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1.发明申请BICYCLIC UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF PAIN 审中-公开双酚尿素，硫脲，胍和氰尿嘧啶化合物可用于治疗疼痛
公开(公告)号：WO2014078454A1
公开(公告)日：2014-05-22
申请号：PCT/US2013/069951
申请日：2013-11-13
Applicant: ARRAY BIOPHARMA INC. , ALLEN, Shelley , ANDREWS, Steven, Wade , BLAKE, James, F. , BRANDHUBER, Barbara, J. , HAAS, Julia , JIANG, Yutong , KERCHER, Timothy , KOLAKOWSKI, Gabrielle, R. , THOMAS, Allen, A. , WINSKI, Shannon, L.
Inventor： ALLEN, Shelley , ANDREWS, Steven, Wade , BLAKE, James, F. , BRANDHUBER, Barbara, J. , HAAS, Julia , JIANG, Yutong , KERCHER, Timothy , KOLAKOWSKI, Gabrielle, R. , THOMAS, Allen, A. , WINSKI, Shannon, L.
IPC: C07D401/14 , C07D405/14 , C07D231/40 , C07D231/54 , C07D401/12 , C07D403/02 , C07D403/04 , C07D403/14 , C07D405/12 , C07D413/12 , C07D453/02 , A61K31/4155 , A61K31/416 , A61K31/4162 , A61P25/00
CPC classification number: C07D491/048 , C07D231/40 , C07D231/52 , C07D231/54 , C07D231/56 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/02 , C07D403/04 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D453/02 , C07D471/08
Abstract: Compounds of Formula I: or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C and X are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis and pelvic pain syndrome.
Abstract translation: 式I化合物或其立体异构体，互变异构体或其药学上可接受的盐，溶剂合物或前药，其中环A，环C和X如本文所定义，是TrkA激酶的抑制剂，并且可用于治疗可治疗的疾病 具有TrkA激酶抑制剂如疼痛，癌症，炎症/炎性疾病，神经变性疾病，某些感染性疾病，干燥综合征，子宫内膜异位症，糖尿病性周围神经病变，前列腺炎和骨盆疼痛综合征。
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2.发明申请SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS 审中-公开取代的吡唑并[1,5-a]吡嗪化合物作为TRK激酶抑制剂
公开(公告)号：WO2011006074A1
公开(公告)日：2011-01-13
申请号：PCT/US2010/041538
申请日：2010-07-09
Applicant: ARRAY BIOPHARMA INC. , ALLEN, Shelley , ANDREWS, Steven S. , CONDROSKI, Kevin Ronald , HAAS, Julia , HUANG, Lily , JIANG, Yutong , KERCHER, Timothy , SEO, Jeongbeob
Inventor： ALLEN, Shelley , ANDREWS, Steven S. , CONDROSKI, Kevin Ronald , HAAS, Julia , HUANG, Lily , JIANG, Yutong , KERCHER, Timothy , SEO, Jeongbeob
IPC: C07D487/04 , A61K31/519 , C07D519/00
CPC classification number: C07D487/04 , A61K31/519 , A61K31/5377 , C07D453/02 , C07D471/22 , C07D498/22 , C07D519/00
Abstract: Compounds of Formula (I) and salts thereof in which R 1 , R 2 , R 3 , R 4 , X, Y and n have the meanings given in the specification, are inhibitors of Trk kinases and are useful in the treatment of diseases which can be treated with a Trk kinase inhibitor such as pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseases.
