公开(公告)号：US20070068873A1

公开(公告)日：2007-03-29

申请号：US11234798

申请日：2005-09-26

Applicant: Anil Oroskar ,  Saurabh Parikh ,  Asha Oroskar ,  Kenneth Johnson ,  Anthony Escarcega

Inventor： Anil Oroskar ,  Saurabh Parikh ,  Asha Oroskar ,  Kenneth Johnson ,  Anthony Escarcega

IPC: B01D15/08

CPC classification number: F16K11/074 ,  B01D15/1821 ,  G01N30/20 ,  G01N30/461 ,  G01N30/6047 ,  G01N2030/201 ,  G01N2030/202 ,  Y10T137/86815

Abstract: A unique valve assembly for simulated bed moving chromatography employs a combination of pressure compatible sealable materials that permit minimal frictional interaction between moving parts, ensures alignment of parts, and provides a method for conducting SMB countercurrent chromatography on a small scale, in which purity and separation efficiency are enhanced. Machine designs are disclosed which embody the SMB concepts. Finally, a quick disconnect connector and adaptor is provided for mounting chromatographic columns in an SMB device. Demonstration of this system in a fructose-glucose isomer separation with purity-recovery trade-off for this device is also presented.

Abstract translation: 用于模拟床移动色谱的独特阀组件采用压力兼容的可密封材料的组合，其允许运动部件之间的最小摩擦相互作用，确保部件的对准，并提供小规模进行SMB逆流色谱的方法，其中纯度和分离 效率提高。 公开了体现SMB概念的机器设计。 最后，提供快速断开连接器和适配器，用于将色谱柱安装在SMB设备中。 还提出了该系统在用于该装置的纯度恢复权衡的果糖 - 葡萄糖异构体分离中的证明。