公开(公告)号：WO1997011067A1

公开(公告)日：1997-03-27

申请号：PCT/EP1996003954

申请日：1996-09-10

Applicant: CIBA-GEIGY AG ,  ALDER, Alex ,  BARNARD, Steven, Mark ,  BECKELMANN, Dirk ,  BERGER, Joseph ,  WALDNER, Adrian

Inventor： CIBA-GEIGY AG

IPC: C07D311/82

CPC classification number: C07D493/10 ,  C07D219/08 ,  C07D311/82 ,  G01N33/533

Abstract: The invention relates to compounds of formula (I), (IIa) or (IIb), wherein R1, R2, R5 and R6 are each independently of one another hydrogen, -SO2-(C1-C6)alkylphenyl, C1-C30alkyl, C1-C30alkyl-CO- or a radical of formula -(CnH2n-O-)m-R10; R3 is hydrogen or -SO2-(C1-C6)alkylphenyl; R4 and R7 are C1-C30 alkylene or a radical of formula -(CnH2n-O-)m-R10; Z is a functional group which is selected from the group consisting of -OH, -SH, -NH2, -COOH, -NCO, -CO-NR8YR9Y, -NH-CO-CH=CH2, -NH-CO-C(CH3)=CH2; R8 and R9 are each independently of the other C1-C30alkylene; R10 is a direct bond or C1-C12alkylene; n is a number from 2 to 6, and m is a number from 1 to 10, with the proviso that the total number of carbon atoms is at most 30; and Y is -OH or -SH. The compounds are used as comonomers for the preparation of copolymer membranes for plasticiser-free ion sensors.

Abstract translation: 本发明涉及式（I），（IIa）或（IIb）的化合物，其中R 1，R 2，R 5和R 6各自独立地为氢，-SO 2 - （C 1 -C 6）烷基苯基，C 1 -C 30烷基， -C 30烷基-CO-或式 - （C n H 2n -O-）m -R 10的基团; R3是氢或-SO2-（C1-C6）烷基苯基; R4和R7是C1-C30亚烷基或式 - （CnH2n-O-）m -R10的基团; Z是选自-OH，-SH，-NH2，-COOH，-NCO，-CO-NR8YR9Y，-NH-CO-CH = CH2，-NH-CO-C（CH3 ）= CH 2; R8和R9各自独立地为C 1 -C 30亚烷基; R10是直接键或C1-C12亚烷基; n为2〜6的数，m为1〜10的数，条件是碳原子数为30以下。 Y为-OH或-SH。 该化合物用作制备用于不含增塑剂的离子传感器的共聚物膜的共聚单体。

公开(公告)号：WO1997008193A1

公开(公告)日：1997-03-06

申请号：PCT/EP1996003473

申请日：1996-08-06

Applicant: CIBA-GEIGY AG ,  GARCIA-ECHEVERRIA, Carlos ,  GAY, Brigitte ,  FURET, Pascal ,  RAHUEL, Joseph ,  CARAVATTI, Giorgio ,  FRETZ, Heinz ,  SCHOEPFER, Joseph

Inventor： CIBA-GEIGY AG

IPC: C07K05/065

CPC classification number: C07K5/1027 ,  A61K38/00 ,  C07K5/0202 ,  C07K5/0207 ,  C07K5/06191 ,  C07K5/0827 ,  C07K14/71 ,  Y02P20/55

Abstract: The invention relates to an acylated peptide, namely a compound of formula (I), wherein n is 0 to 15, X is arylcarbonyl, cycloalkylcarbonyl, tricycloalkylcarbonyl, arylsulfonyl, heterocyclylcarbonyl, heterocyclylsulfonyl, carbamoyl-lower alkanoyl, aryl-lower alkylcarbonyl, cycloalkyl-lower alkylcarbonyl, aryl-lower alkylsulfonyl, heterocyclyl-lower alkylcarbonyl, heterocyclyl-lower alkylsulfonyl with the proviso that in any of the lower alkyl radicals mentioned a methylene group may be replaced with oxa, aza or thia; heterocyclyl-lower alkenylcarbonyl or aryl-lower alkenylcarbonyl; or, if Y is a secondary or tertiary amino group, is one of the moieties X mentioned above or lower alkanoyl, halo-lower alkanoyl, lower-alkoxycarbonyl, aryl-lower alkoxycarbonyl or cycloalkyl-lower alkoxycarbonyl; PTI is the bivalent radical of tyrosine or (preferably) the bivalent radical of phosphotyrosine or a phosphotyrosine mimic, AA stands for a bivalent radical of a natural or unnatural amino acid, and Y is hydroxy, a C-terminal protecting group or a primary, secondary or tertiary amino group, or a salt thereof, said compound being useful for the treatment of diseases that respond to inhibition of the interaction of (a) protein(s) comprising (an) SH2 domain(s) and a protein tyrosine kinase or a modified version thereof.

