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    Analyte measuring method using extraction layer
    1.
    发明专利
    Analyte measuring method using extraction layer 有权
    使用提取层分析测量方法

    公开(公告)号：JP2005164580A

    公开(公告)日：2005-06-23

    申请号：JP2004316454

    申请日：2004-10-29

    Applicant: F Hoffmann La Roche Ag ,  エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft

    Inventor： HOENES JOACHIM ,  NORTMEYER CHRISTINE ,  HORN CARINA

    IPC: G01N33/48 ,  G01N33/483 ,  G01N33/52 ,  G01N33/72 ,  G01N33/86

    CPC classification number: G01N33/86 ,  G01N33/526 ,  G01N33/723

    Abstract: PROBLEM TO BE SOLVED: To provide a method for measuring an analyte in a liquid sample by means of an examination system which includes two compartments. SOLUTION: A detection reaction, necessary for measuring the analyte in the liquid sample, is carried out in the inside of a first compartment, and analytical measurement of an index substance, which is at least one substance concerned with the detective reaction and different from the analyte, is carried out inside side a second compartment. Two compartments allow the index substance to enter the second compartment, and separation is carried out, while at least partially preventing entrance of another substance, capable of disturbing the analytical measurement of the index substance in the second compartment. As a captured substance, at least another substance capable of selectively condensing the index substance in the inside of the second compartment is fixed inside the second compartment. The analyte can be measured by using this examination system. COPYRIGHT: (C)2005,JPO&NCIPI

    Abstract translation: 要解决的问题：提供一种通过包括两个隔室的检查系统来测量液体样品中的分析物的方法。 解决方案：测量液体样品中的分析物所需的检测反应在第一隔室的内部进行，并且分析测量作为与检测反应有关的至少一种物质的指示物质，以及 与分析物不同，在第二隔室内侧进行。 两个隔间允许指示物质进入第二隔室，并进行分离，同时至少部分地防止能够扰乱第二隔室中指示物质的分析测量的另一物质的入口。 作为捕获物质，至少能够将第二隔室内部的指示物质选择性冷凝的另一物质固定在第二隔室内。 可以通过使用该检查系统来测量分析物。 版权所有（C）2005，JPO＆NCIPI

    Fluorometry for analyte by intramolecular quencher-fluorophore conjugate
    4.
    发明专利
    Fluorometry for analyte by intramolecular quencher-fluorophore conjugate 有权
    荧光分光光度计分析仪荧光分光光度计

    公开(公告)号：JP2004258021A

    公开(公告)日：2004-09-16

    申请号：JP2004017685

    申请日：2004-01-26

    Applicant: F Hoffmann La Roche Ag ,  エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft

    Inventor： HORN CARINA ,  JOSEL HANS-PETER ,  SPINKE JUERGEN ,  HERRMANN RUPERT ,  HEINDL DIETER

    IPC: G01N31/22 ,  C12Q1/26 ,  G01N21/64 ,  G01N21/78 ,  G01N33/58 ,  G01N33/66

    CPC classification number: G01N21/6428 ,  G01N2021/6432 ,  Y10S436/80 ,  Y10S436/904

    Abstract: PROBLEM TO BE SOLVED: To provide a method and a reagent kit n for fluorometry of an analyte, and a novel oxidation-reduction active compound serving as a fluorescent reagent for the analyte. SOLUTION: In this method for detecting the analyte by an oxidation-reduction reaction and the fluorometry, a sample containing the analyte is brought into contact with a detecting reagent containing a compound expressed by the following general formula (1): Q-F(Q is a quencher group, and F is a fluorophore group) as a fluorescent oxidation-reduction indicator. Examples favorable as the reducible quencher group are quinones, aromatic nitroso compounds such as nitrosoanilines and other nitrosobenzene derivatives, and N-oxides. COPYRIGHT: (C)2004,JPO&NCIPI

    Abstract translation: 要解决的问题：提供用于分析物的荧光测定的方法和试剂盒n，以及用作分析物的荧光试剂的新型氧化还原活性化合物。 解决方案：在通过氧化还原反应和荧光测定法检测分析物的方法中，使含有分析物的样品与含有由以下通式（1）表示的化合物的检测试剂接触：QF（ Q是猝灭基团，F是荧光团）作为荧光氧化还原指示剂。 可还原的猝灭剂组是醌类，亚硝基苯胺和其它亚硝基苯衍生物等芳香族亚硝基化合物，N-氧化物等。 版权所有（C）2004，JPO＆NCIPI

