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1.发明申请USE OF THE REPRESSOR GLXR FOR THE SYNTHESIS OF LYSINE IN CORYNEBACTERIUM GLUTAMICUM 审中-公开使用代谢物GLXR合成玉米淀粉中的赖氨酸
公开(公告)号：WO03097678A2
公开(公告)日：2003-11-27
申请号：PCT/EP0304969
申请日：2003-05-13
Applicant: BASF AG , KLOPPROGGE CORINNA , ZELDER OSKAR , KROEGER BURKHARD , SCHROEDER HARTWIG , HAEFNER STEFAN , LEE HEUNG-SHICK
Inventor： KLOPPROGGE CORINNA , ZELDER OSKAR , KROEGER BURKHARD , SCHROEDER HARTWIG , HAEFNER STEFAN , LEE HEUNG-SHICK
CPC classification number: C07K14/34
Abstract: Isolated polypeptide sequence having the sequence of SEQ ID NO:1 or muteins thereof having the ability to bind cAMP and repress the expression of the aceB gene of C. glutamicum and which can be obtained from SEQ ID NO:1 by inserting, deleting or substituting up to 20% of the amino acids.
Abstract translation: 具有SEQ ID NO：1的序列的分离的多肽序列或其突变蛋白具有结合cAMP的能力并抑制谷氨酸棒杆菌的aceB基因的表达，并且可以通过插入，缺失或替代从SEQ ID NO：1获得 高达20％的氨基酸。
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2.发明申请
公开(公告)号：WO2007011939A3
公开(公告)日：2007-07-05
申请号：PCT/US2006027855
申请日：2006-07-18
Applicant: BASF AG , ZELDER OSKAR , HAEFNER STEFAN , HEROLD ANDREA , KLOPPROGGE CORINNA , SCHRODER HARTWIG , YOCUM R ROGERS , WILLIAMS MARK K
Inventor： ZELDER OSKAR , HAEFNER STEFAN , HEROLD ANDREA , KLOPPROGGE CORINNA , SCHRODER HARTWIG , YOCUM R ROGERS , WILLIAMS MARK K
IPC: C12P13/12
CPC classification number: C12P13/12
Abstract: The present invention features improved processes and organisms for the production of methionine. The invention demonstrates that a ?metF organism or a ?metE AmetH organism, for example, mutants of C. glutamicum or E. coli, can use a methyl capped sulfide source, e.g., dimethyl disulfide (DMDS), as a source of both sulfur and a methyl group, bypassing the need for MetH/Met? and MetF activity and the need to reduce sulfate, for the synthesis of methionine. Also described in this patent are data implicating MetY (also called MetZ) as an enzyme that incorporates a methyl capped sulfide source, e.g., DMDS, into methionine. A ?metF ?metB strain of C. glutamicum can use a methyl capped sulfide source, e.g., DMDS, as a source of both sulfide and a methyl group. Furthermore, methionine production by engineered prototrophic organisms that overproduce O-acetyl-homoserine was improved by the addition of a methyl capped sulfide source, e.g., DMDS.
Abstract translation: 本发明的特征在于用于生产甲硫氨酸的改进方法和生物体。 本发明证明，metF生物体或αmetE AmetH生物体，例如谷氨酸棒状杆菌或大肠杆菌的突变体可以使用甲基封端的硫化物源，例如二甲基二硫（DMDS）作为硫的来源 和甲基，绕过MetH / Met？ 和MetF活性以及减少硫酸盐的需要，用于合成甲硫氨酸。 该专利中还描述了涉及MetY（也称为MetZ）的数据，其作为将甲基封端的硫化物源（例如DMDS）并入甲硫氨酸中的酶。 谷氨酸棒状芽孢杆菌的ΔFIFFmetB菌株可以使用甲基封端的硫化物源，例如DMDS，作为硫化物和甲基两者的来源。 此外，通过加入甲基封端的硫化物源（例如DMDS），改善过度产生O-乙酰高丝氨酸的工程化原养殖生物体的甲硫氨酸生产。
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3.发明申请
公开(公告)号：WO2007020295A3
公开(公告)日：2007-05-03
申请号：PCT/EP2006065460
申请日：2006-08-18
Applicant: BASF AG , ZELDER OSKAR , HEROLD ANDREA , KLOPPROGGE CORINNA , SCHROEDER HARTWIG , HAEFNER STEFAN , HEINZLE ELMAR , WITTMANN CHRISTOPH , KROEMER JENS , PERO JANICE , YOCUM ROGERS , PATTERSON THOMAS , WILLIAMS MARK , HERMAN THERON
Inventor： ZELDER OSKAR , HEROLD ANDREA , KLOPPROGGE CORINNA , SCHROEDER HARTWIG , HAEFNER STEFAN , HEINZLE ELMAR , WITTMANN CHRISTOPH , KROEMER JENS , PERO JANICE , YOCUM ROGERS , PATTERSON THOMAS , WILLIAMS MARK , HERMAN THERON
Abstract: The present invention concerns methods for the production of microorganisms with increased efficiency for methionine synthesis. The present invention also concerns microorganisms with increased efficiency for methionine synthesis. Furthermore, the present invention concerns methods for determining the optimal metabolic flux for organisms with respect to methionine synthesis.
