公开(公告)号：JP2007267746A

公开(公告)日：2007-10-18

申请号：JP2007125488

申请日：2007-05-10

Applicant: Basf Ag ,  ビーエーエスエフ アクチェンゲゼルシャフトBASF Aktiengesellschaft

Inventor： POMPEJUS MARKUS ,  KROEGER BURKHARD ,  SCHROEDER HARTWIG ,  ZELDER OSKAR ,  HABERHAUER GREGOR

IPC: C12N15/09 ,  G01N33/53 ,  C07K20060101 ,  C07K14/34 ,  C12N20060101 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/00 ,  C12N9/12 ,  C12N9/18 ,  C12N9/88 ,  C12N15/31 ,  C12N15/55 ,  C12P20060101 ,  C12P13/04 ,  C12P13/08 ,  C12P21/02 ,  C12Q20060101 ,  C12Q1/04 ,  C12Q1/68 ,  C12R1/15 ,  G01N33/566 ,  G01N33/569

CPC classification number: C12N9/88 ,  C07K14/34 ,  C12N9/16 ,  C12N9/18

Abstract: PROBLEM TO BE SOLVED: To provide an SMP nucleic acid and a protein molecule, associated with metabolism of carbon compound such as a sugar by a process (oxidative phosphorylation or the like) in Corynebacterium-glutamicum, and formation of an energy molecule. SOLUTION: The isolated nucleic acid molecules selected from a group consisting of a specific sequence associated with the metabolism of the carbon compound such as the sugar by the oxidative phosphorylation or the like of the Corynebacterium-glutamicum, and the formation of the energy molecule, or a complementary molecule thereof is provided. The vector containing the nucleic acid molecule, and the host cell in which the production of a fine chemical is regulated by the expression of the nucleic acid molecule are also provided. COPYRIGHT: (C)2008,JPO&INPIT

Abstract translation: 待解决的问题：提供与谷氨酸棒杆菌中的方法（氧化磷酸化等）等碳化合物如糖的代谢相关的SMP核酸和蛋白质分子，以及能量分子的形成 。 解决方案：选自与碳化合物的代谢相关的特异性序列的分离的核酸分子，例如通过谷氨酸棒杆菌的氧化磷酸化等的糖的形成和能量的形成 分子或其互补分子。 还提供了含有核酸分子的载体和精细化学品的产生受核酸分子的表达调节的宿主细胞。 版权所有（C）2008，JPO＆INPIT

公开(公告)号：JP2007267744A

公开(公告)日：2007-10-18

申请号：JP2007115460

申请日：2007-04-25

Applicant: Basf Ag ,  ビーエーエスエフ アクチェンゲゼルシャフトBASF Aktiengesellschaft

Inventor： POMPEJUS MARKUS ,  KROEGER BURKHARD ,  SCHROEDER HARTWIG ,  ZELDER OSKAR ,  HABERHAUER GREGOR

IPC: C12N15/09 ,  G01N33/53 ,  C07K14/34 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/00 ,  C12N9/10 ,  C12N9/12 ,  C12N15/31 ,  C12N15/54 ,  C12P1/00 ,  C12P1/04 ,  C12P13/04 ,  C12P21/02 ,  C12Q1/04 ,  C12Q1/68 ,  C12R1/13 ,  C12R1/16 ,  G01N33/566 ,  G01N33/569

CPC classification number: C12N9/1223 ,  C12N9/12 ,  C12Y207/03009

Abstract: PROBLEM TO BE SOLVED: To provide a Corynebacterium glutamicum gene encoding phosphoenolpyruvate: sugar phosphotransferase system (PTS) protein. SOLUTION: The isolated nucleic acid encoding a novel PTS protein from Corynebacterium glutamicum is isolated. The antisense nucleic acid molecule, the recombinant expression vector containing a PTS nucleic acid molecule, and the host cell into which the expression vector has been introduced are also prepared. The isolated PTS protein, the mutated PTS protein, the fusion protein, the antigenic peptide and the method for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of the PTS gene are also provided. COPYRIGHT: (C)2008,JPO&INPIT

