公开(公告)号：JPH10243800A

公开(公告)日：1998-09-14

申请号：JP29017597

申请日：1997-10-22

Applicant: RUBIN JEFFREY S ,  FINCH PAUL W ,  AARONSON STUART A

Inventor： RUBIN JEFFREY S ,  FINCH PAUL W ,  AARONSON STUART A

IPC: A61K39/395 ,  A61K38/00 ,  A61K38/18 ,  A61K38/22 ,  A61P17/02 ,  A61P43/00 ,  C07H21/04 ,  C07K1/16 ,  C07K14/00 ,  C07K14/435 ,  C07K14/47 ,  C07K14/475 ,  C07K14/485 ,  C07K14/50 ,  C07K16/00 ,  C07K16/22 ,  C07K19/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/08 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12N15/18 ,  C12N15/63 ,  C12N15/70 ,  C12N15/79 ,  C12P21/00 ,  C12P21/02 ,  C12Q1/68 ,  C12Q1/6876 ,  C12R1/91 ,  G01N33/48 ,  G01N33/50 ,  G01N33/53

Abstract: PROBLEM TO BE SOLVED: To examine the mitogen activity of a test sample by proliferating a keratin cell to a contacting state, adding the test sample in a serum-free medium and measuring the DNA synthesis stimulation of the keratin cell. SOLUTION: This process is a bioassay for examining the mitogen activity of a test sample on keratin cell. Keratin cell is proliferated to a contacting state, the cultured product of the contacting state is maintained in a medium free from serum, the test sample is added to the keratin cell cultured to the contacting state and the DNA synthesis stimulation of the keratin cell is determined in the presence or absence of an antiserum neutralizing a keratin cell growth factor(KGF) to determine the mitogen activity of the test sample on the keratin cell.

公开(公告)号：JP2006149407A

公开(公告)日：2006-06-15

申请号：JP2006060217

申请日：2006-03-06

Applicant: Stuart A Aaronson ,  Paul W Finch ,  Jeffrey S Rubin ,  ジェフェリー・エス・ルビン ,  スチュアート・エー・アーロンソン ,  ポール・ダブリュ・フィンチ

Inventor： RUBIN JEFFREY S ,  FINCH PAUL W ,  AARONSON STUART A

IPC: A61K39/395 ,  C12N15/09 ,  A61K38/00 ,  A61K38/18 ,  A61K38/22 ,  A61P17/00 ,  A61P17/02 ,  A61P43/00 ,  C07H21/04 ,  C07K1/16 ,  C07K14/00 ,  C07K14/435 ,  C07K14/47 ,  C07K14/475 ,  C07K14/485 ,  C07K14/50 ,  C07K16/00 ,  C07K16/22 ,  C07K19/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/08 ,  C12N5/10 ,  C12N15/12 ,  C12N15/18 ,  C12N15/63 ,  C12N15/70 ,  C12N15/79 ,  C12P21/00 ,  C12P21/02 ,  C12Q1/68 ,  C12R1/91 ,  G01N33/48 ,  G01N33/50 ,  G01N33/53

CPC classification number: C12Q1/6876 ,  A61K38/00 ,  C07K14/50 ,  C07K14/501 ,  C07K16/22 ,  C07K2317/73 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/75 ,  C12N15/70 ,  C12N15/79 ,  C12Q2600/158

Abstract: PROBLEM TO BE SOLVED: To provide a chimeric molecule comprising an amino acid sequence of KGF (keratin cell growth factor) and an amino acid sequence of at least one other member of FGF (fibroblast growth factor) peptide family. SOLUTION: A chimeric protein comprises following (1) and (2): (1) an amino acid sequence having selective mitogenic activity on epithelial cells and consisting of (a) an amino acid sequence represented by amino acid No. 32 to 64 and No. 157 to 161 in the following amino acid sequence or (b) an amino acid sequence represented by amino acid No. 32 to 64 in the following amino acid sequence and which is different in deletion of one or more amino acids contiguous from N-terminus; MHKWILTWILPTLLYRSCFHIICLVGTISLACNDMTPEQMATNVNCSSPERHTRSYDYMEGGDIRVRRLFCRTQWYLRIDKRGKVKGTQEMKNNYNIMEIRTVAVGIVAIKGVESEFYLAMNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHNGGEMFVALNQKGIPVRGKKTKKEQKTAHFLPMAIT; and (2) at least one slice of the member of fibroblast growth factor family. COPYRIGHT: (C)2006,JPO&NCIPI

