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公开(公告)号：WO2019012501A1
公开(公告)日：2019-01-17
申请号：PCT/IB2018/055210
申请日：2018-07-13
Applicant: POCARED DIAGNOSTICS LTD.
Inventor： BEN-DAVID, Moshe , ZAHAVY, Eran , INGBER, Gal
Abstract: Single dye fluorescent staining and the combination of differences in both intensity and spectral emission permit determination of the minimum concentration of an antibiotic needed to inactivate bacteria (Minimum Inhibitory Concentration (MIC)), thereby providing a means for rapid Antibiotic Susceptibility Testing (AST). This allows for a quick and easy means for clinicians to determine a suitable treatment regimen for patients suffering from bacterial infections and those that eventually lead to sepsis.
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公开(公告)号：WO2023079511A1
公开(公告)日：2023-05-11
申请号：PCT/IB2022/060647
申请日：2022-11-04
Applicant: POCARED DIAGNOSTICS LTD
Inventor： INGBER, Gal
Abstract: A method of welding a side of a first element to a side of a second element is provided. The side of the first element includes a recessed surface and a protruding surface. The side of the second element includes a recessed surface and a protruding surface. A rib extends from the first element, optionally from the recessed surface of the first element, or from the second element, optionally from the protruding surface of the second element. The method includes a step of moving the first element towards the second element, thereby causing a surface of the rib to contact the first element or the second element. The method also includes, with the rib in contact with the first element or the second element, as step of melting the rib, thereby causing the protruding surface of the first element to contact the recessed surface of the second element.
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3.发明申请METHOD AND APPARATUS FOR PROCESSING AND ANALYZING PARTICLES EXTRACTED FROM TANGENTIAL FILTERING 审中-公开用于处理和分析从过滤中提取的颗粒的方法和装置
公开(公告)号：WO2015083166A1
公开(公告)日：2015-06-11
申请号：PCT/IL2014/051057
申请日：2014-12-04
Applicant: POCARED DIAGNOSTICS LTD.
Inventor： GURFINKEL, Jonathan , INGBER, Gal
IPC: C12N7/02 , B01D27/14 , G01N33/487 , B01D61/18 , B01D61/20
CPC classification number: B01D29/0095 , B01D37/00 , B01L3/502753 , B01L2300/0681 , B01L2400/0487 , B01L2400/0622 , B01L2400/065 , C12Q1/24 , G01F15/125 , G01G17/06 , G01N1/2813 , G01N1/30 , G01N1/4077 , G01N5/02 , G01N33/493 , G01N2001/4088 , G01N2015/0053 , Y10T436/25375
Abstract: A filter arrangement with a top element and a bottom element and a filter element therebetween captures oversized particles on the upper surface of the filter element and tangentially rinses these particles using an elution fluid to provide a concentration of particles in a relatively low volume of fluid for further analysis. A configuration using a slider valve may also be utilized. Additionally, an arrangement of supply and receiving containers may be used to minimize the number of containers required. A mass flow meter may be incorporated to measure the flow of elution fluid. Finally, a wash stage of the filtering process may be used to introduce stain onto the particles for further analysis, such as that associated with Gram staining and these stained particles may be further analyzed.
Abstract translation: 具有顶部元件和底部元件以及过滤元件的过滤器装置在过滤器元件的上表面上捕获过大的颗粒，并使用洗脱流体切向冲洗这些颗粒，以提供相对低体积的流体中的颗粒浓度 进一步分析。 还可以使用使用滑阀的构造。 此外，供应和接收容器的布置可以用于最小化所需容器的数量。 可以结合质量流量计来测量洗脱流体的流动。 最后，过滤过程的洗涤阶段可用于在颗粒上引入污染物用于进一步分析，例如与革兰氏染色相关的染色，并且可以进一步分析这些染色的颗粒。
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公开(公告)号：WO2015083165A1
公开(公告)日：2015-06-11
申请号：PCT/IL2014/051056
申请日：2014-12-04
Applicant: POCARED DIAGNOSTICS LTD.
Inventor： INGBER, Gal , CASTANON, Scott
CPC classification number: B01D29/0095 , B01D37/00 , B01L3/502753 , B01L2300/0681 , B01L2400/0487 , B01L2400/0622 , B01L2400/065 , C12Q1/24 , G01F15/125 , G01G17/06 , G01N1/2813 , G01N1/30 , G01N1/4077 , G01N5/02 , G01N33/493 , G01N2001/4088 , G01N2015/0053 , Y10T436/25375
Abstract: A filter arrangement with a top element and a bottom element and a filter element therebetween captures oversized particles on the upper surface of the filter element and tangentially rinses these particles using an elution fluid to provide a concentration of particles in a relatively low volume of fluid for further analysis. A configuration using a slider valve may also be utilized. Additionally, an arrangement of supply and receiving containers may be used to minimize the number of containers required. A mass flow meter may be incorporated to measure the flow of elution fluid. Finally, a wash stage of the filtering process may be used to introduce stain onto the particles for further analysis, such as that associated with Gram staining and these stained particles may be further analyzed.
