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1.发明申请METHODS FOR DETERMINING ACTIVE INGREDIENTS IN PRO-DRUG PEG PROTEIN CONJUGATES WITH RELEASABLE PEG REAGENTS (IN VITRO DE-PEGYLATION) 审中-公开使用可释放的PEG试剂（在体外去PEG化）中测定丙型肝素PEG蛋白质结合物中活性成分的方法
公开(公告)号：WO2010048184A2
公开(公告)日：2010-04-29
申请号：PCT/US2009061327
申请日：2009-10-20
Applicant: BAXTER INT , BAXTER HEALTHCARE SA , NEKTAR THERAPEUTICS , VARADI KATALIN , SCHRENK GERALD , ROTTENSTEINER HANSPETER , TURECEK PETER , WEBER ALFRED , ANDERLE HEINZ , CULBERTSON SEAN M , FANG ZHIHAO , ZAPPE HAROLD , ZHANG PING , BOSSARD MARY J
Inventor： VARADI KATALIN , SCHRENK GERALD , ROTTENSTEINER HANSPETER , TURECEK PETER , WEBER ALFRED , ANDERLE HEINZ , CULBERTSON SEAN M , FANG ZHIHAO , ZAPPE HAROLD , ZHANG PING , BOSSARD MARY J
IPC: G01N33/542 , G01N33/58 , G01N33/68 , G01N33/86
CPC classification number: G01N33/68 , G01N33/542 , G01N33/582 , G01N33/86 , G01N2333/76
Abstract: The invention relates to the development of in vitro assay systems that force the release of a water-soluble polymer, such as polyethylene glycol (PEG) and polysialic acid (PSA), from proteins modified with a reversibly-linked water-soluble polymer. The invention includes methods for analyzing the release of the water- soluble polymer and measuring regained protein activity. The invention further includes methods appropriate for the quality control of proteins modified with releasable water-soluble polymers, including polymers like PEG and PSA.
Abstract translation: 本发明涉及从用可逆连接的水溶性聚合物改性的蛋白质强制释放水溶性聚合物如聚乙二醇（PEG）和聚唾液酸（PSA）的体外测定系统的开发。 本发明包括分析水溶性聚合物的释放并测量重新获得的蛋白质活性的方法。 本发明还包括适用于用可释放水溶性聚合物（包括聚合物如PEG和PSA）改性的蛋白质的质量控制的方法。
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2.发明申请METHODS FOR THE INACTIVATION OF MICROORGANISMS IN BIOLOGICAL FLUIDS, FLOW THROUGH REACTORS AND METHODS OF CONTROLLING THE LIGHT SUM DOSE TO EFFECTIVELY INACTIVATE MICROORGANIMS IN BATCH REACTORS 审中-公开生物流体中微生物灭活的方法，通过反应器流动的方法和控制轻剂量以有效地灭菌反应器中的微生物体的方法
公开(公告)号：WO2006021314A8
公开(公告)日：2006-05-18
申请号：PCT/EP2005008467
申请日：2005-08-04
Applicant: BAXTER INT , BAXTER HEALTHCARE SA , ANDERLE HEINZ , MATTHIESSEN PETER , SCHWARZ HANS-PETER , TURECEK PETER , KREIL THOMAS , BOGGS DANIEL R
Inventor： ANDERLE HEINZ , MATTHIESSEN PETER , SCHWARZ HANS-PETER , TURECEK PETER , KREIL THOMAS , BOGGS DANIEL R
CPC classification number: A61L2/10 , A23L3/26 , A23L3/28 , A61L2/0011 , A61L2/28 , G01N21/33 , H05B3/0052
Abstract: The present invention relates to a method for determining an effective dose of monochromatic or polychromatic light from one or more light sources to inactivete microorganisms present in a biological fluid, preferably a non-trannsparent fluid. Moreover, there is provided a method for the inactivation of microorganism in a biological fluid in a flow-through-reactor. Moreover, the invention advantageously provides a flow-through-reactor with one or more thermostated light sources. The invention further provides a method of controlling the light sum dose of monochromatic or polychromatic light emitted from one or more light sources to effectively inactivate microorganisms present in a biological fluid in a batch reactor.