Abstract translation: 待解决的问题：提供编码磷酸烯醇丙酮酸的谷氨酸棒杆菌基因：糖磷酸转移酶系统（PTS）蛋白。 解决方案：分离编码来自谷氨酸棒杆菌的新型PTS蛋白的分离的核酸。 还制备了反义核酸分子，含有PTS核酸分子的重组表达载体，以及引入了表达载体的宿主细胞。 还提供了基于PTS基因的遗传工程的分离的PTS蛋白，突变的PTS蛋白，融合蛋白，抗原肽以及用于从谷氨酸棒球菌的谷氨酸棒球菌生产所需化合物的方法。 版权所有（C）2008，JPO＆INPIT

公开(公告)号：JP2006141405A

公开(公告)日：2006-06-08

申请号：JP2006011153

申请日：2006-01-19

Applicant: Basf Ag ,  ビーエーエスエフ アクチェンゲゼルシャフトBASF Aktiengesellschaft

Inventor： POMPEJUS MARKUS ,  KROEGER BURKHARD ,  SCHROEDER HARTWIG ,  ZELDER OSKAR ,  HABERHAUER GREGOR

IPC: C12N15/09 ,  G01N33/53 ,  C07K20060101 ,  C07K14/34 ,  C12N20060101 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/00 ,  C12N9/12 ,  C12N9/18 ,  C12N9/88 ,  C12N15/31 ,  C12N15/55 ,  C12P20060101 ,  C12P13/04 ,  C12P13/08 ,  C12P21/02 ,  C12Q20060101 ,  C12Q1/68 ,  C12R1/13 ,  C12R1/15 ,  G01N33/566 ,  G01N33/569

CPC classification number: C12N9/88 ,  C07K14/34 ,  C12N9/16 ,  C12N9/18

Abstract: PROBLEM TO BE SOLVED: To provide a nucleic acid and protein molecule involved in oxidative phosphorylation (SMP) involved in carbon compound metabolism such as sugars and in the generation of energy molecules in Corynebacterium glutamicum which is a novel microorganism and has a variety of uses. SOLUTION: Disclosed is an isolated Corynebacterium glutamicum nucleic acid molecule selected from the group consisting of sequences represented by specific sequence numbers and not including any specific genes, or a complement thereof. COPYRIGHT: (C)2006,JPO&NCIPI

Abstract translation: 待解决的问题：提供涉及碳化合物代谢如糖的氧化磷酸化（SMP）的核酸和蛋白质分子，以及作为新型微生物的谷氨酸棒杆菌中的能量分子的产生，并且具有多种 的用途。 解决方案：公开了一种分离的谷氨酸棒杆菌核酸分子，其选自由特定序列号表示的序列，不包括任何特定基因或其互补物。 版权所有（C）2006，JPO＆NCIPI

公开(公告)号：JP2007289192A

公开(公告)日：2007-11-08

申请号：JP2007125440

申请日：2007-05-10

Applicant: Basf Ag ,  ビーエーエスエフ アクチェンゲゼルシャフトBASF Aktiengesellschaft

Inventor： POMPEJUS MARKUS ,  KROEGER BURKHARD ,  SCHROEDER HARTWIG ,  ZELDER OSKAR ,  HABERHAUER GREGOR

IPC: C12N15/09 ,  G01N33/53 ,  C07K20060101 ,  C07K14/34 ,  C12N20060101 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/00 ,  C12N9/12 ,  C12N9/18 ,  C12N9/88 ,  C12N15/31 ,  C12N15/55 ,  C12P20060101 ,  C12P1/04 ,  C12P13/04 ,  C12P13/08 ,  C12P21/02 ,  C12Q20060101 ,  C12Q1/06 ,  C12Q1/68 ,  C12R1/15 ,  G01N33/566 ,  G01N33/569 ,  G01N33/68

