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1.发明申请
公开(公告)号：WO2011149492A1
公开(公告)日：2011-12-01
申请号：PCT/US2010/057587
申请日：2010-11-22
Applicant: ABBOTT LABORATORIES , BRUNCKO, Milan , DING, Hong , DOHERTY, George , ELMORE, Steven , HASVOLD, Lisa , HEXAMER, Laura , KUNZER, Aaron R. , SONG, Xiaohong , SOUERS, Andrew, J. , SULLIVAN, Gerard , TAO, Zhi-Fu , WANG, Gary, T. , WANG, Le , WANG, Xilu , WENDT, Michael , MANTEI, Robert , HANSEN, Todd, M.
Inventor： BRUNCKO, Milan , DING, Hong , DOHERTY, George , ELMORE, Steven , HASVOLD, Lisa , HEXAMER, Laura , KUNZER, Aaron R. , SONG, Xiaohong , SOUERS, Andrew, J. , SULLIVAN, Gerard , TAO, Zhi-Fu , WANG, Gary, T. , WANG, Le , WANG, Xilu , WENDT, Michael , MANTEI, Robert , HANSEN, Todd, M.
IPC: C07D471/04 , A61K31/437 , A61K35/00
CPC classification number: C07D401/12 , A61K31/496 , C07D209/82 , C07D401/14 , C07D403/12 , C07D471/04 , C07D519/00 , Y02A50/463
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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公开(公告)号：WO2007040650A2
公开(公告)日：2007-04-12
申请号：PCT/US2006/018799
申请日：2006-05-12
Applicant: ABBOTT LABORATORIES , BRUNCKO, Milan , DING, Hong , ELMORE, Steven, W. , KUNZER, Aaron, R. , LYNCH, Christopher, L. , MCCELLAN, William, J. , PARK, Cheol Min , SONG, Xiahong , WANG, Xilu
Inventor： BRUNCKO, Milan , DING, Hong , ELMORE, Steven, W. , KUNZER, Aaron, R. , LYNCH, Christopher, L. , MCCELLAN, William, J. , PARK, Cheol Min , SONG, Xiahong , WANG, Xilu
IPC: C07D295/14 , C07D487/08 , C07D491/08 , A61K31/496
CPC classification number: C07D295/155 , C07D487/08 , C07D491/08
Abstract: Compounds which inhibit the activity of anti-apoptotic family protein members, compositions containing the compounds and methods of treating diseases during which occur expression one or more than one of an anti?apoptotic family protein member are disclosed.
Abstract translation: 公开了抑制抗凋亡家族蛋白成员活性的化合物，含有该化合物的组合物和治疗疾病的方法，其中发生表达一种或多种抗凋亡家族蛋白成员。
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3.发明申请SULFONAMIDE DERIVATIVES AS BCL-2-SELECTIVE APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE DISEASES 审中-公开作为治疗癌症和免疫疾病的BCL-2-选择性病毒诱导剂的磺酰胺衍生物
公开(公告)号：WO2011068561A1
公开(公告)日：2011-06-09
申请号：PCT/US2010/036919
申请日：2010-06-01
Applicant: ABBOTT LABORATORIES , BRUNCKO, Milan , DING, Hong , DOHERTY, George A. , ELMORE, Steven, W. , HASVOLD, Lisa , HEXAMER, Laura , KUNZER, Aaron , MANTEI, Robert, A. , McCLELLAN, William, J. , PARK, Chang, H. , PARK, Cheol-Min , PETROS, Andrew, M. , SONG, Xiaohong , SOUERS, Andrew, J. , SULLIVAN, Gerard, M. , TAO, Zhi-Fu , WANG, Gary, T. , WANG, Le , WANG, Xilu , WENDT, Michael, D. , HANSEN, Todd, M.
Inventor： BRUNCKO, Milan , DING, Hong , DOHERTY, George A. , ELMORE, Steven, W. , HASVOLD, Lisa , HEXAMER, Laura , KUNZER, Aaron , MANTEI, Robert, A. , McCLELLAN, William, J. , PARK, Chang, H. , PARK, Cheol-Min , PETROS, Andrew, M. , SONG, Xiaohong , SOUERS, Andrew, J. , SULLIVAN, Gerard, M. , TAO, Zhi-Fu , WANG, Gary, T. , WANG, Le , WANG, Xilu , WENDT, Michael, D. , HANSEN, Todd, M.
IPC: C07D405/12 , A61K31/404 , A61P35/00 , C07D209/32 , C07D211/96 , C07D213/64 , C07D215/20 , C07D217/16 , C07D235/26 , C07D249/04 , C07D295/14 , C07D309/14 , C07D401/12 , C07D295/125 , C07D231/56 , C07D405/14
CPC classification number: C07D401/12 , A61K31/407 , A61K31/495 , A61K31/496 , A61K31/501 , A61K31/5377 , A61K45/06 , C07D209/08 , C07D209/32 , C07D211/58 , C07D211/96 , C07D213/64 , C07D215/20 , C07D217/16 , C07D231/56 , C07D235/26 , C07D241/04 , C07D249/04 , C07D295/125 , C07D295/14 , C07D295/155 , C07D309/04 , C07D309/14 , C07D401/06 , C07D403/06 , C07D405/06 , C07D405/12 , C07D405/14 , C07D413/06 , C07D417/12 , C07D471/04 , C07D487/04
Abstract: Disclosed are compounds (I) which inhibit the activity of anti-apoptotic Bc1-2 or Bc1 xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti apoptotic Bc1-2 protein.
