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1.发明申请L-CARNITIN DEHYDROGENASES, THEIR DERIVATIVES AND METHOD FOR PRODUCING SUBSTITUTED (S) ALKANOLS 审中-公开L-肉碱脱氢酶，它们的衍生物和方法对取代的制造（S） - 链烷醇
公开(公告)号：WO2004090094A3
公开(公告)日：2005-03-17
申请号：PCT/EP2004003655
申请日：2004-04-06
Applicant: BASF AG , ALTHOEFER HENNING , KESSELER MARIA
Inventor： ALTHOEFER HENNING , KESSELER MARIA
CPC classification number: C12N9/0006 , C12P7/04 , C12P13/001 , C12P13/008 , C12P13/02 , C12P17/00 , C12P41/002
Abstract: The invention relates to proteins that have an enzymatic activity for reducing substituted alkanones, such as 3-methylamino-1-(2-thienyl)-propane-1-on. The invention also relates to nucleic acids that encode these proteins, to nucleic acid constructs, vectors, genetically modified microorganisms and to methods for producing substituted (S) alkanols, such as for example (S)-3-methylamino-1-(2-thienyl)-(S)-propanol.
Abstract translation: 本发明涉及一种具有用于取代的链烷酮，如3-甲基氨基-1-（2-噻吩基）的还原的酶活性的蛋白质 - 丙-1-酮。 本发明还涉及核酸编码这些蛋白质，核酸构建体，载体，遗传修饰的微生物和一种用于取代的（S）链烷醇，例如的制备方法 （S）-3-甲基氨基-1-（2-噻吩基） - （S） - 丙醇。
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2.发明申请NOVEL GENETIC PRODUCTS OBTAINED FROM ASHBYA GOSSYPII, WHICH ARE ASSOCIATED WITH TRANSCRIPTION MECHANISMS, RNA PROCESSING AND/OR TRANSLATION 审中-公开从阿舒囊霉棉蚜NEW基因产物转录，RNA加工和/或翻译ASSOZIERT的机制被
公开(公告)号：WO03020757A3
公开(公告)日：2003-08-28
申请号：PCT/EP0209656
申请日：2002-08-29
Applicant: BASF AG , KAROS MARVIN , ALTHOEFER HENNING , KROEGER BURKHARD , REVUELTA DOVAL JOSE L
Inventor： KAROS MARVIN , ALTHOEFER HENNING , KROEGER BURKHARD , REVUELTA DOVAL JOSE L
IPC: C12N15/09 , C07K14/37 , C07K16/14 , C12N1/15 , C12N1/19 , C12N5/10 , C12P25/00 , C12Q1/02 , C12N15/80
CPC classification number: C07K14/37
Abstract: The invention relates to novel polynucleotides obtained from Ashbya gossypii, to oligonucleotides that hybridise with the latter, to expression cassettes and vectors containing said polynucleotides, to micro-organisms transformed therewith, to polypeptides that have been coded by said polynucleotides and to the use of the novel polypeptides and polynucleotides as targets for modulating the control of transcription and/or translation and/or the control of RNA processing and in particular the improvement of vitamin B2 production in micro-organisms of the genus Ashbya.
Abstract translation: 本发明涉及从阿舒囊霉棉蚜新的多核苷酸; 寡核苷酸与其杂交的; 表达盒和包含这些多核苷酸的载体; 因此转化的微生物; 由这些多核苷酸编码的多肽; 和新的多肽和多核苷酸作为用于转录和/或翻译控制和/或RNA加工的控制，调制和特别是维生素B2生产的属阿舒囊霉的微生物的改善目标的应用程序。
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3.发明申请PROTEINS PARTICIPATING IN NUCLEOTIDE METABOLISM AND GENES CODING FOR THE SAME FROM ASHBYA GOSSYPII 审中-公开AM核苷酸代谢有关的蛋白确保两编码基因FROM阿舒囊霉棉蚜
公开(公告)号：WO0222673A3
公开(公告)日：2003-03-20
申请号：PCT/EP0110576
申请日：2001-09-13
Applicant: BASF AG , ALTHOEFER HENNING , REVUELTA DOVAL JOSE L , SANTOS MARIA
Inventor： ALTHOEFER HENNING , REVUELTA DOVAL JOSE L , SANTOS MARIA
Abstract: The invention relates to novel nucleic acid molecules and polypeptides encoded thereby, which may be used for identification or classification of Ashbya gossypii or related types of micro-organisms.
