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    Analyte measuring method using extraction layer
    2.
    发明专利
    Analyte measuring method using extraction layer 有权
    使用提取层分析测量方法

    公开(公告)号：JP2005164580A

    公开(公告)日：2005-06-23

    申请号：JP2004316454

    申请日：2004-10-29

    Applicant: F Hoffmann La Roche Ag ,  エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft

    Inventor： HOENES JOACHIM ,  NORTMEYER CHRISTINE ,  HORN CARINA

    IPC: G01N33/48 ,  G01N33/483 ,  G01N33/52 ,  G01N33/72 ,  G01N33/86

    CPC classification number: G01N33/86 ,  G01N33/526 ,  G01N33/723

    Abstract: PROBLEM TO BE SOLVED: To provide a method for measuring an analyte in a liquid sample by means of an examination system which includes two compartments. SOLUTION: A detection reaction, necessary for measuring the analyte in the liquid sample, is carried out in the inside of a first compartment, and analytical measurement of an index substance, which is at least one substance concerned with the detective reaction and different from the analyte, is carried out inside side a second compartment. Two compartments allow the index substance to enter the second compartment, and separation is carried out, while at least partially preventing entrance of another substance, capable of disturbing the analytical measurement of the index substance in the second compartment. As a captured substance, at least another substance capable of selectively condensing the index substance in the inside of the second compartment is fixed inside the second compartment. The analyte can be measured by using this examination system. COPYRIGHT: (C)2005,JPO&NCIPI

    Abstract translation: 要解决的问题：提供一种通过包括两个隔室的检查系统来测量液体样品中的分析物的方法。 解决方案：测量液体样品中的分析物所需的检测反应在第一隔室的内部进行，并且分析测量作为与检测反应有关的至少一种物质的指示物质，以及 与分析物不同，在第二隔室内侧进行。 两个隔间允许指示物质进入第二隔室，并进行分离，同时至少部分地防止能够扰乱第二隔室中指示物质的分析测量的另一物质的入口。 作为捕获物质，至少能够将第二隔室内部的指示物质选择性冷凝的另一物质固定在第二隔室内。 可以通过使用该检查系统来测量分析物。 版权所有（C）2005，JPO＆NCIPI

    Measuring system with distributed functions
    4.
    发明专利
    Measuring system with distributed functions 审中-公开
    具有分布式功能的测量系统

    公开(公告)号：JP2008292476A

    公开(公告)日：2008-12-04

    申请号：JP2008117324

    申请日：2008-04-28

    Applicant: F Hoffmann-La Roche Ag ,  エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト

    Inventor： WERNER KARL ,  HOENES JOACHIM ,  ZIMMER VOLKER ,  SCHERER JOERG ,  THOES BRUNO

    IPC: G01N35/02 ,  G01N27/416

    CPC classification number: G01N33/48771 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1468 ,  A61B2562/0295 ,  Y10T436/11

    Abstract: PROBLEM TO BE SOLVED: To simplify the connection between an analysis apparatus and a test component magazine, work out a design for improvement in reliability of the connection, avoid disposal of electronic parts, and reduce costs by reusing the electronic parts. SOLUTION: An analysis system (300) having an analysis apparatus for determining an analyte in a body fluid and a test piece magazine(134) contains a group (120) of reusable components and a group (140) of disposable components, and components (132, 134) having no electronic elements can be disconnected from the group (120) at a disconnection point (302). Critical interfaces (150, 160) are assembled and tested during production of the apparatus. COPYRIGHT: (C)2009,JPO&INPIT

    Abstract translation: 要解决的问题：为了简化分析装置和测试部件盒之间的连接，制定用于提高连接可靠性的设计，避免电子部件的处置，并且通过重复使用电子部件来降低成本。 解决方案：具有用于确定体液中的分析物的分析装置和试片盒（134）的分析系统（300）包含可重复使用组件的组（120）和一次性组件组（140） 并且在断开点（302）处可以将不具有电子元件的组件（132,134）与组（120）断开连接。 关键界面（150,160）在生产设备期间进行组装和测试。 版权所有（C）2009，JPO＆INPIT

    Manufacturing method of polymer layer
    6.
    发明专利
    Manufacturing method of polymer layer 审中-公开
    聚合物层的制造方法

