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    COMPOSITE FOR BIOMATERIAL AND ITS MANUFACTURING METHOD
    4.
    发明专利
    COMPOSITE FOR BIOMATERIAL AND ITS MANUFACTURING METHOD 失效

    公开(公告)号：JP2001276207A

    公开(公告)日：2001-10-09

    申请号：JP2000092249

    申请日：2000-03-29

    Applicant: JAPAN SCIENCE & TECH CORP ,  NAT INST FOR MATERIALS SCIENCE ,  NITTA GELATIN KK

    Inventor： TANAKA JUNZO ,  KIKUCHI MASANORI ,  NAKATANI SHINICHI ,  BANDAI YOSHINOBU ,  HIRAOKA YOSUKE

    IPC: A61L27/00

    Abstract: PROBLEM TO BE SOLVED: To obtain a composite for biomaterial which has a high strength and physical properties approximating to those of the bones of living things and exhibits a superior resistance to degradation when the material is implanted in an organism and a method for manufacturing the material. SOLUTION: This composite for biomaterial is obtained by performing the coprecipitation of calcium phosphate and collagen by mixing an aqueous solution of phosphoric acid containing the collagen and an aqueous solution containing a calcium slat with each other, and then, press-molding the obtained precipitated. At this time, the precipitate is crosslinked, when press-molding or after press- molding, for obtaining the composite for biomaterial.

    ARTIFICIAL VERTEBRAL BODY
    6.
    发明专利
    ARTIFICIAL VERTEBRAL BODY 失效

    公开(公告)号：JP2002248119A

    公开(公告)日：2002-09-03

    申请号：JP2001049493

    申请日：2001-02-23

    Applicant: JAPAN SCIENCE & TECH CORP ,  NAT INST FOR MATERIALS SCIENCE

    Inventor： SHINOMIYA KENICHI ,  ITO SOICHIRO ,  TANAKA JUNZO ,  KIKUCHI MASANORI

    IPC: A61L27/00 ,  A61B17/80 ,  A61F2/44 ,  A61L27/46 ,  A61L27/58

    Abstract: PROBLEM TO BE SOLVED: To provide a means for developing an artificial vertebral body having a nanocomposite and cubic structure similar to that of autogenetic bone in addition to such excellent features as an invasion of new blood vessels and osteogenetic cells, or the like. SOLUTION: This artificial vertebral body is composed of moldings of pressed anhydrous cosediments of hydroxyapatite(HAp) and collagen(Col) having a capability of regenerating bone marrows, wherein pores for blood vessels and osteogenetic cells to invade are punctured on a composite of HAp/Col of the nanocomposite whose HAp particles are composited in the surrounding of Col fibers and whose c axis of the HAp particles is orientated toward a direction of Col fibers. An in vivo decomposition absorptive retainer for fixing the artificial vertebral body is composed of a plate of polylactic acid orientated toward an axial direction by extension following ejection molding of melted polylactic acid, while four corners of the plate are provided with screw holes for fixing the vertebra with the plate.

    HYDROXY-APATITE NANO PARTICLE AND ITS MANUFACTURING METHOD
    7.
    发明专利
    HYDROXY-APATITE NANO PARTICLE AND ITS MANUFACTURING METHOD 失效