Abstract translation: 本发明涉及酰化肽，即式（I）化合物，其中n为0至15，X为芳基羰基，环烷基羰基，三环烷基羰基，芳基磺酰基，杂环基羰基，杂环基磺酰基，氨基甲酰基 - 低级烷酰基，芳基 - 低级烷基羰基，环烷基 - 低级烷基羰基，芳基 - 低级烷基磺酰基，杂环基 - 低级烷基羰基，杂环基 - 低级烷基磺酰基，条件是在所提及的任何低级烷基中亚甲基可以被氧杂，氮杂或硫代替代; 杂环基低级烯基羰基或芳基 - 低级烯基羰基; 或者如果Y是仲或叔氨基，则是上述部分X或低级烷酰基，卤代低级烷酰基，低级烷氧基羰基，芳基 - 低级烷氧基羰基或环烷基 - 低级烷氧基羰基之一; PTI是酪氨酸或（优选）磷酸酪氨酸或磷酸酪氨酸模拟物的二价基团的二价基团，AA代表天然或非天然氨基酸的二价基团，Y是羟基，C-末端保护基或伯， 仲或叔氨基或其盐，所述化合物可用于治疗响应于（a）包含（a）SH2结构域和蛋白质酪氨酸激酶的蛋白质的相互作用的抑制的疾病，或 其修改版本。

公开(公告)号：WO1997005095A1

公开(公告)日：1997-02-13

申请号：PCT/EP1996003143

申请日：1996-07-17

Applicant: CIBA-GEIGY AG ,  JALETT, Hans-Peter ,  SIEBENHAAR, Bernd

Inventor： CIBA-GEIGY AG

IPC: C07C213/02

CPC classification number: C07D333/36 ,  C07C213/02 ,  C07C217/08 ,  C07C209/52 ,  C07C211/48

Abstract: A process for the hydrogenation of imines with hydrogen under elevated pressure in the presence of iridium catalysts containing diphosphine ligands, with or without an inert solvent, the reaction mixture containing a soluble ammonium chloride, bromide or iodide or a soluble metal chloride, bromide or iodide, wherein the reaction mixture additionally contains at least one solid acid with the exception of ion exchangers. Improved optical yields and high chemical conversion rates are achieved while the catalyst is easily separable.

Abstract translation: 在含有二膦配体的铱催化剂存在下，在升高的压力下氢化亚胺的方法，在有或者没有惰性溶剂的情况下，含有可溶性氯化铵，溴化物或碘化物的反应混合物或可溶性金属氯化物，溴化物或碘化物 ，其中所述反应混合物另外含有除离子交换剂之外的至少一种固体酸。 在催化剂容易分离的同时，获得了提高的光学收率和高化学转化率。

公开(公告)号：WO1997001087A1

公开(公告)日：1997-01-09

申请号：PCT/EP1996002519

申请日：1996-06-10

Applicant: CIBA-GEIGY AG ,  OROSZLAN, Peter ,  ERBACHER, Christoph ,  DUVENECK, Gert, Ludwig ,  VERPOORTE, Elisabeth

Inventor： CIBA-GEIGY AG

IPC: G01N21/05

CPC classification number: G01N21/05 ,  G01N2021/0346

Abstract: A flow cell (1) has in its interior a flow channel (2) and is provided with an inlet opening (3) for the sample and with an outlet opening (4). Also provided are means for producing a sample-free blocked volume located in the flow channel (2). Those means comprise, for example, a further inlet opening (5) for a reference fluid, that inlet opening (5) being so positioned that the reference fluid flows counter to the sample in the flow channel (2). The flow cell (1) is suitable for a sensor apparatus in which one of the boundary surfaces of the flow channel (2) comprises a detection layer that contains selectively sensitive recognition elements for an analyte. The flow cell (1) is also suitable for an optical detection device which preferably utilises luminescence excitation in the evanescent field of an optical waveguide.

Abstract translation: 流动池（1）在其内部具有流动通道（2），并且设置有用于样品的入口开口（3）和出口开口（4）。 还提供了用于产生位于流动通道（2）中的无样品阻塞体积的装置。 这些装置包括例如用于参考流体的另一个入口开口（5），该入口开口（5）被定位成使得参考流体与流动通道（2）中的样品相反。 流动池（1）适用于传感器装置，其中流动通道（2）的边界表面之一包括检测层，该检测层包含用于分析物的选择性敏感的识别元件。 流动池（1）还适用于光学检测装置，其优选地在光波导的消逝场中利用发光激发。

