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公开(公告)号：WO2012121775A9
公开(公告)日：2012-09-13
申请号：PCT/US2011/066130
申请日：2011-12-20
Applicant: ABBOTT LABORATORIES , WU, Chengbin
Inventor： WU, Chengbin
IPC: C07K16/24
Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
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公开(公告)号：WO2010065882A1
公开(公告)日：2010-06-10
申请号：PCT/US2009/066815
申请日：2009-12-04
Applicant: ABBOTT LABORATORIES , JAKOB, Clarissa, G. , WU, Chengbin , WALTER, Karl, A. , GHAYUR, Tariq
Inventor： JAKOB, Clarissa, G. , WU, Chengbin , WALTER, Karl, A. , GHAYUR, Tariq
CPC classification number: C07K16/468 , C07K16/241 , C07K16/244 , C07K2317/24 , C07K2317/31 , C07K2317/64
Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
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公开(公告)号：WO2010087972A2
公开(公告)日：2010-08-05
申请号：PCT/US2010/000244
申请日：2010-01-29
Applicant: ABBOTT LABORATORIES , HSIEH, Chung-ming , WU, Chengbin
Inventor： HSIEH, Chung-ming , WU, Chengbin
CPC classification number: A61K39/3955 , A61K38/00 , A61K45/06 , A61K47/6845 , C07K16/245 , C07K2317/24 , C07K2317/565 , C07K2317/76 , C07K2317/92 , Y02A50/385 , Y02A50/401 , Y02A50/409 , Y02A50/411 , Y02A50/463 , Y02A50/478 , Y02A50/481
Abstract: The present invention encompasses IL-1α binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Antibodies of the invention have high affinity for IL-1α and neutralize IL-1α activity. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting IL-1α and for inhibiting IL-1α activity, e.g., in a human subject suffering from a disorder in which IL-1α activity is detrimental.
Abstract translation: 本发明包括IL-1α结合蛋白。 具体而言，本发明涉及嵌合，CDR嫁接和人源化抗体的抗体。 本发明的抗体对IL-1α具有高亲和力并中和IL-1α活性。 本发明的抗体可以是全长抗体或其抗原结合部分。 还提供了制备方法和使用本发明抗体的方法。 例如，在患有其中IL-1α活性是有害的病症的人受试者中，本发明的抗体或抗体部分可用于检测IL-1α和用于抑制IL-1α活性。
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公开(公告)号：WO2008024188A2
公开(公告)日：2008-02-28
申请号：PCT/US2007/017340
申请日：2007-08-03
Applicant: ABBOTT LABORATORIES , WU, Chengbin , GHAYUR, Tariq , DIXON, Richard, W. , SALFELD, Jochen, G.
Inventor： WU, Chengbin , GHAYUR, Tariq , DIXON, Richard, W. , SALFELD, Jochen, G.
CPC classification number: C07K16/468 , A61K39/3955 , A61K45/06 , A61K47/42 , A61K47/48384 , A61K47/6803 , A61K51/1093 , A61K2039/505 , C07K16/22 , C07K16/24 , C07K16/241 , C07K16/244 , C07K16/245 , C07K16/2809 , C07K16/2887 , C07K16/2896 , C07K16/40 , C07K16/46 , C07K16/467 , C07K2317/24 , C07K2317/31 , C07K2317/51 , C07K2317/522 , C07K2317/56 , C07K2317/64 , C07K2317/76 , Y02A50/386 , Y02A50/41 , Y02A50/412 , Y02A50/58
Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention and/or treatment of acute and chronic inflammatory and other diseases.
Abstract translation: 本发明涉及工程化的多价和多特异性结合蛋白，制备方法，特别涉及其用于预防和/或治疗急性和慢性炎症和其它疾病的用途。
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公开(公告)号：WO2012088290A3
公开(公告)日：2012-06-28
申请号：PCT/US2011/066530
申请日：2011-12-21
Applicant: ABBOTT LABORATORIES , WU, Chengbin , YING, Hua , GHAYUR, Tariq , GOODREAU, Carrie , BARDWELL, Philip
Inventor： WU, Chengbin , YING, Hua , GHAYUR, Tariq , GOODREAU, Carrie , BARDWELL, Philip
Abstract: Engineered multivalent and multispecific binding proteins, as well as methods of making them, and for using the multivalent and multispecific binding proteins of the invention in the prevention, diagnosis, and/or treatment of disease are provided.