Abstract translation: 具有顶部元件和底部元件以及过滤元件的过滤器装置在过滤器元件的上表面上捕获过大的颗粒，并使用洗脱流体切向冲洗这些颗粒，以提供相对低体积的流体中的颗粒浓度 进一步分析。 还可以使用使用滑阀的构造。 此外，供应和接收容器的布置可以用于最小化所需容器的数量。 可以结合质量流量计来测量洗脱流体的流动。 最后，过滤过程的洗涤阶段可用于在颗粒上引入污染物用于进一步分析，例如与革兰氏染色相关的染色，并且可以进一步分析这些染色的颗粒。
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公开(公告)号：WO2018127853A1
公开(公告)日：2018-07-12
申请号：PCT/IB2018/050134
申请日：2018-01-09
Applicant: POCARED DIAGNOSTICS LTD.
Inventor： INGBER, Gal , BEN-DAVID, Moshe , FRIDMAN, Mushki , GLUCKMAN, Yael , GOHMAN, Dina , MUNZ, Orly, Hammer , SHINDERMAN, Anita , ZAHAVY, Eran
Abstract: Single dye fluorescent staining and the combination of differences in both intensity and spectral emission permit determination of the minimum concentration of an antibiotic needed to inactivate bacteria (Minimum Inhibitory Concentration (MIC)), thereby providing a means for rapid Antibiotic Susceptibility Testing (AST). This allows for a quick and easy means for clinicians to determine a suitable treatment regimen for patients suffering from bacterial infections and those that eventually lead to sepsis.
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Patent Agency Ranking
公开(公告)号：WO2014123896A1
公开(公告)日：2014-08-14
申请号：PCT/US2014/014658
申请日：2014-02-04
Applicant: POCARED DIAGNOSTICS LTD.
Inventor： INGBER, Gal
CPC classification number: G01N1/34 , B01L3/502753 , B01L2300/0681 , B01L2300/0816 , B01L2300/0887 , B01L2400/049 , G01N1/4077 , G01N2001/4088
Abstract: A filter arrangement with a top element and a bottom element and a filter element therebetween captures oversized particles on the upper surface of the filter element and tangentially rinses these particles using an elution fluid to provide a concentration of particles in a relatively low volume of fluid for further analysis. In an intermediate step, the particles captured by the filter may be rinsed with a rinsing fluid such as water to pass additional undersized particles through the filter, thereby providing a purer sample. To improve efficiency, check valves may be used for passageways with one-way flow. Additionally, a configuration of three-way stopcocks may also be utilized. Finally, a sandwich arrangement is possible, wherein a single bottom element is sandwiched between two opposing top elements.
Abstract translation: 具有顶部元件和底部元件以及过滤元件的过滤器装置在过滤器元件的上表面上捕获过大的颗粒，并使用洗脱流体切向冲洗这些颗粒，以提供相对低体积的流体中的颗粒浓度 进一步分析。 在中间步骤中，由过滤器捕获的颗粒可以用诸如水的冲洗液冲洗以通过另外的过小的颗粒通过过滤器，从而提供更纯的样品。 为了提高效率，止回阀可用于单向流动的通道。 另外，也可以使用三通旋塞的构造。 最后，三明治布置是可能的，其中单个底部元件夹在两个相对的顶部元件之间。
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公开(公告)号：WO2014093463A1
公开(公告)日：2014-06-19
申请号：PCT/US2013/074342
申请日：2013-12-11
Applicant: POCARED DIAGNOSTICS LTD.
Inventor： INGBER, Gal , ROGERS, Martha, J.
CPC classification number: C12M41/36 , B01L3/508 , B01L2300/0809 , B01L2300/0851 , G01N21/0303 , G01N2021/0382 , G01N2021/6469 , G01N2021/6482 , G01N2035/0436 , G01N2201/0655
Abstract: The present invention relates to a system for conducting the identification and quantification of micro-organisms, e.g., bacteria, in biological samples. More particularly, the invention relates to a system comprising a disposable cartridge and an optics cup or cuvette having a tapered surface; wherein the walls are angled to allow for better coating and better striations of the light. The system may utilize the disposable cartridge in the sample processor and the optics cup or cuvette in the optical analyzer, wherein the optics cup also has a floor in the shape of an inverted arch.
