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    Globo h and related anti-cancer vaccines with novel glycolipid adjuvants
    1.
    发明专利
    Globo h and related anti-cancer vaccines with novel glycolipid adjuvants 有权
    GLOBO H和相关的抗癌药物与新型甘露醇辅剂

    公开(公告)号：JP2014144958A

    公开(公告)日：2014-08-14

    申请号：JP2014035431

    申请日：2014-02-26

    Applicant: Academia Sinica ,  アカデミア シニカAcademia Sinica

    Inventor： WONG CHI-HUEY ,  WU CHUNG-YI ,  YU ALICE ,  YU JOHN

    IPC: A61K39/00 ,  A61K39/385 ,  A61K39/39 ,  A61P35/00

    CPC classification number: A61K39/0011 ,  A61K2039/55511 ,  A61K2039/6037 ,  A61K2039/6081 ,  A61K2039/627 ,  C12N15/1137 ,  C12N2310/14

    Abstract: PROBLEM TO BE SOLVED: To provide: an immunogenic composition capable of high levels of immune responses immune-targeting glycolipid antigen Globo H, which is a tumor associated sugar chain; a cancer vaccine; and a method of treating cancer.SOLUTION: The invention relates to an immunogenic composition comprising: (a) a sugar chain such as Globo H or an immunogenic fragment thereof conjugated with a carrier protein comprising diphtheria toxin cross-reacting material 197 (DT-CRM 197) through a linker such as p-nitrophenol; and (b) an adjuvant with the following structure comprising a glycolipid capable of binding CD1d on a dendritic cell such as an α-galactosyl ceramide derivative.

    Abstract translation: 要解决的问题：提供：能够高水平免疫应答的免疫原性组合物免疫靶向糖脂抗原Globo H，其是肿瘤相关糖链; 癌症疫苗; 和一种治疗癌症的方法。解决方案：本发明涉及免疫原性组合物，其包含：（a）糖链，例如Globo H或其与包含白喉毒素交叉反应材料197（DT-CRM）的载体蛋白缀合的免疫原性片段 197）通过接头如对硝基苯酚; 和（b）具有以下结构的佐剂，其包含能够结合树突状细胞如α-半乳糖基神经酰胺衍生物上的CD1d的糖脂。

    Expression of penicillin binding protein, and application thereof to high throughput detecting of antibiotics
    3.
    发明专利
    Expression of penicillin binding protein, and application thereof to high throughput detecting of antibiotics 审中-公开
    扁桃酸结合蛋白的表达及其对抗生素的高通量检测的应用

    公开(公告)号：JP2009183277A

    公开(公告)日：2009-08-20

    申请号：JP2008178187

    申请日：2008-07-08

    Applicant: Academia Sinica ,  中央研究院

    Inventor： CHENG TING-JEN RACHEL ,  MA CHE ALEX ,  CHENG WEI-CHIEH ,  WONG CHI-HUEY

    IPC: C12P21/02 ,  C12N15/09 ,  C12Q1/18 ,  G01N33/15 ,  G01N33/50

    CPC classification number: Y02A50/473 ,  Y02A50/475 ,  Y02A50/481

    Abstract: PROBLEM TO BE SOLVED: To provide a method for expressing and purifying a full-length class A type penicillin-binding protein from bacteria, and a high-throughput screening method of antibiotics using the protein.
    SOLUTION: The method for preparing the purified full-length class A type penicillin-binding protein comprises: amplifying a DNA sequence of a full-length penicillin-binding protein from a genome DNA of the bacteria; cloning the DNA sequence to a vector; expressing the DNA sequence in the host cell and obtaining the full-length penicillin-binding protein; and solubilizing the protein by a surfactant and purifying the protein.
    COPYRIGHT: (C)2009,JPO&INPIT

    Abstract translation: 待解决的问题：提供从细菌中表达和纯化全长A类青霉素结合蛋白的方法，以及使用该蛋白质的高通量筛选抗生素筛选方法。 解决方案：制备纯化的全长A型青霉素结合蛋白的方法包括：从细菌的基因组DNA扩增全长青霉素结合蛋白的DNA序列; 将DNA序列克隆到载体上; 在宿主细胞中表达DNA序列，获得全长青霉素结合蛋白; 并通过表面活性剂溶解蛋白质并纯化蛋白质。 版权所有（C）2009，JPO＆INPIT