    公开(公告)号：JP2009275233A

    公开(公告)日：2009-11-26

    申请号：JP2009190529

    申请日：2009-08-19

    Applicant: F Hoffmann-La Roche Ag ,  エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト

    Inventor： HORN CARINA ,  HOENES JOACHIM ,  KNAPPE WOLFGANG-REINHOLD

    IPC: C08F2/48 ,  C12M1/34 ,  C08F2/00 ,  C08J7/04 ,  C12M1/40 ,  C12Q1/00 ,  C12Q1/26 ,  C12Q1/32 ,  C12Q1/54 ,  G01N21/78 ,  G01N27/327 ,  G01N33/543

    CPC classification number: C12Q1/32 ,  C12Q1/002 ,  C12Q1/26 ,  G01N33/54353 ,  G01N33/54373 ,  Y02P20/582

    Abstract: PROBLEM TO BE SOLVED: To provide a manufacturing method of a polymer layer on a supporting part, the method being capable of manufacturing the polymer layer having a predetermined uniform thickness by a simple method.
    SOLUTION: The manufacturing method of a polymer layer on a transparent support comprises the steps of: (a) disposing the supporting part; (b) applying a photopolymerizable liquid composition on the support; (c) irradiating the photopolymerizable liquid composition through the support so that the liquid composition is partially polymerized and a polymer layer having a predetermined thickness is formed on the supporting part; and (d) removing the residual liquid composition from the polymer layer.
    COPYRIGHT: (C)2010,JPO&INPIT

    Abstract translation: 要解决的问题：为了提供在支撑部分上的聚合物层的制造方法，该方法能够通过简单的方法制造具有预定均匀厚度的聚合物层。 解决方案：透明支撑体上的聚合物层的制造方法包括以下步骤：（a）设置支撑部分; （b）将可光聚合的液体组合物施加到载体上; （c）通过支撑体照射可光聚合液体组合物，使得液体组合物部分聚合，并且在支撑部分上形成具有预定厚度的聚合物层; 和（d）从聚合物层中除去残留的液体组合物。 版权所有（C）2010，JPO＆INPIT

    Lancet wheel
    7.
    发明专利
    Lancet wheel 审中-公开
    LANCET车轮

    公开(公告)号：JP2009106737A

    公开(公告)日：2009-05-21

    申请号：JP2008263170

    申请日：2008-10-09

    Applicant: F Hoffmann-La Roche Ag ,  エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト

    Inventor： HOENES JOACHIM ,  LIST HANS ,  ZIMMER VOLKER ,  HOERAUF CHRISTIAN ,  KRAEMER UWE

    IPC: A61B5/151

    CPC classification number: A61B5/157 ,  A61B5/150022 ,  A61B5/150282 ,  A61B5/150358 ,  A61B5/150419 ,  A61B5/150435 ,  A61B5/150503 ,  A61B5/15115 ,  A61B5/15146 ,  A61B5/15153 ,  A61B5/15163

    Abstract: PROBLEM TO BE SOLVED: To solve the tips of the lancets are erected prior to a puncture, for example by swiveling them out of the plane of the wheel, in this context, high precision is required in order for the lancet puncture to be associated with little pain, and moreover, erecting the lancet tips should be feasible with as little effort as possible to allow this to be performed in a compact puncturing device. SOLUTION: In the lancet wheel (1) having a plurality of lancets (2) in a ring-shaped arrangement, the lancets (2) includes a lancet body (4) that ends in a lancet tip (3). The lancet wheel (1) has a carrier (5) that carries the lancets (2), whereby the lancets (2) are connected to the carrier (5) via bars (7, 7a, 7b, 7c) that allow for mobility of the lancets (2) relative to the carrier (5). COPYRIGHT: (C)2009,JPO&INPIT

    Abstract translation: 要解决的问题：为了解决在穿刺之前竖立的刺血针的尖端，例如通过将其从轮的平面旋转出来，在这种情况下，为了使刺血针穿刺到 与少许疼痛相关，此外，以尽可能小的努力，可以在紧凑的穿刺装置中执行柳叶刀尖的竖立。 解决方案：在具有环状布置的多个刺血针（2）的柳叶刀轮（1）中，刺血针（2）包括端部在刺血针尖端（3）上的柳叶刀体（4）。 柳叶刀轮（1）具有承载有刺血针（2）的载体（5），借此通过条（7,7a，7b，7c）将刺血针（2）连接到载体（5） 所述刺血针（2）相对于所述载体（5）。 版权所有（C）2009，JPO＆INPIT

