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    Closed loop impedance-based cardiac resynchronization therapy systems, devices, and methods
    2.
    发明授权
    Closed loop impedance-based cardiac resynchronization therapy systems, devices, and methods 有权
    基于闭环阻抗的心脏再同步治疗系统，装置和方法

    公开(公告)号：US08295927B2

    公开(公告)日：2012-10-23

    申请号：US12254631

    申请日：2008-10-20

    Applicant: Jiang Ding ,  Yinghong Yu ,  Julio C. Spinelli ,  Jeffrey E. Stahmann

    Inventor： Jiang Ding ,  Yinghong Yu ,  Julio C. Spinelli ,  Jeffrey E. Stahmann

    IPC: A61N1/365

    CPC classification number: A61N1/3627 ,  A61B5/053 ,  A61N1/36521 ,  A61N1/3682 ,  A61N1/3684

    Abstract: This document discusses, among other things, systems, devices, and methods measure an impedance and, in response, adjust an atrioventricular (AV) delay or other cardiac resynchronization therapy (CRT) parameter that synchronizes left and right ventricular contractions. A first example uses parameterizes a first ventricular volume against a second ventricular volume during a cardiac cycle, using a loop area to create a synchronization fraction (SF). The CRT parameter is adjusted in closed-loop fashion to increase the SF. A second example measures a septal-freewall phase difference (PD), and adjusts a CRT parameter to decrease the PD. A third example measures a peak-to-peak volume or maximum rate of change in ventricular volume, and adjusts a CRT parameter to increase the peak-to-peak volume or maximum rate of change in the ventricular volume.

    Abstract translation: 本文件还讨论了系统，设备和方法测量阻抗，并作为响应调整房室（AV）延迟或同步左心室收缩和右心室收缩的其他心脏再同步治疗（CRT）参数。 第一个例子是使用循环区域创建同步分数（SF），在心动周期中使用第一心室容积对第二心室容积进行参数化。 CRT参数以闭环方式调整以增加SF。 第二个例子是测量隔层相位差（PD），并调整CRT参数以减少PD。 第三个例子测量峰 - 峰体积或最大心室容积变化率，并调整CRT参数以增加心室容积的峰 - 峰体积或最大变化率。

    Method and apparatus for determining the coronary sinus vein branch accessed by a coronary sinus lead
    3.
    发明授权
    Method and apparatus for determining the coronary sinus vein branch accessed by a coronary sinus lead 有权
    用于确定冠状静脉窦导管接近的冠状静脉窦静脉分支的方法和装置

    公开(公告)号：US08214026B2

    公开(公告)日：2012-07-03

    申请号：US12976397

    申请日：2010-12-22

    Applicant: Yinghong Yu ,  Jiang Ding ,  Jeng Mah ,  Julio C. Spinelli

    Inventor： Yinghong Yu ,  Jiang Ding ,  Jeng Mah ,  Julio C. Spinelli

    IPC: A61B5/0452

    CPC classification number: A61B5/0452 ,  A61B5/0456 ,  A61B34/20 ,  A61B2034/2072 ,  A61N1/3627 ,  A61N1/3682

    Abstract: Systems and methods for determining the coronary sinus vein branch location of a left ventricle electrode are disclosed. The systems and methods involve detecting the occurrence of electrical events within the patient's heart including sensing one or more of the electrical events with the electrode and then analyzing the electrical events to determine the electrode's position. The determination of electrode position may be used to automatically adjust operating parameters of a VRT device. Furthermore, the determination of electrode position may be made in real-time during installation of the electrode and a visual indication of the electrode position may be provided on a display screen.

    Abstract translation: 公开了用于确定左心室电极的冠状静脉窦静脉分支位置的系统和方法。 系统和方法涉及检测患者心脏内的电事件的发生，包括用电极感测一个或多个电事件，然后分析电气事件以确定电极的位置。 电极位置的确定可用于自动调整VRT器件的工作参数。 此外，可以在电极的安装期间实时地确定电极位置，并且可以在显示屏上提供电极位置的视觉指示。

    Apparatus and method for optimizing atrioventricular delay
    4.
    发明授权
    Apparatus and method for optimizing atrioventricular delay 有权
    用于优化房室延迟的装置和方法

    公开(公告)号：US07966066B2

    公开(公告)日：2011-06-21

    申请号：US11126490

    申请日：2005-05-11

    Applicant: Yinghong Yu ,  Jiang Ding ,  Jeffrey E. Stahmann

    Inventor： Yinghong Yu ,  Jiang Ding ,  Jeffrey E. Stahmann

    IPC: A61N1/362

    CPC classification number: A61N1/3682 ,  A61N1/3627 ,  A61N1/3706

    Abstract: Systems and methods to optimize atrioventricular delay during sensing or pacing of the atrium and for a plurality of sensed rates or pacing rates. In one example, a paced atrioventricular delay is calculated using a sensed atrioventricular interval and a paced atrioventricular interval. In another example, a plurality of paced atrioventricular delays for different pacing rates can be calculated. In another example embodiment, a plurality of sensed atrioventricular delays for different sensing rates can be calculated. Combinations of the various systems and methods are also possible.

