公开(公告)号：EP2972313B1

公开(公告)日：2018-01-03

申请号：EP14763659.1

申请日：2014-03-14

Applicant: Rinker, Kristina, D. ,  Shepherd, Robert, D.

Inventor： Rinker, Kristina, D. ,  Shepherd, Robert, D.

IPC: G01N33/483 ,  G01N33/487 ,  C12M1/00

CPC classification number: G01N33/5023 ,  B01L3/502 ,  B01L3/5025 ,  B01L2200/025 ,  B01L2200/026 ,  B01L2200/027 ,  B01L2200/0689 ,  B01L2300/044 ,  B01L2300/0609 ,  B01L2300/0627 ,  B01L2300/0822 ,  B01L2300/0829 ,  B01L2300/0877 ,  B01L2400/0487 ,  B01L2400/086 ,  C12M35/04 ,  C12M41/46 ,  C12Q1/6876 ,  C12Q2600/158 ,  G01N33/487 ,  G01N33/5064

Abstract: Flow chambers are provided. In some embodiments, the flow chambers include an inner panel having at least one flow channel having an inlet/outlet opening on each end thereof formed therein, wherein the inlet/outlet openings are adapted to releasably receive a septum; one or more ports adapted to releasably receive a plug and for at least liquid communication with the at least one flow channel, and an outer frame that defines an outer portion of the at least one flow channel and that defines a perimeter of the flow chamber. In some embodiments, the flow chamber has overall dimensions of a standard multiwell plate and the at least one flow channel is located in a position that corresponds to a column location of the standard multiwell plate. Also provided are methods for producing the presently disclosed flow chambers and employing the same to assay biological features of cultured cells and/or tissues.

公开(公告)号：EP2972313A1

公开(公告)日：2016-01-20

申请号：EP14763659.1

申请日：2014-03-14

Applicant: Rinker, Kristina, D. ,  Shepherd, Robert, D.

Inventor： Rinker, Kristina, D. ,  Shepherd, Robert, D.

IPC: G01N33/483 ,  G01N33/487 ,  C12M1/00

CPC classification number: G01N33/5023 ,  B01L3/502 ,  B01L3/5025 ,  B01L2200/025 ,  B01L2200/026 ,  B01L2200/027 ,  B01L2200/0689 ,  B01L2300/044 ,  B01L2300/0609 ,  B01L2300/0627 ,  B01L2300/0822 ,  B01L2300/0829 ,  B01L2300/0877 ,  B01L2400/0487 ,  B01L2400/086 ,  C12M35/04 ,  C12M41/46 ,  C12Q1/6876 ,  C12Q2600/158 ,  G01N33/487 ,  G01N33/5064

Abstract: Flow chambers are provided. In some embodiments, the flow chambers include an inner panel having at least one flow channel having an inlet/outlet opening on each end thereof formed therein, wherein the inlet/outlet openings are adapted to releasably receive a septum; one or more ports adapted to releasably receive a plug and for at least liquid communication with the at least one flow channel, and an outer frame that defines an outer portion of the at least one flow channel and that defines a perimeter of the flow chamber. In some embodiments, the flow chamber has overall dimensions of a standard multiwell plate and the at least one flow channel is located in a position that corresponds to a column location of the standard multiwell plate. Also provided are methods for producing the presently disclosed flow chambers and employing the same to assay biological features of cultured cells and/or tissues.

Abstract translation: 提供流动室。 在一些实施例中，流动室包括具有至少一个流动通道的内部板，每个流动通道在其每个端部上形成有入口/出口开口，其中入口/出口开口适于可释放地接收隔膜; 一个或多个端口，其适于可释放地接收塞子并且用于与所述至少一个流动通道至少液体连通;以及外框架，其限定所述至少一个流动通道的外部部分并限定所述流动室的周边。 在一些实施例中，流动室具有标准多孔板的总体尺寸，并且至少一个流动通道位于对应于标准多孔板的柱位置的位置。 还提供了用于生产当前公开的流动室的方法，并使用其来测定培养的细胞和/或组织的生物学特征。

公开(公告)号：EP2972313A4

公开(公告)日：2016-11-30

申请号：EP14763659

申请日：2014-03-14

Applicant: RINKER KRISTINA D ,  SHEPHERD ROBERT D

Inventor： RINKER KRISTINA D ,  SHEPHERD ROBERT D

IPC: G01N33/483 ,  C12M1/00 ,  G01N33/487

CPC classification number: G01N33/5023 ,  B01L3/502 ,  B01L3/5025 ,  B01L2200/025 ,  B01L2200/026 ,  B01L2200/027 ,  B01L2200/0689 ,  B01L2300/044 ,  B01L2300/0609 ,  B01L2300/0627 ,  B01L2300/0822 ,  B01L2300/0829 ,  B01L2300/0877 ,  B01L2400/0487 ,  B01L2400/086 ,  C12M35/04 ,  C12M41/46 ,  C12Q1/6876 ,  C12Q2600/158 ,  G01N33/487 ,  G01N33/5064