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Patent Agency Ranking
公开(公告)号：WO2011047266A1
公开(公告)日：2011-04-21
申请号：PCT/US2010/052849
申请日：2010-10-15
Applicant: ABBOTT LABORATORIES , HSIEH, Chung-ming , WU, Chengbin , MILLER, Renee , AMBROSI, Dominic J.
Inventor： HSIEH, Chung-ming , WU, Chengbin , MILLER, Renee , AMBROSI, Dominic J.
IPC: A61K39/395 , G01N33/53
CPC classification number: C07K16/245 , A61K39/3955 , A61K45/06 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N9/96 , G01N2333/545
Abstract: The present invention describes IL-1β binding proteins, including chimeric, CDR-grafted, and humanized antibodies that bind IL-1β. Binding proteins of the invention have high affinity for IL-1β and neutralize IL-1β activity. A binding protein of the invention can be a full-length antibody or an IL-1β -binding portion thereof. Methods of making and methods of using the binding proteins of the invention are also described. The IL-1β binding proteins of the invention are useful for detecting IL-1β and for inhibiting IL-1β activity, including in a human subject suffering from a disease or disorder in which IL-1β activity is detrimental.
Abstract translation: 本发明描述了IL-1β结合蛋白，包括结合IL-1β的嵌合，CDR移植和人源化抗体。 本发明的结合蛋白对IL-1β具有高亲和力并中和IL-1β活性。 本发明的结合蛋白可以是全长抗体或其IL-1β结合部分。 还描述了制备方法和使用本发明的结合蛋白的方法。 本发明的IL-1β结合蛋白可用于检测IL-1β和抑制IL-1β活性，包括在患有IL-1β活性有害的疾病或病症的人类受试者中。
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公开(公告)号：WO2009149189A2
公开(公告)日：2009-12-10
申请号：PCT/US2009/046137
申请日：2009-06-03
Applicant: ABBOTT LABORATORIES , GHAYUR, Tariq , ISAKSON, Peter, C. , OLSON, Lisa, M. , WU, Chengbin , HUGUNIN, Margaret , KAMATH, Rajesh, V. , CUFF, Carolyn, A. , ALLEN, Hamish, J.
Inventor： GHAYUR, Tariq , ISAKSON, Peter, C. , OLSON, Lisa, M. , WU, Chengbin , HUGUNIN, Margaret , KAMATH, Rajesh, V. , CUFF, Carolyn, A. , ALLEN, Hamish, J.
CPC classification number: C07K16/2887 , A61K39/3955 , A61K45/06 , A61K47/6845 , A61K2039/505 , A61K2039/70 , C07K16/22 , C07K16/241 , C07K16/244 , C07K16/245 , C07K16/247 , C07K16/248 , C07K16/2866 , C07K16/468 , C07K2317/24 , C07K2317/31 , C07K2317/35 , C07K2317/64 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92 , G01N33/6869 , G01N2333/545 , Y02A50/386 , Y02A50/41 , Y02A50/412
Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
Abstract translation: 本发明涉及工程化的多价和多特异性结合蛋白，制备方法，具体涉及用于预防，诊断和/或治疗疾病的用途。
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公开(公告)号：WO2009099545A1
公开(公告)日：2009-08-13
申请号：PCT/US2009/000568
申请日：2009-01-29
Applicant: ABBOTT LABORATORIES , ARGIRIADI, Maria A. , BORHANI, David W. , XIANG, Tao , WU, Chengbin , GHAYUR, Tariq
Inventor： ARGIRIADI, Maria A. , BORHANI, David W. , XIANG, Tao , WU, Chengbin , GHAYUR, Tariq
IPC: A61K39/395
CPC classification number: C30B29/58 , C07K1/306 , C07K16/244 , C07K2299/00 , C07K2317/21 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/76 , C07K2317/92 , C30B7/00
Abstract: The invention provides methods of crystallizing antibodies and fragments thereof as well as crystals produced thereby. More particularly, the invention provides methods of crystallizing human and non-human Fab fragments of antibodies, either alone or as co-crystals with their target ligand. For example, a crystal comprising a murine Fab fragment of the antibody 125-2H or a human Fab fragment of the antibody ABT-325, which bind to IL-18, are provided as well as a co-crystal of a murine Fab fragment bound to IL-18. ABT-325 and 125-2H differ significantly in combining site character and architecture, thus explaining their ability to bind IL-18 simultaneously at distinct epitopes.