    Abstract translation: 在心房的感测或起搏期间以及多个感测速率或起搏速率下优化房室延迟的系统和方法。 在一个示例中，使用感测的房室间隔和起搏房室间隔来计算起搏房室延迟。 在另一个示例中，可以计算用于不同起搏速率的多个起搏房室延迟。 在另一示例性实施例中，可以计算用于不同感测速率的多个感测的房室延迟。 各种系统和方法的组合也是可能的。

    CARDIAC PACING USING ADJUSTABLE ATRIO-VENTRICULAR DELAYS
    5.
    发明申请
    CARDIAC PACING USING ADJUSTABLE ATRIO-VENTRICULAR DELAYS 有权
    使用可调节ATRIO-VENTRICULAR延迟的心脏瓣膜

    公开(公告)号：US20110071588A1

    公开(公告)日：2011-03-24

    申请号：US12955218

    申请日：2010-11-29

    Applicant: Jiang Ding ,  Yinghong Yu ,  Andrew P. Kramer ,  Julio Spinelli

    Inventor： Jiang Ding ,  Yinghong Yu ,  Andrew P. Kramer ,  Julio Spinelli

    IPC: A61N1/365

    CPC classification number: E21B17/01 ,  A61N1/3627 ,  A61N1/3682 ,  E21B43/36

    Abstract: A pacing system for providing optimal hemodynamic cardiac function for parameters such as contractility (peak left ventricle pressure change during systole or LV+dp/dt), or stroke volume (aortic pulse pressure) using system for calculating atrio-ventricular delays for optimal timing of a ventricular pacing pulse. The system providing an option for near optimal pacing of multiple hemodynamic parameters. The system deriving the proper timing using electrical or mechanical events having a predictable relationship with an optimal ventricular pacing timing signal.

    Abstract translation: 一种起搏系统，用于为诸如收缩性（收缩期峰值左心室压力变化或LV + dp / dt）之间的参数或行程体积（主动脉脉压）提供最佳血液动力学心脏功能，使用用于计算心室延迟的系统以获得最佳时机 心室起搏脉搏。 该系统为多个血液动力学参数的近似最佳起搏提供了选择。 该系统使用与最佳心室起搏定时信号具有可预测关系的电或机械事件导出适当的定时。

    Method and system for setting cardiac resynchronization therapy parameters
    6.
    发明授权
    Method and system for setting cardiac resynchronization therapy parameters 有权
    设置心脏再同步治疗参数的方法和系统

    公开(公告)号：US07869873B2

    公开(公告)日：2011-01-11

    申请号：US11681244

    申请日：2007-03-02

    Applicant: Jiang Ding ,  Yinghong Yu ,  Bruce H. KenKnight

    Inventor： Jiang Ding ,  Yinghong Yu ,  Bruce H. KenKnight

    IPC: A61N1/00

    CPC classification number: A61N1/3627 ,  A61N1/3682 ,  A61N1/3684

    Abstract: A method or system for computing and/or setting optimal cardiac resynchronization pacing parameters as derived from intrinsic conduction data is presented. The intrinsic conduction data includes intrinsic atrio-ventricular and interventricular delay intervals which may be collected via the sensing channels of an implantable cardiac device. Among the parameters which may be optimized in this manner are an atrio-ventricular delay interval and a biventricular offset interval. In one of its aspects, the invention provides for computing optimum pacing parameters for patients having some degree of AV block or with atrial conduction deficits. Another aspect of the invention relates to a pacing mode and configuration for providing cardiac resynchronization therapy to patients with a right ventricular conduction disorder.

    Abstract translation: 提出了一种用于计算和/或设置从内在传导数据导出的最佳心脏再同步起搏参数的方法或系统。 内在传导数据包括可通过可植入心脏装置的感测通道收集的本征心室和室间延迟间隔。 可以以这种方式优化的参数是心房延迟间隔和双心室偏移间隔。 在其一个方面，本发明提供了对具有一定程度的AV阻滞或具有心房传导缺陷的患者计算最佳起搏参数。 本发明的另一方面涉及用于向患有右心室传导障碍的患者提供心脏再同步治疗的起搏模式和配置。

    Cardiac resynchronization therapy parameter optimization
    10.
    发明申请
    Cardiac resynchronization therapy parameter optimization 有权
    心脏再同步治疗参数优化

    公开(公告)号：US20100023078A1

    公开(公告)日：2010-01-28

    申请号：US11338935

    申请日：2006-01-25

    Applicant: Yanting Dong ,  Yinghong Yu ,  Jiang Ding ,  Scott A. Meyer ,  Xuan Wei ,  Michael John Stucky

    Inventor： Yanting Dong ,  Yinghong Yu ,  Jiang Ding ,  Scott A. Meyer ,  Xuan Wei ,  Michael John Stucky

    IPC: A61N1/00

    CPC classification number: A61N1/3627 ,  A61N1/36585 ,  A61N1/3684

    Abstract: Systems and methods involve determination of CRT parameters using a number of CRT optimization processes. Each CRT optimization process attempts to return recommended parameters. The CRT parameters are determined based on the recommended parameters returned by one or more of the CRT optimization processes. The CRT optimization processes may be sequentially implemented and the CRT parameters may be determined based on the recommended parameters returned by a first CRT optimization process to return recommended parameters. The CRT parameters may be determined based on a combination of the recommended parameters returned. The CRT optimization processes implemented may be selected from available CRT optimization processes based on patient conditions.

    Abstract translation: 系统和方法涉及使用多个CRT优化过程来确定CRT参数。 每个CRT优化过程都会尝试返回推荐的参数。 CRT参数根据一个或多个CRT优化过程返回的推荐参数来确定。 可以顺序地实施CRT优化过程，并且可以基于由第一CRT优化过程返回的推荐参数来返回推荐参数来确定CRT参数。 可以基于返回的推荐参数的组合来确定CRT参数。 可以根据患者条件从可用的CRT优化过程中选择实现的CRT优化处理。

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