Abstract translation: 其中R1，R2，R3，R4，X，Y和n具有本说明书中给出的含义的式（I）化合物及其盐是Trk激酶的抑制剂，可用于治疗可用 一种Trk激酶抑制剂，如疼痛，癌症，炎症，神经变性疾病和某些传染病。
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3.发明申请N-PYRROLIDINYL, N'-PYRAZOLYL- UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS AS TRKA KINASE INHIBITORS 审中-公开作为TRKA激酶抑制剂的N-吡咯烷酮，N' - 吡唑并 - 尿素，硫脲，胍和氰基胍化合物
公开(公告)号：WO2014078323A1
公开(公告)日：2014-05-22
申请号：PCT/US2013/069729
申请日：2013-11-12
Applicant: ARRAY BIOPHARMA INC. , ALLEN, Shelley , BRANDHUBER, Barbara, J. , KERCHER, Timothy , KOLAKOWSKI, Gabrielle, R. , WINSKI, Sharon, L.
Inventor： ALLEN, Shelley , BRANDHUBER, Barbara, J. , KERCHER, Timothy , KOLAKOWSKI, Gabrielle, R. , WINSKI, Sharon, L.
IPC: C07D403/12 , C07D401/14 , C07D403/14 , A61K31/4155 , A61P35/00 , A61P29/00 , A61P31/00 , A61P27/02
CPC classification number: C07D401/14 , C07D403/12 , C07D403/14
Abstract: Compounds of Formula (I) or stereoisomers, tautomers, or pharmaceutically acceptable salts, or solvates or prodrugs thereof, where R 1 , R 2 , R a , R b , R c , R d , X, Ring B, and Ring C are as defined herein, and wherein Ring B and the NH-C(=X)-NH moiety are in the trans configuration, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis or pelvic pain syndrome.
Abstract translation: 其中R 1，R 2，R a，R b，R c，R d，X，环B和环C如本文所定义的式（I）化合物或其立体异构体，互变异构体或其药学上可接受的盐或溶剂合物或前药， 环B和NH-C（= X）-NH部分是反式构型，是TrkA激酶的抑制剂，可用于治疗可用TrkA激酶抑制剂治疗的疾病，例如疼痛，癌症，炎症/ 炎性疾病，神经变性疾病，某些传染病，干燥综合征，子宫内膜异位症，糖尿病性周围神经病变，前列腺炎或骨盆疼痛综合征。
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公开(公告)号：WO2008005511A2
公开(公告)日：2008-01-10
申请号：PCT/US2007/015530
申请日：2007-06-05
Applicant: INTERMUNE, INC. , ARRAY BIOPHARMA, INC. , BLATT, Lawrence M. , SEIWERT, Scott , BEIGELMAN, Leonid , KERCHER, Timothy , KENNEDY, April L. , ANDREWS, Steven W.
Inventor： BLATT, Lawrence M. , SEIWERT, Scott , BEIGELMAN, Leonid , KERCHER, Timothy , KENNEDY, April L. , ANDREWS, Steven W.
IPC: C07D231/56 , C07D403/14 , C07D471/04 , A61K31/4035 , A61K31/416 , A61K31/437 , A61P31/14
CPC classification number: C07D403/14 , C07D231/56 , C07D471/04
Abstract: The embodiments provide compounds of the general Formula (I), as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments provide compounds of the general Formula (II), as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments provide compounds of the general Formula (III), as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
Abstract translation: 实施方案提供了通式（I）的化合物，以及包含主题化合物的组合物，包括药物组合物。 实施方案提供了通式（II）的化合物以及包含主题化合物的组合物，包括药物组合物。 实施方案提供了通式（III）的化合物以及包含主题化合物的组合物，包括药物组合物。 实施方案还提供治疗方法，包括治疗丙型肝炎病毒感染的方法和治疗肝纤维化的方法，所述方法通常涉及向有需要的个体施用有效量的主题化合物或组合物。
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5.发明申请N-(MONOCYCLIC ARYL),N'-PYRAZOLYL-UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS AS TRKA KINASE INHIBITORS 审中-公开作为TRKA激酶抑制剂的N-（单环芳烃），N'-吡唑并 - 尿酸，硫脲，胍和氰基胍化合物
公开(公告)号：WO2014078325A1
公开(公告)日：2014-05-22
申请号：PCT/US2013/069732
申请日：2013-11-12
Applicant: ARRAY BIOPHARMA INC. , ANDREWS, Steven Wade , BLAKE, James F. , BRANDHUBER, Barbara J. , KERCHER, Timothy , WINSKI, Shannon L.