Abstract translation: 待解决的问题：提供包含KGF（角蛋白细胞生长因子）的氨基酸序列和FGF（成纤维细胞生长因子）肽家族的至少一种其他成员的氨基酸序列的嵌合分子。 解决方案：嵌合蛋白包括以下（1）和（2）：（1）在上皮细胞上具有选择性促有丝分裂活性的氨基酸序列，由（a）氨基酸序列号32〜 64和157至161的氨基酸序列，或（b）下述氨基酸序列中的氨基酸32-64表示的氨基酸序列，并且与一个或多个与 N-末端; MHKWILTWILPTLLYRSCFHIICLVGTISLACNDMTPEQMATNVNCSSPERHTRSYDYMEGGDIRVRRLFCRTQWYLRIDKRGKVKGTQEMKNNYNIMEIRTVAVGIVAIKGVESEFYLAMNKEGKLYAKKECNEDCNFKELILENHYNTYASAKWTHNGGEMFVALNQKGIPVRGKKTKKEQKTAHFLPMAIT; 和（2）至少一片成纤维细胞生长因子家族成员。 版权所有（C）2006，JPO＆NCIPI

公开(公告)号：JP2001157594A

公开(公告)日：2001-06-12

申请号：JP2000311208

申请日：2000-10-11

Applicant: RUBIN JEFFREY S ,  FINCH PAUL W ,  AARONSON STUART A

Inventor： RUBIN JEFFREY S ,  FINCH PAUL W ,  AARONSON STUART A

IPC: A61K39/395 ,  A61K38/00 ,  A61K38/18 ,  A61K38/22 ,  A61P17/02 ,  A61P43/00 ,  C07H21/04 ,  C07K1/16 ,  C07K14/00 ,  C07K14/435 ,  C07K14/47 ,  C07K14/475 ,  C07K14/485 ,  C07K14/50 ,  C07K16/00 ,  C07K16/22 ,  C07K19/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/08 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12N15/18 ,  C12N15/63 ,  C12N15/70 ,  C12N15/79 ,  C12P21/00 ,  C12P21/02 ,  C12Q1/68 ,  C12Q1/6876 ,  C12R1/91 ,  G01N33/48 ,  G01N33/50 ,  G01N33/53

Abstract: PROBLEM TO BE SOLVED: To provide a method for testing the mitogenic activity a test sample a keratin cell. SOLUTION: This method is a bioassary for testing the mitogenic activity of the test sample on the keratin cell and comprises (i) a process for cultivating the keratin cell to increase it to a meticulous state and maintaining the cultured cell in the meticulous state in a culture medium free from serum, (ii) a process for adding the test sample into the meticulous cultured cell of the keratin cell and (iii) a process for measuring DNA synthetic stimulation on the keratin cell.

公开(公告)号：JP2000102396A

公开(公告)日：2000-04-11

申请号：JP28551799

申请日：1999-10-06

Applicant: RUBIN JEFFREY S ,  FINCH PAUL W ,  AARONSON STUART A

Inventor： RUBIN JEFFREY S ,  FINCH PAUL W ,  AARONSON STUART A

IPC: A61K39/395 ,  A61K38/00 ,  A61K38/18 ,  A61K38/22 ,  A61P17/02 ,  A61P43/00 ,  C07H21/04 ,  C07K1/16 ,  C07K14/00 ,  C07K14/435 ,  C07K14/47 ,  C07K14/475 ,  C07K14/485 ,  C07K14/50 ,  C07K16/00 ,  C07K16/22 ,  C07K19/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/08 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12N15/18 ,  C12N15/63 ,  C12N15/70 ,  C12N15/79 ,  C12P21/00 ,  C12P21/02 ,  C12Q1/68 ,  C12Q1/6876 ,  C12R1/91 ,  G01N33/48 ,  G01N33/50 ,  G01N33/53

Abstract: PROBLEM TO BE SOLVED: To obtain a new keratin cell growth factor protein having N-terminal region and C terminal region in number to cause selective mitogen activity on epithelium-derived cell, useful for examining the mitogen activity of test sample on keratin cell, etc. SOLUTION: This isolated glycosylated or nonglycosylated keratin cell growth factor(KGF) protein is a new KGF protein having N-terminal region containing amino acid 32-64 and C-terminal region containing amino acid 65-156 and 161-189 in number enough to cause selective mitogen activity on an epithelium-derived cell bonded to the protein and is useful for a method for examining mitogen activity of a test sample on a keratin cell. The KGF protein is obtained by constructing a cDNA library by using an RNA extracted from a human fetal pulmonary fibroblast system, screening the library by using a DNA encoding a KGF amino acid sequence as a probe and expressing an obtained gene in an expression system.

公开(公告)号：EP2057598A4

公开(公告)日：2011-09-07

申请号：EP07814577

申请日：2007-08-30

Applicant: LUTNICK HOWARD ,  HERSCH STUART A ,  ROSE LAURENCE

Inventor： LUTNICK HOWARD ,  HERSCH STUART A ,  ROSE LAURENCE

IPC: G06Q30/00

CPC classification number: G06Q30/06 ,  G06Q40/06 ,  G06Q40/08

公开(公告)号：EP0695368A1

公开(公告)日：1996-02-07

申请号：EP94916542.0

申请日：1994-04-19

Applicant: KAUFFMAN, Stuart A.

