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公开(公告)号：US20250164481A1
公开(公告)日：2025-05-22
申请号：US19030235
申请日：2025-01-17
Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY , BENAROYA RESEARCH INSTITUTE AT VIRGINIA MASON
Inventor： Joshua LaBaer , Ji Qiu , Kailash Karthikeyan , Jane Buckner , Gerald Nepom
IPC: G01N33/564 , G01N33/68
Abstract: Compositions and methods for detection of anti-citrullinated protein antibodies (ACPAs) in rheumatoid arthritis (RA) patients. Patient samples known or suspected of containing ACPAs were probed against citrullinated proteins, and antibody responses to 190 citrullinated proteins in 20 RA patients were investigated. Unique antibody reactivity patterns in both clinical anti-cyclic citrullinated peptide assay positive (CCP+) and negative (CCP−) RA patients were observed. At individual antigen levels, six novel antibody/antigen complexes were discovered and validated against specific citrullinated antigens (Myelin Basic Protein (MBP), osteopontin (SPP1), flap endonuclease (FEN1), insulin like growth factor binding protein 6 (IGFBP6), insulin like growth factor I (IGF1) and stanniocalcin-2 (STC2)) in RA patients. Identification of immune-dominant epitope(s) for citrullinated MBP was also performed. The identified biomarkers have high specificity, especially MBP.
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2.发明公开公开(公告)号：US20240011019A1
公开(公告)日：2024-01-11
申请号：US18348201
申请日：2023-07-06
Inventor： Joshua LaBaer
CPC classification number: C12N15/1062 , G01N33/6845 , G01N33/6854 , G01N2458/10
Abstract: Methods and compositions for multiplexed protein-protein interaction profiling (e.g., immunoprofiling), based on nucleic acid tagging of polypeptides (e.g., by RNA display) are described. In some embodiments the described compositions and methods utilize a library of prey polypeptide targets linked to prey RNAs encoding them, and a population of bait polypeptides, e.g., a mixture of antibodies, that bind to one or more of the prey polypeptide targets and are used to isolate and identify the bound prey polypeptide targets by amplification of their associated prey RNAs and sequencing of the corresponding cDNAs. In other embodiments the prey polypeptide targets are linked to DNA Bar Codes, which serve as unique identifiers of the tagged polypeptide.
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公开(公告)号：US11525831B2
公开(公告)日：2022-12-13
申请号：US16743906
申请日：2020-01-15
Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY , THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
Inventor： Joshua LaBaer , Jie Wang , Ji Qui , Garrick Wallstrom , Karen Anderson , Jin Park , Jonine Figueroa
IPC: G01N33/564 , G01N33/574 , C07K16/30 , C12Q1/6886 , C12N15/11
Abstract: Cancer patients make antibodies to tumor-derived proteins that are potential biomarkers for early detection. Twenty-eight antigens have been identified as potential biomarkers for the early detection of basal-like breast cancer (Tables 1, 2). Also, a 13-AAb classifier has been developed that differentiate patients with BLBC from healthy controls with 33% sensitivity at 98% specificity (Table 3).
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公开(公告)号：US11243208B2
公开(公告)日：2022-02-08
申请号：US16317184
申请日：2017-07-11
Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY , THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
Inventor： Benjamin Katchman , Karen Anderson , Garrick Wallstrom , Joshua LaBaer , Daniel Cramer
IPC: G01N31/00 , G01N33/53 , G01N33/574
Abstract: Compositions and methods relating to a panel of antigen biomarkers for the early detection of ovarian cancer. The compositions and methods encompass antigen biomarkers coupled to a substrate, with the biomarkers being selected from the group consisting of one or more of ICAM3, CTAG2, p53, STYXL1, PVR, POMC, NUDT11, TRIM39, UHMK1, KSR1, and NXF3.
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5.发明申请公开(公告)号：US20210381028A1
公开(公告)日：2021-12-09
申请号：US17346008
申请日：2021-06-11
Applicant: Arizona Board of Regents on Behalf of Arizona State University , Mayo Foundation for Medical Education and Research
Inventor： Joshua LaBaer , Vel Murugan , Merica Vorachitti , Rahul Pannala , Douglas Faigel
IPC: C12Q1/6806 , C12Q1/6851 , C12Q1/689
Abstract: Provided herein are qPCR-based methods for quantitatively detecting and differentiating between live and dead pathogenic bacteria such as carbapenem-resistant Enterobacteriaceae (CRE). Also provided herein are simple, fast, and reliable genomic DNA extraction methods with improved efficiency.