    ANTIBODY-MEDIATED ANTI-TUMOR ACTIVITY INDUCED BY REISHI MUSHROOM POLYSACCHARIDES
    4.
    发明申请
    ANTIBODY-MEDIATED ANTI-TUMOR ACTIVITY INDUCED BY REISHI MUSHROOM POLYSACCHARIDES 审中-公开
    由REISHI MUSHROOM POLYSACCHARIDES诱导的抗体介导的抗肿瘤活性

    公开(公告)号：WO2015026484A9

    公开(公告)日：2015-04-16

    申请号：PCT/US2014048325

    申请日：2014-07-26

    Applicant: ACADEMIA SINICA ,  WONG CHI-HUEY ,  WU CHUNG-YI ,  HSU HSIEN-YEH ,  LIAO SHIH-FEN ,  LIANG CHI-HUI

    Inventor： WONG CHI-HUEY ,  WU CHUNG-YI ,  HSU HSIEN-YEH ,  LIAO SHIH-FEN ,  LIANG CHI-HUI

    IPC: A61K31/715 ,  A61K31/736 ,  A61K36/074

    CPC classification number: A61K39/0002 ,  A61K36/074 ,  A61K39/0011 ,  A61K2039/55572 ,  A61K2039/575

    Abstract: Immunogenic compositions, cancer vaccines and methods for treating cancer comprising FMS, the fucose-enriched polysaccharide fraction from Reishi F3, are provided. Compositions comprise fucose-enriched Reishi polysaccharide fraction (FMS) MW = ~35kDa, wherein the FMS is isolated by size-exclusion chromatography from Reishi F3, and the FMS comprises polysaccharides having primarily a backbone selected from 1,4-mannan and 1,6-a-galactan, wherein the backbone is linked to a terminal fucose-containing side-chain. Immunogenic compositions comprising glycolipid adjuvants are provided. Antibodies generated by immunogenic compositions disclosed herein bind cancer cells comprising antigens Globo H, Globo H, Gb3, Gb4, Gb5 (SSEA-3) and SSEA-4 on the cell surface.

    Abstract translation: 提供免疫原性组合物，癌症疫苗和治疗癌症的方法，其包括FMS，来自Reishi F3的岩藻糖富集的多糖部分。 组合物包含岩藻糖富集的赖斯多糖级分（FMS）MW =〜35kDa，其中通过来自Reishi F3的大小排阻色谱分离FMS，并且FMS包含主要选自1,4-甘露聚糖和1,6 α-半乳聚糖，其中所述主链与含末端岩藻糖的侧链连接。 提供包含糖脂佐剂的免疫原性组合物。 由本文公开的免疫原性组合物产生的抗体结合细胞表面上包含抗原Globo H，Globo H，Gb 3，Gb 4，Gb 5（SSEA-3）和SSEA-4的癌细胞。

    ALPHA-GALACTOSYL CERAMIDE ANALOGS AND THEIR USE AS IMMUNOTHERAPIES
    6.
    发明申请
    ALPHA-GALACTOSYL CERAMIDE ANALOGS AND THEIR USE AS IMMUNOTHERAPIES 审中-公开
    ALPHA-GALACTOSYL CERAMIDE ANALOGS及其作为免疫球蛋白使用

    公开(公告)号：WO2008128207A1

    公开(公告)日：2008-10-23

    申请号：PCT/US2008060275

    申请日：2008-04-14

    Applicant: ACADEMIA SINICA ,  WONG CHI-HUEY ,  YU ALICE ,  CHANG YA-JEN

    Inventor： WONG CHI-HUEY ,  YU ALICE ,  CHANG YA-JEN

    IPC: A61K8/42 ,  A61K8/00 ,  C07C235/80 ,  C07C237/10

    CPC classification number: C07H15/26 ,  A61K8/68 ,  A61K2800/91 ,  A61Q17/005 ,  C07H15/06 ,  C07H15/18

