公开(公告)号：CA2515366C

公开(公告)日：2010-04-20

申请号：CA2515366

申请日：2004-02-10

Applicant: ROSALIND FRANKLIN UNIVERSITY O

Inventor： BEAMAN KENNETH

IPC: A61K39/395 ,  A61K20060101 ,  A61K6/00 ,  A61K31/7088 ,  A61K31/7105 ,  A61K31/713 ,  A61K38/17 ,  A61K48/00 ,  A61P29/00 ,  A61P35/00 ,  C07K16/40

Abstract: The present invention is directed to compositions and methods to modulate inflammatory and immune responses in a subject, which includes immune activation and inhibiting inflammatory responses, by modulating the regeneration and tolerance factor (RTF).

公开(公告)号：AU2006203851A1

公开(公告)日：2006-07-13

申请号：AU2006203851

申请日：2006-01-10

Applicant: ROSALIND FRANKLIN UNIVERSITY O

Inventor： PERBAL BERNARD ,  RISER BRUCE L

IPC: A01N37/18

公开(公告)号：CA2515366A1

公开(公告)日：2004-08-26

申请号：CA2515366

申请日：2004-02-10

Applicant: ROSALIND FRANKLIN UNIVERSITY O

Inventor： BEAMAN KENNETH

IPC: A61K20060101 ,  A61K6/00 ,  A61K31/7088 ,  A61K31/7105 ,  A61K31/713 ,  A61K38/17 ,  A61K39/395 ,  A61K48/00 ,  A61P29/00 ,  A61P35/00 ,  C07K16/40

Abstract: The present invention is directed to compositions and methods to modulate inflammatory and immune responses in a subject, which includes immune activation and inhibiting inflammatory responses, by modulating the regeneration and tolerance factor (RTF).

公开(公告)号：CA2597794A1

公开(公告)日：2006-07-13

申请号：CA2597794

申请日：2006-01-10

Applicant: ROSALIND FRANKLIN UNIVERSITY O

Inventor： RISER BRUCE L ,  PERBAL BERNARD

IPC: A01N37/18

公开(公告)号：EP3724335A1

公开(公告)日：2020-10-21

申请号：EP18830581.7

申请日：2018-12-10

Applicant: Rosalind Franklin University of Medicine and Science ,  The McLean Hospital Corporation

Inventor： HASTINGS, Michelle, L. ,  ISACSON, Ole ,  KORECKA-ROET, Joanna, A.

IPC: C12N15/113

公开(公告)号：EP2349454B1

公开(公告)日：2016-09-21

申请号：EP09825478.2

申请日：2009-11-06

Applicant: Rosalind Franklin University of Medicine and Science

Inventor： GAZMURI, Raul J.

IPC: A61K38/18 ,  A61N1/39 ,  A61P9/00

CPC classification number: A61K38/1816 ,  A61N1/39

公开(公告)号：EP2968229A1

公开(公告)日：2016-01-20

申请号：EP14763243.4

申请日：2014-03-14

Applicant: Rosalind Franklin University of Medicine and Science

Inventor： STUTZMANN, Grace, E. ,  DAHL, Russell ,  KAIHO, Christopher, H.

IPC: A61K31/15 ,  A61P25/28

CPC classification number: C07D307/52 ,  A61K31/341 ,  A61K31/4166 ,  A61K31/4427 ,  C07D307/54 ,  C07D405/12 ,  C07D407/12

Abstract: Disclosed herein are methods and compositions comprising compounds capable of normalizing neuronal calcium dyshomeostasis. Also disclosed are methods comprising these compounds for treating neuronal or neurological disorders, including Alzheimer's disease, Parkinson's disease, Huntington's disease, fronto-temporal dementia, Pick's disease, chronic traumatic encepholopathy, traumatic brain injury, stroke, cerebellar ataxia, multiple sclerosis, Down syndrome, and aging-related CNS disorders.

Abstract translation: 本文公开了包含能够使神经元钙异位稳态正常化的化合物的方法和组合物。 还公开了包含这些化合物用于治疗神经元或神经障碍的方法，包括阿尔茨海默氏病，帕金森病，亨廷顿舞蹈病，颞叶性痴呆，皮克病，慢性创伤性脑病，创伤性脑损伤，中风，小脑共济失调，多发性硬化，唐氏综合征 ，以及与老化有关的CNS疾病。

公开(公告)号：EP2126141A4

公开(公告)日：2010-08-11

申请号：EP08726769

申请日：2008-03-13

Applicant: UNIV CLEVELAND HOSPITALS ,  ROSALIND FRANKLIN UNIVERSITY O ,  RIBONOMICS INC

Inventor： GORODESKI GEORGE ,  POTASHKIN JUDITH ,  CHEATHAM BENTLEY

IPC: C12Q1/70 ,  C07H21/04 ,  C12N15/00 ,  C12Q1/68

CPC classification number: C12N15/1138 ,  C12N2310/14 ,  C12N2320/11 ,  C12N2330/10 ,  C12Q1/6809 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/178 ,  C12Q2522/10

公开(公告)号：EP1841316A4

公开(公告)日：2008-07-09

申请号：EP06717966

申请日：2006-01-10

Applicant: ROSALIND FRANKLIN UNIVERSITY O

Inventor： RISER BRUCE L ,  PERBAL BERNARD

IPC: A01N37/18 ,  A61K38/00 ,  A61P13/00 ,  A61P35/00

CPC classification number: C07K14/4702 ,  A61K48/00

Abstract: The present invention discloses a role of CCN3 in diseases associated with the overexpression of CCN2, which include but are not limited to kidney disease, fibrosis, and cancer. The full length CCN3 protein or fragments thereof or isoforms (or combinations) of CCN3 are involved in these diseases. The isolated and purified CCN3 protein or its fragments or isoforms (or combinations) of CCN3 can be potentially used in the treatment or prevention of these diseases by regulating the expression and/or activity of the CCN2 protein. The level of CCN3 in tissue or body fluids can also be used to predict, diagnose and/or follow the progression of diseases as well as to determine the effectiveness of therapeutic intervention.

公开(公告)号：EP3870292A1

公开(公告)日：2021-09-01

申请号：EP19875392.3

申请日：2019-10-25

Applicant: The Research Foundation for The State University of New York ,  Rosalind Franklin University of Medicine and Science ,  Board Of Trustees Of Michigan State University

Inventor： BISHOP, Chrisopher ,  WEST, Anthony ,  MANFREDSSON, Fredric

IPC: A61P25/00 ,  A61P25/14 ,  A61P25/16 ,  A61P1/06 ,  A61K31/506