公开(公告)号：US20180127435A1

公开(公告)日：2018-05-10

申请号：US15860058

申请日：2018-01-02

Applicant: ANGUS Chemical Company

Inventor： Daniel M. Trauth ,  George D. Green ,  Raymond J. Swedo ,  Richard L. James ,  Ian A. Tomlinson

IPC: C07D498/10 ,  A01N43/76 ,  C07C215/28 ,  C07C205/04 ,  C07C205/05 ,  C07C205/15 ,  C07C205/16 ,  C07C215/20 ,  A01N43/90 ,  C07C201/08 ,  C07C201/12 ,  C07C205/02 ,  C07C205/06 ,  C07C205/18 ,  C07C215/08 ,  C07C215/42 ,  C07C239/10 ,  C07D263/04 ,  C07D263/52 ,  C08G18/32 ,  C07D498/04

CPC classification number: C07D498/10 ,  A01N43/76 ,  A01N43/90 ,  C07C201/08 ,  C07C201/12 ,  C07C205/02 ,  C07C205/04 ,  C07C205/05 ,  C07C205/06 ,  C07C205/15 ,  C07C205/16 ,  C07C205/18 ,  C07C215/08 ,  C07C215/20 ,  C07C215/28 ,  C07C215/42 ,  C07C239/10 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/18 ,  C07C2602/10 ,  C07D263/04 ,  C07D263/52 ,  C07D498/04 ,  C08G18/3271 ,  Y02P20/582

Abstract: Provided is a process for the formation of nitrated compounds by the nitration of hydrocarbon compounds with dilute nitric acid. Also provided are processes for preparing industrially useful downstream derivatives of the nitrated compounds, as well as novel nitrated compounds and derivatives, and methods of using the derivatives in various applications.

公开(公告)号：US09862937B2

公开(公告)日：2018-01-09

申请号：US15515303

申请日：2015-10-07

Applicant: SYNGENTA PARTICIPATIONS AG

Inventor： Denis Gribkov

IPC: C07C45/63 ,  C07C45/46 ,  C07C201/12 ,  C12N9/10 ,  C12P19/44

CPC classification number: C12N9/1085 ,  C07C45/63 ,  C07C201/08 ,  C12P19/44 ,  C07C205/45 ,  C07C49/80

Abstract: The invention relates to a process for the preparation of a compound of formula I (I), wherein R1 is hydrogen, fluoro or chloro; which process comprises a) reacting a compound of formula II (II), wherein R1 is hydrogen, fluoro or chloro; with a nitration agent to the compound of formula (III), wherein R1 is hydrogen, fluoro or chloro; and b) reacting the compound of formula III with chlorine gas at temperature from 180° C. to 250° C. to the compound of formula I.

公开(公告)号：US20170327456A1

公开(公告)日：2017-11-16

申请号：US15667131

申请日：2017-08-02

Applicant: Vertex Pharmaceuticals Incorporated

Inventor： John DEMATTEI ,  Adam R. LOOKER ,  Bobbianna NEUBERT-LANGILLE ,  Martin TRUDEAU ,  Stefanie ROEPER ,  Michael P. RYAN ,  Dahrika Milfred Yap GUERETTE ,  Brian R. KRUEGER ,  Peter D.J. GROOTENHUIS ,  Fredrick F. VAN GOOR ,  Martyn C. BOTFIELD ,  Gregor ZLOKARNIK

IPC: C07C205/43

CPC classification number: C07C205/43 ,  C07C68/02 ,  C07C69/96 ,  C07C201/08 ,  C07C213/02 ,  C07C229/66 ,  C07D215/233 ,  C07D215/56 ,  G01N33/5041 ,  G01N33/6872 ,  Y02P20/55

Abstract: The invention provides a process for the preparation of a compound of Formula 1, comprising coupling a carboxylic acid of Formula 2 with an aniline of Formula 3 in the presence of a coupling agent.

