公开(公告)号：WO2010019547A1

公开(公告)日：2010-02-18

申请号：PCT/US2009/053369

申请日：2009-08-11

Applicant: ABBOTT LABORATORIES ,  CARROLL, William, A. ,  DART, Michael, J. ,  FROST, Jennifer, M. ,  KOLASA, Teodozyj ,  LATSHAW, Steven, P. ,  LIU, Bo ,  PATEL, Meena, V. ,  PEREZ-MEDRANO, Arturo ,  WANG, Xueqing

Inventor： CARROLL, William, A. ,  DART, Michael, J. ,  FROST, Jennifer, M. ,  KOLASA, Teodozyj ,  LATSHAW, Steven, P. ,  LIU, Bo ,  PATEL, Meena, V. ,  PEREZ-MEDRANO, Arturo ,  WANG, Xueqing

IPC: C07D261/14 ,  C07D407/06 ,  C07D417/06 ,  C07D285/135 ,  A61K31/433 ,  A61P29/00

CPC classification number: C07D261/14 ,  C07D285/135 ,  C07D407/06 ,  C07D417/06

Abstract: Disclosed herein are cannabinoid receptor ligands of formula (I), wherein Y, X 1 , X 2 , X 3 , R 1 , and R 2 are as defined in the specification. Compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions are also disclosed.

Abstract translation: 本文公开了式（I）的大麻素受体配体，其中Y，X1，X2，X3，R1和R2如说明书中所定义。 还公开了包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和障碍的方法。

公开(公告)号：WO2011075522A1

公开(公告)日：2011-06-23

申请号：PCT/US2010/060485

申请日：2010-12-15

Applicant: ABBOTT LABORATORIES ,  NELSON, Derek ,  DART, Michael ,  WANG, Xueqing ,  LIU, Bo ,  KOLASA, Teodozyj ,  PATEL, Meena

Inventor： NELSON, Derek ,  DART, Michael ,  WANG, Xueqing ,  LIU, Bo ,  KOLASA, Teodozyj ,  PATEL, Meena

IPC: C07D513/04

CPC classification number: C07D513/04

Abstract: The present invention provides for compounds of formula (I) wherein A 2 , L 2 , R 1g , R 2A , R 3A , R 4A , R 1a , R 1b , q1, and z are as defined in the specification, are prodrugs of CB 2 receptors ligands and as such are useful in the prevention and treatment of various diseases and conditions including, but not limited to, pain.

Abstract translation: 本发明提供式（I）化合物，其中A2，L2，R1g，R2A，R3A，R4A，R1a，R1b，q1和z如本说明书中所定义，是CB2受体配体的前药，因此有用 在预防和治疗各种疾病和病症，包括但不限于疼痛。

公开(公告)号：WO2010033543A2

公开(公告)日：2010-03-25

申请号：PCT/US2009/057088

申请日：2009-09-16

Applicant: ABBOTT LABORATORIES ,  CARROLL, William A ,  DART, Michael J. ,  FROST, Jennifer M. ,  LATSHAW, Steven P. ,  KOLASA, Teodozyi ,  LI, Tongmei ,  PEDDI, Sridhar ,  LIU, Bo ,  PEREZ-MEDRANO, Arturo ,  PATEL, Meena ,  WANG, Xueqing ,  NELSON, Derek W.

Inventor： CARROLL, William A ,  DART, Michael J. ,  FROST, Jennifer M. ,  LATSHAW, Steven P. ,  KOLASA, Teodozyi ,  LI, Tongmei ,  PEDDI, Sridhar ,  LIU, Bo ,  PEREZ-MEDRANO, Arturo ,  PATEL, Meena ,  WANG, Xueqing ,  NELSON, Derek W.

IPC: C07D231/40 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14

CPC classification number: C07D405/12 ,  C07D231/40 ,  C07D285/135 ,  C07D403/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

Abstract: Disclosed herein are cannabinoid receptor ligands of formula (I), wherein A 1 , A 5 , R x , X 4 , and z are as defined in the specification. Compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions are also disclosed.

