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公开(公告)号：WO2014088882A3
公开(公告)日：2015-08-20
申请号：PCT/US2013071861
申请日：2013-11-26
Applicant: EMD MILLIPORE CORP
Inventor： PERREAULT JEREMY , FOLEY SEAN , RAUTIO KEVIN
CPC classification number: B01D19/0031 , A61L2/0017 , B01D61/142 , B01D61/18 , B01D63/084 , B01D2313/16 , B01D2313/44 , B01D2315/08 , B01D2317/025 , B01D2317/06 , B01D2325/36 , B01D2325/38
Abstract: Redundant filtration system that includes at least one barrier filter as a process filter, the barrier filter having both hydrophilic and hydrophobic paths, allowing both fluid and gas permeability. The need for vents is eliminated, as is an intermediate drain filter. The device also can be dried in series. The filtration system includes a network of conduits and receptacles, the network receiving liquid raw and/or starting material at one end, conducting it through the process stream defined thereby, and producing the desired liquid product at another end. The network is provided with one or more inputs for introducing liquid raw material into the fluid process stream, and one or more output ports for discharging fluid out of the fluid process stream. The network is preferably an essentially closed network, and also, preferably sterile and/or aseptic.
Abstract translation: 冗余过滤系统，其包括至少一个阻挡过滤器作为过程过滤器，该阻隔过滤器具有亲水和疏水路径，允许流体和气体渗透性。 消除了通风口的需要，中间排水过滤器也是如此。 该装置也可以串联干燥。 过滤系统包括管道和容器的网络，网络在一端接收液体原料和/或起始材料，将其通过由其限定的工艺流进行，并在另一端产生所需的液体产物。 该网络具有用于将液体原料引入流体工艺流中的一个或多个输入，以及用于将流体从流体工艺流中排出的一个或多个输出端口。 网络优选是基本上封闭的网络，并且优选地是无菌和/或无菌的。
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公开(公告)号：WO2010098867A8
公开(公告)日：2011-04-28
申请号：PCT/US2010000578
申请日：2010-02-26
Applicant: MILLIPORE CORP , KOZLOV MIKHAIL , RAUTIO KEVIN
Inventor： KOZLOV MIKHAIL , RAUTIO KEVIN
CPC classification number: B01D71/56 , B01D67/0006 , B01D67/009 , B01D69/125 , B01D2323/30 , B01D2323/34 , B01D2325/14 , B01D2325/30 , C07K1/24 , C07K1/34
Abstract: A negatively charged microporous filtration medium having a high charge density comprising a porous substrate and a polymerized cross-linked polymeric coating located on the inner and outer surfaces of the substrate. The coating may be formed from a reactant solution comprising negatively charged cross-linkable polymerizeable acrylamidoalkyl monomers and acrylamido cross-linking agents which are polymerized in situ on the substrate. The negatively charged microporous filtration medium are suitable for use as prefiltration membranes for selectively removing protein aggregates from a protein solution.