    Manufacturing method of polymer layer
    5.
    发明专利
    Manufacturing method of polymer layer 审中-公开
    聚合物层的制造方法

    公开(公告)号：JP2009275233A

    公开(公告)日：2009-11-26

    申请号：JP2009190529

    申请日：2009-08-19

    Applicant: F Hoffmann-La Roche Ag ,  エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト

    Inventor： HORN CARINA ,  HOENES JOACHIM ,  KNAPPE WOLFGANG-REINHOLD

    IPC: C08F2/48 ,  C12M1/34 ,  C08F2/00 ,  C08J7/04 ,  C12M1/40 ,  C12Q1/00 ,  C12Q1/26 ,  C12Q1/32 ,  C12Q1/54 ,  G01N21/78 ,  G01N27/327 ,  G01N33/543

    CPC classification number: C12Q1/32 ,  C12Q1/002 ,  C12Q1/26 ,  G01N33/54353 ,  G01N33/54373 ,  Y02P20/582

    Abstract: PROBLEM TO BE SOLVED: To provide a manufacturing method of a polymer layer on a supporting part, the method being capable of manufacturing the polymer layer having a predetermined uniform thickness by a simple method.
    SOLUTION: The manufacturing method of a polymer layer on a transparent support comprises the steps of: (a) disposing the supporting part; (b) applying a photopolymerizable liquid composition on the support; (c) irradiating the photopolymerizable liquid composition through the support so that the liquid composition is partially polymerized and a polymer layer having a predetermined thickness is formed on the supporting part; and (d) removing the residual liquid composition from the polymer layer.
    COPYRIGHT: (C)2010,JPO&INPIT

    Abstract translation: 要解决的问题：为了提供在支撑部分上的聚合物层的制造方法，该方法能够通过简单的方法制造具有预定均匀厚度的聚合物层。 解决方案：透明支撑体上的聚合物层的制造方法包括以下步骤：（a）设置支撑部分; （b）将可光聚合的液体组合物施加到载体上; （c）通过支撑体照射可光聚合液体组合物，使得液体组合物部分聚合，并且在支撑部分上形成具有预定厚度的聚合物层; 和（d）从聚合物层中除去残留的液体组合物。 版权所有（C）2010，JPO＆INPIT

    Stabilization of nad/nadh
    6.
    发明专利
    Stabilization of nad/nadh 有权
    NAD / NADH的稳定性

    公开(公告)号：JP2007054052A

    公开(公告)日：2007-03-08

    申请号：JP2006205087

    申请日：2006-07-27

    Applicant: F Hoffmann-La Roche Ag ,  エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト

    Inventor： HEINDL DIETER ,  HOENES JOACHIM DR ,  HORN CARINA ,  HERDEWIJN PIET

    IPC: C12Q1/32 ,  C07H19/167 ,  C12Q1/54

    CPC classification number: C07D405/14 ,  C07D403/12 ,  C07D403/14 ,  C07H19/04 ,  C07H19/167 ,  C12Q1/32 ,  C12Q1/54 ,  G01N2333/90209

    Abstract: PROBLEM TO BE SOLVED: To provide a stable nicotinamide adenine dinucleotide (NAD/NADH) and nicotinamide adenine dinucleotide phosphate (NADP/NADPH) useful for biochemical detection. SOLUTION: A test element for specimen measurement contains a compound having a specific structure or its salt or arbitrary reduced-type derivatives free from sensitivity to hydrolysis and active as a coenzyme in enzymatic reaction. A system for stable bioanalysis, especially for the determination of glucose can be attained by the test element. COPYRIGHT: (C)2007,JPO&INPIT

    Abstract translation: 要解决的问题：提供可用于生物化学检测的稳定的烟酰胺腺嘌呤二核苷酸（NAD / NADH）和烟酰胺腺嘌呤二核苷酸磷酸（NADP / NADPH）。 解决方案：用于样品测量的测试元件包含具有特定结构的化合物或其盐或任意的还原型衍生物，其对水解没有敏感性，并且作为辅酶在酶促反应中是活性的。 通过测试元件可以获得用于稳定生物分析的系统，特别是用于葡萄糖测定的系统。 版权所有（C）2007，JPO＆INPIT

