Abstract:
A process for the preparation of 5−methyl−1−phenyl−2(1H) −pyridinone of the general formula (2) useful as an original drug, which can dispense with special reagents and apparatuses and by which the objective compound can be obtained in decreased steps by easy operation. That is, a process for the preparation of 5−methyl−1−phenyl−2(1H)−pyridinone represented by the general formula (2), characterized by reacting 5−methyl −2(1H)−pyridinone represented by the general formula (1) with bromobenzene or chlorobenzene in the presence of both at least one copper catalyst selected from among cuprous catalysts and cupric catalysts and a base.
Abstract:
Processes for producing a (4E)-5-chloro-2-isopropyl-4-pentenoic ester and an optically active isomer thereof which are useful as intermediates for medicines and agricultural chemicals. One of the processes, which is for producing a (4E)-5-chloro-2-isopropyl-4-pentenoic ester represented by the following formula (4), is characterized by reacting a compound represented by the following formula (2) with a base (II) in the presence of an aprotic solvent (II) and subsequently with (1E)-1,3-dichloro-1-propene to obtain a compound represented by the following formula (3) and then eliminating the alkoxycarbonyl group from one of the ester groups of the compound represented by the following formula (3). The other process, which is for producing an (S)-(4E)-5-chloro-2-isopropyl-4-pentenoic ester represented by the following formula (5), is characterized by optically resolving the (4E)-5-chloro-2-isopropyl-4-pentenoic ester represented by the formula (4), which is obtained by that production process. (In the formulae, R represents lower alkyl or aralkyl.)
Abstract:
Disclosed are a novel fluoroadamantane derivative, a novel polymerizable fluoroadamantane derivative, a novel fluorine-containing polymer and a production method. Specifically disclosed are a compound (3) shown below, a compound (4) shown below, a polymer obtained by polymerizing the compound (4), and a method for producing the same. In this connection, Qs respectively represent -CHF- or -CF 2 - (six Qs may be the same as or different from one another); Zs respectively represent -H, -F, or -CH 2 OH (three Zs may be the same as or different from one another); W represents -H or a hydrocarbon group having 1-10 carbon atoms; R represents -H, -F, -CH 3 or -CF 3 ; and Js respectively represent -H, -F, -CHWOH or -CHWOCOCR=CH 2 (three Js may be the same as or different from one another).