Abstract translation: 具有高电荷密度的带负电荷的微孔过滤介质，包括多孔基底和位于基底的内表面和外表面上的聚合的交联聚合物涂层。 涂层可以由包含带负电荷的可交联聚合性丙烯酰氨基烷基单体和丙烯酰胺交联剂的反应物溶液形成，所述交联剂在基材上原位聚合。 带负电荷的微孔过滤介质适用于从蛋白质溶液中选择性去除蛋白聚集体的预过滤膜。
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公开(公告)号：JP2011045876A
公开(公告)日：2011-03-10
申请号：JP2010179457
申请日：2010-08-10
Applicant: Millipore Corp , ミリポア・コーポレイションMillipore Corporation
Inventor： GIGLIA SAL , RAUTIO KEVIN , BLANCHARD MARK
IPC: B01D65/10
CPC classification number: B01D69/02 , B01D65/10 , B01D2325/20 , G01N15/0826 , Y10T29/496 , Y10T29/49604 , Y10T29/4978
Abstract: PROBLEM TO BE SOLVED: To provide a method for reducing the performance variability of a membrane scaling device. SOLUTION: Scaling device performance uncertainty is reduced, thereby reducing the scaling safety factor, by specifying a narrow range or subset of the set of the membrane of all qualified manufactured membranes for installation into scaling devices. In certain embodiments, the scalability factor is reduced by determining where within the performance distribution a particular membrane lies, and adjusting the scaling factor accordingly. COPYRIGHT: (C)2011,JPO&INPIT
Abstract translation: 要解决的问题：提供降低膜缩放装置的性能变异性的方法。 解决方案：缩小设备性能不确定度，从而通过指定所有合格制造膜的膜组的窄范围或子集来安装到缩放设备中，从而降低了比例安全系数。 在某些实施例中，通过确定特定膜所在的性能分布内的哪里以及相应地调整缩放因子来减小可伸缩性因子。 版权所有（C）2011，JPO＆INPIT
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公开(公告)号：ES2912939T3
公开(公告)日：2022-05-30
申请号：ES13859871
申请日：2013-11-26
Applicant: EMD MILLIPORE CORP
Inventor： PERREAULT JEREMY , FOLEY SEAN , RAUTIO KEVIN
Abstract: Método para filtrar una materia prima líquida en un flujo de proceso para producir un producto, que comprende proporcionar un sistema de filtración que comprende: una red que define un flujo de proceso de fluidos, donde dicha red tiene una o más entradas para introducir fluido en dicho flujo de proceso de fluidos, y una o más salidas para descargar fluido de dicho flujo de proceso de fluidos; un primer filtro (F-1) de proceso de grado de esterilización dentro de dicho flujo de proceso de fluidos; un segundo filtro (F-2) de proceso de grado de esterilización dentro de dicho flujo de proceso de fluidos, donde dicho segundo filtro (F-2) de proceso de grado de esterilización se encuentra situado en serie con dicho primer filtro (F-1) de proceso de grado de esterilización y aguas abajo del mismo; en donde al menos uno de entre dicho primer filtro (F-1) de proceso de grado de esterilización y dicho segundo filtro (F-2) de proceso de grado de esterilización es un filtro de barrera (BF) que comprende, dentro de un alojamiento común, una pluralidad de membranas de filtro hidrófilas y una pluralidad de membranas de filtro hidrófobas, y en donde dichas membranas de filtro hidrófilas se encuentran intercaladas entre dichas membranas de filtro hidrófobas, donde el alojamiento común tiene una entrada de fluidos, una salida de fluidos, y una trayectoria de fluido entre las mismas, estando todas las membranas de filtración del filtro de barrera situadas dentro de la trayectoria de fluido; y la filtración de dicha materia prima líquida con dicho primer filtro (F-1) de proceso de grado de esterilización y dicho segundo filtro (F-2) de proceso de grado de esterilización para producir dicho producto.
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公开(公告)号：ES2755402T3
公开(公告)日：2020-04-22
申请号：ES08767805
申请日：2008-05-15
Applicant: EMD MILLIPORE CORP
Inventor： RAUTIO KEVIN
IPC: B01D63/08 , B01D61/14 , B01D65/00 , B01D69/10 , B01D69/12 , B01D71/34 , B01D71/68 , B29C65/00 , B29C65/18 , B29K27/00 , B29K81/00 , B29K105/00 , B29K105/04 , B29L22/00 , B29L31/14
Abstract: Un dispositivo de filtración que comprende una primera y una segunda placa de soporte, en el que la primera y segunda placas de soporte están formadas por fluoruro de polivinilideno, cada una de las placas de soporte primera y segunda tienen una primera superficie enfrentada y una segunda superficie opuesta a la primera superficie de cada soporte placa, las placas de soporte primera y segunda tienen cada una al menos un puerto formado desde la primera superficie hasta la segunda superficie de cada placa de soporte respectivamente, en la que la primera superficie de la primera placa de soporte está unida por calor a una membrana porosa seleccionada del grupo que consiste de polisulfona, polietersulfona, mezclas de los mismos y copolímeros de los mismos y la primera superficie de la primera placa de soporte está unida por calor a la primera superficie de la segunda placa de soporte alrededor de una periferia de la primera superficie, en la que la periferia es un área fuera del área donde la primera superficie de la primera placa de soporte está unida por calor a la membrana porosa, proporcionando así una membrana porosa sellada integralmente pase a la primera placa de soporte y una segunda placa de soporte herméticamente sellada integralmente a la primera placa de soporte.