Abstract translation: 本发明涉及用于在生物样品中进行微生物（例如细菌）的鉴定和定量的系统。 更具体地，本发明涉及一种包括一次性盒和具有锥形表面的光学杯或杯的系统， 其中壁是成角度的，以允许更好的涂层和更好的光线条纹。 系统可以利用样品处理器中的一次性盒，以及光学分析器中的光学杯或试管，其中光学杯还具有倒拱形状的底板。
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公开(公告)号：WO2010089749A1
公开(公告)日：2010-08-12
申请号：PCT/IL2010/000108
申请日：2010-02-07
Applicant: Pocared Diagnostics Ltd. , INGBER, Gal
Inventor： INGBER, Gal
IPC: G01J3/42
CPC classification number: G01J1/32 , G01J3/42 , G01J2003/2866 , G01N21/031 , G01N21/253 , G01N2201/0415 , G01N2201/0469 , G01N2201/0692
Abstract: A method and device for enhancing the power correction of optical measurements in an optical measurement arrangement, the steps including: providing a light source for producing a light beam; splitting the light beam into two beams; directing a first split light beam through an interrogation area and into an optics separation device; directing the light beams from the optics separation device and a second split light beam representing the intensity of the illumination of the main light beam of the light source into cells of a detector array; measuring and assessing the information obtained in the cells; and using this information to calculate the corrected value for the cells receiving the light beams from the optics separation device in order to adjust the power for the intensity of the light beam of the light source and/or to correct the intensity of the light beams from the interrogation area.
Abstract translation: 一种用于增强光学测量装置中的光学测量的功率校正的方法和装置，所述步骤包括：提供用于产生光束的光源; 将光束分成两束; 将第一分裂光束引导通过询问区并进入光学分离装置; 引导来自光学分离装置的光束和将光源的主光束的照明强度表示为检测器阵列的单元的第二分裂光束; 测量和评估细胞中获得的信息; 并且使用该信息来计算接收来自光学分离装置的光束的单元的校正值，以便调整光源的光束强度的功率和/或校正来自光源的光束的强度 询问区。
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公开(公告)号：WO2008107881A2
公开(公告)日：2008-09-12
申请号：PCT/IL2008/000283
申请日：2008-03-05
Applicant: POCARED DIAGNOSTICS LTD. , INGBER, Gal , GURFINKEL, Jonathan
Inventor： INGBER, Gal , GURFINKEL, Jonathan
IPC: C12Q1/18
CPC classification number: G01N33/9446
Abstract: The method includes several steps including obtaining a bacterial sample; identifying the type of bacteria in the bacterial sample; selecting a set of antibiotics based on the identity of the bacteria in the bacterial sample; obtaining a control sample from the bacterial sample; placing the bacterial sample in solutions containing the set of antibiotics; determining concentration of bacteria in the respective antibiotic solutions; determining growth curves for the respective antibiotic solutions based on the determined bacterial concentration; and comparing the growth curves for the respective antibiotic solutions with a growth curve determined from the control sample. An identification and quantification system may be used to select the set of antibiotics, and further may be used in the steps of determining concentration of bacteria in the respective antibiotic solutions and determining growth curves for the respective antibiotic solutions based on the determined bacterial concentration.
Abstract translation: 该方法包括获得细菌样品的几个步骤; 鉴定细菌样品中细菌的类型; 根据细菌样本中细菌的特征选择一组抗生素; 从细菌样品获得对照样品; 将细菌样品置于含有该组抗生素的溶液中; 确定各抗生素溶液中细菌的浓度; 基于确定的细菌浓度确定各抗生素溶液的生长曲线; 并将各抗生素溶液的生长曲线与从对照样品测定的生长曲线进行比较。 可以使用鉴定和定量系统来选择该组抗生素，并且还可以用于确定各抗生素溶液中的细菌浓度并基于确定的细菌浓度确定各抗生素溶液的生长曲线的步骤。
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10.发明申请
公开(公告)号：WO2019026026A1
公开(公告)日：2019-02-07
申请号：PCT/IB2018/055827
申请日：2018-08-02
Applicant: POCARED DIAGNOSTICS LTD.
Inventor： INGBER, Gal
Abstract: An apparatus for processing a biological sample for optical analysis having a cartridge with a sample supply container and a couvette, a cartridge/magazine holding the cartridge, and a cassette fan positioned over the cartridge. A filter cassette is mounted within the cassette fan, wherein the filter cassette has an inlet for receiving a sample from the sample supply container, an outlet for discharging the filter sample into the couvette, and valves therein to manipulate the sample for filtering. A cassette clamp is positioned over the filter cassette to secure the cassette and operate the filter cassette. A method for implementing this apparatus is also described herein. Additionally an apparatus is used for and a method measures waste fluid that passes over a filter element to control the amount of rinse fluid passing over the filter element.
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