Abstract translation: 公开了抑制抗凋亡Bc1-2或Bc1 xL蛋白活性的化合物（I），含有该化合物的组合物和治疗其中表达抗凋亡Bc1-2蛋白的疾病的方法。
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4.发明申请APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES 审中-公开细胞凋亡诱导剂治疗癌症和免疫及自身免疫疾病
公开(公告)号：WO2010138588A2
公开(公告)日：2010-12-02
申请号：PCT/US2010/036198
申请日：2010-05-26
Applicant: ABBOTT LABORATORIES , BRUNCKO, Milan , DING, Hong , DOHERTY, George , ELMORE, Steven , HASVOLD, Lisa , HEXAMER, Laura , KUNZER, Aaron R. , SONG, Xiaohong , SOUERS, Andrew J. , SULLIVAN, Gerard , TAO, Zhi-Fu , WANG, Gary T. , WANG, Le , WANG, Xilu , WENDT, Michael , MANTEI, Robert , HANSEN, Todd M.
Inventor： BRUNCKO, Milan , DING, Hong , DOHERTY, George , ELMORE, Steven , HASVOLD, Lisa , HEXAMER, Laura , KUNZER, Aaron R. , SONG, Xiaohong , SOUERS, Andrew J. , SULLIVAN, Gerard , TAO, Zhi-Fu , WANG, Gary T. , WANG, Le , WANG, Xilu , WENDT, Michael , MANTEI, Robert , HANSEN, Todd M.
IPC: C07D471/04
CPC classification number: C07D471/04 , C07D491/052 , C07D519/00
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
Abstract translation: 公开了抑制抗凋亡Bcl-2蛋白活性的化合物，含有该化合物的组合物和治疗表达抗凋亡Bcl-2蛋白的疾病的方法。
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公开(公告)号：WO2008130970A1
公开(公告)日：2008-10-30
申请号：PCT/US2008/060427
申请日：2008-04-16
Applicant: ABBOTT LABORATORIES , BRUNCKO, Milan , SONG, Xiaohong , DING, Hong , TAO, Zhi-fu , KUNZER, Aaron R
Inventor： BRUNCKO, Milan , SONG, Xiaohong , DING, Hong , TAO, Zhi-fu , KUNZER, Aaron R
IPC: C07D209/42 , C07D403/04 , A61K31/404 , A61K31/405 , A61P35/00
CPC classification number: C07D209/42 , C07D403/04
Abstract: Compounds of formula (I) which inhibit the activity of anti-apoptotic Mcl-1 protein, compositins containing the compounds, and methods of treating diseases involving overexpressed or unregulated Mcl-1 protein are disclosed.
Abstract translation: 公开了抑制抗细胞凋亡Mcl-1蛋白活性的式（I）化合物，含有该化合物的组合物，以及治疗涉及过表达或未调节的Mcl-1蛋白的疾病的方法。
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Patent Agency Ranking
公开(公告)号：WO2007040650A3
公开(公告)日：2007-04-12
申请号：PCT/US2006/018799
申请日：2006-05-12
Applicant: ABBOTT LABORATORIES , BRUNCKO, Milan , DING, Hong , ELMORE, Steven, W. , KUNZER, Aaron, R. , LYNCH, Christopher, L. , MCCELLAN, William, J. , PARK, Cheol Min , SONG, Xiahong , WANG, Xilu
Inventor： BRUNCKO, Milan , DING, Hong , ELMORE, Steven, W. , KUNZER, Aaron, R. , LYNCH, Christopher, L. , MCCELLAN, William, J. , PARK, Cheol Min , SONG, Xiahong , WANG, Xilu
IPC: C07D295/14 , C07D487/08 , C07D491/08 , A61K31/496 , A61P35/00
Abstract: Compounds which inhibit the activity of anti-apoptotic family protein members, compositions containing the compounds and methods of treating diseases during which occur expression one or more than one of an anti?apoptotic family protein member are disclosed.
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公开(公告)号：WO2007008627A3
公开(公告)日：2007-01-18
申请号：PCT/US2006/026424
申请日：2006-07-07
Applicant: ABBOTT LABORATORIES , WENDT, Michael, D. , SHEN, Wang , DICKMAN, Daniel, A. , DING, Hong , THOMAS, Sheela, A. , AUGERI, David , ELMORE, Steven, W.
