公开(公告)号：US20080089861A1

公开(公告)日：2008-04-17

申请号：US11827251

申请日：2007-07-10

Applicant: Gregory Went ,  Ivan Lieberburg

Inventor： Gregory Went ,  Ivan Lieberburg

IPC: A61K31/19 ,  A61K31/13 ,  A61K38/21 ,  A61P21/00 ,  A61K39/395 ,  A61K31/135

CPC classification number: A61K31/13 ,  A61K31/135 ,  A61K31/19 ,  A61K38/215 ,  Y02A50/401 ,  A61K2300/00

Abstract: The invention provides compositions and methods for treating autoimmune diseases such as multiple sclerosis. The compositions include a combination of an NMDA Receptor antagonist, such as memantine or rimantadine, and a fumarate agent, such as dimethyl fumarate.

Abstract translation: 本发明提供用于治疗自身免疫疾病如多发性硬化的组合物和方法。 组合物包括NMDA受体拮抗剂如美金刚或金刚烷胺与富马酸酯如富马酸二甲酯的组合。

公开(公告)号：US20060252788A1

公开(公告)日：2006-11-09

申请号：US11399879

申请日：2006-04-06

Applicant: Gregory Went ,  Timothy Fultz

Inventor： Gregory Went ,  Timothy Fultz

IPC: A61K31/473 ,  A61K31/445 ,  A61K31/137 ,  A61K31/13

CPC classification number: A61K9/2054 ,  A61K9/0053 ,  A61K9/1635 ,  A61K9/1652 ,  A61K9/20 ,  A61K9/2009 ,  A61K9/2013 ,  A61K9/2059 ,  A61K9/2813 ,  A61K9/282 ,  A61K9/48 ,  A61K9/4808 ,  A61K9/7061 ,  A61K31/13 ,  A61K31/445 ,  A61K45/06 ,  Y02A50/401 ,  A61K2300/00

Abstract: The present invention provides novel methods and compositions for the treatment and prevention of CNS-related conditions. One of the CNS-related conditions treated by the methods and compositions of the invention is Alzheimer's disease.

Abstract translation: 本发明提供了用于治疗和预防CNS相关病症的新方法和组合物。 通过本发明的方法和组合物治疗的CNS相关病症之一是阿尔茨海默氏病。

公开(公告)号：US20060142398A1

公开(公告)日：2006-06-29

申请号：US11285905

申请日：2005-11-22

Applicant: Gregory Went ,  Timothy Fultz ,  Seth Porter ,  Laurence Meyerson ,  Timothy Burkoth

Inventor： Gregory Went ,  Timothy Fultz ,  Seth Porter ,  Laurence Meyerson ,  Timothy Burkoth

IPC: A61K31/13

CPC classification number: A61K31/13 ,  A61K9/4891 ,  Y10S514/964

Abstract: The invention provides methods and compositions for administering an NMDA receptor antagonist (e.g., memantine) to a subject.

Abstract translation: 本发明提供了用于向受试者施用NMDA受体拮抗剂（例如美金刚）的方法和组合物。

公开(公告)号：US20060052370A1

公开(公告)日：2006-03-09

申请号：US11211900

申请日：2005-08-24

Applicant: Laurence Meyerson ,  Gregory Went ,  Timothy Burkoth

Inventor： Laurence Meyerson ,  Gregory Went ,  Timothy Burkoth

IPC: A61K31/5415 ,  A61K31/485 ,  A61K31/13

CPC classification number: A61K45/06 ,  A61K31/13 ,  A61K31/135 ,  A61K31/19 ,  A61K31/245 ,  A61K31/415 ,  A61K31/465 ,  A61K31/485 ,  A61K31/5415 ,  A61K2300/00

Abstract: The present invention provides methods and compositions useful for the treatment and prevention of pain.

Abstract translation: 本发明提供了可用于治疗和预防疼痛的方法和组合物。

公开(公告)号：US20050209218A1

公开(公告)日：2005-09-22

申请号：US11058118

申请日：2005-02-14

Applicant: Laurence Meyerson ,  Gregory Went ,  Timothy Fultz

Inventor： Laurence Meyerson ,  Gregory Went ,  Timothy Fultz

IPC: A61K9/00 ,  A61K9/20 ,  A61K9/28 ,  A61K31/135 ,  A61K31/137 ,  A61K31/343 ,  A61K31/357 ,  A61K31/506 ,  A61K31/55 ,  A61K31/551

CPC classification number: A61K31/135 ,  A61K31/137 ,  A61K31/343 ,  A61K31/357 ,  A61K31/506 ,  A61K31/55 ,  A61K31/551 ,  A61K45/06 ,  A61K2300/00

Abstract: This invention relates to methods and compositions for treating psychiatric conditions, such as depression.

Abstract translation: 本发明涉及用于治疗精神疾病如抑郁症的方法和组合物。

公开(公告)号：US20100160431A1

公开(公告)日：2010-06-24

申请号：US12545007

申请日：2009-08-20

Applicant: Gregory Went ,  David Chernoff ,  Paul Spence ,  Terry Burkoth ,  Timothy Fultz

Inventor： Gregory Went ,  David Chernoff ,  Paul Spence ,  Terry Burkoth ,  Timothy Fultz

IPC: A61K31/215 ,  A61K31/13 ,  A61P31/16

CPC classification number: A61K45/06 ,  A61K9/2009 ,  A61K9/2054 ,  A61K9/2846 ,  A61K9/5026 ,  A61K9/5047 ,  A61K9/5073 ,  A61K9/5084 ,  A61K31/13 ,  A61K2300/00

Abstract: Compositions for treating flu comprise an M2 inhibitor, and optionally a neuraminidase inhibitor, wherein at least one of said M2 inhibitor or said neuraminidase inhibitor is provided in an extended release dosage form.