CPC classification number: C12N9/88 ,  C07K14/34 ,  C12N9/16 ,  C12N9/18

Abstract: PROBLEM TO BE SOLVED: To provide a SMP nucleic acid involved in the metabolisms of carbon compounds such as sugars and the production of energy molecules in processes (oxidative phosphation or the like) in Corynebacterium glutamicum, and to provide a protein molecule. SOLUTION: Corynebacterium glutamicum nucleic acid selected and isolated from a group consisting of specific sequences, or its complementary material. The whole genome DNA of Corynebacterium glutamicum ATCC 13032 strain is extracted. The DNA is used to produce a plasmid or cosmid library. The base sequence of the library is determined. The sequence is subjected to a computer analysis to analyze functions. The selected library is used in an expression system to confirm its functions. COPYRIGHT: (C)2008,JPO&INPIT

Abstract translation: 待解决的问题：提供参与碳化合物如糖的代谢中的SMP核酸和谷氨酸棒杆菌中的过程（氧化磷酸化等）中能量分子的产生，并提供蛋白质分子。 解决方案：从由特定序列组成的组或其互补材料中选择和分离的谷氨酸棒杆菌核酸。 提取谷氨酸棒杆菌ATCC 13032菌株的全基因组DNA。 DNA用于产生质粒或粘粒文库。 确定文库的碱基序列。 对序列进行计算机分析以分析功能。 所选的库用于表达式系统以确认其功能。 版权所有（C）2008，JPO＆INPIT

公开(公告)号：JP2007252389A

公开(公告)日：2007-10-04

申请号：JP2007141323

申请日：2007-05-29

Applicant: Basf Ag ,  ビーエーエスエフ アクチェンゲゼルシャフトBASF Aktiengesellschaft

Inventor： POMPEJUS MARKUS ,  KROEGER BURKHARD ,  SCHROEDER HARTWIG ,  ZELDER OSKAR ,  HABERHAUER GREGOR

IPC: C12N15/09 ,  G01N33/53 ,  C07K20060101 ,  C07K14/34 ,  C12N20060101 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/00 ,  C12N9/04 ,  C12N9/12 ,  C12N9/18 ,  C12N9/88 ,  C12N15/31 ,  C12N15/55 ,  C12P20060101 ,  C12P13/04 ,  C12P13/06 ,  C12P13/08 ,  C12P13/12 ,  C12P13/14 ,  C12P13/20 ,  C12P13/22 ,  C12P13/24 ,  C12P21/02 ,  C12Q20060101 ,  C12Q1/32 ,  C12Q1/68 ,  C12R1/15 ,  G01N33/566 ,  G01N33/569

CPC classification number: C12N9/88 ,  C07K14/34 ,  C12N9/16 ,  C12N9/18

Abstract: PROBLEM TO BE SOLVED: To provide SMP nucleic acid and protein molecules, which relate to metabolism of carbon compounds such as sugars and generation of energy molecules, in a process (such as oxidative phosphorylation) of Corynebacterium glutamicum. SOLUTION: Isolated nucleic acid molecules of a specific sequence, or a complement thereof, which nucleic acid molecules are selected from a sequence group relating to metabolism of carbon compounds such as sugars and generation of energy molecules, in a process of Corynebacterium glutamicum, are provided, and cells containing the nucleic acid molecules and of genus Corynebacterium or genus Brevibacterium are provided. A method for producing fine chemicals such as an amino acid by using the cells, and a method for detecting existence and activity of Corynebacterium diphtheriae is provided. COPYRIGHT: (C)2008,JPO&INPIT

公开(公告)号：JP2006271389A

公开(公告)日：2006-10-12

申请号：JP2006132306

申请日：2006-05-11

Applicant: Basf Ag ,  ビーエーエスエフ アクチェンゲゼルシャフトBASF Aktiengesellschaft

Inventor： POMPEJUS MARKUS ,  KROEGER BURKHARD ,  SCHROEDER HARTWIG ,  ZELDER OSKAR ,  HABERHAUER GREGOR

IPC: C12N15/09 ,  G01N33/53 ,  C07K20060101 ,  C07K14/34 ,  C12N20060101 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/00 ,  C12N9/18 ,  C12N15/31 ,  C12N15/52 ,  C12P20060101 ,  C12P1/04 ,  C12P13/04 ,  C12P21/02 ,  C12Q20060101 ,  C12Q1/04 ,  C12Q1/68 ,  C12R1/13 ,  C12R1/15 ,  C12R1/16 ,  G01N33/569

