公开(公告)号：US10316012B1

公开(公告)日：2019-06-11

申请号：US16246531

申请日：2019-01-13

Applicant: FUDAN UNIVERSITY

Inventor： Fener Chen ,  Haihui Peng ,  Sha Hu ,  Ge Meng ,  Yan Wu ,  Dang Cheng ,  Zedu Huang ,  Guanfeng Liang

IPC: C07D307/93

Abstract: Disclosed is a method of synthesizing a series of compounds with the structure of (1S, 5R)-lactone. In the method, under the catalysis of a chiral phosphonic acid, substituted bicyclo[3.2.0]-hept-2-en-6-one (II) as a substrate is reacted with hydrogen peroxide for enantioselective Baeyer-Villiger oxidation to produce a chiral lactone (I). This method involves mild reaction conditions, simple operation, quantitatively recyclable catalyst and high reaction selectivity and stereoselectivity, which is suitable for industrial production.