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Patent Agency Ranking
公开(公告)号：US20190302122A1
公开(公告)日：2019-10-03
申请号：US16317184
申请日：2017-07-11
Applicant: Benjamin KATCHMAN , Karen ANDERSON , Garrick WALLSTROM , Joshua LABAER , Daniel CRAMER , ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY , THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
Inventor： Benjamin Katchman , Karen Anderson , Garrick Wallstrom , Joshua LaBaer , Daniel Cramer
IPC: G01N33/574
Abstract: Compositions and methods relating to a panel of antigen biomarkers for the early detection of ovarian cancer. The compositions and methods encompass antigen biomarkers coupled to a substrate, with the biomarkers being selected from the group consisting of one or more of ICAM3, CTAG2, p53, STYXL1, PVR, POMC, NUDT11, TRIM39, UHMK1, KSR1, and NXF3.
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7.发明申请公开(公告)号：US20180201923A1
公开(公告)日：2018-07-19
申请号：US15904905
申请日：2018-02-26
Inventor： Joshua LaBaer
CPC classification number: C12N15/1062 , G01N33/6845 , G01N33/6854 , G01N2458/10
Abstract: Methods and compositions for multiplexed protein-protein interaction profiling (e.g., immunoprofiling), based on nucleic acid tagging of polypeptides (e.g., by RNA display) are described. In some embodiments the described compositions and methods utilize a library of prey polypeptide targets linked to prey RNAs encoding them, and a population of bait polypeptides, e.g., a mixture of antibodies, that bind to one or more of the prey polypeptide targets and are used to isolate and identify the bound prey polypeptide targets by amplification of their associated prey RNAs and sequencing of the corresponding cDNAs. In other embodiments the prey polypeptide targets are linked to DNA Bar Codes, which serve as unique identifiers of the tagged polypeptide.
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公开(公告)号：US20170363631A1
公开(公告)日：2017-12-21
申请号：US15534203
申请日：2015-12-09
Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY , NATIONAL INSTITUTES OF HEALTH
Inventor： Joshua LaBaer , Jie Wang , Ji Qiu , Garrick Wallstrom , Karen Anderson , Jin Park , Jonine Figueroa
IPC: G01N33/574 , C12Q1/68 , C07K16/30 , C12N15/11
CPC classification number: G01N33/57415 , C07K16/3015 , C12N15/11 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , G01N33/564
Abstract: Cancer patients make antibodies to tumor-derived proteins that are potential biomarkers for early detection. Twenty-eight antigens have been identified as potential biomarkers for the early detection of basal-like breast cancer (Tables 1, 2). Also, a 13-AAb classifier has been developed that differentiate patients with BLBC from healthy controls with 33% sensitivity at 98% specificity (Table 3).
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公开(公告)号：US20250019765A1
公开(公告)日：2025-01-16
申请号：US18896122
申请日：2024-09-25
Inventor： Joshua LaBaer , Kristin Gillis , Garrick Wallstrom , Jin Park , Vel Murugan , Mitch Magee
IPC: C12Q1/6883 , C12Q1/6827
Abstract: Disclosed herein are compositions and methods for accurately estimating the absorbed dose of radiation indicated by a subject based on the expression pattern of a panel of radiation-modulated (RM) genes at various time points following exposure of the subject to ionizing radiation.
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公开(公告)号：US20240310369A1
公开(公告)日：2024-09-19
申请号：US18489398
申请日：2023-10-18
Inventor： Joshua LaBaer , Bharath Takulapalli
IPC: G01N33/543
CPC classification number: G01N33/54373 , G01N2440/00
Abstract: Described herein are biosensor microarrays comprising detector polypeptide monolayers substantially free of contaminants. Also provided are methods for generation of such biosensor microarrays by capture of polypeptides by arrays comprising capture moieties and associated sensors.
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