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Patent Agency Ranking6.发明公开METHODS AND DEVICES USED FOR REDUNDANT STERILE FILTRATION 审中-公开VERFAHREN UND VORRICHTUNGENFÜRREDUNDANTE STERILE FILTRATION
公开(公告)号：EP2925420A4
公开(公告)日：2016-09-21
申请号：EP13859871
申请日：2013-11-26
Applicant: EMD MILLIPORE CORP
Inventor： PERREAULT JEREMY , FOLEY SEAN , RAUTIO KEVIN
CPC classification number: B01D19/0031 , A61L2/0017 , B01D61/142 , B01D61/18 , B01D63/084 , B01D2313/16 , B01D2313/44 , B01D2315/08 , B01D2317/025 , B01D2317/06 , B01D2325/36 , B01D2325/38
Abstract: Redundant filtration system that includes at least one barrier filter as a process filter, the barrier filter having both hydrophilic and hydrophobic paths, allowing both fluid and gas permeability. The need for vents is eliminated, as is an intermediate drain filter. The device also can be dried in series. The filtration system includes a network of conduits and receptacles, the network receiving liquid raw and/or starting material at one end, conducting it through the process stream defined thereby, and producing the desired liquid product at another end. The network is provided with one or more inputs for introducing liquid raw material into the fluid process stream, and one or more output ports for discharging fluid out of the fluid process stream. The network is preferably an essentially closed network, and also, preferably sterile and/or aseptic.
Abstract translation: 冗余过滤系统，其包括至少一个阻挡过滤器作为过程过滤器，阻隔过滤器具有亲水和疏水路径，允许流体和气体渗透性。 消除了通风口的需要，中间排水过滤器也是如此。 该装置也可以串联干燥。 过滤系统包括管道和容器的网络，网络在一端接收液体原料和/或起始材料，将其通过由其限定的工艺流进行，并在另一端产生所需的液体产物。 该网络设置有一个或多个投入物，用于将液体原料引入到流体工艺流中，以及一个或多个输出端口，用于将流体从流体工艺流中排出。 网络优选地是基本上封闭的网络，并且优选地是无菌的和/或无菌的。
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公开(公告)号：JP2012086220A
公开(公告)日：2012-05-10
申请号：JP2011281491
申请日：2011-12-22
Applicant: Emd Millipore Corp , イー・エム・デイー・ミリポア・コーポレイシヨン
Inventor： STRAEFFER GREGORY , RAUTIO KEVIN
CPC classification number: B01D63/12 , B01D63/103 , B01D2313/44 , B01D2315/08
Abstract: PROBLEM TO BE SOLVED: To provide a filtration apparatus which utilizes spiral wound filter cartridge construction to minimize permeate flow losses while providing satisfactory permeate production capacity.SOLUTION: The filtration apparatus includes: a housing having an inlet (14) and an outlet (16); and a plurality of spirally wound filtration cartridges (18, 24). The filtration cartridges include two filter layers, a feed spacer layer and a permeate spacer layer. Seals are provided to prevent admixtures of feed and permeate and to permit recovery of permeate in a dead-end filtration mode.
