公开(公告)号：WO2017210494A1

公开(公告)日：2017-12-07

申请号：PCT/US2017/035560

申请日：2017-06-01

Applicant: CARNEGIE MELLON UNIVERSITY ,  MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： ABIDI, Sabia ,  PAPAGEORGIOU, Dimitrios, P. ,  DAO, Ming ,  SURESH, Subra

IPC: B01L1/02 ,  B01L5/00 ,  C12M1/34 ,  C12Q1/00 ,  F15C5/00 ,  G01N15/10

CPC classification number: G01N15/10 ,  B01L3/50 ,  B01L3/502761 ,  C12Q1/00 ,  C12Q1/025 ,  G01N15/147 ,  G01N15/1484 ,  G01N19/04 ,  G01N2015/0073 ,  G01N2015/1497 ,  G01N2203/0089

Abstract: The invention in some aspects relates to high throughput methods and devices for evaluating mechanical and morphological properties of cells, such as blood cells under conditions of cell attachment and regulated gas conditions. In some aspects, the invention relates to methods for assessing cell adhesion under regulated conditions, for example gas concentration, temperature, shear force, and attachment to proteins. In some aspects, the invention relates to methods and devices for identifying therapeutic agents. In some aspects, the invention relates to methods and devices for diagnosing and/or characterizing a condition or disease in a subject, for example, by measuring a property of a cell from the subject under controlled conditions.

Abstract translation: 本发明在一些方面涉及用于在细胞附着和调节气体条件下评估细胞（例如血细胞）的机械和形态特性的高通量方法和装置。 在一些方面，本发明涉及用于在调节条件下评估细胞粘附的方法，例如气体浓度，温度，剪切力和与蛋白质的附着。 在一些方面，本发明涉及用于鉴定治疗剂的方法和装置。 在一些方面，本发明涉及用于诊断和/或表征受试者中的病症或疾病的方法和装置，例如通过在受控条件下测量来自受试者的细胞的特性。

公开(公告)号：WO2022046897A8

公开(公告)日：2022-03-03

申请号：PCT/US2021/047540

申请日：2021-08-25

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  NANYANG TECHNOLOGICAL UNIVERSITY

Inventor： SURESH, Subra ,  DAO, Ming ,  LI, Ju ,  SHI, Zhe

IPC: G06F17/18 ,  G06N3/02 ,  G05B17/02 ,  B81B2201/018 ,  B81B2203/0118 ,  B81B2203/051 ,  B81B2203/053 ,  B81B2203/056 ,  B81B3/0062 ,  G06F2111/10 ,  G06F30/27

Abstract: Methods for training statistical models for modeling phononic energy and/or frequency dispersion, as well as phononic stability of materials as a function of an applied strain, as well as uses of these trained statistical models for elastic strain engineering of materials, are described.

公开(公告)号：WO2007081902A2

公开(公告)日：2007-07-19

申请号：PCT/US2007/000442

申请日：2007-01-05

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  MANALIS, Scott ,  SURESH, Subra ,  BURG, Thomas ,  BABCOCK, Ken

Inventor： MANALIS, Scott ,  SURESH, Subra ,  BURG, Thomas ,  BABCOCK, Ken

IPC: C12Q1/04

CPC classification number: G01N33/5005 ,  G01N15/1056 ,  G01N33/5091 ,  G01N33/54366 ,  G01N2015/1043 ,  Y02A50/58

Abstract: The method and apparatus of the present invention detects changes in cell biomechanics caused by any of a variety of diseases and conditions. In one embodiment, the method and apparatus of the invention detect infection of red blood cells. In one embodiment, the invention is a method and apparatus comprising a microfluidic channel with a constriction, for trapping infected red blood cells while allowing healthy red blood cells to deform and pass through the channel. In another embodiment, the invention comprises a suspended microchannel resonator for detecting and counting red blood cells at the constriction of the microfluidic channel.

Abstract translation: 本发明的方法和装置检测由各种疾病和病症中的任何一种引起的细胞生物力学变化。 在一个实施方案中，本发明的方法和装置检测红细胞的感染。 在一个实施方案中，本发明是包括具有收缩部的微流体通道的方法和装置，用于捕获感染的红细胞，同时允许健康的红细胞变形并通过通道。 在另一个实施例中，本发明包括用于在微流体通道收缩处检测和计数红细胞的悬浮微通道谐振器。

公开(公告)号：EP3987271A1

公开(公告)日：2022-04-27

申请号：EP20830808.0

申请日：2020-03-06

Applicant: Nanyang Technological University ,  MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  Brown University

Inventor： LU, Lu ,  DAO, Ming ,  SURESH, Subra ,  KARNIADAKIS, George E.

IPC: G01N3/42 ,  G01N3/44 ,  G06N3/02 ,  G06N3/08

公开(公告)号：WO2022046896A1

公开(公告)日：2022-03-03

申请号：PCT/US2021/047538

申请日：2021-08-25

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  NANYANG TECHNOLOGICAL UNIVERSITY

Inventor： SURESH, Subra ,  DAO, Ming ,  LI, Ju ,  SHI, Zhe

IPC: H01L21/04 ,  H01L21/30 ,  H01L21/46 ,  H01L21/67 ,  H01L31/18 ,  H01L21/02 ,  H01L21/64 ,  H01L29/36 ,  B82Y40/00

Abstract: Compositions and methods related to multiaxially straining defect doped materials as well as their use in electrical circuits are generally described.