Abstract translation: 本发明涉及一种用于确定来自一种或多种光源的单色或多色光的有效剂量以使存在于生物流体，优选非透明流体中的微生物灭活的方法。 此外，提供了在流通反应器中的生物流体中的微生物灭活的方法。 此外，本发明有利地提供具有一个或多个恒温光源的流通反应器。 本发明还提供一种控制从一个或多个光源发射的单色或多色光的光总量的方法，以有效地灭活间歇反应器中存在于生物流体中的微生物。
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公开(公告)号：WO2006021314A2
公开(公告)日：2006-03-02
申请号：PCT/EP2005008467
申请日：2005-08-04
Applicant: BAXTER INT , BAXTER HEALTHCARE SA , ANDERLE HEINZ , MATTHIESSEN PETER , SCHWARZ HANS-PETER , TURECEK PETER , KREIL THOMAS , BOGGS DANIEL R
Inventor： ANDERLE HEINZ , MATTHIESSEN PETER , SCHWARZ HANS-PETER , TURECEK PETER , KREIL THOMAS , BOGGS DANIEL R
CPC classification number: A61L2/10 , A23L3/26 , A23L3/28 , A61L2/0011 , A61L2/28 , G01N21/33 , H05B3/0052
Abstract: The present invention relates to a method for determining an effective dose of monochromatic or polychromatic light from one or more light sources to inactivete microorganisms present in a biological fluid, preferably a non-trannsparent fluid. Moreover, there is provided a method for the inactivation of microorganism in a biological fluid in a flow-through-reactor. Moreover, the invention advantageously provides a flow-through-reactor with one or more thermostated light sources. The invention further provides a method of controlling the light sum dose of monochromatic or polychromatic light emitted from one or more light sources to effectively inactivate microorganisms present in a biological fluid in a batch reactor.
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4.发明申请METHOD FOR THE VALIDATABLE INACTIVATION OF PATHOGENS IN A BIOLOGICAL FLUID BY IRRADIATION 审中-公开通过辐照在生物流体中有效灭活病原体的方法
公开(公告)号：WO2004075931A3
公开(公告)日：2004-12-23
申请号：PCT/EP2004001994
申请日：2004-02-27
Applicant: BAXTER INT , BAXTER HEALTHCARE SA , ANDERLE HEINZ , MATTHIESSEN PETER , SCHWARZ HANS-PETER , TURECEK PETER , KREIL THOMAS , BOGGS DANIEL R
Inventor： ANDERLE HEINZ , MATTHIESSEN PETER , SCHWARZ HANS-PETER , TURECEK PETER , KREIL THOMAS , BOGGS DANIEL R
IPC: A61L2/00 , A61L2/08 , A61L2/10 , A61L2/28 , G01J1/00 , G01J1/08 , G01J1/42 , G01J1/48 , G01N21/00
CPC classification number: G01J1/08 , A61L2/0011 , A61L2/0017 , A61L2/0052 , A61L2/10 , A61L2/28 , A61L2202/22 , A61M1/3681 , A61M1/3683 , A61M2205/053 , C02F1/32 , C02F2201/326 , G01J1/42 , G01J1/48
Abstract: A validatable method for determining a photochemically effective dose for inactivating pathogens in a fluid sample is described herein. In particular, the instant invention covers methods for determining a photochemically effective doses sufficient to inactivate pathogens in a biological sample while leaving biologically active substances of interest unaffected. A batch irradiation reactor effective for inactivating pathogens in biological samples is also described.
Abstract translation: 本文描述了用于确定用于灭活流体样品中病原体的光化学有效剂量的可验证方法。 特别地，本发明包括确定足以灭活生物样品中的病原体的光化学有效剂量同时使感兴趣的生物活性物质不受影响的方法。 还描述了有效用于灭活生物样品中的病原体的批量照射反应器。
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公开(公告)号：CA2828629C
公开(公告)日：2019-07-16
申请号：CA2828629
申请日：2012-03-01
Applicant: BAXTER INT , BAXTER HEALTHCARE SA
Inventor： WEBER ALFRED , ENGELMAIER ANDREA , ANDERLE HEINZ , SCHWARZ HANS-PETER
Abstract: The present invention relates to a method for the determination of polysorbate in a protein-containing sample. The method of the present invention involves the pretreatment of the sample by alkaline hydrolysis followed by colorimetric determination on the basis of the metal complex of the analyte with a thiocyanate reagent, the complex being extracted in an immiscible organic solvent. The alkaline hydrolysis accounts for the removal of the interfering proteins and enhance selectivity over surfactants similar to the analyte, e.g. for Tween 80 over Triton X-100.