CPC classification number: C07K14/34

Abstract: PROBLEM TO BE SOLVED: To provide a new nucleic acid molecule encoding a protein capable of involving in the metabolism, etc. of a compound necessary for the synthesis of cell membrane of C. glutamicum, i.e. an MCT protein. SOLUTION: Isolated nucleic acid molecules of Corynebacterium glutamicum containing a nucleic acid sequence or its complementary sequence selected from the group of specific sequences encoding an MCT protein which is a protein capable of involving in the metabolism of a compound necessary for the synthesis of cell membrane are described, a host cell based on the nucleic acid, a method for producing MCT protein by using the host cell and a method for the diagnosis of the presence or activity of Corynebacterium diphteriae are further provided. COPYRIGHT: (C)2007,JPO&INPIT

Abstract translation: 要解决的问题：提供编码能够涉及合成谷氨酸棒状杆菌（即谷氨酸棒状杆菌）细胞膜即MCT蛋白质所必需的化合物的代谢等的蛋白质的新型核酸分子。 解决方案：含有谷氨酸棒杆菌的分离的核酸分子，其含有选自编码MCT蛋白的特异性序列的核酸序列或其互补序列，所述MCT蛋白是能够涉及合成所必需的化合物的代谢的蛋白质 进一步提供了基于核酸的宿主细胞，通过使用宿主细胞产生MCT蛋白的方法和用于诊断棒状杆菌的存在或活性的方法。 版权所有（C）2007，JPO＆INPIT

公开(公告)号：JP2007252390A

公开(公告)日：2007-10-04

申请号：JP2007141360

申请日：2007-05-29

Applicant: Basf Ag ,  ビーエーエスエフ アクチェンゲゼルシャフトBASF Aktiengesellschaft

Inventor： POMPEJUS MARKUS ,  KROEGER BURKHARD ,  SCHROEDER HARTWIG ,  ZELDER OSKAR ,  HABERHAUER GREGOR

IPC: C12N15/09 ,  G01N33/53 ,  C07K20060101 ,  C07K14/34 ,  C12N20060101 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/00 ,  C12N9/12 ,  C12N9/18 ,  C12N9/88 ,  C12N15/31 ,  C12N15/55 ,  C12P20060101 ,  C12P13/04 ,  C12P13/06 ,  C12P13/08 ,  C12P13/10 ,  C12P13/12 ,  C12P13/14 ,  C12P13/20 ,  C12P13/22 ,  C12P13/24 ,  C12P21/02 ,  C12Q20060101 ,  C12Q1/04 ,  C12Q1/527 ,  C12Q1/68 ,  C12R1/15 ,  G01N33/566 ,  G01N33/569

CPC classification number: C12N9/88 ,  C07K14/34 ,  C12N9/16 ,  C12N9/18

Abstract: PROBLEM TO BE SOLVED: To provide SMP nucleic acid and protein molecules, which relate to metabolism of carbon compounds such as sugars and generation of energy molecules, in a process (such as oxidative phosphorylation) of Corynebacterium glutamicum. SOLUTION: Isolated nucleic acid molecules, or complements thereof are provided, wherein the nucleic acid molecules contain a nucleotide sequence comprising a specific sequence and are isolated from Corynebacterium glutamicum whose cells can increase usable high energy compound amount by conversion of sugars to useful energy molecules or efficiency of oxidative phosphorylation. COPYRIGHT: (C)2008,JPO&INPIT

