Abstract:
PROBLEM TO BE SOLVED: To provide a method and apparatus for substantially eliminating destructive transients of the pressure or flow rate which can degrade the efficiency and useful lifetime of chromatography columns.SOLUTION: A rotary shear seal injection valve comprises: a stator having a plurality of stator ports, at least one of which is in fluid communication with a pump; and a rotor which is in rotatable contact with the stator and has a plurality of channels connecting fluidically at least two of the stator ports, at least one of the channels having sufficient length to maintain a continuous path of flow from the pump to a column during valve transition.
Abstract:
PROBLEM TO BE SOLVED: To provide a switching device for high pressure fluids that can switch the high pressure fluids without deteriorating sealing performance of a turn switch surface of the fluids.SOLUTION: A flow through isolation valve 100 includes: a stationary member; a movable member 50, with a surface of the stationary member interfacing with a surface of the movable member 50; and at least one of the pin isolation valve 56, 78. The pin isolation valves 56, 78 have flow through internal conduits 58, 82, which is movable so that the internal conduits 58, 82 can fluidically communicate with at least one blank opening 88 in the movable member and with a flow through internal conduit 40 in the movable member 50. Movement is based on by rotation, linear or curvilinear translation. At least one of the pin isolation valves is fluidically coupled typically to a sample loop 20 of a face seal valve, or to a pump supplying high pressure liquid to or to a column discharging the liquid from a face seal valve of a high pressure liquid chromatography (HPLC) system or directly to the face seal valve.
Abstract:
PROBLEM TO BE SOLVED: To form a light-guiding member in a flow cell body as well as the flow cell body itself. SOLUTION: The flow cell body 20 of the flow cell includes: the light-guiding member 28 extending between two ends; and two ends interface 40 disposed near the two respective ends. The light-guiding member 28 defines a through-hole 30 that receives fluids. Each of the end interfaces 40 includes an interface housing 42 having an optical transmission member (optical fiber) and a fluid conduction member (capillary). The two end interfaces 40 are fastened by two end clamp fastening members 12 at the two ends of the flow cell body 20. Each of the end interfaces 40 fits together each end. The fluid conduction member is fluidly connected with the through-hole 30. The optical transmission member is optically connected with the through-hole 30. COPYRIGHT: (C)2011,JPO&INPIT
Abstract:
PROBLEM TO BE SOLVED: To provide a porous hybrid inorganic/organic material including an order region, to provide a method for manufacturing the material, and to provide use of the material for chromatography.SOLUTION: The porous hybrid inorganic/organic material includes the order region and has a hole shape improved in chromatography. The porous hybrid inorganic/organic material includes an inorganic structure in which organic functionality is integrated with both of an inner structure or a bone inorganic structure and a hybrid material surface, the order region indicates a diffraction peak in a scan range of 0.8 to 20° measured by X-ray powder diffraction (XRPD) and is a region shown in the porous inorganic/organic hybrid material, a hole whose diameter is less than 34Å contributes to less than 110 m2/g of a specific surface area of the material, and a maximum diffraction peak observed in the material indicates a 2θ position on which a diffraction peak obtained by an atom range order by an amorphous material is excluded.
Abstract:
PROBLEM TO BE SOLVED: To provide a nano-composite monolith material whose resistance to contraction is improved and which has new physical characteristics, and a chromatography column which contains the material.SOLUTION: There are described new materials for chromatography separation, a preparation method of them, especially, a hybrid inorganic/organic monolith material which includes a scaffolding functionality capable of chemically interacting with the surface of a second material and a polymerized scaffolding nano-composite (PSN). In the hybrid inorganic/organic material, adhesiveness with a wall is improved and the resistance to contraction is improved in comparison with a monolith material of a conventional technology. By improvement of the adhesiveness of a monolith, a capillary column with an inner diameter (I.D.)≥50 μm can be manufactured.
Abstract:
PROBLEM TO BE SOLVED: To couple a first fluid conduit to one or more other fluid conduits, or an element such as an electrode or a heating element. SOLUTION: A method includes a positioning step, in which the first fluid conduit 14 is substantially brought into contact with the other fluid conduit or the element 12 and positioned, and a coupling area 16 is formed. The coupling area is damped by liquefied thermoplastic polymer 34, the thermoplastic polymer is cooled thereafter, and substantial fluid-tight coupling is formed between the first fluid conduit 14 and the other fluid conduit or the element 14. COPYRIGHT: (C)2011,JPO&INPIT
Abstract:
PROBLEM TO BE SOLVED: To provide a pump that can generate sufficient pressure and that creates substantially constant flow rate in a range sufficient for ultra-high pressure liquid chromatography. SOLUTION: The hydraulic amplifier system 1 includes a primary piston chamber 20 in which a primary piston 22 is disposed and a secondary piston chamber 30 in which a secondary piston 26 is disposed. The cross-sectional area of the primary piston 22 is larger than the cross-sectional area of the secondary piston 26. The difference in the cross-sectional areas of the pistons 22 and 26 creates an amplification of the pressure in the primary piston chamber 20 and a reduction in flow rate. COPYRIGHT: (C)2009,JPO&INPIT
Abstract:
PROBLEM TO BE SOLVED: To provide novel materials for chromatographic separations, processes for their preparation, and separation devices containing the chromatographic materials, in particular, hybrid inorganic/organic monolith materials comprising a polymerized scaffolding nanocomposite (PSN), in which the nanocomposite contains a scaffolding functionality capable of chemically interacting with a surface of a second material.SOLUTION: The hybrid inorganic/organic materials, prepared according to the outline shown in the figure 1, have enhanced wall adhesion and increased resistance to shrinkage as compared to prior art monolith materials. The improved adhesion of the monoliths enables the preparation of capillary columns with an internal diameter (I.D.)≥50 μm.