Abstract: Flow chambers are provided. In some embodiments, the flow chambers include an inner panel having at least one flow channel having an inlet/outlet opening on each end thereof formed therein, wherein the inlet/outlet openings are adapted to releasably receive a septum; one or more ports adapted to releasably receive a plug and for at least liquid communication with the at least one flow channel, and an outer frame that defines an outer portion of the at least one flow channel and that defines a perimeter of the flow chamber. In some embodiments, the flow chamber has overall dimensions of a standard multiwell plate and the at least one flow channel is located in a position that corresponds to a column location of the standard multiwell plate. Also provided are methods for producing the presently disclosed flow chambers and employing the same to assay biological features of cultured cells and/or tissues.

公开(公告)号：WO2009134490A1

公开(公告)日：2009-11-05

申请号：PCT/US2009/032829

申请日：2009-02-02

Applicant: BELL HELICOPTER TEXTRON INC. ,  SHEPHERD, Robert, A. ,  SCHLICHTE, David, R. ,  SHEPHERD, Richard, A. ,  GOODMAN, Kendall, E.

Inventor： SHEPHERD, Robert, A. ,  SCHLICHTE, David, R. ,  SHEPHERD, Richard, A. ,  GOODMAN, Kendall, E.

IPC: F41G7/00

CPC classification number: F41G3/22 ,  F41G3/14 ,  G01S3/7803 ,  G01S3/7864

Abstract: A method for measuring an infrared signature of a moving target includes: tracking the moving target with a tracking system along a path from a start position to an end position, measuring infrared radiation data of the moving target along the path, repositioning the tracking system to the start position, retracing the path to measure the infrared radiation data of the background, and determining the infrared signature of the moving target by comparing the infrared radiation data of the moving object with the infrared radiation data of the background without the moving object.

Abstract translation: 用于测量移动目标的红外特征的方法包括：利用跟踪系统沿着从起始位置到终点位置的路径跟踪移动目标，测量沿着路径的移动目标的红外辐射数据，将跟踪系统重新定位到 开始位置，回溯测量背景的红外辐射数据的路径，以及通过将移动物体的红外辐射数据与背景的红外辐射数据进行比较而确定运动目标的红外特征，而不用移动物体。

公开(公告)号：WO2005017272A1

公开(公告)日：2005-02-24

申请号：PCT/GB2004/003131

申请日：2004-07-20

Applicant: STORSACK UK LTD ,  SHEPHERD, Robert, Wallace ,  BLACK, Tony

Inventor： SHEPHERD, Robert, Wallace ,  BLACK, Tony

IPC: E04B2/86

CPC classification number: E02D29/05 ,  E04B1/168

Abstract: The present invention relates to a method for forming keystones using a collapsible framework and a fabric container, the fabric container (3) having means for reversibly attaching the container (3) to the framework (1).

Abstract translation: 本发明涉及一种使用可折叠框架和织物容器形成梯形体的方法，织物容器（3）具有用于将容器（3）可逆地附接到框架（1）的装置。

公开(公告)号：WO2003100364A3

公开(公告)日：2003-12-04

申请号：PCT/US2003/016484

申请日：2003-05-23

Applicant: BELL HELICOPTER TEXTRON INC. ,  RILEY, Bryan, A. ,  SHEPHERD, Robert, A.

Inventor： RILEY, Bryan, A. ,  SHEPHERD, Robert, A.

IPC: B22D11/06

Abstract: A honeycomb structure (Fig. 4) mounted on a back panel (Fig. 5) especially on a vehicle, where the honeycomb structures are filled with an infrared absorbing material (Fig. 2) to reduce the radar and heat signature of a vehicle.

公开(公告)号：WO1994000088A1

公开(公告)日：1994-01-06

申请号：PCT/AU1993000291

申请日：1993-06-17

Applicant: THE UNIVERSITY OF MELBOURNE ,  XU, Shi-Ang ,  XU, Jin ,  CLARK, Graeme, Milbourne ,  SELDON, Henry, Lee ,  NIELSEN, Frank, Jens, Paul ,  SHEPHERD, Robert, Keith

Inventor： THE UNIVERSITY OF MELBOURNE

IPC: A61F11/04

CPC classification number: A61N1/0541

Abstract: An electrode array (10) for intracochlear insertion, having a terminal curved portion (18) and a straight portion (16), the curved portion having between one and two turns. Optionally included are an angled portion (21) and a flange (22) to facilitate insertion.