Abstract translation: 本发明提供结晶抗体及其片段以及由此制备的晶体的方法。 更具体地，本发明提供了将人抗体和非人Fab片段单独或与其靶配体共晶结晶的方法。 例如，提供了包含结合IL-18的抗体125-2H的鼠Fab片段或抗体ABT-325的人Fab片段的结晶以及结合于鼠Fab片段的共晶体 到IL-18。 ABT-325和125-2H在组合位点特征和结构上有显着差异，从而说明了它们在不同表位同时结合IL-18的能力。
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公开(公告)号：WO2008127271A2
公开(公告)日：2008-10-23
申请号：PCT/US2007/019660
申请日：2007-09-07
Applicant: ABBOTT LABORATORIES , WU, Chengbin , DIXON, Richard, W. , BELK, Jonathan, P. , YING, Hua , ARGIRIADI, Maria, A. , CUFF, Carolyn, A. , HINTON, Paul, R. , KUMAR, Shankar , MELIM, Terry, L. , CHEN, Yan
Inventor： WU, Chengbin , DIXON, Richard, W. , BELK, Jonathan, P. , YING, Hua , ARGIRIADI, Maria, A. , CUFF, Carolyn, A. , HINTON, Paul, R. , KUMAR, Shankar , MELIM, Terry, L. , CHEN, Yan
IPC: C07K14/00 , C07K16/00 , C07H21/00 , C12N1/00 , C12N1/21 , C12N5/00 , C12N5/04 , C12N1/15 , C12N5/06 , C12N1/16 , C12P21/00
CPC classification number: A61K45/06 , A61K38/00 , A61K39/3955 , C07K14/47 , C07K16/244 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92 , Y02A50/385 , Y02A50/401 , Y02A50/409 , Y02A50/411 , Y02A50/463 , Y02A50/473 , Y02A50/478 , Y02A50/481
Abstract: The present invention encompasses IL- 13 binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hIL-13 and neutralize hIL-13 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-13 and for inhibiting hlL-13 activity, e.g., in a human subject suffering from a disorder in which hTL-13 activity is detrimental.
Abstract translation: 本发明包括IL-13结合蛋白。 具体地，本发明涉及作为嵌合，CDR移植和人源化抗体的抗体。 优选的抗体对hIL-13具有高亲和力，并在体外和体内中和hIL-13活性。 本发明的抗体可以是全长抗体或其抗原结合部分。 还提供了制备方法和使用本发明抗体的方法。 本发明的抗体或抗体部分可用于检测hIL-13和抑制hIL-13活性，例如在患有hTL-13活性有害的病症的人类受试者中。
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公开(公告)号：WO2007024715A9
公开(公告)日：2007-03-01
申请号：PCT/US2006/032398
申请日：2006-08-18
Applicant: ABBOTT LABORATORIES , WU, Chengbin , GHAYUR, Tariq , DIXON, Richard, W. , SALFELD, Jochen, G.
Inventor： WU, Chengbin , GHAYUR, Tariq , DIXON, Richard, W. , SALFELD, Jochen, G.
Abstract: The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention and/or treatment of acute and chronic inflammatory and other diseases.
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