公开(公告)号：WO2020076519A1

公开(公告)日：2020-04-16

申请号：PCT/US2019/053368

申请日：2019-09-27

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  NANYANG TECHNOLOGICAL UNIVERSITY

Inventor： DAO, Ming ,  LI, Ju ,  SHI, Zhe ,  SURESH, Subra

IPC: H01L21/00 ,  H01L23/00 ,  H01L29/167

Abstract: Compositions and methods related to straining defect doped materials as well as their methods of use in electrical circuits are generally described.

公开(公告)号：WO2012051572A1

公开(公告)日：2012-04-19

申请号：PCT/US2011/056425

申请日：2011-10-14

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  NANYANG TECHNOLOGICAL UNIVERSITY ,  AMALADOSS, Anburaj ,  CHEN, Qingfeng ,  DAO, Ming ,  PREISER, Peter ,  CHEN, Jianzhu ,  SURESH, Subra

Inventor： AMALADOSS, Anburaj ,  CHEN, Qingfeng ,  DAO, Ming ,  PREISER, Peter ,  CHEN, Jianzhu ,  SURESH, Subra

IPC: A01K67/00

CPC classification number: A01K67/0271 ,  A01K2207/12 ,  A01K2207/15 ,  A01K2227/105 ,  A01K2267/0337

Abstract: Provided herein are non-human mammal models (e.g., mouse models) of human malaria and uses thereof in, e.g., identification of anti-malaria agents. Also provided are related compositions and methods.

Abstract translation: 本文提供了人类疟疾的非人哺乳动物模型（例如，小鼠模型）及其在例如抗疟剂的鉴定中的用途。 还提供了相关的组合物和方法。

公开(公告)号：WO2011119492A3

公开(公告)日：2011-09-29

申请号：PCT/US2011/029220

申请日：2011-03-21

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  BROWN UNIVERSITY RESEARCH FOUNDATION ,  SURESH, Subra ,  HAN, Jongyoon ,  BOW, Hansen ,  HUANG, Sha ,  DIEZ SILVA, Monica ,  PIVKIN, Igor, V. ,  BERRIS, Michal, (michelle) ,  DAO, Ming ,  KARNIADAKIS, George, E. ,  CASWELL, Bruce ,  FEDOSV, Dmitry ,  QUINN, David, J. ,  CHEN, Jianzhu ,  CHANG, Irene, Yin-ting ,  ALMEIDA CARVALHO, Patricia, Maria

Inventor： SURESH, Subra ,  HAN, Jongyoon ,  BOW, Hansen ,  HUANG, Sha ,  DIEZ SILVA, Monica ,  PIVKIN, Igor, V. ,  BERRIS, Michal, (michelle) ,  DAO, Ming ,  KARNIADAKIS, George, E. ,  CASWELL, Bruce ,  FEDOSV, Dmitry ,  QUINN, David, J. ,  CHEN, Jianzhu ,  CHANG, Irene, Yin-ting ,  ALMEIDA CARVALHO, Patricia, Maria

IPC: G01N33/483 ,  C12Q1/02 ,  G01N33/15

Abstract: The invention in some aspects relates to methods, devices and compositions for evaluating material properties, such as mechanical and rheological properties of substances, particularly biological substances, such as cells, tissues, and biological fluids. In some aspects, the invention relates to methods, devices and compositions for evaluating material properties of deformable objects, such as cells. In further aspects, the invention relates to methods, devices and compositions for diagnosing and/or characterizing disease based on material properties of biological cells.

公开(公告)号：WO2022046897A1

公开(公告)日：2022-03-03

申请号：PCT/US2021/047540

申请日：2021-08-25

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  NANYANG TECHNOLOGICAL UNIVERSITY

Inventor： SURESH, Subra ,  DAO, Ming ,  LI, Ju ,  SHI, Zhe

IPC: G06F17/18 ,  G06N3/02 ,  G05B17/02

Abstract: Methods for training statistical models for modeling phononic energy and/or frequency dispersion, as well as phononic stability of materials as a function of an applied strain, as well as uses of these trained statistical models for elastic strain engineering of materials, are described.

公开(公告)号：WO2022046896A8

公开(公告)日：2022-03-03

申请号：PCT/US2021/047538

申请日：2021-08-25

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  NANYANG TECHNOLOGICAL UNIVERSITY

Inventor： SURESH, Subra ,  DAO, Ming ,  LI, Ju ,  SHI, Zhe

IPC: H01L21/04 ,  H01L21/30 ,  H01L21/46 ,  H01L21/67 ,  H01L31/18 ,  H01L21/02 ,  H01L21/64 ,  H01L29/36 ,  B82Y40/00 ,  B81B2201/018 ,  B81B2203/0118 ,  B81B2203/051 ,  B81B2203/053 ,  B81B2203/056 ,  B81B3/0062 ,  G06F2111/10 ,  G06F30/27

Abstract: Compositions and methods related to multiaxially straining defect doped materials as well as their use in electrical circuits are generally described.