Abstract translation: 要解决的问题：提供一种利用螺旋缠绕过滤器滤芯结构的过滤装置，以最小化渗透物流动损失，同时提供令人满意的渗透物生产能力。 过滤装置包括：具有入口（14）和出口（16）的壳体; 和多个螺旋缠绕的过滤筒（18,24）。 过滤筒包括两个过滤层，进料间隔层和渗透物隔离层。 提供密封件以防止进料和渗透物的混合，并允许以死端过滤模式回收渗透物。 版权所有（C）2012，JPO＆INPIT
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公开(公告)号：JP2007105725A
公开(公告)日：2007-04-26
申请号：JP2006275063
申请日：2006-10-06
Applicant: Millipore Corp , ミリポア・コーポレイションMillipore Corporation
Inventor： NAUSEDA CURTIS , BACKES KARI , RAUTIO KEVIN
CPC classification number: B01D29/21 , B01D29/232 , B01D29/58 , B01D46/0023 , B01D63/082 , B01D63/14 , B01D65/102 , B01D2273/10 , B01D2273/18 , B01D2313/90 , B01D2319/022
Abstract: PROBLEM TO BE SOLVED: To provide a device allowing individual test of each layer of thin membrane of an integral multi-layered device.
SOLUTION: This multi-layered filtration apparatus is provided with a filter casing having two or more filtering layers. Each layer is preferably disposed with a clearance from each other to provide a chamber or gap between them. A port or a vent is disposed in the chamber or gap between the two layers. This port or vent provides an intermediate passage for gas or liquid passing through one layer of the filter or thin film and discharged from the port or vent for the integrity test.
COPYRIGHT: (C)2007,JPO&INPITAbstract translation: 要解决的问题：提供一种能够对整个多层装置的每层薄膜进行单独测试的装置。 解决方案：该多层过滤装置设置有具有两个或更多个过滤层的过滤器壳体。 每个层优选地彼此间隔设置以在它们之间提供腔室或间隙。 端口或排气口设置在两层之间的室或间隙中。 该端口或通风口为通过一层过滤器或薄膜的气体或液体提供中间通道，并从端口或排气口排出以进行完整性测试。 版权所有（C）2007，JPO＆INPIT
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公开(公告)号：JP2007105724A
公开(公告)日：2007-04-26
申请号：JP2006275059
申请日：2006-10-06
Applicant: Millipore Corp , ミリポア・コーポレイションMillipore Corporation
Inventor： RAUTIO KEVIN
CPC classification number: B01D65/102 , B01D29/111 , B01D29/21 , B01D29/58 , B01D65/104 , B01D2201/188 , B01D2201/298 , Y10T29/49826
Abstract: PROBLEM TO BE SOLVED: To provide a device capable of individually testing each layer of thin membrane of an integral multi-layered device. SOLUTION: This device can perform a continuous (or serial) filter via two or more filtering layers for obtaining a desired characteristics of preserving ratio or the like, and test the integrity of respective layers separately, and has two or more separate filtering layers. Each of them is formed of two or more filtering regions containing one each filter layer 2 and 20. Each region has one each filter layer 2, 20, and a first end cap 6 connected to a first end part of the filter, and a second end cap 10 connected to a second end part of the filter. These regions are disposed concentrically in such a manner that a first region is disposed inside a second region, and the second region is disposed inside a third region. Each region is separately formed, and integrity test is performed separately before a final assembly. COPYRIGHT: (C)2007,JPO&INPIT
Abstract translation: 要解决的问题：提供能够单独测试整个多层装置的每个薄膜层的装置。 解决方案：该装置可以通过两个或更多个滤波层执行连续（或串联）滤波，以获得所需的保持比等特性，并分别测试各层的完整性，并具有两个或多个分离滤波 层。 它们中的每一个由包含一个每个过滤层2和20的两个或更多个过滤区域形成。每个区域具有一个每个过滤层2,20和连接到过滤器的第一端部的第一端盖6， 端帽10连接到过滤器的第二端部。 这些区域以这样的方式同心地设置，使得第一区域设置在第二区域内，并且第二区域设置在第三区域内。 每个区域分开形成，在最终组装之前单独执行完整性测试。 版权所有（C）2007，JPO＆INPIT
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公开(公告)号：DK2152392T3
公开(公告)日：2019-12-02
申请号：DK08767805
申请日：2008-05-15
Applicant: EMD MILLIPORE CORP
Inventor： RAUTIO KEVIN
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