Abstract translation: 本发明提供新的核酸分子和编码的多肽制备的可用于识别或分类微生物阿舒囊霉棉蚜或相关物种。
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公开(公告)号：WO9829538A3
公开(公告)日：1998-12-10
申请号：PCT/EP9707309
申请日：1997-12-29
Applicant: BASF AG , ALTMANN JOEHL REGULA , PHILIPPSEN PETER , ALTHOEFER HENNING , SEULBERGER HARALD
Inventor： ALTMANN-JOEHL REGULA , PHILIPPSEN PETER , ALTHOEFER HENNING , SEULBERGER HARALD
IPC: C12N15/09 , C07K14/37 , C12N1/15 , C12N9/02 , C12N9/04 , C12N9/10 , C12N9/88 , C12N15/00 , C12N15/31 , C12N15/60 , C12P25/00 , C12Q1/18 , C12Q1/68 , C12R1/645 , C12R1/865
CPC classification number: C07K14/37 , C12N9/0006 , C12N9/1077 , C12N9/88 , C12P25/00
Abstract: A gene is disclosed which contains the nucleotide sequence represented by SE ID NO:1 and which extends from nucleotide 671 to nucleotide 6295, or a nucleotide sequence derived therefrom by substitution, insertion or deletion of up to 30 %, 20 %, 10 % or 5 % of its nucleotides, the lower percentages being preferable, and whose genetic product exhibits the enzymatic activity of an adenylate cyclase. Also disclosed is its use.
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公开(公告)号：WO2004022776A3
公开(公告)日：2004-07-08
申请号：PCT/EP0309369
申请日：2003-08-23
Applicant: BASF AG , FREUND ANNETTE , ROEHL FRANZ , ALTHOEFER HENNING , KAROS MARVIN , KAESLER BRUNO , LACOUR THIERRY
Inventor： FREUND ANNETTE , ROEHL FRANZ , ALTHOEFER HENNING , KAROS MARVIN , KAESLER BRUNO , LACOUR THIERRY
CPC classification number: A01N61/00 , A01N43/90 , C12N9/78 , C12Q1/34 , C12Y305/04025 , G01N2500/02
Abstract: The present invention relates to inhibition of GTP cyclohydrolase II as target for the identification of fungicides. Binding assays are claimed and coupled enzymatic assays are disclosed involving the conversion of formate (product of the reaction catalyzed by GTP-cyclohydrolases) by formate dehydrogenase and spectroscopically measuring the NADH formed. Furthermore in vivo assays with organisms containing a GTP-cyclohydrolase II are claimed as well as a DNA sequence for a fungal GTP-cyclohydrolase II. 3-Butyl-10-(3-chlorophenyl)- 10H-pyrimido[4,5-b]quinoline-2,4-dione is identified by the enzymatic method as a fungicide. Finally, methods of controlling fungi (e.g. on plants, in soil) by applying this agent are claimed.
Abstract translation: 本发明涉及抑制GTP环化水解酶II作为鉴定杀真菌剂的靶标。 公开了结合测定法，并公开了偶联的酶测定法，其涉及通过甲酸脱氢酶转化甲酸盐（由GTP-环化水解酶催化的反应产物）并光谱测量形成的NADH。 此外还要求具有含有GTP-环化水解酶II的生物体的体内测定以及用于真菌GTP-环化水解酶II的DNA序列。 通过酶法将3-丁基-10-（3-氯苯基）-10H-嘧啶并[4,5-b]喹啉-2,4-二酮鉴定为杀真菌剂。 最后，要求保护通过施用该试剂控制真菌（例如在土壤中的植物上）的方法。
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Patent Agency Ranking6.发明申请ASHBYA GOSSYPII GENES CODING FOR PROTEINS INVOLVED IN MEMBRANE TRANSPORT 审中-公开阿舒囊霉棉蚜基因编码蛋白质在所涉及的膜转运
公开(公告)号：WO0222824A3
公开(公告)日：2002-12-19
申请号：PCT/EP0110575
申请日：2001-09-13
Applicant: BASF AG , ALTHOEFER HENNING , REVUELTA DOVAL JOSE L , SANTOS MARIA
Inventor： ALTHOEFER HENNING , REVUELTA DOVAL JOSE L , SANTOS MARIA
Abstract: The invention relates to novel nucleic acid molecules and polypeptides coded by the same which can be used for identifying or classifying Ashbya gossypii or related species of fungus.
Abstract translation: 本发明提供了编码准备新的核酸分子和多肽可以用于识别或分类的阿舒囊霉棉蚜的或相关的真菌物种。
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公开(公告)号：WO9961623A3
公开(公告)日：2000-01-27
申请号：PCT/EP9903196
申请日：1999-05-10
Applicant: BASF AG , ALTHOEFER HENNING , SEULBERGER HARALD , ZELDER OSKAR , REVUELTA DOVAL JOSE LUIS
Inventor： ALTHOEFER HENNING , SEULBERGER HARALD , ZELDER OSKAR , REVUELTA DOVAL JOSE LUIS
IPC: C12N15/09 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/54 , C12N15/80 , C12P25/00 , C12N15/52
Abstract: The invention relates to a genetic method for producing riboflavin. The production of riboflavin in organisms is increased by specially selecting genes of the riboflavin biosynthesis or of the combination thereof in organisms, especially in bacteria, fungi, yeasts and plants, and of the expression thereof. The invention also relates to a nucleic acid fragment containing genes with the sequences SEQ ID No. 1, SEQ ID No. 3 or SEQ ID No. 5 or the functional equivalents thereof, to expression vectors containing the nucleic acid fragments, and to organisms containing at least one nucleic acid fragment or at least one vector.