Inventor： KAUFFMAN, Stuart A., Suite A ,  REBEK, Julius Jr., Apartment 5-3A

IPC: C07B61 ,  C07K1 ,  C12N9 ,  C12N15 ,  C12P1 ,  C12P19 ,  C12P21 ,  C12Q1

CPC classification number: C12N15/1093 ,  C07K1/047 ,  C12N9/0002 ,  C12P1/00 ,  C12P19/34 ,  C12Q1/6811 ,  C40B40/10 ,  C40B50/06

Abstract: Methods for the generation of new compounds are disclosed. The present invention eliminates the need to know in advance the structure or chemical composition of a compound having a desired property. The disclosure of the present invention provides that diversity of unknown compounds may be produced by 'random' chemistry, and such a diversity of unknown compounds may be screened for one or more desired properties to detect the presence of suitable compounds. In one aspect, a starting group of organic compounds is caused to undergo a series of chemical reactions to create a diversity of new organic compounds that are screened for the presence of organic compounds having the desired property. In another aspect of the present invention, a diversity of compounds is generated from a group of substrates which are subjected to a group of enzymes representing a diversity of catalytic activities.

公开(公告)号：EP0338020A4

公开(公告)日：1991-03-13

申请号：EP88900758

申请日：1987-12-23

Applicant: LARSEN, STUART A. ,  CHRISTENSEN, CHARLES S. JR.

Inventor： LARSEN, STUART A.

IPC: B60P3/08 ,  B65D85/68 ,  B65D88/12 ,  B65D90/00 ,  B60P3/07

CPC classification number: B65D88/546 ,  B60P3/08 ,  B65D88/121 ,  B65D2585/6867 ,  B65G2201/0294

Abstract: Method and apparatus to enhance intermodal containers (10) for transport of vehicles wherein multiple longitudinal rails (14) on container walls support movable and removable transverse cargo pallets (16) having foot members (18) which are articulatably connected to the pallets. Cargo, preferably an automobile fixed to front and rear pallets, is loaded by inserting each pallet's feet onto appropriate rail(s) at door opening, then sliding to stowage spot, the rail selection determining height and tilt. Stowage of any mix of automobiles in intermodal containers is optimized by double-decking, half-decking, double half-decking, mirror-imaging, and envelope intervention. On back haul, pallets serve other cargo as restraints, hangers, pallets, or dunnage deck supports, or they are stowed out of the way. Method and apparatus permit automated load planning and container stuffing and make containerized shipment of large volumes of automobiles cost competitive with current methods.

公开(公告)号：EP2057598A2

公开(公告)日：2009-05-13

申请号：EP07814577.8

申请日：2007-08-30

Applicant: LUTNICK, Howard ,  Hersch, Stuart A. ,  Rose, Laurence

Inventor： LUTNICK, Howard ,  Hersch, Stuart A. ,  Rose, Laurence

IPC: G06Q40/00

CPC classification number: G06Q30/06 ,  G06Q40/06 ,  G06Q40/08

Abstract: A method comprising receiving at least one document that is associated with a life insurance policy; assigning a respective value to each of the at least one document, in which the value indicates a level of importance; determining a summation of the at least one document; determining an indication for the life insurance policy, in which the indication is based on the summation of the at least one document and at least one of the values; and displaying the indication.

公开(公告)号：EP0590689B2

公开(公告)日：2006-08-16

申请号：EP93116225.9

申请日：1985-06-17

Applicant: KAUFFMAN, Stuart A.

Inventor： Ballivet, Marc ,  Kauffman, Stuart A.

IPC: C12N15/11 ,  C12P21/00 ,  C07K2/00 ,  G01N33/48 ,  A61K38/02 ,  A61K39/00 ,  A61K39/29

CPC classification number: C12N15/1093 ,  A61K39/00 ,  C07K14/005 ,  C07K14/485 ,  C07K2319/00 ,  C12N9/2471 ,  C12N15/10 ,  C12N15/1034 ,  C12N15/1048 ,  C12N15/64 ,  C12N15/66 ,  C12N15/68 ,  C12N15/70 ,  C12N2730/10122 ,  C12Y302/01023

公开(公告)号：EP0964802B1

公开(公告)日：2003-07-02

申请号：EP98906780.6

申请日：1998-03-06

Applicant: Busse, Stuart A.

Inventor： Busse, Stuart A.

IPC: B60R19/00 ,  B60R19/42

CPC classification number: B60B7/00 ,  B60B30/00 ,  B60R1/00 ,  B60R19/00 ,  B60R19/42 ,  B60R21/34

Abstract: The present invention provides a restraining system (2) for an axle mounted wheel (4) of a vehicle, the vehicle having a frame (14) to which the axle (7) is secured, leaving sufficient clearance to avoid road hazards and not interfere with the wheels (4) motion during normal operation of the vehicle. The system (2) comprises a cage (10) assembly secured to the frame (14) in the vicinity of the vehicle so as to leave a lower part of the wheel (4) exposed, allowing the wheel (4) to contact the road and to retain the wheel (4) in close proximity to its original installation point and entrap the wheel (4) and carry it along with the vehicle should it become detached from the axle (7).