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    APPARATUS FOR EFFECTIVE ABLATION AND NERVE SENSING ASSOCIATED WITH DENERVATION
    2.
    发明申请
    APPARATUS FOR EFFECTIVE ABLATION AND NERVE SENSING ASSOCIATED WITH DENERVATION 有权

    公开(公告)号：US20210204854A1

    公开(公告)日：2021-07-08

    申请号：US17127443

    申请日：2020-12-18

    Applicant: Ablative Solutions, Inc.

    Inventor： David R. Fischell ,  Tim A. Fischell ,  Vartan Ghazarossian ,  Steven Almany ,  Michael Sasha John

    IPC: A61B5/24 ,  A61B5/00 ,  A61B18/14

    Abstract: An intravascular catheter for nerve activity ablation and/or sensing includes one or more needles advanced through supported guide tubes (needle guiding elements) which expand to contact the interior surface of the wall of the renal artery or other vessel of a human body allowing the needles to be advanced though the vessel wall into the extra-luminal tissue including the media, adventitia and periadvential space. The catheter also includes structures which provide radial and lateral support to the guide tubes so that the guide tubes open uniformly and maintain their position against the interior surface of the vessel wall as the sharpened needles are advanced to penetrate into the vessel wall. Electrodes near the distal ends of the needles allow sensing of nerve activity before and after attempted renal denervation. In a combination embodiment ablative energy or fluid is delivered from the needles in or near the adventitia to ablate nerves outside of the media while sparing nerves within the media.

    METHOD AND APPARATUS FOR SPARING PAIN CONDUCTING NERVES DURING RENAL DENERVATION
    4.
    发明申请
    METHOD AND APPARATUS FOR SPARING PAIN CONDUCTING NERVES DURING RENAL DENERVATION 审中-公开
    用于在肾衰竭期间产生疼痛导致神经的方法和装置

    公开(公告)号：US20150119875A1

    公开(公告)日：2015-04-30

    申请号：US14064077

    申请日：2013-10-25

    Applicant: Ablative Solutions, Inc.

    Inventor： David R. Fischell ,  Tim A. Fischell ,  Vartan Ghazarossian ,  Steven Almany

    IPC: A61B18/14

    CPC classification number: A61B18/1492 ,  A61B2018/00214 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/1425 ,  A61B2018/143 ,  A61B2018/1432 ,  A61B2018/1475

    Abstract: An intravascular catheter for peri-vascular nerve activity ablation and/or sensing includes multiple needles advanced through supported guide tubes (needle guiding elements) which expand with open ends around a central axis to contact the interior surface of the wall of the renal artery or other vessel of a human body allowing the needles to be advanced though the vessel wall into the perivascular space. The catheter also includes structures which provide radial and lateral support to the guide tubes so that the guide tubes open uniformly and maintain their position against the interior surface of the vessel wall as the sharpened needles are advanced to penetrate into the vessel wall. Ablative energy or fluid is delivered from the needles in or near the adventitia to ablate nerves outside of the media while sparing nerves within the media.

    Abstract translation: 用于周围血管神经活动消融和/或感测的血管内导管包括通过支撑的导管（针引导元件）前进的多个针，其以围绕中心轴线的开口端膨胀以接触肾动脉壁或其它的内壁 人体的血管允许针通过血管壁进入血管周围空间。 导管还包括向引导管提供径向和横向支撑的结构，使得引导管均匀地打开并且当尖锐的针被推进以穿透到血管壁时，它们保持其抵靠血管壁的内表面的位置。 烧蚀能量或液体从外膜中或附近的针头输送，以消除介质外部的神经，同时将神经保持在介质内。

    INTRAVASCULAR CATHETER WITH PERI-VASCULAR NERVE ACTIVITY SENSORS
    9.
    发明申请
    INTRAVASCULAR CATHETER WITH PERI-VASCULAR NERVE ACTIVITY SENSORS 有权

    公开(公告)号：US20210015381A1

    公开(公告)日：2021-01-21

    申请号：US16984671

    申请日：2020-08-04

    Applicant: Ablative Solutions, Inc.

    Inventor： David R. Fischell ,  Tim A. Fischell ,  Vartan Ghazarossian ,  Steven Almany

    IPC: A61B5/04 ,  A61B5/00

    Abstract: An intravascular catheter for peri-vascular nerve activity sensing or measurement includes multiple needles advanced through supported guide tubes (needle guiding elements) which expand with open ends around a central axis to contact the interior surface of the wall of the renal artery or other vessel of a human body allowing the needles to be advanced though the vessel wall into the perivascular space. The system also may include means to limit and/or adjust the depth of penetration of the needles. The catheter also includes structures which provide radial and lateral support to the guide tubes so that the guide tubes open uniformly and maintain their position against the interior surface of the vessel wall as the sharpened needles are advanced to penetrate into the vessel wall. The addition of an injection lumen at the proximal end of the catheter and openings in the needles adds the functionality of ablative fluid injection into the perivascular space for an integrated nerve sending and ablation capability.

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