Abstract translation: 要解决的问题：在谷氨酸棒杆菌的过程（如氧化磷酸化）中提供涉及碳化合物如糖的代谢和产生能量分子的SMP核酸和蛋白质分子。 提供了分离的核酸分子或其互补物，其中所述核酸分子含有包含特异性序列的核苷酸序列，并从谷氨酸棒杆菌分离，其细胞可以通过将糖转化为有用的方式增加可用的高能量化合物量 能量分子或氧化磷酸化的效率。 版权所有（C）2008，JPO＆INPIT

公开(公告)号：JP2007244392A

公开(公告)日：2007-09-27

申请号：JP2007121173

申请日：2007-05-01

Applicant: Basf Ag ,  ビーエーエスエフ アクチェンゲゼルシャフトBASF Aktiengesellschaft

Inventor： POMPEJUS MARKUS ,  KROEGER BURKHARD ,  SCHROEDER HARTWIG ,  ZELDER OSKAR ,  HABERHAUER GREGOR ,  LEE HEUNG-SHICK ,  KIM HYUNG-JOON

IPC: C12N15/09 ,  G01N33/53 ,  C07K20060101 ,  C07K14/34 ,  C12N20060101 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/00 ,  C12N9/18 ,  C12N15/31 ,  C12P20060101 ,  C12P1/04 ,  C12P7/02 ,  C12P7/40 ,  C12P7/64 ,  C12P13/00 ,  C12P13/04 ,  C12P21/02 ,  C12Q20060101 ,  C12Q1/04 ,  C12Q1/68 ,  C12R1/13 ,  C12R1/15 ,  C12R1/16 ,  G01N33/569 ,  G01N37/00

CPC classification number: C12N9/00 ,  C07K14/34 ,  C12N9/18

Abstract: PROBLEM TO BE SOLVED: To provide a new SRT nucleic acid molecule encoding an SRT protein capable of imparting Corynebacterium glutamicum with resistance to chemically or environmentally harmful conditions and provide its application. SOLUTION: The invention provides an isolated nucleic acid molecule encoding a new SRT protein derived from Corynebacterium glutamicum, a designated SRT nucleic acid molecule, its antisense nucleic acid molecule, a recombinant expression vector containing the SRT nucleic acid molecule, and host cell into which the expression vector is to be introduced. The invention further provides isolated SRT protein, mutated SRT protein, fusion protein, antigenic peptide and a method for the improvement of the production of a desired compound from C. glutamicum based on genetic engineering of SRT genes of this organism. COPYRIGHT: (C)2007,JPO&INPIT

Abstract translation: 要解决的问题：提供编码能够赋予谷氨酸棒杆菌对抗化学或环境有害的条件并提供其应用的SRT蛋白质的新的SRT核酸分子。 解决方案：本发明提供了编码来源于谷氨酸棒杆菌的新SRT蛋白质的分离的核酸分子，指定的SRT核酸分子，其反义核酸分子，含有SRT核酸分子的重组表达载体和宿主细胞 其中将引入表达载体。 本发明还提供了基于该生物体的SRT基因的遗传工程的分离的SRT蛋白，突变的SRT蛋白，融合蛋白，抗原肽以及用于从谷氨酸棒球菌的谷氨酸棒球菌生产所需化合物的方法。 版权所有（C）2007，JPO＆INPIT

公开(公告)号：JP2007202566A

公开(公告)日：2007-08-16

申请号：JP2007123785

申请日：2007-05-08

Applicant: Basf Ag ,  ビーエーエスエフ アクチェンゲゼルシャフトBASF Aktiengesellschaft

Inventor： POMPEJUS MARKUS ,  KROEGER BURKHARD ,  SCHROEDER HARTWIG ,  ZELDER OSKAR ,  HABERHAUER GREGOR

IPC: C12N15/09 ,  G01N33/53 ,  C07H21/04 ,  C07K20060101 ,  C07K14/34 ,  C12N20060101 ,  C12N1/15 ,  C12N1/19 ,  C12N1/20 ,  C12N1/21 ,  C12N5/10 ,  C12N9/00 ,  C12N9/10 ,  C12N9/18 ,  C12N9/90 ,  C12N15/31 ,  C12N15/61 ,  C12N15/74 ,  C12P20060101 ,  C12P13/04 ,  C12P13/08 ,  C12P21/02 ,  C12P21/06 ,  C12Q20060101 ,  C12Q1/04 ,  C12Q1/68 ,  C12R1/15 ,  G01N33/566 ,  G01N33/569