    Stable nad/nadh derivative
    7.
    发明专利
    Stable nad/nadh derivative 有权
    稳定的NAD / NADH衍生物

    公开(公告)号：JP2012224638A

    公开(公告)日：2012-11-15

    申请号：JP2012172878

    申请日：2012-08-03

    Applicant: F Hoffmann-La Roche Ag ,  エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト

    Inventor： HOENES JOACHIM ,  HEINDL DIETER ,  HORN CARINA ,  GAESSLER-DIETSCHE CLAUDIA

    IPC: C07H19/207 ,  G01N33/52 ,  G01N33/66

    CPC classification number: C12Q1/32

    Abstract: PROBLEM TO BE SOLVED: To provide a stable bioanalytical measuring system, in particular for determining glucose, which avoids the sensitivity to hydrolysis of NAD/NADP and at the same time acts as a coenzyme in an enzyme reaction.SOLUTION: Nicotinamide adenine dinucleotide (NAD/NADH) derivatives and nicotinamide adenine dinucleotide phosphate (NADP/NADPH) derivatives represented by formula (I), enzyme complexes of these derivatives, their use in biochemical detection methods, and reagent kits thereof are provided.

    Abstract translation: 要解决的问题：提供稳定的生物分析测量系统，特别是用于测定葡萄糖，其避免对NAD / NADP水解的敏感性，并且同时作为酶反应中的辅酶。 解决方案：由式（I）表示的烟酰胺腺嘌呤二核苷酸（NAD / NADH）衍生物和烟酰胺腺嘌呤二核苷酸磷酸（NADP / NADPH）衍生物，这些衍生物的酶复合物，它们在生物化学检测方法中的用途及其试剂盒是 提供。 版权所有（C）2013，JPO＆INPIT

    Fluorescence spectroscopy in absorption medium
    8.
    发明专利
    Fluorescence spectroscopy in absorption medium 审中-公开
    吸收介质中的荧光光谱

    公开(公告)号：JP2007121301A

    公开(公告)日：2007-05-17

    申请号：JP2006290284

    申请日：2006-10-25

    Applicant: F Hoffmann-La Roche Ag ,  エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト

    Inventor： PETRICH WOLFGANG ,  GAESSLER-DIETSCHE CLAUDIA ,  HORN CARINA ,  HEBESTREIT KAI ,  ASFOUR JEAN-MICHEL ,  BARDELANG KLEMENS ,  KOCHERSCHEIDT GERRIT

    IPC: G01N21/64

    CPC classification number: C12Q1/008 ,  C12Q1/26 ,  C12Q1/32 ,  C12Q1/54 ,  G01N33/52 ,  G01N33/66 ,  Y10T436/144444

    Abstract: PROBLEM TO BE SOLVED: To remarkably reduce a dependency with respect to a wavelength of fluorescent excitation light, and to change the fluorescent excitation maximum of a fluorescence emission group. SOLUTION: A detecting medium containing the fluorescence emission group or a precursor of the fluorescence emission group is mixed with an absorber having an absorption spectrum overlapped with a fluorescent excitation range of the fluorescence emission group. A system generated in the detecting medium and comprising the fluorescence emission group and the absorber has a changed effective fluorescent excitation range accompanied with the changed fluorescent excitation maximum. Irradiation by the fluorescent excitation light is executed within the range of the changed excitation maximum. A measured signal obtained from fluorescence emission measurement indicates only the low dependency with respect to the wavelength of the excitation light. Further, an inexpensive light source such as UV LEDs may be usable because of the changed wave length of the excitation light. COPYRIGHT: (C)2007,JPO&INPIT

    Abstract translation: 要解决的问题：显着降低相对于荧光激发光的波长的依赖性，并且改变荧光发射基团的荧光激发最大值。 解决方案：将含有荧光发射基团或荧光发射基团的前体的检测介质与具有与荧光发射基团的荧光激发范围重叠的吸收光谱的吸收剂混合。 在检测介质中产生并且包括荧光发射基团和吸收体的系统具有伴随改变的荧光激发最大值的改变的有效荧光激发范围。 通过荧光激发光的照射在变化的激发最大值的范围内进行。 从荧光发射测量获得的测量信号仅表示相对于激发光的波长的低依赖性。 此外，由于激发光的波长变化，可以使用诸如UV LED的便宜的光源。 版权所有（C）2007，JPO＆INPIT

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