公开(公告)号：US09771290B2

公开(公告)日：2017-09-26

申请号：US14784443

申请日：2014-04-15

Applicant: BAYER MATERIALSCIENCE AG

Inventor： Thomas Knauf ,  Antoni Mairata ,  Erik Sluyts ,  Jan Van Tricht

IPC: C02F9/00 ,  C02F1/02 ,  C02F1/20 ,  C02F1/66 ,  C07C201/16 ,  C07C201/08 ,  C02F101/32 ,  C02F101/38 ,  C02F103/18 ,  C02F101/16 ,  C02F103/36

CPC classification number: C02F9/00 ,  C02F1/025 ,  C02F1/20 ,  C02F1/66 ,  C02F2101/16 ,  C02F2101/322 ,  C02F2101/38 ,  C02F2103/18 ,  C02F2103/36 ,  C02F2301/066 ,  C07C201/08 ,  C07C201/16 ,  C07C205/06

Abstract: The present invention provides a process for working up alkaline waste water which is formed during washing of crude nitrobenzene obtained by nitration of benzene, wherein (i) the alkaline waste water is heated to a temperature of from 150° C. to 500° C. under an increased pressure with respect to atmospheric pressure with exclusion of oxygen; (ii) a base is added to the waste water obtained in (i); and (iii) the waste water obtained in (ii) is purified further by stripping with a stripping gas and the stripping gas stream loaded with impurities is then cooled to a temperature of from 10° C. to 60° C.

公开(公告)号：US20170174612A1

公开(公告)日：2017-06-22

申请号：US15320804

申请日：2015-06-22

Applicant: Covestro Deutschland AG

Inventor： Thomas Knauf ,  Peter Drinda

IPC: C07C201/08 ,  B01J19/24 ,  C07C201/16

CPC classification number: C07C201/08 ,  B01J19/0006 ,  B01J19/002 ,  B01J19/1881 ,  B01J19/24 ,  B01J19/2465 ,  B01J2219/00006 ,  B01J2219/0004 ,  B01J2219/00268 ,  C07C201/16 ,  C07C205/06

Abstract: The present invention relates to a process for the continuous production of nitrobenzene by the nitration of benzene with nitric acid and sulphuric acid under adiabatic conditions, not the entire production plant being shut down during a production stop, but the production plant being entirely or at least partly operated in recirculation mode. The invention further relates to a plant for producing nitrobenzene and to a method for operating a plant for producing nitrobenzene.

公开(公告)号：US20170174603A1

公开(公告)日：2017-06-22

申请号：US15311951

申请日：2015-05-18

Applicant: BASF SE

Inventor： Andreas PLETSCH ,  Nicole HOLUB ,  Thomas ULRICH ,  Petr KVITA ,  Laurent CAVIN

IPC: C07C51/353 ,  C07C37/76 ,  C07C67/00 ,  C07C209/36 ,  C07C201/08 ,  C07C51/00 ,  C07C37/045 ,  C07C241/02

CPC classification number: C07C51/353 ,  C07C37/045 ,  C07C37/76 ,  C07C51/00 ,  C07C51/15 ,  C07C51/367 ,  C07C67/00 ,  C07C201/08 ,  C07C209/365 ,  C07C241/02 ,  C07C39/30 ,  C07C65/05 ,  C07C65/21

Abstract: The present invention relates to a process for reacting chemical compounds comprising the step of reacting a compound of formula (IV) wherein Hal is independently selected from CI or Br, and X″ is a monovalent anion, in the presence of an inorganic acid, wherein the aqueous inorganic acid has a concentration of at least about 60%, at a temperature of about 140° C. to Cabout 250° C., to obtain a compound of formula (V) wherein Hal is as defined above.

公开(公告)号：US09676722B2

公开(公告)日：2017-06-13

申请号：US15246246

申请日：2016-08-24

Applicant: Optimus Drugs Private Limited

Inventor： Srinivas Reddy Desi Reddy ,  Dnyandev Ragho Rane ,  Venkata Srinivasa Rao Velivela

IPC: C07D215/233 ,  C07D215/56 ,  C07C213/02

CPC classification number: C07D215/56 ,  C07C68/02 ,  C07C201/08 ,  C07C213/02 ,  C07C227/08 ,  C07C229/30 ,  C07C205/43 ,  C07C205/22 ,  C07C215/76 ,  C07C69/96

Abstract: The present invention relates to an improved process for the preparation of Ivacaftor intermediates. The present invention is also provides industrial applicable, commercially and eco-friendly viable process for the preparation of Ivacaftor.

