公开(公告)号：US09686540B2

公开(公告)日：2017-06-20

申请号：US14799969

申请日：2015-07-15

Applicant: Xerox Corporation

Inventor： Jing Zhou ,  Nancy Y. Jia ,  Wei Hong ,  Mandakini Kanungo ,  Xing Liu

IPC: H04N17/02 ,  G01N21/25 ,  G06K9/46 ,  G06K9/62 ,  G01N21/78 ,  G01N21/84 ,  G06T7/90 ,  G01N21/77 ,  G01N21/27

CPC classification number: H04N17/02 ,  G01N21/253 ,  G01N21/274 ,  G01N21/78 ,  G01N21/8483 ,  G01N2021/7759 ,  G01N2201/0461 ,  G06K9/4652 ,  G06K9/6201 ,  G06K2009/4666 ,  G06T7/90

Abstract: The present disclosure proposes a colorimetric method that couples sensor design with image processing to enable automated evaluation of test results obtained by paper-based sensors. The proposed method can match ink color and dye used in colorimetric reaction in terms of their absorption in spectral range (e.g., red, green, blue). A near-zero absorption channel can then be used to normalize absorption channels and construct a composite image.

公开(公告)号：US20160051980A1

公开(公告)日：2016-02-25

申请号：US14799832

申请日：2015-07-15

Applicant: Xerox Corporation

Inventor： Wei Hong ,  Jing Zhou ,  Mandakini Kanungo ,  Xing Liu ,  Nancy Y. Jia ,  Sarah J. Vella ,  Laura Lu

IPC: B01L3/00

CPC classification number: B01L3/5023 ,  B01L2300/069 ,  B01L2300/0803 ,  B01L2300/0864 ,  B01L2300/0887 ,  B01L2300/126 ,  B01L2300/165 ,  G01N33/525 ,  G01N33/558

Abstract: The present disclosure proposes a design of a biomedical paper sensor which can determine the concentration of biological materials in fluids such as blood, urine, and saliva. The sensor contains a plurality of axially radiating test zones, each test zone separated from other test zones by wax ink barriers formed by a process that produces thin walls. Each test zone can contain a unique test reagent, or a unique concentration of a test reagent, and can also be identified by printed text. The region of the device outside of the test zone area is printed with a uniform reference color. Benefits of the invention include increased accuracy in the measurement of the concentration of biological materials due to the larger test zone area. Benefits also include the integration of the reference or calibration color which simplifies the calibration needed for quantification of the concentration.

Abstract translation: 本公开提出了一种生物医学纸传感器的设计，其可以确定诸如血液，尿液和唾液的流体中的生物材料的浓度。 传感器包含多个轴向辐射测试区域，每个测试区域通过由产生薄壁的工艺形成的蜡油墨屏障与其他测试区域分离。 每个测试区可以包含独特的测试试剂或独特浓度的测试试剂，也可以通过印刷文本进行鉴定。 测试区域外部的设备区域以均匀的参考颜色打印。 本发明的优点包括由于较大的测试区域而在生物材料的浓度测量中提高了精度。 优点还包括参考或校准颜色的集成，这简化了浓度定量所需的校准。

公开(公告)号：US09586204B2

公开(公告)日：2017-03-07

申请号：US14799832

申请日：2015-07-15

Applicant: Xerox Corporation

Inventor： Wei Hong ,  Jing Zhou ,  Mandakini Kanungo ,  Xing Liu ,  Nancy Y. Jia ,  Sarah J. Vella ,  Laura Lu

IPC: G01N21/75 ,  B01L3/00 ,  G01N33/52 ,  G01N33/558

CPC classification number: B01L3/5023 ,  B01L2300/069 ,  B01L2300/0803 ,  B01L2300/0864 ,  B01L2300/0887 ,  B01L2300/126 ,  B01L2300/165 ,  G01N33/525 ,  G01N33/558

Abstract: The present disclosure proposes a design of a biomedical paper sensor which can determine the concentration of biological materials in fluids such as blood, urine, and saliva. The sensor contains a plurality of axially radiating test zones, each test zone separated from other test zones by wax ink barriers formed by a process that produces thin walls. Each test zone can contain a unique test reagent, or a unique concentration of a test reagent, and can also be identified by printed text. The region of the device outside of the test zone area is printed with a uniform reference color. Benefits of the invention include increased accuracy in the measurement of the concentration of biological materials due to the larger test zone area. Benefits also include the integration of the reference or calibration color which simplifies the calibration needed for quantification of the concentration.

Abstract translation: 本公开提出了一种生物医学纸传感器的设计，其可以确定诸如血液，尿液和唾液的流体中的生物材料的浓度。 传感器包含多个轴向辐射测试区域，每个测试区域通过由产生薄壁的工艺形成的蜡油墨屏障与其他测试区域分离。 每个测试区可以包含独特的测试试剂或独特浓度的测试试剂，也可以通过印刷文本进行鉴定。 测试区域外部的设备区域以均匀的参考颜色打印。 本发明的优点包括由于较大的测试区域而在生物材料的浓度测量中提高了精度。 优点还包括参考或校准颜色的集成，这简化了浓度定量所需的校准。

公开(公告)号：US20160057413A1

公开(公告)日：2016-02-25

申请号：US14799969

申请日：2015-07-15

Applicant: Xerox Corporation

Inventor： Jing Zhou ,  Nancy Y. Jia ,  Wei Hong ,  Mandakini Kanungo ,  Xing Liu

IPC: H04N17/02 ,  G01N21/25 ,  G06K9/62 ,  G01N21/78 ,  G06T7/40 ,  G06K9/46

CPC classification number: H04N17/02 ,  G01N21/253 ,  G01N21/274 ,  G01N21/78 ,  G01N21/8483 ,  G01N2021/7759 ,  G01N2201/0461 ,  G06K9/4652 ,  G06K9/6201 ,  G06K2009/4666 ,  G06T7/90

Abstract: The present disclosure proposes a colorimetric method that couples sensor design with image processing to enable automated evaluation of test results obtained by paper-based sensors. The proposed method can match ink color and dye used in colorimetric reaction in terms of their absorption in spectral range (e.g., red, green, blue). A near-zero absorption channel can then be used to normalize absorption channels and construct a composite image.

Abstract translation: 本公开提出了一种比色方法，其将传感器设计与图像处理相结合，以便能够对由纸基传感器获得的测试结果进行自动评估。 所提出的方法可以根据其在光谱范围内的吸收（例如，红，绿，蓝）来匹配用于比色反应中的油墨颜色和染料。 然后可以使用近零吸收通道来归一化吸收通道并构建合成图像。