CPC classification number: C12N9/18 ,  C07K14/34 ,  C12N9/00 ,  C12N9/1096 ,  C12P13/04 ,  C12P13/06 ,  C12P13/08 ,  C12P13/10 ,  C12P13/12 ,  C12P13/14 ,  C12P13/20 ,  C12P13/24 ,  C12Y206/01005

Abstract: PROBLEM TO BE SOLVED: To provide a novel bacterial nucleic acid molecule having various uses. SOLUTION: Disclosed are isolated nucleic acid molecules, designated MP (metabolic pathway) nucleic acid molecules, which encode novel MP proteins from Corynebacterium glutamicum. Also disclosed are antisense nucleic acid molecules, recombinant expression vectors containing MP nucleic acid molecules, and host cells into which the expression vectors have been introduced. Further disclosed are isolated MP proteins, mutated MP proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of MP genes in this organism. COPYRIGHT: (C)2007,JPO&INPIT

Abstract translation: 待解决的问题：提供具有各种用途的新型细菌核酸分子。 解决方案：公开了分离的核酸分子，称为MP（代谢途径）核酸分子，其编码来自谷氨酸棒杆菌的新型MP蛋白。 还公开了反义核酸分子，含有MP核酸分子的重组表达载体，以及引入了表达载体的宿主细胞。 进一步公开了基于该生物体中MP基因的遗传工程的分离的MP蛋白，突变的MP蛋白，融合蛋白，抗原肽和用于从谷氨酸棒状病毒从谷氨酸棒球菌生产所需化合物的方法。 版权所有（C）2007，JPO＆INPIT

公开(公告)号：JP2007259859A

公开(公告)日：2007-10-11

申请号：JP2007113881

申请日：2007-04-24

Applicant: Basf Ag ,  ビーエーエスエフ アクチェンゲゼルシャフトBASF Aktiengesellschaft

Inventor： POMPEJUS MARKUS ,  KROEGER BURKHARD ,  SCHROEDER HARTWIG ,  ZELDER OSKAR ,  HABERHAUER GREGOR

IPC: C12N15/09 ,  C07K20060101 ,  C07K14/34 ,  C12N20060101 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/00 ,  C12N9/02 ,  C12N9/18 ,  C12N15/31 ,  C12N15/52 ,  C12P20060101 ,  C12P1/00 ,  C12P13/04 ,  C12P21/02 ,  C12Q20060101 ,  C12Q1/04 ,  C12Q1/68 ,  C12R1/15

CPC classification number: C07K14/34 ,  C12N9/0069 ,  C12P13/04

Abstract: PROBLEM TO BE SOLVED: To provide Corynebacterium glutamicum genes encoding proteins involved in homeostasis and adaptation, and to provide utilization thereof for adjusting the production of fine chemicals. SOLUTION: Isolated nucleic acid molecules, designated HA nucleic acid molecules, which encode novel HA proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing HA nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated HA proteins, mutated HA proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C. glutamicum based on genetic engineering of HA genes in this organism. COPYRIGHT: (C)2008,JPO&INPIT

Abstract translation: 待解决的问题：提供编码参与体内平衡和适应的蛋白质的谷氨酸棒杆菌基因，并提供其用于调节精细化学品生产的用途。 解决方案：描述了编码来自谷氨酸棒杆菌的新型HA蛋白质的分离的核酸分子，命名为HA核酸分子。 本发明还提供反义核酸分子，含有HA核酸分子的重组表达载体，以及引入了表达载体的宿主细胞。 本发明还进一步提供了分离的HA蛋白，突变的HA蛋白，融合蛋白，抗原肽以及基于该生物体中HA基因的遗传工程改进从谷氨酸棒球菌生产所需化合物的方法。 版权所有（C）2008，JPO＆INPIT