Abstract translation: 一种用于耳蜗内插入的电极阵列（10），具有端部弯曲部分（18）和直线部分（16），所述弯曲部分具有一到两匝之间。 可选地包括倾斜部分（21）和有助于插入的凸缘（22）。

公开(公告)号：WO2012150042A1

公开(公告)日：2012-11-08

申请号：PCT/EP2012/001926

申请日：2012-05-04

Applicant: CELLZOME AG ,  GLAXO GROUP LIMITED ,  FREEMAN, Jay ,  HARRISON, John ,  KRUSE, Ulrich ,  SHEPHERD, Robert John ,  WILSON, David Matthew ,  WOODROW, Michael David

Inventor： FREEMAN, Jay ,  HARRISON, John ,  KRUSE, Ulrich ,  SHEPHERD, Robert John ,  WILSON, David Matthew ,  WOODROW, Michael David

IPC: C07D295/135 ,  A61K31/198 ,  A61P35/00

CPC classification number: C07D295/135

Abstract: The present invention relates to immobilization compounds, immobilization products and preparations thereof as well as methods and uses for the identification of histone demethylase interacting compounds or for the purification or identification of histone demethylase proteins.

Abstract translation: 本发明涉及固定化合物，固定产物及其制备方法以及用于鉴定组蛋白去甲基化酶相互作用化合物或用于纯化或鉴定组蛋白脱甲基酶蛋白质的方法和用途。

公开(公告)号：WO2012148472A2

公开(公告)日：2012-11-01

申请号：PCT/US2011/061720

申请日：2011-11-21

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE ,  ILIEVSKI, Filip ,  CHEN, Xin ,  MAZZEO, Aaron, D. ,  WHITESIDES, George, M. ,  SHEPHERD, Robert ,  MARTINEZ, Ramses ,  CHOI, Won, Jae ,  KWOK, Sen, W. ,  MORIN, Stephen ,  STOKES, Adam ,  NIE, Zhihong

Inventor： ILIEVSKI, Filip ,  CHEN, Xin ,  MAZZEO, Aaron, D. ,  WHITESIDES, George, M. ,  SHEPHERD, Robert ,  MARTINEZ, Ramses ,  CHOI, Won, Jae ,  KWOK, Sen, W. ,  MORIN, Stephen ,  STOKES, Adam ,  NIE, Zhihong

IPC: F41H3/00

CPC classification number: F15B15/10 ,  B25J9/1075 ,  B25J9/142 ,  B25J11/00 ,  F15B7/06

Abstract: A soft robotic device includes a flexible body having a width, a length and a thickness, wherein the thickness is at least 1 mm, the flexible body having at least one channel disposed within the flexible body, the channel defined by upper, lower and side walls, wherein at least one wall is strain limiting; and a pressurizing inlet in fluid communication with the at least one channel, the at least one channel positioned and arranged such that the wall opposite the strain limiting wall preferentially expands when the soft robotic device is pressurized through the inlet.

Abstract translation: 软机器人装置包括具有宽度，长度和厚度的柔性体，其中所述厚度为至少1mm，所述柔性体具有设置在所述柔性体内的至少一个通道，所述通道由上部，下部和侧面限定 壁，其中至少一个壁是应变限制; 以及与所述至少一个通道流体连通的加压入口，所述至少一个通道定位和布置成使得当所述软自动装置通过所述入口被加压时，与所述应变限制壁相对的壁优先地膨胀。

公开(公告)号：WO2008013728A3

公开(公告)日：2008-01-31

申请号：PCT/US2007/016342

申请日：2007-07-19

Applicant: GED INTEGRATED SOLUTIONS, INC. ,  MCGLINCHY, Timothy, B. ,  SHEPHERD, Robert, R., II ,  BRIESE, William, A.

Inventor： MCGLINCHY, Timothy, B. ,  SHEPHERD, Robert, R., II ,  BRIESE, William, A.

IPC: E06B3/24

Abstract: Method and Apparatus for fabricating a spacer frame for use in an insulating glass unit. A spacer frame separates spaced apart window panes in an insulating glass unit for use in fabricating a window. The spacer includes an elongated frame that is bent into a multi-sided closed form having outwardly facing surfaces for supporting the spaced window panes. An intermediate or bridging body portion of the frame transmits heat between the spaced window panes. Thermal interruptions in this intermediate body portion disrupt heat flow to raise the inside window temperature in winter and lower it in summer. This is referred to as the warm edge value. A thermal insulating film material preferably covers at least a portion of the intermediate body portion and covers the thermal interruptions.