Inventor： ANDREWS, Steven Wade , BLAKE, James F. , BRANDHUBER, Barbara J. , KERCHER, Timothy , WINSKI, Shannon L.
IPC: C07D403/12 , C07D401/14 , C07D231/40 , C07D231/44 , C07D401/04 , C07D413/12 , A61K31/4155 , A61P35/00 , A61P29/00 , A61P27/02
CPC classification number: C07D405/12 , A61K31/4155 , C07D231/40 , C07D231/44 , C07D231/52 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/04 , C07D413/12
Abstract: Compounds of Formula (I) or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C and X are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis or pelvic pain syndrome.
Abstract translation: 式（I）化合物或其立体异构体，互变异构体或其药学上可接受的盐，溶剂合物或前药，其中环A，环C和X如本文所定义，是TrkA激酶的抑制剂，并且可用于治疗可以 用TrkA激酶抑制剂治疗，如疼痛，癌症，炎症/炎性疾病，神经变性疾病，某些传染病，干燥综合征，子宫内膜异位症，糖尿病性周围神经病变，前列腺炎或骨盆疼痛综合征。
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Patent Agency Ranking6.发明申请NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION 审中-公开HEPATITIS C病毒复制的新型MACROCYCLIC抑制剂
公开(公告)号：WO2008137779A2
公开(公告)日：2008-11-13
申请号：PCT/US2008/062552
申请日：2008-05-02
Applicant: INTERMUNE, INC. , ARRAY BIOPHARMA, INC. , BLATT, Lawrence, M. , PAN, Lin , SEIWERT, Scott , ANDREWS, Steven, W. , MARTIN, Pierre , SCHUMACHER, Andreas , BEIGELMAN, Leonid , LIU, Jyanwei , CONDROSKI, Kevin , JIANG, Yutong , KAUS, Robert , KENNEDY, April , KERCHER, Timothy , LYON, Michael , WANG, Bin
Inventor： BLATT, Lawrence, M. , PAN, Lin , SEIWERT, Scott , ANDREWS, Steven, W. , MARTIN, Pierre , SCHUMACHER, Andreas , BEIGELMAN, Leonid , LIU, Jyanwei , CONDROSKI, Kevin , JIANG, Yutong , KAUS, Robert , KENNEDY, April , KERCHER, Timothy , LYON, Michael , WANG, Bin
IPC: C07D487/04 , C08H1/00 , A61K31/407 , A61P31/12
CPC classification number: C07D487/04
Abstract: The embodiments provide compounds of the general Formula I, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
Abstract translation: 实施方案提供了通式I的化合物，以及包含主题化合物的组合物，包括药物组合物。 实施方案还提供治疗方法，包括治疗丙型肝炎病毒感染的方法和治疗肝纤维化的方法，所述方法通常涉及向有需要的个体施用有效量的主题化合物或组合物。
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7.发明申请BICYCLIC HETEROARYL UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS AS TRKA KINASE INHIBITORS 审中-公开作为TRKA激酶抑制剂的双相异构尿素，硫脲，胍和氰基化合物
公开(公告)号：WO2014078408A1
公开(公告)日：2014-05-22
申请号：PCT/US2013/069886
申请日：2013-11-13
Applicant: ARRAY BIOPHARMA INC. , ALLEN, Shelley , BRANDHUBER, Barbara J. , CONDROSKI, Kevin Ronald , HUANG, Lily , KERCHER, Timothy , WINSKI, Shannon L.
Inventor： ALLEN, Shelley , BRANDHUBER, Barbara J. , CONDROSKI, Kevin Ronald , HUANG, Lily , KERCHER, Timothy , WINSKI, Shannon L.