    Flexible lancet
    8.
    发明专利
    Flexible lancet 审中-公开
    灵活的LANCET

    公开(公告)号：JP2008296015A

    公开(公告)日：2008-12-11

    申请号：JP2008136534

    申请日：2008-05-26

    Applicant: F Hoffmann-La Roche Ag ,  エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト

    Inventor： HOENES JOACHIM ,  KRAEMER UWE

    IPC: A61B5/151

    CPC classification number: A61B5/1411 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/150526 ,  A61B5/151 ,  A61B5/15128 ,  A61B5/15142 ,  A61B5/15146 ,  A61B5/15153 ,  A61B5/15169 ,  A61B5/15171 ,  A61B5/15173 ,  A61B5/15178 ,  A61B5/15186

    Abstract: PROBLEM TO BE SOLVED: To provide a lancing assisting instrument, enabling simple handling, used with little mechanical complicatedness, and stored in a space-saving manner. SOLUTION: A body fluid withdrawing system includes a housing with at least one opening 6 and at least one lancet 1 which is elongate and substantially straight in its original and unused form. The lancet has a distal end with a lancet tip for carrying out a lancing operation. The system also includes a drive unit 4 for driving the lancet in a drive direction and at least one guide element which makes contact with the lancet at least during the lancing operation and guides the lancet movement such that the lancet is bent relative to the drive direction. The lancet can have a high restoring force such that it returns to its original substantially straight shape after contacting the guide element 3. COPYRIGHT: (C)2009,JPO&INPIT

    Abstract translation: 要解决的问题：提供一种穿刺辅助仪器，使得能够简单的处理，以小的机械复杂性使用，并以节省空间的方式存储。 解决方案：体液抽出系统包括具有至少一个开口6和至少一个刺血针1的壳体，该刺血针1是其原始和未使用形式的细长且基本上直的。 柳叶刀具有用于进行穿刺操作的具有刺血针头的远端。 该系统还包括用于驱动柳叶刀的驱动方向的驱动单元4和至少一个至少在穿刺操作期间与柳叶刀接触的引导元件，并且引导柳叶刀运动使得柳叶刀相对于驱动方向弯曲 。 刺血针可以具有高的恢复力，使得在接触引导元件3之后，其恢复到其原始的基本上直的形状。版权所有（C）2009，JPO＆INPIT

    Stable nad/nadh derivative
    9.
    发明专利
    Stable nad/nadh derivative 有权
    稳定的NAD / NADH衍生物

    公开(公告)号：JP2012224638A

    公开(公告)日：2012-11-15

    申请号：JP2012172878

    申请日：2012-08-03

    Applicant: F Hoffmann-La Roche Ag ,  エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト

    Inventor： HOENES JOACHIM ,  HEINDL DIETER ,  HORN CARINA ,  GAESSLER-DIETSCHE CLAUDIA

    IPC: C07H19/207 ,  G01N33/52 ,  G01N33/66

    CPC classification number: C12Q1/32

    Abstract: PROBLEM TO BE SOLVED: To provide a stable bioanalytical measuring system, in particular for determining glucose, which avoids the sensitivity to hydrolysis of NAD/NADP and at the same time acts as a coenzyme in an enzyme reaction.SOLUTION: Nicotinamide adenine dinucleotide (NAD/NADH) derivatives and nicotinamide adenine dinucleotide phosphate (NADP/NADPH) derivatives represented by formula (I), enzyme complexes of these derivatives, their use in biochemical detection methods, and reagent kits thereof are provided.

    Abstract translation: 要解决的问题：提供稳定的生物分析测量系统，特别是用于测定葡萄糖，其避免对NAD / NADP水解的敏感性，并且同时作为酶反应中的辅酶。 解决方案：由式（I）表示的烟酰胺腺嘌呤二核苷酸（NAD / NADH）衍生物和烟酰胺腺嘌呤二核苷酸磷酸（NADP / NADPH）衍生物，这些衍生物的酶复合物，它们在生物化学检测方法中的用途及其试剂盒是 提供。 版权所有（C）2013，JPO＆INPIT

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