Abstract translation: 本文公开了式（I）的大麻素受体配体，其中A1，A5，Rx，X4和z如说明书中所定义。 还公开了包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和障碍的方法。

公开(公告)号：WO2005030734A1

公开(公告)日：2005-04-07

申请号：PCT/US2004/031115

申请日：2004-09-23

Applicant: ABBOTT LABORATORIES ,  XIN, Zhili ,  LIU, Bo ,  LIU, Gang ,  LIU, Mei ,  SERBY, Michael, D. ,  ZHAO, Hongyu

Inventor： XIN, Zhili ,  LIU, Bo ,  LIU, Gang ,  LIU, Mei ,  SERBY, Michael, D. ,  ZHAO, Hongyu

IPC: C07D239/48

CPC classification number: C07D239/48 ,  C07D401/12 ,  C07D403/12 ,  C07D405/04 ,  C07D405/12 ,  C07D409/12

Abstract: The present invention is related to compounds of formula (I), (I), or a therapeutically suitable salt or prodrug thereof, the preparation of the compounds, compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders regulated by the action of ghrelin receptor, including Prader-Willi syndrome, eating disorder, weight gain, weight-loss maintainance following diet and exercise, obesity and disorders associated with obesity such as non-insulin dependent diabetes mellitus.

Abstract translation: 本发明涉及式（I），（I）的化合物或其治疗上合适的盐或前药，化合物的制备，含有化合物的组合物以及该化合物在预防或治疗调节疾病中的用途 通过生长激素释放肽受体的作用，包括Prader-Willi综合征，进食障碍，体重增加，饮食和运动后的体重减轻维持，肥胖症和与肥胖相关的疾病如非胰岛素依赖性糖尿病。

公开(公告)号：WO2010028338A2

公开(公告)日：2010-03-11

申请号：PCT/US2009/056179

申请日：2009-09-08

Applicant: ABBOTT LABORATORIES ,  CARROLL, William, A. ,  DART, Michael, J. ,  FROST, Jennifer, M. ,  KOLASA, Teodozyj ,  LI, Tongmei ,  LIU, Bo ,  PEREZ-MEDRANO, Arturo ,  PATEL, Meena ,  WANG, Xueqing ,  PEDDI, Sridhar

Inventor： CARROLL, William, A. ,  DART, Michael, J. ,  FROST, Jennifer, M. ,  KOLASA, Teodozyj ,  LI, Tongmei ,  LIU, Bo ,  PEREZ-MEDRANO, Arturo ,  PATEL, Meena ,  WANG, Xueqing ,  PEDDI, Sridhar

IPC: C07D277/46 ,  C07D417/06 ,  C07D417/14 ,  A61K31/427 ,  A61P29/00

CPC classification number: C07D417/06 ,  C07D277/46 ,  C07D417/14

Abstract: The present application relates to cannabinoid receptor ligands of formula (I), wherein X 1 , A 1 , R x , R 2 , R 3 , R 4 , and z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions.

Abstract translation: 本申请涉及式（I）的大麻素受体配体，其中X1，A1，Rx，R2，R3，R4和z如说明书中所定义。 本申请还涉及包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和障碍的方法。

公开(公告)号：WO2010111574A1

公开(公告)日：2010-09-30

申请号：PCT/US2010/028796

申请日：2010-03-26

Applicant: ABBOTT LABORATORIES ,  WANG, Xueqing ,  DART, Michael, J. ,  LIU, Bo

Inventor： WANG, Xueqing ,  DART, Michael, J. ,  LIU, Bo

IPC: C07D231/40 ,  C07D285/135 ,  A61K31/433 ,  A61P25/04

CPC classification number: C07D231/40 ,  C07D285/135

Abstract: Cannabinoid receptor ligands of formula (I) wherein Ring A and R1 are as defined in the specification. Compositions including such compounds, and methods of treating conditions and disorders using such compounds and compositions are also described.

Abstract translation: 式（I）的大麻素受体配体，其中环A和R 1如说明书中所定义。 还描述了包括这些化合物的组合物，以及使用这些化合物和组合物治疗病症和病症的方法。

公开(公告)号：WO2010111573A1

公开(公告)日：2010-09-30

申请号：PCT/US2010/028794

申请日：2010-03-26

Applicant: ABBOTT LABORATORIES ,  WANG, Xueqing ,  FROST, Jennifer, M. ,  DART, Michael, J. ,  LIU, Bo

Inventor： WANG, Xueqing ,  FROST, Jennifer, M. ,  DART, Michael, J. ,  LIU, Bo

IPC: C07D231/40 ,  C07D403/12 ,  C07D285/135 ,  A61K31/433 ,  A61P25/04

CPC classification number: C07D231/40 ,  C07D285/135 ,  C07D403/12

Abstract: Disclosed herein are cannabinoid receptor ligands of formula (I) wherein Ring A and R1 are as defined in the specification. Compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions are also described.

