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公开(公告)号：WO2007058989A3
公开(公告)日：2007-09-07
申请号：PCT/US2006043895
申请日：2006-11-13
Applicant: VERTEX PHARMA , WILSON DEAN , FANNING LEV T D , KRENITSKY PAUL , TERMIN ANDREAS , JOSHI PRAMOD , SHETH URVI
Inventor： WILSON DEAN , FANNING LEV T D , KRENITSKY PAUL , TERMIN ANDREAS , JOSHI PRAMOD , SHETH URVI
IPC: C07D403/04 , A61K31/505 , A61P29/00
CPC classification number: C07D403/04
Abstract: The present invention relates to compounds of the following formula useful as inhibitors of voltage-gate sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
Abstract translation: 本发明涉及可用作电压 - 门钠通道抑制剂的下式的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：WO2006028904A9
公开(公告)日：2006-06-22
申请号：PCT/US2005031146
申请日：2005-08-31
Applicant: VERTEX PHARMA , WILSON DEAN M , TERMIN ANDREAS P , GONZALEZ JESUS E III , FANNING LEV T D , NEUBERT TIMOTHY D , KRENITSKY PAUL , JOSHI PRAMOD , HURLEY DENNIS J , SHETH URVI , BOGER JOSHUA S
Inventor： WILSON DEAN M , TERMIN ANDREAS P , GONZALEZ JESUS E III , FANNING LEV T D , NEUBERT TIMOTHY D , KRENITSKY PAUL , JOSHI PRAMOD , HURLEY DENNIS J , SHETH URVI , BOGER JOSHUA S
IPC: C07D239/94 , A61K31/498 , A61P9/06 , A61P25/00 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14
CPC classification number: C07D401/04 , C07D239/94 , C07D401/12 , C07D401/14 , C07D403/04 , C07D405/12 , C07D405/14
Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
Abstract translation: 本发明涉及用作电压门控钠通道抑制剂的化合物。 本发明还提供了包含本发明化合物的药学上可接受的组合物以及使用该组合物治疗各种疾病的方法。
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3.发明申请
公开(公告)号：WO2009049180A2
公开(公告)日：2009-04-16
申请号：PCT/US2008079542
申请日：2008-10-10
Applicant: VERTEX PHARMA , JOSHI PRAMOD , KRENITSKY PAUL , TERMIN ANDREAS , WILSON DEAN
Inventor： JOSHI PRAMOD , KRENITSKY PAUL , TERMIN ANDREAS , WILSON DEAN
IPC: C07D213/82 , A61K31/341 , A61P29/00 , C07D249/10 , C07D261/18 , C07D263/34 , C07D277/56 , C07D285/12 , C07D307/68 , C07D333/38
CPC classification number: C07D277/56 , C07D213/82 , C07D249/10 , C07D261/18 , C07D263/34 , C07D285/12 , C07D307/68 , C07D333/38
Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
Abstract translation: 本发明涉及可用作电压门控钠通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：WO2007146284A3
公开(公告)日：2008-04-03
申请号：PCT/US2007013776
申请日：2007-06-12
Applicant: VERTEX PHARMA , FANNING LEV T D , JOSHI PRAMOD , KRENITSKY PAUL , TERMIN ANDREAS , WILSON DEAN , ZHANG YULIAN
Inventor： FANNING LEV T D , JOSHI PRAMOD , KRENITSKY PAUL , TERMIN ANDREAS , WILSON DEAN , ZHANG YULIAN
IPC: A61K31/519 , A61P25/00
CPC classification number: C07D495/14 , C07D333/20 , C07D495/04
Abstract: The present invention relates to compounds of formula (I) useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
Abstract translation: 本发明涉及可用作离子通道抑制剂的式（I）化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：WO2007120647A2
公开(公告)日：2007-10-25
申请号：PCT/US2007008818
申请日：2007-04-11
Applicant: VERTEX PHARMA , JOSHI PRAMOD , KRENITSKY PAUL , GONZALEZ JESUS , WANG JIAN , WILSON DEAN , TERMIN ANDREAS
Inventor： JOSHI PRAMOD , KRENITSKY PAUL , GONZALEZ JESUS , WANG JIAN , WILSON DEAN , TERMIN ANDREAS
IPC: C07C311/46 , C07C323/62 , C07D207/32 , C07D213/65 , C07D213/74 , C07D233/54 , C07D295/20 , C07D317/60
CPC classification number: C07C311/46 , C07C323/62 , C07D207/327 , C07D213/56 , C07D213/65 , C07D213/68 , C07D213/74 , C07D213/82 , C07D231/12 , C07D233/36 , C07D233/64 , C07D233/70 , C07D239/34 , C07D257/04 , C07D285/08 , C07D295/096 , C07D295/155 , C07D295/205 , C07D317/68
Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
Abstract translation: 本发明涉及可用作电压门控钠通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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Patent Agency Ranking
