公开(公告)号：US10265891B2

公开(公告)日：2019-04-23

申请号：US14957790

申请日：2015-12-03

Applicant: Zimmer, Inc.

Inventor： Dirk Pletcher

IPC: C08J3/12 ,  B29C69/02 ,  C08L23/06 ,  A61L27/16 ,  A61F2/30 ,  A61L27/56 ,  B29C43/02 ,  B29C67/00 ,  B29C70/00 ,  B29C71/04 ,  B29K23/00 ,  B29L31/00 ,  B29K105/00

Abstract: Various embodiments disclosed relate to antioxidant-stabilized materials including ultra high molecular weight polyethylene (UHMWPE), methods of making the same, and medical implants including the same. In various embodiments, the present invention provides a method of adding antioxidant to UHMWPE. The method includes obtaining or providing a porous solid material including UHMWPE. The method includes coating the porous solid material with a liquid composition including at least one antioxidant such that at least some of the liquid composition enters void space of the porous solid material, to provide an antioxidant-infused solid material. The method also includes melt-consolidating the antioxidant-infused solid material, to provide a melt-consolidated material.

公开(公告)号：US20160145416A1

公开(公告)日：2016-05-26

申请号：US14983006

申请日：2015-12-29

Applicant: Zimmer, Inc.

Inventor： Alicia Rufner ,  John Knight ,  Toni Rowe ,  Dirk Pletcher ,  Ray Gsell ,  Hallie E. Brinkerhuff ,  Werner Schneider

IPC: C08K5/1545 ,  A61L31/14 ,  A61L31/04 ,  C08J3/28 ,  C08J3/24

CPC classification number: C08K5/1545 ,  A61B17/8085 ,  A61L27/16 ,  A61L27/505 ,  A61L31/048 ,  A61L31/143 ,  C08J3/24 ,  C08J3/28 ,  C08J2323/26 ,  C08L23/06 ,  C08L2312/06 ,  Y10T428/31 ,  Y10T428/315

Abstract: An antioxidant combined with UHMWPE prior to subjecting the UHMWPE to crosslinking irradiation. In one exemplary embodiment, the antioxidant is tocopherol. After the antioxidant is combined with the UHMWPE, the resulting blend may be formed into slabs, bar stock, and/or incorporated into a substrate, such as a metal, for example. The resulting product may then be subjected to crosslinking irradiation. In one exemplary embodiment, the UHMWPE blend is preheated prior to subjecting the same to crosslinking irradiation. Once irradiated, the UHMWPE blended product may be machined, packaged, and sterilized in accordance with conventional techniques.

Abstract translation: 在超高分子量聚乙烯（UHMWPE）交联照射之前，与UHMWPE结合使用的抗氧化剂。 在一个示例性实施方案中，抗氧化剂是生育酚。 在将抗氧化剂与UHMWPE组合之后，所得到的共混物可以形成为板坯，棒料，和/或结合到例如金属等基材中。 然后将所得产物进行交联照射。 在一个示例性实施方案中，在对其进行交联照射之前，将UHMWPE共混物预热。 一旦照射，UHMWPE共混产品可以根据常规技术被加工，包装和灭菌。

公开(公告)号：US09277949B2

公开(公告)日：2016-03-08

申请号：US14157695

申请日：2014-01-17

Applicant: Zimmer, Inc.

Inventor： Alicia Rufner ,  John Knight ,  Toni Rowe ,  Dirk Pletcher ,  Ray Gsell ,  Werner Schneider ,  Hallie E Brinkerhuff

IPC: C08L23/06 ,  A61B17/80 ,  A61L27/16 ,  A61L27/50 ,  C08K5/00 ,  C08K5/1545 ,  C08K9/10

CPC classification number: C08J3/247 ,  A61B17/8085 ,  A61L27/16 ,  A61L27/505 ,  C08J3/28 ,  C08J2323/26 ,  C08K5/005 ,  C08K5/1545 ,  C08K9/10 ,  C08L23/06 ,  C08L2312/06 ,  Y10T428/31 ,  Y10T428/315

Abstract: An antioxidant combined with UHMWPE prior to subjecting the UHMWPE to crosslinking irradiation. In one exemplary embodiment, the antioxidant is tocopherol. After the antioxidant is combined with the UHMWPE, the resulting blend may be formed into slabs, bar stock, and/or incorporated into a substrate, such as a metal, for example. The resulting product may then be subjected to crosslinking irradiation. In one exemplary embodiment, the UHMWPE blend is preheated prior to subjecting the same to crosslinking irradiation. Once irradiated, the UHMWPE blended product may be machined, packaged, and sterilized in accordance with conventional techniques.