IPC: C07D231/56 , C07D471/04 , C07D487/04 , C07D491/048 , C07D495/04 , A61K31/4985 , A61K31/437 , A61K31/416 , A61P29/00 , A61P35/00 , A61P25/00 , A61P31/00
CPC classification number: C07D487/04 , C07D231/56 , C07D403/12 , C07D471/04 , C07D491/048 , C07D495/04 , C07D519/00
Abstract: Compounds of Formula I or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C and X are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis and pelvic pain syndrome.
Abstract translation: 其中环A，环C和X如本文所定义的式I或其立体异构体，互变异构体或其药学上可接受的盐，溶剂合物或前药的化合物是TrkA激酶的抑制剂，并且可用于治疗可以用 一种TrkA激酶抑制剂，如疼痛，癌症，炎症/炎性疾病，神经变性疾病，某些传染病，干燥综合征，子宫内膜异位症，糖尿病性周围神经病变，前列腺炎和骨盆疼痛综合征。
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8.发明申请PYRROLIDINYL UREA AND PYRROLIDINYL THIOUREA COMPOUNDS AS TRKA KINASE INHIBITORS 审中-公开吡咯烷酮尿素和吡咯烷酮类化合物作为TRKA激酶抑制剂
公开(公告)号：WO2012158413A2
公开(公告)日：2012-11-22
申请号：PCT/US2012/037003
申请日：2012-05-09
Applicant: ARRAY BIOPHARMA INC. , ALLEN, Shelley , ANDREWS, Steven, W. , BLAKE, James, F. , CONDROSKI, Kevin, R. , HAAS, Julia , HUANG, Lily , JIANG, Yutong , KERCHER, Timothy , KOLAKOWSKI, Gabrielle R. , SEO, Jeongbeob
Inventor： ALLEN, Shelley , ANDREWS, Steven, W. , BLAKE, James, F. , CONDROSKI, Kevin, R. , HAAS, Julia , HUANG, Lily , JIANG, Yutong , KERCHER, Timothy , KOLAKOWSKI, Gabrielle R. , SEO, Jeongbeob
IPC: C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/04 , C07D495/04 , A61K31/4155 , A61K31/4162 , A61K31/4178 , A61K31/4192 , A61K31/4196 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/4439 , A61K31/4375 , A61K31/454 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/5377 , A61P25/28 , A61P29/02 , A61P35/00 , A61P33/00
CPC classification number: C07D403/12 , A61K31/4155 , A61K31/4162 , A61K31/4178 , A61K31/4192 , A61K31/4196 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/4375 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/5377 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/04 , C07D491/048 , C07D495/04 , Y02A50/414
Abstract: Compounds of Formula I: or stereoisomers, tautomers, or pharmaceutically acceptable salts, or solvates or prodrugs thereof, where R 1 , R 2 , R a , R b , R c , R d , X, Y, B, and Ring C are as defined herein, and wherein the Y-B moiety and the NH-C(=X)-NH moiety are in the trans configuration, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseases.
