公开(公告)号：US20240351044A1

公开(公告)日：2024-10-24

申请号：US18577265

申请日：2022-07-08

Applicant: IXENSOR CO., LTD.

Inventor： Jiun-Yann YU ,  Yenyu CHEN

IPC: B01L7/00 ,  C12Q1/6851 ,  G01N21/64

CPC classification number: B01L7/52 ,  C12Q1/6851 ,  G01N21/6428 ,  B01L2200/0647 ,  B01L2300/1861 ,  B01L2300/1894 ,  G01N2021/6439 ,  G01N2201/0636

Abstract: Example methods and systems for performing quantitative polymerase chain reaction (qPCR) are provided. One example system may include a first lighting subsystem and a second lighting subsystem. The first lighting subsystem includes a first light source configured to illuminate a qPCR testing solution including a sample, a fluorescence dye and a nanoparticle in a tube with a first light to increase a temperature of the qPCR testing solution. The second lighting subsystem includes a light detector configured to detect an amount of fluorescence emitted by the fluorescence dye in a first thermal cycle of the qPCR. The first lighting subsystem is configured to turn off the first light source for a period of time in any thermal cycle of the qPCR after the first thermal cycle based on one or more heat transmission parameters which are determined based on the amount of fluorescence.

公开(公告)号：US12117395B2

公开(公告)日：2024-10-15

申请号：US17954199

申请日：2022-09-27

Applicant: Waymo LLC

Inventor： Hui Seong Son

IPC: G01N21/55 ,  G01S7/497 ,  G01S17/10

CPC classification number: G01N21/55 ,  G01S7/497 ,  G01S17/10 ,  G01N2021/551 ,  G01N2201/06113 ,  G01N2201/0636

Abstract: An apparatus includes an optical emitter configured to emit a first optical signal along an optical path towards a target object in an outdoor environment. The apparatus includes an optical detector positioned collinearly with respect to the optical emitter. The optical detector is configured to detect a second optical signal that is retro-reflected from the target object. The apparatus includes a lock-in amplifier coupled to the optical detector. The lock-in amplifier is configured to generate, based on the first optical signal and the second optical signal, a signal indicative of a retro-reflectivity of the target object in the outdoor environment.

公开(公告)号：US20240315592A1

公开(公告)日：2024-09-26

申请号：US18578995

申请日：2022-07-11

Applicant: UNIWERSYTET WARSZAWSKI

Inventor： Tadeusz STACEWICZ ,  Mateusz WINKOWSKI

IPC: A61B5/08 ,  A61B5/097 ,  A61B10/00 ,  G01N21/3504

CPC classification number: A61B5/082 ,  A61B5/097 ,  G01N21/3504 ,  A61B2010/0087 ,  G01N2201/06113 ,  G01N2201/0636

Abstract: The invention relates to a system for the detection of biomarkers in the air exhaled from patient's lungs, comprising a leak-proof multipass cell provided with a gas inlet and outlet, into which a sample of the exhaled air is introduced by means of a pneumatic system, wherein the multipass cell is provided with one laser whose light beam is directed along a coaxial optical path to the multipass cell comprising at least two concave mirrors arranged in parallel and a gas inlet and outlet, which is filled with a sample of the analyzed exhaled gas, wherein the pneumatic system is connected to the gas inlet and outlet of the multipass cell by means of lines supplying the exhaled air, characterized in that the pneumatic system comprises a preliminary container of the exhaled air comprising an air inlet and outlet, wherein the air outlet additionally comprises an air flow meter, the preliminary container is further connected by an elastic line supplying the air to the multipass cell on one side and on the other side to a pump, baratron, and also the air outlet of the multipass cell. The invention also relates to a method for the detection of biomarkers in the air exhaled from patient's lungs, with the use of such a system and to a system for the detection of gases, especially biomarker gases, using multiplexing and demultiplexing of optical signals.

公开(公告)号：US12099002B2

公开(公告)日：2024-09-24

申请号：US17566675

申请日：2021-12-30

Applicant: Shanghai Institute of Optics And Fine Mechanics, Chinese Academy of Sciences ,  Shanghai Hengyi Optics And Fine Mechanics Co., Ltd.