Abstract translation: 在超高分子量聚乙烯（UHMWPE）交联照射之前，与UHMWPE结合使用的抗氧化剂。 在一个示例性实施方案中，抗氧化剂是生育酚。 在将抗氧化剂与UHMWPE组合之后，所得到的共混物可以形成为板坯，棒料，和/或结合到例如金属等基材中。 然后将所得产物进行交联照射。 在一个示例性实施方案中，在对其进行交联照射之前，将UHMWPE共混物预热。 一旦照射，UHMWPE共混产品可以根据常规技术被加工，包装和灭菌。

公开(公告)号：US20140194934A1

公开(公告)日：2014-07-10

申请号：US14157695

申请日：2014-01-17

Applicant: Zimmer, Inc.

Inventor： Alicia Rufner ,  John Knight ,  Toni Rowe ,  Dirk Pletcher ,  Ray Gsell ,  Werner Schneider ,  Hallie E. Brinkerhuff

IPC: A61B17/80

CPC classification number: C08J3/247 ,  A61B17/8085 ,  A61L27/16 ,  A61L27/505 ,  C08J3/28 ,  C08J2323/26 ,  C08K5/005 ,  C08K5/1545 ,  C08K9/10 ,  C08L23/06 ,  C08L2312/06 ,  Y10T428/31 ,  Y10T428/315

Abstract: An antioxidant combined with UHMWPE prior to subjecting the UHMWPE to crosslinking irradiation. In one exemplary embodiment, the antioxidant is tocopherol. After the antioxidant is combined with the UHMWPE, the resulting blend may be formed into slabs, bar stock, and/or incorporated into a substrate, such as a metal, for example. The resulting product may then be subjected to crosslinking irradiation. In one exemplary embodiment, the UHMWPE blend is preheated prior to subjecting the same to crosslinking irradiation. Once irradiated, the UHMWPE blended product may be machined, packaged, and sterilized in accordance with conventional techniques.

Abstract translation: 在超高分子量聚乙烯（UHMWPE）交联照射之前，与UHMWPE结合使用的抗氧化剂。 在一个示例性实施方案中，抗氧化剂是生育酚。 在将抗氧化剂与UHMWPE组合之后，所得到的共混物可以形成为板坯，棒料，和/或结合到例如金属等基材中。 然后将所得产物进行交联照射。 在一个示例性实施方案中，在对其进行交联照射之前，将UHMWPE共混物预热。 一旦照射，UHMWPE共混产品可以根据常规技术被加工，包装和灭菌。

公开(公告)号：US10184031B2

公开(公告)日：2019-01-22

申请号：US15124454

申请日：2015-02-26

Applicant: Zimmer, Inc.

Inventor： Dirk Pletcher

IPC: C08J3/205 ,  A61L27/16 ,  B29C71/00 ,  B29C71/02 ,  B29C43/00 ,  C08J7/06 ,  C08J7/12 ,  C08K5/00 ,  C08K5/134 ,  C08K5/1545 ,  C08L23/06 ,  C08L23/26 ,  A61L27/50 ,  B29K23/00 ,  B29K105/00 ,  B29L31/00

Abstract: Various embodiments disclosed relate to melt-stabilized materials including ultra high molecular weight polyethylene (UHMWPE), methods of making the same, and medical implants including the same. In various embodiments, the present invention provides a method of melt-stabilizing a material including UHMWPE. The method includes obtaining or providing a solid material including UHMWPE including a first concentration of free-radicals. The method includes coating at least part of the solid material with a liquid composition including at least one antioxidant, to provide a coated solid material. The method includes heating the coated solid material in an environment including oxygen, the heating being sufficient to melt at least part of the UHMWPE, to provide a heated material. The method also includes solidifying the heated material, to provide a melt-stabilized material including UHMWPE including a second concentration of free-radicals, wherein the second concentration of free-radicals is less than the first concentration of free-radicals.

公开(公告)号：US09822224B2

公开(公告)日：2017-11-21

申请号：US14978598

申请日：2015-12-22

Applicant: Zimmer, Inc.