    Abstract: The present disclosure relates to synthetic alpha-galactosyl ceramide (a-GalCer) analogs, and their use as immunotherapies. In one aspect, a method of activating a cytokine response in a subject includes administering an effective amount of a compound to a subject, wherein the subject has an adaptive immune system that includes a population of cells, the population including at least one lymphocyte and at least one antigen-presenting cell, and wherein the compound is represented by the structure of formula (1) wherein, n is 0 to 25; X is selected from O and S; R 1 is selected from H, CH 3 , and phenyl, where phenyl is optionally substituted with H, OH, OCH 3 , F, CF 3 , phenyl, phenyl-F, C 1 -C 6 alkyl, or C 2 -C 6 branched alkyl; R 2 is selected from OH and H; R 3 is selected from C 1 -C 15 alkyl, and phenyl, where phenyl is optionally substituted with H, OH, OCH 3 , F, CF 3 , phenyl, C 1 -C 6 alkyl, or C 2 -C 6 branched alkyl; R 4 is selected from OH, OSO 3 H, OSO 3 Na, and OSO 3 K; and R 5 is selected from CH 2 OH and CO 2 H; or a pharmaceutically acceptable salt thereof; forming a complex between the compound and the antigen-presenting cell, wherein the formation of the complex results in the activation of a receptor on the lymphocyte; and activating the lymphocyte to produce the cytokine response.

    Abstract translation: 本公开内容涉及合成的α-半乳糖神经酰胺（a-GalCer）类似物，以及它们作为免疫治疗的用途。 一方面，在受试者中激活细胞因子应答的方法包括向受试者施用有效量的化合物，其中所述受试者具有包括细胞群的适应性免疫系统，所述群体包括至少一种淋巴细胞和 至少一个抗原呈递细胞，并且其中所述化合物由式（1）的结构表示，其中n为0至25; X选自O和S; R 1选自H，CH 3和苯基，其中苯基任选被H，OH，OCH 3，F，CF 苯基，苯基-F，C 1 -C 6烷基或C 2 -C 6亚烷基 >支链烷基; R 2选自OH和H; R 3选自C 1 -C 15烷基和苯基，其中苯基任选被H，OH，OCH 3取代， 3，F，CF 3，苯基，C 1 -C 6烷基或C 2 H 2 -C 6 -C 6支链烷基; R 4选自OH，OSO 3 H，OSO 3 Na和OSO 3 K; 和R 5选自CH 2 OH和CO 2 H; 或其药学上可接受的盐; 在化合物和抗原呈递细胞之间形成复合物，其中复合物的形成导致淋巴细胞上受体的活化; 并激活淋巴细胞以产生细胞因子反应。

    METHODS AND COMPOSITIONS ASSOCIATED WITH ADMINISTRATION OF AN EXTRACT OF GANODERMA LUCIDUM
    8.
    发明申请
    METHODS AND COMPOSITIONS ASSOCIATED WITH ADMINISTRATION OF AN EXTRACT OF GANODERMA LUCIDUM 审中-公开
    与甘草提取物相关的方法和组合物

    公开(公告)号：WO2006044616A3

    公开(公告)日：2006-08-24

    申请号：PCT/US2005036961

    申请日：2005-10-14

    Applicant: ACADEMIA SINICA ,  WONG CHI-HUEY ,  HSU HSIEN-YEH ,  HUA KUO-FENG ,  LIN CHUN-HUNG ,  HSU JASON ,  CHEN SHUI-TEIN ,  LIN KUO-I ,  YANG WEN-BIN ,  YU JOHN ,  YU ALICE

    Inventor： WONG CHI-HUEY ,  HSU HSIEN-YEH ,  HUA KUO-FENG ,  LIN CHUN-HUNG ,  HSU JASON ,  CHEN SHUI-TEIN ,  LIN KUO-I ,  YANG WEN-BIN ,  YU JOHN ,  YU ALICE

