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    Identification of novel broadly cross-reactive neutralizing human monoclonal antibodies using sequential antigen panning of phage display libraries
    8.
    发明专利
    Identification of novel broadly cross-reactive neutralizing human monoclonal antibodies using sequential antigen panning of phage display libraries 未知

    公开(公告)号：AU2009200792B2

    公开(公告)日：2011-11-10

    申请号：AU2009200792

    申请日：2009-02-27

    Applicant: THE GOVERNMENT OF THE UNITED STATES OF AMERICA REPRESENTED BY THE SECRETARY

    Inventor： DIMITROV DIMITER S ,  MEI-YUN ZHANG

    IPC: C07K16/00 ,  C07K16/10 ,  C12N15/10

    Abstract: The present invention provides a method of identifying novel broadly crossreactive neutralizing monoclonal anti-bodies using sequential antigen panning of phage display libraries, antibodies obtained in accordance with such a method, as well as fusion proteins and conjugates comprising same, and related isolated or purified nucleic acid molecules, vectors, host cells, compositions, and methods of use to inhibit an infection, reduce the severity of an infection, treat an infection, treat an infection, and inhibit cancer. Flow chart of sequential antigen panning (m12 and m14) pComb3H phage Preabsorption on pre-washed M-280 streptavidin beads Depletion with sCD4 1" round of panning (rp) against 50 nM biotinylated gpl40sg. 6-sCD4 1" round panned library Preabsorption on pre-washed M-280 streptavidin beads Depletion with sCD4 2 nd rp against 10 nM biotinylated gpl4089.6-sCD4 complexes 2 "d round panned library Preabsorption on pre-washed M-280 streptavidin beads 3 rd rp against 2 nM biotinylated gpl40sg.6-sCD4 complexes 3rd round panned library 4, rp against 2 nM biotinylated gpl40WHXB2-SCD4 complexes 4h round panned library screen individual clones from 4*, 5* and 6"1 round panned libraries by phage ELISA using gpl20/l4089.6/HBx2 and gpl20 Ma and their complexes with sCD4 as antigens selection of clones with highest binding activity to all antigens

    In situ assembly of protein microarrays
    9.
    发明专利
    In situ assembly of protein microarrays 未知

    公开(公告)号：AU2006304659B2

    公开(公告)日：2011-09-22

    申请号：AU2006304659

    申请日：2006-10-18

    Applicant: GOVERNMENT OF THE UNITED STATES OF AMERICA REPRESENTED BY THE SECRETARY

    Inventor： CHATTERJEE DEB K ,  CASSIO BAPTISTA ,  HARTLEY JAMES L ,  MUNROE DAVID J ,  KALAVATHY SITARAMAN

    IPC: C12Q1/68 ,  G01N33/543

    Abstract: The invention provides a microarray and methods for producing a protein microarray. The array comprises multiple nucleic acid molecules immobilized on a substrate, each comprising (i) a protein-binding domain and (ii) a nucleic acid sequence encoding a fusion protein comprising a polypeptide of interest and a DNA-binding protein that binds the protein-binding domain, and one or more fusion proteins produced from the multiple nucleic acid molecules. Each fusion protein is immobilized on the substrate via binding to a nucleic acid sequence comprising the protein-binding domain present on the nucleic acid molecule from which the fusion protein is produced or on the substrate. The invention also provides a method of analyzing protein interactions with, for example, other proteins, lipids and drugs.

    Nandrolone 17beta-carbonates
    10.
    发明专利
    Nandrolone 17beta-carbonates 未知

    公开(公告)号：AU2006211907B2

    公开(公告)日：2011-09-08

    申请号：AU2006211907

    申请日：2006-01-24

    Applicant: GOVERNMENT OF THE UNITED STATES OF AMERICA REPRESENTED BY THE SECRETARY

    Inventor： KIM HYUN K ,  BLYE RICHARD P

    IPC: C07J1/00 ,  A61K31/565 ,  A61P5/26 ,  A61P5/28

    Abstract: Disclosed are compounds of the formula (I) wherein R is C-C alkyl, which may be optionally further substituted with one or more C-C cycloalkyl groups, or a C-C cycloalkyl, which may be optionally substituted with one or more C-C alkyl groups, R’ is hydrogen or lower alkyl, R” is a C-C alkyl or halo, and the bond between C14 and C15 can be a single bond or double bond. Also disclosed are pharmaceutical compositions comprising such compounds and methods of use thereof. These compounds can find use in treating a number of diseases or conditions such as hypogonadism, hypergonadism, osteoporosis, and anemia, in providing hormonal therapy and contraception, as an anabolic agent, and in suppressing the release of hormones such as the luteinizing hormone.

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