Inventor： Alicia Rufner ,  John Knight ,  Toni Rowe ,  Dirk Pletcher ,  Ray Gsell ,  Werner Schneider ,  Hallie E Brinkerhuff

IPC: C08L23/06 ,  C08J3/24 ,  A61L27/16 ,  A61L27/50 ,  A61B17/80 ,  C08J3/28 ,  C08K5/00 ,  C08K5/1545 ,  C08K9/10

CPC classification number: C08J3/247 ,  A61B17/8085 ,  A61L27/16 ,  A61L27/505 ,  C08J3/28 ,  C08J2323/26 ,  C08K5/005 ,  C08K5/1545 ,  C08K9/10 ,  C08L23/06 ,  C08L2312/06 ,  Y10T428/31 ,  Y10T428/315

Abstract: An antioxidant combined with UHMWPE prior to subjecting the UHMWPE to crosslinking irradiation. In one exemplary embodiment, the antioxidant is tocopherol. After the antioxidant is combined with the UHMWPE, the resulting blend may be formed into slabs, bar stock, and/or incorporated into a substrate, such as a metal, for example. The resulting product may then be subjected to crosslinking irradiation. In one exemplary embodiment, the UHMWPE blend is preheated prior to subjecting the same to crosslinking irradiation. Once irradiated, the UHMWPE blended product may be machined, packaged, and sterilized in accordance with conventional techniques.

公开(公告)号：US09718241B2

公开(公告)日：2017-08-01

申请号：US14156726

申请日：2014-01-16

Applicant: Zimmer, Inc.

Inventor： Kirt Case ,  Oludele O. Popoola ,  Robby Kissling ,  Brion R. Mimnaugh ,  Archie Newsome ,  Clarence M. Panchison ,  Dirk Pletcher ,  Randy Schlemmer ,  Zhibin Fang ,  Juan Vivanco ,  Alicia Rufner ,  John Knight

IPC: B29C43/18 ,  B29C70/68 ,  A61F2/34 ,  A61L27/18 ,  A61L27/50 ,  A61L27/56 ,  B29C45/14 ,  A61B17/86 ,  A61F2/30 ,  A61F2/32

CPC classification number: B29C70/682 ,  A61B17/86 ,  A61F2/30942 ,  A61F2/34 ,  A61F2002/30329 ,  A61F2002/305 ,  A61F2002/3092 ,  A61F2002/3096 ,  A61F2002/30981 ,  A61F2002/3291 ,  A61F2002/3401 ,  A61F2002/3411 ,  A61F2220/0025 ,  A61F2310/00131 ,  A61L27/18 ,  A61L27/50 ,  A61L27/56 ,  B29C43/18 ,  B29C45/14 ,  C08L71/00

Abstract: An orthopedic component having multiple layers that are selected to provide an overall modulus that is substantially lower than the modulus of known orthopedic components to more closely approximate the modulus of the bone into which the orthopedic component is implanted. In one exemplary embodiment, the orthopedic component is an acetabular shell. For example, the acetabular shell may include an outer layer configured for securement to the natural acetabulum of a patient and an inner layer configured to receive an acetabular liner. The head of a femoral prosthesis articulates against the acetabular liner to replicate the function of a natural hip joint. Alternatively, the inner layer of the acetabular shell may act as an integral acetabular liner against which the head of the femoral prosthesis articulates.

公开(公告)号：US20160280863A1

公开(公告)日：2016-09-29

申请号：US15073042

申请日：2016-03-17

Applicant: Zimmer, Inc.

Inventor： Dirk Pletcher

IPC: C08J3/20 ,  C08J3/28 ,  B05D3/06 ,  A61L27/16 ,  A61L27/50 ,  C08J3/24 ,  C08K5/529

CPC classification number: C08J3/203 ,  A61L27/16 ,  A61L27/505 ,  A61L2430/02 ,  B05D3/068 ,  B29C71/02 ,  B29C71/04 ,  B29C2035/0877 ,  B29K2023/0683 ,  C08J3/24 ,  C08J3/28 ,  C08J7/065 ,  C08J7/08 ,  C08J7/123 ,  C08J2323/04 ,  C08J2323/06 ,  C08K5/005 ,  C08K5/1545 ,  C08K5/529 ,  C08K2201/013 ,  C08L23/06

Abstract: Various embodiments disclosed relate to melt-stabilized ultra high molecular weight antioxidant, methods of making the same, and medical implants made from the same. In various embodiments, the present invention provides a method of melt-stabilizing ultra high molecular weight polyethylene (UHMWPE). The method can include coating a solid material including LIMA/PE with an antioxidant, to provide an antioxidant-coated solid material. The method can include pre-irradiatively heating the antioxidant-coated solid material to diffuse the antioxidant therein, to provide an antioxidant-diffused solid material. The method can include irradiating the antioxidant-diffused solid material, to provide an irradiated solid material. The method can include post-irradiatively heating the irradiated solid material, the heating sufficient to melt at least part of the UHMWPE, to provide a heated material. The method can also include solidifying the heated material, to provide a melt-stabilized material.