Abstract translation: 本文公开了式（I）的大麻素受体配体，其中环A和R 1如说明书中所定义。 还描述了包含这些化合物的组合物，以及使用这些化合物和组合物治疗病症和病症的方法。

公开(公告)号：WO2006083673A2

公开(公告)日：2006-08-10

申请号：PCT/US2006/002789

申请日：2006-01-24

Applicant: ABBOTT LABORATORIES ,  LIU, Gang ,  SHAM, Hing, L. ,  SZCZEPANKIEWICZ, Bruce, G. ,  XIN, Zhili ,  ZHAO, Hongyu ,  SERBY, Michael, D. ,  LIU, Bo ,  LIU, Mei

Inventor： LIU, Gang ,  SHAM, Hing, L. ,  SZCZEPANKIEWICZ, Bruce, G. ,  XIN, Zhili ,  ZHAO, Hongyu ,  SERBY, Michael, D. ,  LIU, Bo ,  LIU, Mei

IPC: C07D213/85 ,  C07D405/12 ,  C07D409/12 ,  C07D401/12 ,  C07D409/04 ,  C07D405/04 ,  C07D213/73 ,  C07D401/14 ,  A61K31/44 ,  A61P3/00 ,  A61P19/00 ,  A61P25/00

CPC classification number: C07D417/12 ,  C07D213/73 ,  C07D213/81 ,  C07D213/84 ,  C07D213/85 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D405/04 ,  C07D405/12 ,  C07D409/04 ,  C07D409/12 ,  C07D409/14 ,  C07D413/04 ,  C07D413/06 ,  C07D413/10 ,  C07D417/06 ,  C07D417/10

Abstract: The present invention relates to compounds that are inhibitors of c-jun N-terminal kinase 1, 2, or 3 (JNK1, JNK2, or JNK3), compositions containing the compounds and the use of the compounds in the prevention or treatment of disorders regulated by the activation of JNK1, JNK2 and JNK3.

Abstract translation: 本发明涉及作为c-jun N-末端激酶1,2或3（JNK1，JNK2或JNK3）的抑制剂的化合物，含有这些化合物的组合物和该化合物在预防或治疗调节疾病中的用途 通过激活JNK1，JNK2和JNK3。

公开(公告)号：WO2010111572A1

公开(公告)日：2010-09-30

申请号：PCT/US2010/028790

申请日：2010-03-26

Applicant: ABBOTT LABORATORIES ,  CARROLL, William A ,  DART, Michael J. ,  FROST, Jennifer M. ,  LATSHAW, Steven P. ,  LI, Tongmei ,  LIU, Bo ,  PEDDI, Sridhar ,  WANG, Xueqing ,  KOLASA, Teodozyi ,  NELSON, Derek W. ,  PEREZ-MEDRANO, Arturo

Inventor： CARROLL, William A ,  DART, Michael J. ,  FROST, Jennifer M. ,  LATSHAW, Steven P. ,  LI, Tongmei ,  LIU, Bo ,  PEDDI, Sridhar ,  WANG, Xueqing ,  KOLASA, Teodozyi ,  NELSON, Derek W. ,  PEREZ-MEDRANO, Arturo

IPC: C07D405/06 ,  C07D413/06 ,  C07D417/06 ,  A61K31/433 ,  A61P25/04

CPC classification number: C07D417/06 ,  C07D405/06 ,  C07D413/06

Abstract: Disclosed herein are compounds of formula (I) wherein Ring A and R 1 are as defined in the specification. Pharmaceutical compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and pharmaceutical compositions are also disclosed.

Abstract translation: 本文公开了式（I）的化合物，其中环A和R 1如说明书中所定义。 还公开了包含这些化合物的药物组合物，以及使用这些化合物和药物组合物治疗病症和障碍的方法。

公开(公告)号：EP2334646A2

公开(公告)日：2011-06-22

申请号：EP09792591.1

申请日：2009-09-16

Applicant: Abbott Laboratories

Inventor： CARROLL, William A ,  DART, Michael J. ,  FROST, Jennifer M. ,  LATSHAW, Steven P. ,  KOLASA, Teodozyj ,  LI, Tongmei ,  PEDDI, Sridhar ,  LIU, Bo ,  PEREZ-MEDRANO, Arturo ,  PATEL, Meena ,  WANG, Xueqing ,  NELSON, Derek W.

IPC: C07D231/40 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14

CPC classification number: C07D405/12 ,  C07D231/40 ,  C07D285/135 ,  C07D403/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12

Abstract: Disclosed herein are cannabinoid receptor ligands of formula (I), wherein A
1 , A
5 , R
x , X
4 , and z are as defined in the specification. Compositions comprising such compounds, and methods for treating conditions and disorders using such compounds and compositions are also disclosed.