Abstract translation: 本发明涉及一种用于核黄素的制备遗传程序。 由核黄素生物合成或在生物体它们的组合，特别是在细菌，真菌，酵母，植物和它们的表达的基因的特殊选择，核黄素产量在这些生物中增加。 本发明还涉及核酸片段具有序列SEQ ID号含有基因 1，SEQ ID号 3或SEQ ID号 其5个或功能等同物，包括含有至少一种核酸片段或至少一种载体中的核酸片段和有机体的表达载体。
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8.发明申请ANIMAL FOOD ADDITIVES CONTAINING A VITAMIN B6 AND/OR THE SALTS THEREOF AND METHOD FOR PRODUCING SAID ADDITIVES 审中-公开维生素B6和/或它们的含盐饲料添加剂及其制备方法
公开(公告)号：WO2004034810A3
公开(公告)日：2004-05-21
申请号：PCT/EP0311130
申请日：2003-10-08
Applicant: BASF AG , ALTHOEFER HENNING , ACHATZ BRIGITTE , SCHOENHERR MICHAEL
Inventor： ALTHOEFER HENNING , ACHATZ BRIGITTE , SCHOENHERR MICHAEL
CPC classification number: C12P17/12 , A23K20/174 , A23K20/20 , A23K40/10 , A23K40/20
Abstract: The invention relates to animal food additives containing a vitamin B6, a method for producing said additives, animal food compounds containing the inventive additive and a method for introducing said additives into the animal food compounds.
Abstract translation: 本发明涉及含维生素B6的饲料添加剂，其制备方法，添加有本发明饲料添加剂的动物饲料组合物，以及使用本发明添加剂添加动物饲料组合物的方法。
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9.发明申请PROTEINS INVOLVED IN THE STRESS RESPONSE AND GENES FROM ASHBYA GOSSYPII CODING FOR THE SAME 审中-公开对涉及及应激反应蛋白。确保编码基因FROM阿舒囊霉棉蚜
公开(公告)号：WO0222823A3
公开(公告)日：2003-04-10
申请号：PCT/EP0110573
申请日：2001-09-13
Applicant: BASF AG , ALTHOEFER HENNING , REVUELTA DOVAL JOSE L , SANTOS MARIA
Inventor： ALTHOEFER HENNING , REVUELTA DOVAL JOSE L , SANTOS MARIA
CPC classification number: C07K14/37
Abstract: The invention relates to nucleic acid molecules and polypeptides coded by the same which can be used for identifying or classifying Ashbya gossypii or related species of micro-organisms.
Abstract translation: 本发明涉及可用于核酸分子和编码的多肽，用于阿舒囊霉棉蚜或相关的微生物的鉴定或分类的物种。
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10.发明申请
公开(公告)号：WO0111052A3
公开(公告)日：2001-07-05
申请号：PCT/EP0007370
申请日：2000-07-31
Applicant: BASF AG , FORSCHUNGSZENTRUM JUELICH GMBH , ALTHOEFER HENNING , ZELDER OSKAR , REVUELTA DOVAL JOSE L , SANTOS GARCIA MARIA ANGELES , SAHM HERMANN , STAHMANN KLAUS PETER , MAETING INES
Inventor： ALTHOEFER HENNING , ZELDER OSKAR , REVUELTA DOVAL JOSE L , SANTOS GARCIA MARIA ANGELES , SAHM HERMANN , STAHMANN KLAUS-PETER , MAETING INES
IPC: C12N15/09 , C12N1/14 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/04 , C12N15/53 , C12P25/00 , C12R1/645 , C12N15/80
CPC classification number: C12N9/0006 , C12P25/00
Abstract: The invention relates to a monocellular or multicellular organism, especially a microorganism, for biotechnological production of riboflavin, whereby the enzymatic activity thereof with respect to NAD(P)H formation is higher than that of a wild type of species Ashbya gossypii ATCC10895.
Abstract translation: 本发明涉及一种单细胞或多细胞生物体中，在用于生物技术生产核黄素的方法，其中相对于所述NAD（P）H形式的酶的活性比野生型物种阿舒囊霉棉蚜ATCC10895的更高特定微生物。
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