Abstract translation: 所公开的各种实施方案涉及熔融稳定的超高分子量抗氧化剂，其制备方法和由其制备的医用植入物。 在各种实施方案中，本发明提供了一种熔融稳定超高分子量聚乙烯（UHMWPE）的方法。 该方法可以包括用抗氧化剂涂覆包括LIMA / PE的固体材料，以提供抗氧化剂涂覆的固体材料。 该方法可以包括预先加热抗氧化剂涂覆的固体材料以使其中的抗氧化剂扩散，以提供抗氧化剂扩散的固体材料。 该方法可以包括照射抗氧化剂扩散的固体材料，以提供照射的固体材料。 该方法可以包括对辐射的固体材料进行后照射加热，足以熔化至少部分UHMWPE的加热，以提供加热的材料。 该方法还可以包括固化加热的材料，以提供熔融稳定的材料。

公开(公告)号：US09265545B2

公开(公告)日：2016-02-23

申请号：US14157708

申请日：2014-01-17

Applicant: Zimmer, Inc.

Inventor： Alicia Rufner ,  John Knight ,  Toni Rowe ,  Dirk Pletcher ,  Ray Gsell ,  Hallie E Brinkerhuff ,  Werner Schneider

IPC: A61L27/16 ,  A61B17/80 ,  A61L27/50 ,  C08L23/06

CPC classification number: C08K5/1545 ,  A61B17/8085 ,  A61L27/16 ,  A61L27/505 ,  A61L31/048 ,  A61L31/143 ,  C08J3/24 ,  C08J3/28 ,  C08J2323/26 ,  C08L23/06 ,  C08L2312/06 ,  Y10T428/31 ,  Y10T428/315

Abstract: An antioxidant combined with UHMWPE prior to subjecting the UHMWPE to crosslinking irradiation. In one exemplary embodiment, the antioxidant is tocopherol. After the antioxidant is combined with the UHMWPE, the resulting blend may be formed into slabs, bar stock, and/or incorporated into a substrate, such as a metal, for example. The resulting product may then be subjected to crosslinking irradiation. In one exemplary embodiment, the UHMWPE blend is preheated prior to subjecting the same to crosslinking irradiation. Once irradiated, the UHMWPE blended product may be machined, packaged, and sterilized in accordance with conventional techniques.

Abstract translation: 在超高分子量聚乙烯（UHMWPE）交联照射之前，与UHMWPE结合使用的抗氧化剂。 在一个示例性实施方案中，抗氧化剂是生育酚。 在将抗氧化剂与UHMWPE组合之后，所得到的共混物可以形成为板坯，棒料，和/或结合到例如金属等基材中。 然后将所得产物进行交联照射。 在一个示例性实施方案中，在对其进行交联照射之前，将UHMWPE共混物预热。 一旦照射，UHMWPE共混产品可以根据常规技术被加工，包装和灭菌。

公开(公告)号：US20180051141A1

公开(公告)日：2018-02-22

申请号：US15783649

申请日：2017-10-13

Applicant: Zimmer, Inc.

Inventor： Alicia Rufner ,  John Knight ,  Toni Rowe ,  Dirk Pletcher ,  Ray Gsell ,  Werner Schneider ,  Hallie E. Brinkerhuff

IPC: C08J3/24 ,  A61B17/80 ,  C08J3/28

CPC classification number: C08J3/247 ,  A61B17/8085 ,  A61L27/16 ,  A61L27/505 ,  C08J3/28 ,  C08J2323/26 ,  C08K5/005 ,  C08K5/1545 ,  C08K9/10 ,  C08L23/06 ,  C08L2312/06 ,  Y10T428/31 ,  Y10T428/315

Abstract: An antioxidant combined with UHMWPE prior to subjecting the UHMWPE to crosslinking irradiation. In one exemplary embodiment, the antioxidant is tocopherol. After the antioxidant is combined with the UHMWPE, the resulting blend may be formed into slabs, bar stock, and/or incorporated into a substrate, such as a metal, for example. The resulting product may then be subjected to crosslinking irradiation. In one exemplary embodiment, the UHMWPE blend is preheated prior to subjecting the same to crosslinking irradiation. Once irradiated, the UHMWPE blended product may be machined, packaged, and sterilized in accordance with conventional techniques.