Abstract translation: 本发明涉及生产甲硫氨酸合成效率提高的微生物的方法。 本发明还涉及甲硫氨酸合成效率提高的微生物。 此外，本发明涉及用于确定与甲硫氨酸合成有关的生物体的最佳代谢通量的方法。
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公开(公告)号：WO2005121349A3
公开(公告)日：2006-04-13
申请号：PCT/IB2004004463
申请日：2004-12-17
Applicant: BASF AG , ZELDER OSKAR , KLOPPROGGE CORINNA , SCHROEDER HARTWIG , HAEFNER STEFAN , KROEGER BURKHARD , KIEFER PATRICK , HEINZLE ELMAR , WITTMANN CHRISTOPH
Inventor： ZELDER OSKAR , KLOPPROGGE CORINNA , SCHROEDER HARTWIG , HAEFNER STEFAN , KROEGER BURKHARD , KIEFER PATRICK , HEINZLE ELMAR , WITTMANN CHRISTOPH
CPC classification number: C12P13/08
Abstract: The present invention features methods of increasing the production of a fine chemical, e.g., lysine from a microorganism, e.g.,
Abstract translation: 本发明的特征在于增加精细化学品例如来自微生物的赖氨酸的生产的方法，例如，
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5.发明申请METHOD FOR ZYMOTIC PRODUCTION OF FINE CHEMICALS (METY) CONTAINING SULPHUR 审中-公开过程为硫FINE CHEMICALS的发酵制备（METY）
公开(公告)号：WO2004024933A3
公开(公告)日：2004-04-22
申请号：PCT/EP0309453
申请日：2003-08-26
Applicant: BASF AG , KROEGER BURKHARD , ZELDER OSKAR , KLOPPROGGE CORINNA , SCHROEDER HARTWIG , HAEFNER STEFAN
Inventor： KROEGER BURKHARD , ZELDER OSKAR , KLOPPROGGE CORINNA , SCHROEDER HARTWIG , HAEFNER STEFAN
Abstract: The invention relates to methods for the zymotic production of fine chemicals, especially L-methionine, containing sulphur using bacteria, wherein a nucleotide sequence coding for a methionine-synthase (metY)-gene is expressed.
Abstract translation: 本发明涉及一种用于发酵生产的含硫精细化学品，特别是L-甲硫氨酸的方法，利用细菌，其中用于甲硫氨酸合酶一个（metY）基因编码核苷酸序列被表达。
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Patent Agency Ranking
公开(公告)号：WO2005059093A3
公开(公告)日：2006-03-02
申请号：PCT/EP2004014266
申请日：2004-12-15
Applicant: BASF AG , KROEGER BURKHARD , ZELDER OSKAR , KLOPPROGGE CORINNA , SCHROEDER HARTWIG , HAEFNER STEFAN
Inventor： KROEGER BURKHARD , ZELDER OSKAR , KLOPPROGGE CORINNA , SCHROEDER HARTWIG , HAEFNER STEFAN
IPC: C07K14/34 , C12N20060101 , C12N1/00 , C12N15/63 , C12N15/67 , C12N15/77 , C12P1/00 , C12P13/08 , C12P13/12 , C12N1/21
Abstract: The invention relates to the use of nucleic acid sequences for regulating gene transcription and expression, said novel promoters and expression units, methods for modifying or inducing the gene transcription rate and/or expression rate, expression cassettes containing said expression units, genetically modified microorganisms having a modified or induced transcription rate and/or expression rate, and methods for producing biosynthetic products by cultivating said genetically modified microorganisms.
Abstract translation: 本发明涉及使用核酸序列的调节基因，所述新的启动子和表达单元本身的转录和表达，用于改变或引起转录和/或基因的表达率的速率的方法，含有该表达单元的表达盒，具有改变的遗传修饰的微生物或 引起转录速率和/或表达的速率以及通过培养遗传修饰的微生物的制备生物合成产物的方法。
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7.发明申请METHODS FOR THE PREPARATION OF LYSINE BY FERMENTATION OF CORYNEBACTERIUM GLUTAMICUM 审中-公开通过发酵玉米淀粉制备赖氨酸的方法
公开(公告)号：WO2005059139A3
公开(公告)日：2005-08-11
申请号：PCT/IB2004004429
申请日：2004-12-17
Applicant: BASF AG , ZELDER OSKAR , KLOPPROGGE CORINNA , SCHROEDER HARTWIG , HAEFNER STEFAN , KROEGER BURKHARD , KIEFER PATRICK , HEINZLE ELMAR , WITTMANN CHRISTOPH
Inventor： ZELDER OSKAR , KLOPPROGGE CORINNA , SCHROEDER HARTWIG , HAEFNER STEFAN , KROEGER BURKHARD , KIEFER PATRICK , HEINZLE ELMAR , WITTMANN CHRISTOPH
Abstract: The present invention features methods of increasing the production of a fine chemical, e.g., lysine from a microorganism, e.g., Corynebacterium by way of deregulating an enzyme encoding gene, i.e., fructose- l,6-bisphosphatase. In a preferred embodiment, the invention provides methods of increasing the production of lysine in Corynebacterium glutamicum by way of increasing the expression of fructose-1,6-bisphosphatase activity. The invention also provides a novel process for the production of lysine by way of regulating carbon flux towards oxaloacetate (OAA). In a preferred embodiment, the invention provides methods for the production of lysine by way of utilizing fructose or sucrose as a carbon source.
