResearch Corporation Technologies, Inc.

    Inventor： YEAMAN GRANT R

    IPC: A61K9/127 ,  A61K39/00 ,  A61K39/395 ,  A61K47/44 ,  A61P15/08

    Abstract: PROBLEM TO BE SOLVED: To provide a method for detecting endometriosis in a patient, and to improve invasive and expensive surgical procedures. SOLUTION: The method employs immunoassays which detect autoantibodies in a serum sample which react with Thomsen-Friedenreich antigen (Tf). Increased levels of autoantibodies in a serum sample from the patient which bind to Tf-like antigen is indicative of endometriosis in the patient. A method of treating endometriosis in a patient comprises administering to the patient a Tf-like antigen or an antibody that specifically binds a Tf-like antigen. COPYRIGHT: (C)2004,JPO&NCIPI

    Abstract translation: 要解决的问题：提供一种用于检测患者子宫内膜异位症的方法，并改善侵入性和昂贵的手术过程。 解决方案：该方法采用免疫测定法，其检测与Thomsen-Friedenreich抗原（Tf）反应的血清样品中的自身抗体。 结合Tf样抗原的来自患者的血清样品中自身抗体水平的提高表明患者子宫内膜异位症。 治疗患者子宫内膜异位症的方法包括向患者施用特异性结合Tf样抗原的Tf样抗原或抗体。 版权所有（C）2004，JPO＆NCIPI

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