Inventor： WENDT, Michael, D. , SHEN, Wang , DICKMAN, Daniel, A. , DING, Hong , THOMAS, Sheela, A. , AUGERI, David , ELMORE, Steven, W.
IPC: A61K31/192 , C07C15/12 , A61P35/00
Abstract: Compounds which inhibit the activity of anti-apoptotic Mcl-I protein, compositions containing the compounds and methods of treating diseases during which are expressed the Mcl- 1 protein are disclosed.
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公开(公告)号：WO2005049594A1
公开(公告)日：2005-06-02
申请号：PCT/US2004/037911
申请日：2004-11-12
Applicant: ABBOTT LABORATORIES , BRUNCKO, Milan , DING, Hong , ELMORE, Steven , KUNZER, Aaron R. , LYNCH, Christopher L. , MCCLELLAN, William , PARK, Cheol-Min , PETROS, Andrew , SONG, Xiaohong , WANG, Xilu , TU, Noah , WENDT, Michael D.
Inventor： BRUNCKO, Milan , DING, Hong , ELMORE, Steven , KUNZER, Aaron R. , LYNCH, Christopher L. , MCCLELLAN, William , PARK, Cheol-Min , PETROS, Andrew , SONG, Xiaohong , WANG, Xilu , TU, Noah , WENDT, Michael D.
IPC: C07D295/14
CPC classification number: C07D277/74 , C04B35/632 , C07C323/25 , C07C2601/16 , C07D205/04 , C07D207/16 , C07D211/46 , C07D211/60 , C07D211/74 , C07D213/70 , C07D213/75 , C07D233/06 , C07D233/84 , C07D239/06 , C07D263/58 , C07D277/36 , C07D295/13 , C07D295/192 , C07D307/64 , C07D335/02 , C07D401/12 , C07D403/04 , C07D409/12 , C07D487/04 , C07D487/08
Abstract: Disclosed are N-acylsulfonamide compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression of one or more than one anti-apoptotic protein family member.
Abstract translation: 公开了抑制抗凋亡蛋白家族成员的活性的N-酰基磺酰胺化合物，含有该化合物的组合物和该化合物用于制备用于治疗疾病的药物的用途，其中发生一种或多种抗凋亡蛋白家族成员的表达。
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9.发明申请
公开(公告)号：WO2011119345A3
公开(公告)日：2011-09-29
申请号：PCT/US2011/027895
申请日：2011-03-10
Applicant: ABBOTT LABORATORIES , DING, Hong , ELMORE, Steven , HEXAMER, Laura , KUNZER, Aaron, R. , PARK, Cheol-Min , SOUERS, Andrew, J. , SULLIVAN, Gerard , WENDT, Michael
Inventor： DING, Hong , ELMORE, Steven , HEXAMER, Laura , KUNZER, Aaron, R. , PARK, Cheol-Min , SOUERS, Andrew, J. , SULLIVAN, Gerard , WENDT, Michael
IPC: C07D295/112 , C07D295/195 , C07D417/04 , C07D211/58 , C07C311/51 , A61K31/451 , A61K31/495 , A61K31/18 , A61P35/00
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti apoptotic Bcl-2 protein.
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10.发明申请
公开(公告)号：WO2011068560A1
公开(公告)日：2011-06-09
申请号：PCT/US2010/036844
申请日：2010-06-01
Applicant: ABBOTT LABORATORIES , BRUNCKO, Milan , DAI, Yujia , DING, Hong , DOHERTY, George A. , ELMORE, Steven W. , HASVOLD, Lisa , HEXAMER, Laura , KUNZER, Aaron , MANTEI, Robert A. , McCLELLAN, William J. , PARK, Chang H. , PARK, Cheol-Min , PETROS, Andrew M. , SONG, Xiaohong , SOUERS, Andrew J. , SULLIVAN, Gerard M. , TAO, Zhi-Fu , WANG, Gary T. , WANG, Le , WANG, Xilu , WENDT, Michael D. , HANSEN, Todd M.
Inventor： BRUNCKO, Milan , DAI, Yujia , DING, Hong , DOHERTY, George A. , ELMORE, Steven W. , HASVOLD, Lisa , HEXAMER, Laura , KUNZER, Aaron , MANTEI, Robert A. , McCLELLAN, William J. , PARK, Chang H. , PARK, Cheol-Min , PETROS, Andrew M. , SONG, Xiaohong , SOUERS, Andrew J. , SULLIVAN, Gerard M. , TAO, Zhi-Fu , WANG, Gary T. , WANG, Le , WANG, Xilu , WENDT, Michael D. , HANSEN, Todd M.
IPC: C07D209/08 , C07D211/58 , C07D213/74 , C07D213/84 , C07D231/56 , C07D235/06 , C07D277/24 , C07D309/04 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04
CPC classification number: C07D209/08 , A61K31/635 , C07D211/58 , C07D213/74 , C07D213/84 , C07D231/56 , C07D235/06 , C07D277/24 , C07D295/30 , C07D309/04 , C07D309/08 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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