HSP60, HSP60 PEPTIDES AND T CELL VACCINES FOR IMMUNOMODULATION
    1.
    发明申请
    HSP60, HSP60 PEPTIDES AND T CELL VACCINES FOR IMMUNOMODULATION 审中-公开
    HSP60,HSP60肽和T细胞疫苗用于免疫调节

    公开(公告)号:US20140219979A1

    公开(公告)日:2014-08-07

    申请号:US14221887

    申请日:2014-03-21

    Abstract: The present invention provides novel uses for peptide p277—positions 437-460 of human heat shock protein 60 (HSP60)—in modulation of immune responses and inflammatory diseases. The invention further provides novel uses for HSP60 and p277 in the treatment or prevention of hepatic disorders. The invention discloses methods for treating, preventing or ameliorating the symptoms of T cell mediated inflammatory and autoimmune disorders, including hepatic disorders, which comprise administering to a subject in need thereof a composition comprising as an active ingredient an effective quantity of a molecule selected from: HSP60, p277, fragments, analogs, homologs and derivatives thereof, and nucleic acids encoding same. Also disclosed are T cell vaccination methods for treating or preventing T cell mediated disorders.

    Abstract translation: 本发明提供了人类热休克蛋白60(HSP60)的肽p277-位置437-460在调节免疫应答和炎性疾病方面的新用途。 本发明进一步提供HSP60和p277在治疗或预防肝病中的新用途。 本发明公开了治疗,预防或改善T细胞介导的炎症和自身免疫性疾病(包括肝脏疾病)的症状的方法,其包括向有需要的受试者施用包含有效量的选自以下的分子的组合物: HSP60,p277,其片段,类似物,同源物及其衍生物,以及编码其的核酸。 还公开了用于治疗或预防T细胞介导的病症的T细胞疫苗接种方法。

    Optical method for detecting alzheimer disease
    3.
    发明专利
    Optical method for detecting alzheimer disease 有权
    用于检测阿尔茨海默病的光学方法

    公开(公告)号:JP2014122245A

    公开(公告)日:2014-07-03

    申请号:JP2014071034

    申请日:2014-03-31

    CPC classification number: A61K49/0021 A61K49/006

    Abstract: PROBLEM TO BE SOLVED: To provide an optical method for detecting Alzheimer disease.SOLUTION: The main subject of the present invention relates to a non-invasive optical imaging method for monitoring an initial pathological event (e.g., generation of amyloid plaque, the amount and position thereof) specific to Alzheimer disease (AD). The capability of monitoring such an event provides a basis for AD diagnosis, prognosis prediction and potential therapy evaluation, above all. Further, the main subject of the present invention is to introduce a new method for treating AD and a retinal disease related with AD. Aβ plaque detection is extremely limited particularly in terms of high resolution. Therefore, the present invention is based on a study focusing on an eye, as alternative means of a tissue from the brain, which can be directly, repeatedly and non-invasively imaged.

    Abstract translation: 要解决的问题:提供用于检测阿尔茨海默病的光学方法。解决方案:本发明的主要课题涉及用于监测初始病理事件的非侵入性光学成像方法(例如,淀粉样斑块的产生,量和 位置),其特异于阿尔茨海默病(AD)。 首先,监测这种事件的能力为AD诊断,预后预测和潜在治疗评估提供了依据。 此外,本发明的主要目的是引入一种治疗AD和与AD相关的视网膜疾病的新方法。 A&BGR; 特别是在高分辨率方面,斑块检测非常有限。 因此,本发明基于着眼于眼睛的研究,作为可以直接,重复和非侵入性成像的来自脑的组织的替代手段。

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