公开(公告)号：WO1997000859A1

公开(公告)日：1997-01-09

申请号：PCT/EP1996002520

申请日：1996-06-10

Applicant: CIBA-GEIGY AG ,  ZURFLÜH, René

Inventor： CIBA-GEIGY AG

IPC: C07C327/60

CPC classification number: A01N43/80 ,  A01N41/02 ,  C07C327/60 ,  C07D261/20

Abstract: Thioamide S-oxides of formula (I) are suitable as fungicidally, insecticidally and acaricidally active ingredients in crop protection, in which R1 is hydrogen or C1-C4alkyl, and R2 is hydrogen, C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl or C3-C6cycloalkyl, and in which R3 and R4 independently of one another are hydrogen, cyano, C1-C4alkyl, halo-C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C3-C6cycloalkyl, cyclopropylmethyl, C1-C4alkoxy, C2-C5alkoxyalkyl, C1-C4alkoxycarbonyl, C1-C4alkylthio, C2-C5alkylthioalkyl; an unsubstituted or up to trisubstituted ring which has not more than 15 ring carbon atoms, which can be polycyclic and which contains 0-3 hetero atoms N, O or S, it being possible for this ring to be bonded via an aliphatic bridge having not more than 4 carbon atoms and/or via either CO, oxygen or sulfur; or in which R3 and R4 together with the joint carbon atom form an unsubstituted or up to trisubstituted ring which has not more than 15 ring carbon atoms, which can be polycyclic and which contains 0-3 hereto atoms N, O or S. They can be used on their own or as formulated compositions, preferably for controlling or preventing infestation with microorganisms.

Abstract translation: 式（I）的硫酰胺S-氧化物在作物保护中适合作为杀真菌，杀虫和杀螨活性成分，其中R1是氢或C1-C4烷基，R2是氢，C1-C4烷基，C2-C4链烯基，C2-C4炔基或 C 3 -C 6环烷基，其中R 3和R 4彼此独立地是氢，氰基，C 1 -C 4烷基，卤代-C 1 -C 4烷基，C 2 -C 4烯基，C 2 -C 4炔基，C 3 -C 6环烷基，环丙基甲基，C 1 -C 4烷氧基，C 2 -C 5烷氧基烷基 ，C 1 -C 4烷氧基羰基，C 1 -C 4烷硫基，C 2 -C 5烷硫基烷基; 具有不多于15个环碳原子的未被取代或最多三取代的环，其可以是多环的并且含有0-3个杂原子N，O或S，该环可能通过没有 多于4个碳原子和/或经由CO，氧或硫; 或其中R 3和R 4与连接碳原子一起形成具有不多于15个环碳原子的未取代或至多三取代的环，其可以是多环的并且含有0-3个原子N ，O或S.它们可以单独使用或作为配制的组合物使用，优选用于控制或预防用微生物侵染。

公开(公告)号：WO1997000669A1

公开(公告)日：1997-01-09

申请号：PCT/EP1996002539

申请日：1996-06-12

Applicant: CIBA-GEIGY AG ,  TSAO, Fu-Pao

Inventor： CIBA-GEIGY AG

IPC: A61K09/00

CPC classification number: A61K9/0048 ,  C08K5/5317 ,  Y10S514/912 ,  Y10S514/913 ,  Y10S514/914 ,  Y10S514/915 ,  C08L33/02

Abstract: Compositions and methods for reducing the decomposition rate of polymeric bioadhesives and viscosity enhancers, such as poly(acrylic acids). The compositions include at least one strong, stable chelating agent, preferably an organophosphorous compound such as diethylene triamine penta(methylene phosphonic acid). These biocompatible compositions are especially useful in the ophthalmic field.

Abstract translation: 用于降低聚合物生物粘合剂和粘度增强剂（例如聚（丙烯酸））的分解速率的组合物和方法。 组合物包括至少一种强稳定的螯合剂，优选有机亚磷化合物，例如二亚乙基三胺五（亚甲基膦酸）。 这些生物相容性组合物特别适用于眼科领域。

公开(公告)号：WO1996030392A1

公开(公告)日：1996-10-03

申请号：PCT/EP1996001154

申请日：1996-03-18

Applicant: CIBA-GEIGY AG ,  RINK, Hans ,  VETTER, Dirk ,  GERCKEN, Bertold ,  FELDER, Eduard

Inventor： CIBA-GEIGY AG

IPC: C07K01/04

CPC classification number: C07K1/047 ,  A61K38/00 ,  B01J2219/005 ,  B01J2219/00572 ,  B01J2219/00596 ,  B01J2219/00725 ,  C40B40/10 ,  C40B70/00

Abstract: Described is a process for the production of a library from a plurality of different units consisting of a solid or semisolid carrier (bead), a synthetic ligand and a binary information structure (tag), by means of which the building blocks of the ligand are coded, and the use of that library for searching for novel classes of active ingredient and individual active ingredients. Also described are compounds found using that process. The process is characterized by the use of element atoms or ions as binary tags which are bound non covalently to the beads. Their unique combination which can be measured by e.g. mass spectrometry codes for the specific ligand.