Abstract translation: 本发明的特征在于通过使酶编码基因（即果糖-1,6-二磷酸酶）失调来增加精细化学品例如来自微生物例如棒状杆菌的赖氨酸的生产方法。 在优选的实施方案中，本发明提供了通过增加果糖-1,6-二磷酸酶活性的表达来增加谷氨酸棒杆菌中赖氨酸的产生的方法。 本发明还提供了通过调节向草酰乙酸（OAA）的碳通量来生产赖氨酸的新方法。 在优选的实施方案中，本发明提供了通过使用果糖或蔗糖作为碳源来生产赖氨酸的方法。
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8.发明申请
公开(公告)号：WO2004024932A3
公开(公告)日：2004-04-22
申请号：PCT/EP0309452
申请日：2003-08-26
Applicant: BASF AG , KROEGER BURKHARD , ZELDER OSKAR , KLOPPROGGE CORINNA , SCHROEDER HARTWIG , HAEFNER STEFAN
Inventor： KROEGER BURKHARD , ZELDER OSKAR , KLOPPROGGE CORINNA , SCHROEDER HARTWIG , HAEFNER STEFAN
Abstract: The invention relates to methods for the zymotic production of fine chemicals, especially L-methionine, containing sulphur using bacteria, wherein a nucleotide sequence coding for a methionine-synthase (methA)-gene is expressed.
Abstract translation: 本发明涉及使用其中表达编码甲硫氨酸合酶（methA）基因核苷酸序列的细菌来发酵生产含硫精细化学品，特别是L-甲硫氨酸的方法。
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9.发明申请METHOD FOR THE PRODUCTION BY FERMENTATION OF SULPHUR-CONTAINING FINE CHEMICALS (METF) 审中-公开过程为硫FINE CHEMICALS的发酵制备（metF）
公开(公告)号：WO2004024931A3
公开(公告)日：2004-04-22
申请号：PCT/EP0309451
申请日：2003-08-26
Applicant: BASF AG , KROEGER BURKHARD , ZELDER OSKAR , KLOPPROGGE CORINNA , SCHROEDER HARTWIG , HAEFNER STEFAN
Inventor： KROEGER BURKHARD , ZELDER OSKAR , KLOPPROGGE CORINNA , SCHROEDER HARTWIG , HAEFNER STEFAN
Abstract: The invention relates to methods for the production by fermentation of sulphur-containing fine chemicals, in particular L-methionine, using bacteria in which a nucleic acid sequence coding for a methionine synthase gene (metF) is expressed.
Abstract translation: 本发明涉及一种用于发酵生产的含硫精细化学品的方法，特别是L-甲硫氨酸，利用细菌，其中用于甲硫氨酸合酶一个（metF）基因编码核苷酸序列被表达。
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公开(公告)号：WO2007051725A3
公开(公告)日：2007-06-28
申请号：PCT/EP2006067680
申请日：2006-10-23
Applicant: BASF AG , ZELDER OSKAR , HEROLD ANDREA , KLOPPROGGE CORINNA , SCHROEDER HARTWIG , HAEFNER STEFAN , HEINZLE ELMAR , WITTMANN CHRISTOPH , KROEMER JENS , PERO JANICE G , YOCUM R ROGERS , PATTERSON THOMAS A , WILLIAMS MARK , HERMAN THERON
Inventor： ZELDER OSKAR , HEROLD ANDREA , KLOPPROGGE CORINNA , SCHROEDER HARTWIG , HAEFNER STEFAN , HEINZLE ELMAR , WITTMANN CHRISTOPH , KROEMER JENS , PERO JANICE G , YOCUM R ROGERS , PATTERSON THOMAS A , WILLIAMS MARK , HERMAN THERON
CPC classification number: C12P13/12 , A23K10/16 , A23K20/142 , A23K40/10 , C12N15/52
Abstract: The present invention relates to microorganisms and processes for the efficient preparation of L-amino acids such as L-methionine. In particular, the present invention relates to microorganisms and processes in which the formation and/or accumulation of homolanthionine in the methionine pathway is reduced and/or prevented.
Abstract translation: 本发明涉及用于有效制备L-氨基酸如L-甲硫氨酸的微生物和方法。 特别地，本发明涉及微生物和其中甲硫氨酸途径中高山ion素的形成和/或积累减少和/或预防的方法。
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