Abstract translation: 其中R1，R2，Ra，Rb，Rc，Rd，X，Y，B和环C如本文所定义的式I化合物或其立体异构体，互变异构体或其药学上可接受的盐或溶剂合物或前药，其中 YB部分和NH-C（= X）-NH部分是反式构型，是TrkA激酶的抑制剂，可用于治疗可用TrkA激酶抑制剂如疼痛，癌症，炎症治疗的疾病 ，神经变性疾病和某些传染病。
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9.发明申请5, 7-SUBSTITUTED-IMIDAZO [1, 2-C] PYRIMIDINES AS INHIBITORS OF JAK KINASES 审中-公开作为JAK KINASES的抑制剂的5,7-取代的咪唑并[1,2-C]吡啶
公开(公告)号：WO2011130146A1
公开(公告)日：2011-10-20
申请号：PCT/US2011/031896
申请日：2011-04-11
Applicant: ARRAY BIOPHARMA INC. , BOYS, Mark Laurence , BURGESS, Laurence, E. , GRONEBERG, Robert, D. , HARVEY, Darren, M. , HUANG, Lily , KERCHER, Timothy , KRASER, Christopher, F. , LAIRD, Ellen , TARLTON, Eugene , ZHAO, Qian
Inventor： BOYS, Mark Laurence , BURGESS, Laurence, E. , GRONEBERG, Robert, D. , HARVEY, Darren, M. , HUANG, Lily , KERCHER, Timothy , KRASER, Christopher, F. , LAIRD, Ellen , TARLTON, Eugene , ZHAO, Qian
IPC: C07D487/04 , A61P29/00 , A61P37/00 , A61K31/519
CPC classification number: C07D487/04 , C07D498/04
Abstract: Compounds of Formula I: (Formula should be inserted here) and stereoisomers and pharmaceutically acceptable salts and solvates thereof in which R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , X 1 and X 2 have the meanings given in the specification, are inhibitors of one or more JAK kinases and are useful in the treatment of autoimmune diseases, inflammatory diseases, rejection of transplanted organs, tissues and cells, as well as hematologic disorders and malignancies and their co-morbidities.
Abstract translation: 式I化合物（此处应该插入式）及其其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，X 1和X 2具有本说明书中给出的含义的立体异构体及其药学上可接受的盐和溶剂化物是抑制剂 的一种或多种JAK激酶，并且可用于治疗自身免疫性疾病，炎性疾病，移植器官，组织和细胞的排斥，以及血液系统疾病和恶性肿瘤及其并发症。
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10.发明申请PYRROLIDINYL UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS AS TRKA KINASE INHIBITORS 审中-公开吡咯烷酮尿素，硫脲，胍和氰尿嘧啶化合物作为TRKA激酶抑制剂
公开(公告)号：WO2014078378A1
公开(公告)日：2014-05-22
申请号：PCT/US2013/069838
申请日：2013-11-13
Applicant: ARRAY BIOPHARMA INC. , ALLEN, Shelley , ANDREWS, Steven, Wade , BLAKE, James, F. , BRANDHUBER, Barbara, J. , CONDROSKI, Kevin, Ronald , HAAS, Julia , JIANG, Yutong , KERCHER, Timothy , KOLAKOWSKI, Gabrielle, R. , WINSKI, Shannon, L.
Inventor： ALLEN, Shelley , ANDREWS, Steven, Wade , BLAKE, James, F. , BRANDHUBER, Barbara, J. , CONDROSKI, Kevin, Ronald , HAAS, Julia , JIANG, Yutong , KERCHER, Timothy , KOLAKOWSKI, Gabrielle, R. , WINSKI, Shannon, L.
IPC: C07D403/12 , C07D401/14 , C07D401/12 , C07D413/12 , C07D417/12 , C07D417/14 , A61K31/4025 , A61P29/00 , A61P35/00 , A61P25/28 , A61P27/02 , A61P13/08 , A61P13/06
CPC classification number: C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , C07D417/12 , C07D417/14
Abstract: Compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts, or solvates or prodrugs thereof, where R 1 , R 2 , R a , R b , R c , R d , X, Ring B, and Ring C are as defined herein, and wherein Ring B moiety and the NH-C(=X)-NH moiety are in the trans configuration, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis and pelvic pain syndrome.
Abstract translation: 式（I）的化合物或其立体异构体，互变异构体或其药学上可接受的盐或溶剂合物或前药，其中R 1，R 2，R a，R b，R c，R d，X，环B和环C如本文所定义， 其中环B部分和NH-C（= X）-NH部分处于反式构型，是TrkA激酶的抑制剂，并且可用于治疗可用TrkA激酶抑制剂如疼痛，癌症， 炎症/炎性疾病，神经变性疾病，某些传染病，干燥综合征，子宫内膜异位症，糖尿病性周围神经病变，前列腺炎和骨盆疼痛综合征。
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