Abstract translation: 用于治疗流感的组合物包含M2抑制剂和任选的神经氨酸酶抑制剂，其中所述M2抑制剂或所述神经氨酸酶抑制剂中的至少一种以延长释放剂型形式提供。

公开(公告)号：US20100137448A1

公开(公告)日：2010-06-03

申请号：US12504515

申请日：2009-07-16

Applicant: Stuart A. Lipton ,  Gregory Went

Inventor： Stuart A. Lipton ,  Gregory Went

IPC: A61K31/13 ,  A61P25/28 ,  A61P25/22

CPC classification number: A61K31/21

Abstract: The present invention relates to compositions and methods for treating a human patient afflicted with a neuropsychiatric disorder. Specifically, the invention provides for compositions and methods of modulating or antagonizing the activity of neuronal NMDA receptors, wherein such antagonistic activity is capable of modulating the glutamate induced excitatory response of the neurons, thereby inhibiting an excitotoxic effect, promoting a neurotrophic effect, and thereby providing a therapeutic effect that treats the neuropsychiatric disorder.

Abstract translation: 本发明涉及用于治疗患有神经精神障碍的人类患者的组合物和方法。 具体地，本发明提供调节或拮抗神经元NMDA受体活性的组合物和方法，其中这种拮抗活性能调节谷氨酸诱导的神经元兴奋性反应，从而抑制兴奋性毒性作用，促进神经营养作用，从而 提供治疗神经精神障碍的治疗效果。

公开(公告)号：US20070208041A1

公开(公告)日：2007-09-06

申请号：US11581180

申请日：2006-10-13

Applicant: Jonathan Stamler ,  Gregory Went

Inventor： Jonathan Stamler ,  Gregory Went

IPC: A61K31/519 ,  A61K31/401 ,  A61K31/198 ,  A61K31/366 ,  A61K31/343 ,  A61K31/22

CPC classification number: A61K45/06 ,  A61K31/047 ,  A61K31/198 ,  A61K31/22 ,  A61K31/34 ,  A61K31/343 ,  A61K31/366 ,  A61K31/40 ,  A61K31/401 ,  A61K31/403 ,  A61K31/519 ,  A61K31/52 ,  A61K2300/00

Abstract: The combination of nitric oxide generating compounds which are not dependent upon aldehyde dehydrogenase for bioactivation, or are specifically targeted to nNOS or the sarcoplasmic reticulum of cardiac muscle cells, and xanthine oxidase inhibitors are effective in the treatment of heart disease, specifically congestive heart failure and ischemic coronary disease. This treatment is particularly effective in patients who have particularly heavy oxidative burdens, e.g. diabetics, patients with lung disorders, patients with sickle cell anemia and patients of Asian descent.

Abstract translation: 不依赖于醛脱氢酶用于生物活化或特异性靶向心肌细胞的nNOS或肌浆网的一氧化氮产生化合物和黄嘌呤氧化酶抑制剂的组合对于治疗心脏病，特别是充血性心力衰竭和 缺血性冠状动脉疾病 这种治疗对于具有特别重的氧化负担的患者尤其有效。 糖尿病患者，肺功能障碍患者，镰状细胞性贫血患者和亚裔患者。

公开(公告)号：US20070042431A1

公开(公告)日：2007-02-22

申请号：US11585507

申请日：2006-10-23

Applicant: Michael Urdea ,  Gregory Landes ,  Gregory Went

Inventor： Michael Urdea ,  Gregory Landes ,  Gregory Went

IPC: G01N33/53 ,  C07K16/40

CPC classification number: G01N33/6848 ,  G01N33/6803 ,  G01N2800/52 ,  Y10T436/10

Abstract: The present invention relates generally to methods for reducing the complexity of a sample. More specifically, the present invention relates to proteomics, the measurement of the protein levels in biological samples, and analysis of proteins in a sample using antibodies that recognize small epitopes.

Abstract translation: 本发明一般涉及降低样品复杂性的方法。 更具体地，本发明涉及蛋白质组学，生物样品中蛋白质水平的测量，以及使用识别小表位的抗体分析样品中的蛋白质。

公开(公告)号：US20060240043A1

公开(公告)日：2006-10-26

申请号：US11247775

申请日：2005-10-11

Applicant: Laurence Meyerson ,  Gregory Went ,  Timothy Fultz ,  Timothy Burkoth

Inventor： Laurence Meyerson ,  Gregory Went ,  Timothy Fultz ,  Timothy Burkoth

IPC: A61K39/08 ,  A61K31/56 ,  A61K31/485 ,  A61K31/48 ,  A61K31/445 ,  A61K31/137 ,  A61K31/138 ,  A61K31/13 ,  A61K31/405

CPC classification number: A61K31/55 ,  A61K31/13 ,  A61K31/137 ,  A61K31/138 ,  A61K31/275 ,  A61K31/404 ,  A61K31/405 ,  A61K31/445 ,  A61K31/48 ,  A61K31/485 ,  A61K31/56 ,  A61K31/57 ,  A61K38/4886 ,  A61K45/06 ,  A61K2300/00

Abstract: The present invention provides novel methods and compositions for the treatment and prevention of headaches, vascular headaches, migraine headaches, cluster headaches, and migraine. One of the headaches, vascular headaches, migraine headaches, cluster headaches, and migraine treated by the methods and compositions of the invention is migraine.

Abstract translation: 本发明提供用于治疗和预防头痛，血管性头痛，偏头痛，丛集性头痛和偏头痛的新颖方法和组合物。 通过本发明的方法和组合物治疗的头痛，血管性头痛，偏头痛，丛集性头痛和偏头痛之一是偏头痛。