公开(公告)号：US20150087902A1

公开(公告)日：2015-03-26

申请号：US14388847

申请日：2013-03-15

Applicant: Trustees of Boston University

Inventor： Jerome Charles Mertz ,  Timothy Nehiley Ford ,  Kengyeh Ken Chu

IPC: G06T5/00 ,  G02B21/00 ,  A61B1/00 ,  G01N21/25 ,  A61B1/04 ,  G02B21/06 ,  G01N21/27

CPC classification number: G06T5/009 ,  A61B1/00009 ,  A61B1/00172 ,  A61B1/04 ,  G01N21/255 ,  G01N21/27 ,  G01N21/4795 ,  G01N2021/4797 ,  G01N2201/062 ,  G01N2201/0866 ,  G02B21/0012 ,  G02B21/06 ,  G02B21/14 ,  G06T2207/10068 ,  G06T2207/20208 ,  G06T2207/20221

Abstract: A method of creating a phase contrast image is provided. In some embodiments the method comprises illuminating the target region of a sample with a first light source to provide a first oblique back illumination of the target region of the sample, and detecting a first phase contrast image from light originating from the first light source and back illuminating the target region of the sample. In some embodiments the method further comprises illuminating the sample with a second light source to provide a second oblique back illumination of the target region of the sample, and detecting a second phase contrast image from light originating from the second light source and back illuminating the target region of the sample. In some embodiments a difference image of the target region of the sample is created by subtracting the second phase contrast image of the target region of the sample from the first phase contrast image of the target region of the sample. Apparatus for carrying out the methods are also provided. The methods and apparatus find use, for example, in endoscopy.

Abstract translation: 提供了创建相位对比图像的方法。 在一些实施例中，该方法包括用第一光源照射样品的目标区域，以提供样品的目标区域的第一倾斜背照射，以及从源自第一光源和背部的光检测第一相位对比图像 照亮样品的目标区域。 在一些实施例中，该方法还包括用第二光源照亮样品以提供样品的目标区域的第二倾斜背照射，以及从源自第二光源的光检测第二相位对比图像，并且反射照射目标 样品区域。 在一些实施例中，通过从样本的目标区域的第一相位对比图像中减去样本的目标区域的第二相位对比图像来创建样本的目标区域的差异图像。 还提供了用于执行方法的装置。 该方法和装置可用于例如内窥镜检查。