    IPC: A01N65/00

    CPC classification number: A61K36/074

    Abstract: A fucose-containing glycoprotein fraction obtainable from an extract of Ganoderma Lucidum Reishi, compositions comprising the fuconse-containing glycoprotein fraction, a method to mediate immunomodulating events associated with IL-1 gene expression, a method to stimulate the expression of an inflammatory cytokine, a method to modulate protein kinase pathways associated with inflammatory cytokine Interleukin 1, a method to induce a TLR mediated event; a method to modulate differentiation of a mononuclear cell, a method to enhance cytotoxicity of an NK cell against an NK-sensitive tumor cell, a method to activate the expression of cytokines, a method to induce Blimp-1 expression in a mouse splenic B cell or human B cell, human mature splenocytes or dendritic cell, a method to inhibit LPS induced nitric oxide production in macrophages, a method to activate spleen cells proliferation, and a method to modify the proteome of a spleen cell.

    Abstract translation: 从灵芝提取物获得的含岩藻糖的糖蛋白部分，包含含有蛋白质的糖蛋白部分的组合物，介导与IL-1基因表达相关的免疫调节事件的方法，刺激炎性细胞因子的表达的方法 调节与炎症细胞因子相关的蛋白激酶途径白细胞介素1的方法，诱导TLR介导的事件的方法; 调节单核细胞分化的方法，增强NK细胞对NK敏感性肿瘤细胞的细胞毒性的方法，激活细胞因子表达的方法，在小鼠脾B细胞中诱导Blimp-1表达的方法 或人B细胞，人成熟脾细胞或树突状细胞，抑制巨噬细胞中LPS诱导的一氧化氮产生的方法，活化脾细胞增殖的方法以及修饰脾细胞的蛋白质组的方法。

    GLYCAN ARRAYS ON PTFE-LIKE ALUMINUM COATED GLASS SLIDES AND RELATED METHODS
    10.
    发明申请
    GLYCAN ARRAYS ON PTFE-LIKE ALUMINUM COATED GLASS SLIDES AND RELATED METHODS 审中-公开
    类聚四氟乙烯涂层玻璃载玻片上的甘氨酸阵列及相关方法

    公开(公告)号：WO2010009271A3

    公开(公告)日：2010-04-22

    申请号：PCT/US2009050754

    申请日：2009-07-15

    Applicant: ACADEMIA SINICA ,  WONG CHI-HUEY ,  WU CHUNG-YI ,  TSENG SUSAN Y

    Inventor： WONG CHI-HUEY ,  WU CHUNG-YI ,  TSENG SUSAN Y

    IPC: G01N33/50 ,  G01N33/66 ,  G01N33/68

    CPC classification number: G01N33/553 ,  C40B40/12 ,  C40B50/14 ,  G01N33/582 ,  G01N2333/942 ,  G01N2400/10 ,  H01J49/40

    Abstract: Aluminum coated glass slides provide a novel glycan array platform. Specifically, aluminum coated glass slides increase sensitivity of fluorescent based assay methods. Additionally, aluminum coated glass slides allows for mass spectroscopic analysis of carbohydrates and provide a platform for examining activity of cellulases. The unique properties of ACG slides include: 1) the metal oxide layer on the surface can be activated for grafting organic compounds such as modified oligosaccharides; 2) the surface remains electrically conductive, and the grafted oligosaccharides can be simultaneously characterized by mass spectrometry and carbohydrate-binding assay; and 3) the slides are more sensitive than transparent glass slides in binding analysis.

    Abstract translation: 镀铝玻璃载玻片提供了一种新型聚糖阵列平台。 具体而言，镀铝玻璃载玻片增加了基于荧光的测定方法的灵敏度。 此外，镀铝玻璃载玻片允许对碳水化合物进行质谱分析，并为检查纤维素酶的活性提供平台。 ACG玻片的独特性能包括：1）表面的金属氧化物层可以被活化以接枝有机化合物，如修饰的低聚糖; 2）表面保持导电性，并且接枝的低聚糖可以通过质谱和碳水化合物结合测定同时表征; 和3）在结合分析中，载玻片比透明载玻片更敏感。

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