公开(公告)号：WO2006124865A2
公开(公告)日：2006-11-23
申请号：PCT/US2006018871
申请日：2006-05-15
Applicant: VERTEX PHARMA , TERMIN ANDREAS , WILSON DEAN , JOSHI PRAMOD
Inventor： TERMIN ANDREAS , WILSON DEAN , JOSHI PRAMOD
IPC: C07D295/14 , A61K31/495 , C07D295/18
CPC classification number: C07D295/185 , C07D295/15
Abstract: The present invention relates to compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
Abstract translation: 本发明涉及可用作离子通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：WO2009020470A3
公开(公告)日：2010-10-21
申请号：PCT/US2007087411
申请日：2007-12-13
Applicant: VERTEX PHARMA , GUTIERREZ COREY DON , TERMIN ANDREAS , HADIDA-RUAH SARA , BERGERON DANIELE , YOO SANGHEE , BINCH HAYLEY , JOSHI PRAMOD , COME JON , NANTHAKUMAR SUGANTHI , CAO JINGRONG , KRUEGER ELAINE , MAXWELL JOHN , LE TIRAN ARNAUD , LIAO YUSHENG
Inventor： GUTIERREZ COREY DON , TERMIN ANDREAS , HADIDA-RUAH SARA , BERGERON DANIELE , YOO SANGHEE , BINCH HAYLEY , JOSHI PRAMOD , COME JON , NANTHAKUMAR SUGANTHI , CAO JINGRONG , KRUEGER ELAINE , MAXWELL JOHN , LE TIRAN ARNAUD , LIAO YUSHENG
IPC: C07D277/14 , A61K31/4468 , A61K31/517 , C07D417/06 , C07D417/14 , C07D471/04 , C07D471/10 , C07D498/10 , C07D513/10
CPC classification number: C07D277/14 , C07D417/06 , C07D417/14 , C07D471/04 , C07D471/10 , C07D498/10 , C07D513/10
Abstract: The present invention relates to CGRP receptor antagonists of formula I, wherein: X is S, Si, or SO2; pharmaceutical compositions thereof, and methods therewith for treating CGRP receptor-mediated diseases and conditions.
Abstract translation: 本发明涉及式I的CGRP受体拮抗剂，其中：X是S，Si或SO 2; 其药物组合物及其用于治疗CGRP受体介导的疾病和病症的方法。
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公开(公告)号：WO2006130493A8
公开(公告)日：2008-02-21
申请号：PCT/US2006020521
申请日：2006-05-26
Applicant: VERTEX PHARMA , WILSON DEAN M , TERMIN ANDREAS P , FANNING LEV T D , KRENITSKY PAUL , JOSHI PRAMOD
Inventor： WILSON DEAN M , TERMIN ANDREAS P , FANNING LEV T D , KRENITSKY PAUL , JOSHI PRAMOD
IPC: C07D417/04 , A61K31/44 , A61K31/496
CPC classification number: C07D277/38 , C07D285/08 , C07D417/04
Abstract: The present invention relates to compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
Abstract translation: 本发明涉及可用作离子通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：WO2007146349A2
公开(公告)日：2007-12-21
申请号：PCT/US2007013896
申请日：2007-06-13
Applicant: VERTEX PHARMA , GUTIERREZ COREY , TERMIN ANDREAS , HADIDA-RUAH SARA , JOSHI PRAMOD , BERGERON DANIELE , YOO SANGHEE , BINCH HAYLEY , COME JON , NANTHAKUMAR SUGANTHI , CAO JINGRONG
Inventor： GUTIERREZ COREY , TERMIN ANDREAS , HADIDA-RUAH SARA , JOSHI PRAMOD , BERGERON DANIELE , YOO SANGHEE , BINCH HAYLEY , COME JON , NANTHAKUMAR SUGANTHI , CAO JINGRONG
CPC classification number: C07D417/14 , C07D277/14 , C07D417/06 , C07D471/04 , C07D471/10 , C07D498/10 , C07D513/10
Abstract: The present invention relates to CGRP receptor antagonists, pharmaceutical compositions thereof, and methods therewith for treating CGRP receptor-mediated diseases and conditions.
Abstract translation: 本发明涉及CGRP受体拮抗剂，其药物组合物及其用于治疗CGRP受体介导的疾病和病症的方法。
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公开(公告)号：WO2006130493A3
公开(公告)日：2007-03-01
申请号：PCT/US2006020521
申请日：2006-05-26
Applicant: VERTEX PHARMA , KRENITSKY PAUL , JOSHI PRAMOD , WILSON DEAN M , TERMIN ANDREAS P , FANNING LEV T D
Inventor： KRENITSKY PAUL , JOSHI PRAMOD , WILSON DEAN M , TERMIN ANDREAS P , FANNING LEV T D
IPC: C07D417/04 , A61K31/44 , A61K31/496
CPC classification number: C07D277/38 , C07D285/08 , C07D417/04
Abstract: The present invention relates to compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
Abstract translation: 本发明涉及可用作离子通道抑制剂的化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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