    公开(公告)号：JP2002137910A

    公开(公告)日：2002-05-14

    申请号：JP2000333638

    申请日：2000-10-31

    Applicant: JAPAN SCIENCE & TECH CORP ,  NAT INST FOR MATERIALS SCIENCE ,  NAT CARDIOVASCULAR CT

    Inventor： TANAKA JUNZO ,  FURUZONO TSUTOMU

    IPC: B01J20/281 ,  A61K6/838 ,  A61L27/00 ,  C01B25/32 ,  G01N30/88 ,  A61K6/033 ,  G01N30/48

    Abstract: PROBLEM TO BE SOLVED: To manufacture hydroxy-apatite nano particles in a certain shape, large crystallization with large surface area. SOLUTION: A hydroxy-atatite nano particle is 50 nm-5 μm in a maximum diameter of a minor axis and 75 nm-10 μm in a maximum diameter of a major axis. The particle is grown in a c-axis direction with a 1-5 aspect ratio (c-axis length/a-axis length) of crystallization, and is truncated column structure having an oblique angle plane at a top-end angle. In manufacturing the hydroxy-apatite fine particles, a calcium solution and a phosphoric acid solution are dissolved in, mixed with, and reacted to a surfactant/water/oil type emulsion phase at a surfactant clouding point or more. By changing ratio of a surfactant functional group and a hydrophile/hydrophobe ratio, a size of hydroxy-apatite nano particles is controlled. The hydroxy-apatite nano particles are used for surface modification of organic high polymer in order to enhance reaction of the particles and the matrix, and are suitable as chromatography packing agents.

    MODULARIZED ARTIFICIAL BONE
    9.
    发明专利
    MODULARIZED ARTIFICIAL BONE 失效

    公开(公告)号：JP2001231797A

    公开(公告)日：2001-08-28

    申请号：JP2000046450

    申请日：2000-02-23

    Applicant: NAT INST FOR MATERIALS SCIENCE ,  JAPAN SCIENCE & TECH CORP ,  TAMACHI KOGYO KK ,  ESUKOMU KK

    Inventor： TANAKA JUNZO ,  KIKUCHI MASANORI ,  IKOMA TOSHIYUKI ,  OTA KUNIHIRO ,  YOKOYAMA YOSHICHIKA

    IPC: A61L27/00 ,  A61F2/28 ,  C04B35/00

    Abstract: PROBLEM TO BE SOLVED: To provide a modularized artificial bone which makes it possible to easily obtain shapes and dimensions desired to be complemented, does not exert burden to the living body and may be easily integrated with the osteostructure of the living body. SOLUTION: The artificial bone to be replaced in the defective part of the hard tissue or soft tissue of the living body is formed by bundling plural rod-like modules 3 and integrally fixing the bundles. The modules 3 are recommended to have >=1 annular grooves on the circumferences and to be formed with tubular spaces (corresponding to Haversian canals) in a direction orthogonal with an axial direction. The sectional shapes of the modules 3 are preferably polygonal shapes having rounded corners and tubular spaces (corresponding to Volkmann's vessels) are preferably formed between the modules 3 and the modules 3. The module defective part for at least one piece exists and this part is preferably the tubular space 2 (corresponding to the spinal fluid vessel) in the axial direction. The modules 3 are preferably made from metals for the living body, bioactive ceramics, bioinert ceramics, high-polymer materials or >=2 kinds of the composites selected from the groups consisting thereof.

    SOLID-LIQUID MIXED TYPE TWO-COMPONENT SYSTEM IN VIVO DECOMPOSING AND ABSORBING ADHESIVE MEDICAL MATERIAL
    10.
    发明专利
    SOLID-LIQUID MIXED TYPE TWO-COMPONENT SYSTEM IN VIVO DECOMPOSING AND ABSORBING ADHESIVE MEDICAL MATERIAL 审中-公开

    公开(公告)号：JP2006346049A

    公开(公告)日：2006-12-28

    申请号：JP2005174414

    申请日：2005-06-14

    Applicant: NAT INST FOR MATERIALS SCIENCE ,  FURUUCHI KAGAKU KK

    Inventor： TAGUCHI TETSUSHI ,  KAKINOKI SACHIRO ,  TANAKA JUNZO ,  SAITO HIROSHI

    IPC: A61L24/00

    Abstract: PROBLEM TO BE SOLVED: To provide an in vivo decomposing and absorbing adhesive medical material to be strongly adhered in a short time without using dimethylsulfoxide which is an organic solvent as a solvent. SOLUTION: In the solid-liquid mixed type two-component system in vivo decomposing and absorbing adhesive medical material, biodegradable polymer dissolved in the solvent composed of distilled water, an aqueous solution containing metal ions to electrostatically interact with the biodegradable polymer and interact by a chelate effect or a buffer solution is used as an adhesive component, and an organic acid derivative in a powder shape obtained by modifying two carboxyl groups of dicarboxylic acid or two or three carboxyl groups of tricarboxylic acid by an electron withdrawing group is used as a hardening component. COPYRIGHT: (C)2007,JPO&INPIT

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