Abstract translation: 描述了从由固体或半固体载体（珠粒），合成配体和二元信息结构（标签）组成的多个不同单元生产文库的方法，通过该文库，配体的结构单元 编码，以及使用该库搜索新类别的活性成分和各种活性成分。 还描述了使用该方法发现的化合物。 该方法的特征在于使用元素原子或离子作为与珠不共价结合的二进制标记。 它们独特的组合可以通过例如 用于特定配体的质谱法编码。

公开(公告)号：WO1996029870A1

公开(公告)日：1996-10-03

申请号：PCT/EP1996001086

申请日：1996-03-14

Applicant: CIBA-GEIGY AG ,  GLOCK, Jutta ,  HUDETZ, Manfred ,  KERBER, Elmar

Inventor： CIBA-GEIGY AG

IPC: A01N43/54

CPC classification number: A01N43/54 ,  A01N43/66 ,  A01N25/32 ,  A01N2300/00

Abstract: A selective herbicidal composition comprising, in addition to conventional formulation assistants, a mixture of a) a herbicidally effective amount of a herbicide of formula (I), or a salt or a stereoisomer of the compounds of formula (I), and b) to antagonise the herbicide, an antidotally effective amount of a safener of formula (IIa) of a compound of formula (IIb1), of a compound of formula (IIb2), of a compound of formula (IIc), of a compound of formula (IId), of a compound of formula (IIe), of a compound of formula (IIf), of a compound of formula (IIg), or of a compound of formula (IIh), wherein the substituents have the meanings claimed in claim 1.

Abstract translation: 一种选择性除草组合物，除了常规制剂助剂外还包含a）除草有效量的式（I）除草剂或式（I）化合物的盐或立体异构体的混合物，和b）至 拮抗除草剂，式（IIb1）化合物，式（IIb2）化合物，式（IIc）化合物，式（IId）化合物的式（IIa）化合物的安定剂 ）式（IIe）化合物，式（IIf）化合物，式（IIg）化合物或式（IIh）化合物，其中取代基具有权利要求1所述的含义。

公开(公告)号：WO1996029461A1

公开(公告)日：1996-09-26

申请号：PCT/EP1996000896

申请日：1996-03-04

Applicant: CIBA-GEIGY AG ,  REINERT, Gerhard ,  FUSO, Francesco ,  HILFIKER, Rolf

Inventor： CIBA-GEIGY AG

IPC: D06P03/62

CPC classification number: D06P1/6536 ,  D06P1/628 ,  D06P1/6426 ,  D06P1/6495 ,  D06P1/65112 ,  D06P1/65118 ,  D06P1/65125 ,  D06P3/62

Abstract: Process for increasing the sun protection factor of cellulosic fibre materials by treating the cellulosic fibre materials with at least one direct dye and at least one UV absorber.

Abstract translation: 通过用至少一种直接染料和至少一种UV吸收剂处理纤维素纤维材料来增加纤维素纤维材料的防晒因子的方法。

公开(公告)号：WO1996027486A1

公开(公告)日：1996-09-12

申请号：PCT/EP1996000772

申请日：1996-02-24

Applicant: CIBA-GEIGY AG ,  SANER, Niklaus ,  WOMBWELL, Paul, Terrence

Inventor： CIBA-GEIGY AG

IPC: B29C33/00

CPC classification number: B29C33/0077 ,  B29C39/24

Abstract: A casting device with which, by introducing a thermocurable plastics into a heatable casting mould (1), the plastics is thermally cured in that casting mould at least to such a degree that a casting moulded in that manner can be released from the mould, comprises a reservoir for the thermocurable plastics and a feed means for feeding plastics from the reservoir into the casting mould (1), which mould has an inlet opening that extends at least along a substantial portion of the length of the casting to be moulded, wherein the casting device comprises a separate adapter (2) in which the feed means (20, 221, 23) for the plastics is arranged and which can be connected to the casting mould (1) in such a manner that, when the adapter (2) has been connected, an outlet opening (23) provided in the adapter (2) is arranged sealed to and substantially congruent with the inlet opening of the casting mould (1).

Abstract translation: 一种铸造装置，其中通过将可热固化的塑料引入可加热铸模（1）中，塑料在该铸模中热固化至少使得以这种方式模制的铸件可以从模具中释放的程度包括 用于热固性塑料的储存器和用于将塑料从储存器输送到铸模（1）中的进料装置，该模具具有至少沿着待模制的铸件的长度的大部分延伸的入口，其中， 浇铸装置包括单独的适配器（2），其中布置用于塑料的进料装置（20,221,23），并且可以以这样的方式连接到铸模（1），使得当适配器（2） 设置在适配器（2）中的出口开口（23）被设置成与铸模（1）的入口密封并基本上一致。