公开(公告)号：US09630866B2

公开(公告)日：2017-04-25

申请号：US13511256

申请日：2010-12-13

Applicant: Ruediger Fritz ,  Renate Hempel ,  Michael Zoellinger ,  Holger Allardt ,  Reiner Reetz

Inventor： Ruediger Fritz ,  Renate Hempel ,  Michael Zoellinger ,  Holger Allardt ,  Reiner Reetz

IPC: C02F1/66 ,  C02F9/00 ,  C01B21/40 ,  C07C201/08 ,  C02F1/20 ,  C02F1/78 ,  C02F103/36

CPC classification number: C02F9/00 ,  C01B21/40 ,  C02F1/20 ,  C02F1/78 ,  C02F2103/36 ,  C02F2209/008 ,  C02F2209/02 ,  C02F2209/06 ,  C07C201/08 ,  C07C205/06

Abstract: The present invention relates to a process for workup of nitrite-comprising alkaline process wastewaters from the nitration of aromatic compounds, wherein the alkaline process wastewater is acidified by addition of acids and the offgas which comprises nitrogen oxides and escapes from the acidified process wastewater is worked up, comprising the steps of a) acidifying the process wastewater by adding acid to a pH below 5, which forms an organic phase which separates out, an acidic aqueous phase and a gaseous NOx-containing phase, and b) removing the gaseous NOx-containing phase.

公开(公告)号：US09527801B2

公开(公告)日：2016-12-27

申请号：US14978556

申请日：2015-12-22

Applicant: Zhejiang Rongyao Biotech CO., LTD.

Inventor： Rener Chen ,  Fei Shi ,  Jianhua Chen ,  Na Zhang

IPC: C07C231/02 ,  C07C201/08 ,  C07C201/12 ,  B01J19/18 ,  C01B17/94

CPC classification number: C07C231/02 ,  C01B17/94 ,  C07C201/08 ,  C07C201/12 ,  C07C205/57

Abstract: A process and a device for recycling waste acid produced in the process of producing Zoalene. The process comprises steps: heating, depressurizing and distilling the waste acid recycled after nitration reaction; collecting acid liquid A and distilled water A; mixing the acid liquid A with new concentrated sulfuric acid in proportion, and putting the mixture to a new Zoalene nitration reaction process; and putting the distilled water A into a diluting pot for diluting the liquid produced in the nitration reaction. The waste acid produced in the process of producing Zoalene is recycled and not directly discharged; water resources are recycled, waste of the water resources is reduced, and discharge of waste water produced in the process of producing Zoalene is greatly reduced, so that not only production cost is saved, but also environment pressure is reduced.

Abstract translation: 用于回收在生产Zoalene过程中产生的废酸的方法和装置。 该方法包括以下步骤：对硝化反应后再循环的废酸进行加热，减压和蒸馏; 收集酸性液体A和蒸馏水A; 将酸性液体A与新的浓硫酸成比例混合，并将混合物置于新的Zoalene硝化反应过程中; 并将蒸馏水A放入用于稀释硝化反应中产生的液体的稀释罐中。 在生产Zoalene过程中产生的废酸被回收利用，不能直接排放; 水资源循环利用，水资源浪费减少，生产Zoalene过程中产生的废水排放量大大减少，不仅节省了生产成本，而且降低了环境压力。

公开(公告)号：US09504933B2

公开(公告)日：2016-11-29

申请号：US13973142

申请日：2013-08-22

Applicant: ANGUS Chemical Company

Inventor： Mahesh Sawant ,  Daniel M. Trauth ,  John G. Pendergast, Jr. ,  Ravindra S. Dixit

IPC: B01J19/00 ,  B01J19/24 ,  B01D3/00 ,  C07C201/00 ,  C07C201/06 ,  C07C201/08 ,  C07C205/00 ,  C07C205/01 ,  C07C205/02 ,  C07C205/05

CPC classification number: B01D3/009 ,  B01J2219/00006 ,  C07C201/08 ,  C07C205/02 ,  C07C205/05

Abstract: Disclosed is an apparatus for synthesizing nitroalkanes by reaction of a hydrocarbon feedstock with aqueous nitric acid. The apparatus may be designed such that it can synthesize more than one nitroalkane using the same equipment.