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Patent Agency Ranking
公开(公告)号：DK2266630T3
公开(公告)日：2014-03-17
申请号：DK10009727
申请日：2004-02-27
Applicant: BAXTER INT , BAXTER HEALTHCARE SA
Inventor： ANDERLE HEINZ , MATTHIESSEN PETER , SCHWARZ HANS-PETER , TURECEK PETER , KREIL THOMAS , BOGGS DANIEL R
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公开(公告)号：CA2740904A1
公开(公告)日：2010-04-29
申请号：CA2740904
申请日：2009-10-20
Applicant: BAXTER INT , BAXTER HEALTHCARE SA , NEKTAR THERAPEUTICS
Inventor： VARADI KATALIN , SCHRENK GERALD , ROTTENSTEINER HANSPETER , TURECEK PETER , WEBER ALFRED , ANDERLE HEINZ , CULBERTSON SEAN M , FANG ZHIHAO , ZAPPE HAROLD , ZHANG PING , BOSSARD MARY J
IPC: G01N33/542 , G01N33/58 , G01N33/68 , G01N33/86
Abstract: The invention relates to the development of in vitro assay systems that force the release of a water-soluble polymer, such as polyethylene glycol (PEG) and polysialic acid (PSA), from proteins modified with a reversibly-linked water-soluble polymer. The invention includes methods for analyzing the release of the water- soluble polymer and measuring regained protein activity. The invention further includes methods appropriate for the quality control of proteins modified with releasable water-soluble polymers, including polymers like PEG and PSA.
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公开(公告)号：ES2433601T3
公开(公告)日：2013-12-11
申请号：ES11009919
申请日：2009-10-20
Applicant: BAXTER INT , BAXTER HEALTHCARE SA , NEKTAR THERAPEUTICS
Inventor： VARADI KATALIN , SCHRENK GERALD , ROTTENSTEINER HANSPETER , TURECEK PETER , WEBER ALFRED , ANDERLE HEINZ , CULBERTSON SEAN M , FANG ZHIHAO , ZAPPE HAROLD , ZHANG PING , BOSSARD MARY J
IPC: G01N33/542 , G01N33/58 , G01N33/68 , G01N33/86
Abstract: Un método in vitro de liberación de un polímero soluble en agua ligado de manera reversible de una proteínamodificada mediante el polímero soluble en agua o aumento de la actividad de una proteína modificada con unpolímero soluble en agua ligado de manera reversible que comprende la etapa de incubar la proteína en condicioneseficaces para liberar el polímero soluble en agua, en el que las condiciones eficaces para liberar el polímero solubleen agua comprenden aumentar la concentración de amina libre de un tampón que comprende la proteína por adiciónde lisina libre, histidina o una combinación de las mismas al tampón en una concentración eficaz para liberar elpolímero soluble en agua.
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公开(公告)号：CA2828629A1
公开(公告)日：2012-09-13
申请号：CA2828629
申请日：2012-03-01
Applicant: BAXTER INT , BAXTER HEALTHCARE SA
Inventor： WEBER ALFRED , ENGELMAIER ANDREA , ANDERLE HEINZ , SCHWARZ HANS-PETER
Abstract: The present invention relates to a method for the determination of polysorbate in a protein-containing sample. The method of the present invention involves the pretreatment of the sample by alkaline hydrolysis followed by colorimetric determination on the basis of the metal complex of the analyte with a thiocyanate reagent, the complex being extracted in an immiscible organic solvent. The alkaline hydrolysis accounts for the removal of the interfering proteins and enhance selectivity over surfactants similar to the analyte, e.g. for Tween 80 over Triton X-100.
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公开(公告)号：AU2005276707A1
公开(公告)日：2006-03-02
申请号：AU2005276707
申请日：2005-08-04
Applicant: BAXTER HEALTHCARE SA , BAXTER INT
Inventor： BOGGS DANIEL R , TURECEK PETER , MATTHIESSEN PETER , ANDERLE HEINZ , SCHWARZ HANS-PETER , KREIL THOMAS
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