Inventor： Shijie Liu ,  Kaizao Ni ,  Jianda Shao ,  Weiwei Wang ,  Tianzhu Xu ,  Yingjia Li ,  Qi Lu

IPC: G01N21/31 ,  G01N21/958 ,  G02B26/10 ,  G02B27/14 ,  G02B27/28

CPC classification number: G01N21/31 ,  G01N21/958 ,  G02B26/105 ,  G02B27/14 ,  G02B27/283 ,  G02B27/286 ,  G01N2201/06113 ,  G01N2201/0636

Abstract: A single-beam photothermal measurement apparatus and a measurement method for absorptive defects. The apparatus comprises a common-path-type structure and a non-common-path-type structure. The present invention is simple in optical structure and convenient to align and adjustment. The measurement result is stable, and measurement signal anomalies caused by environmental vibration and sample tilt are avoided. By detecting a power change on the edge of a beam spot, the measurement sensitivity of a system is remarkably improved.

公开(公告)号：US20240310276A1

公开(公告)日：2024-09-19

申请号：US18596622

申请日：2024-03-06

Applicant: Asahi Kasei Microdevices Corporation

Inventor： Shota ISSHIKI ,  Takaaki FURUYA ,  Hans MARTIN

IPC: G01N21/3504

CPC classification number: G01N21/3504 ,  G01N2201/0636

Abstract: An optical concentration measuring apparatus (1) that includes: a light emitter (3) on a main surface (20) of a substrate (2) that emits light from a light-emitting surface; a light receiver (4) on the main surface of the substrate that receives light at a light-receiving surface; and a light guide (5) that guides light emitted by the light emitter to the light receiver. The light guide includes a first reflector (51) and a second reflector (52) that are connected to the main surface of the substrate and are opposite each other in an overhead view of the main surface of the substrate. The second reflector includes two quadric surfaces. The first reflector includes a main reflective surface (53) that is a quadric surface and two secondary reflective surfaces (54) that are quadric surfaces and are integrally formed at portions of the main reflective surface.

公开(公告)号：US12076724B2

公开(公告)日：2024-09-03

申请号：US16998040

申请日：2020-08-20

Applicant: SYSMEX CORPORATION

Inventor： Kazuhiro Yamada ,  Kazuki Asao ,  Keisuke Kuwano

IPC: B01L3/00 ,  B01L9/06 ,  G01N21/01 ,  G01N21/64 ,  G01N21/85 ,  G01N33/49

CPC classification number: B01L3/5085 ,  B01L9/06 ,  G01N21/01 ,  G01N21/6428 ,  G01N21/85 ,  G01N33/4915 ,  B01L2200/025 ,  B01L2200/143 ,  B01L2300/0627 ,  G01N2021/6439 ,  G01N2201/06113 ,  G01N2201/0633 ,  G01N2201/0636

Abstract: A specimen processing apparatus performs processing on a specimen contained in a container. The specimen processing apparatus includes: holders having different shapes, each of the holders being configured to hold the container; a holder placement unit that comprises holder receiving portions having different shapes, the shapes of the holder receiving portions corresponding to the shapes of the holders; and a specimen processing unit that performs processing on the specimen contained in the container held by one of the holders placed on the holder placement unit.

公开(公告)号：US20240288368A1

公开(公告)日：2024-08-29

申请号：US18564526

申请日：2021-05-28

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Viktor Shkolnikov ,  Alexander Govyadinov

IPC: G01N21/64 ,  G01N21/03 ,  G01N21/05 ,  G01N33/50

CPC classification number: G01N21/6428 ,  G01N21/0332 ,  G01N21/05 ,  G01N33/5005 ,  G01N2021/0325 ,  G01N2021/052 ,  G01N2201/0636 ,  G01N2201/0638 ,  G01N2201/0806

Abstract: In one example in accordance with the present disclosure, a fluorescence detection system is described. The fluorescence detection system includes a microfluidic chamber to receive a sample containing a compound to be detected. The system also includes a light guide, a portion of which is adjacent the microfluidic chamber. The light guide refracts excitation light into the microfluidic chamber to excite fluorophores in the microfluidic chamber. The light guide has total internal reflection in those portions that are not adjacent the microfluidic chamber. The fluorescence detection system also includes a heating element to trigger a reaction in the microfluidic chamber, an illumination source to provide the excitation, and a detection system to detect fluorescence generated by the excitation of the fluorophores in the microfluidic chamber.

公开(公告)号：US20240288360A1

公开(公告)日：2024-08-29

申请号：US18689840

申请日：2022-09-06

Applicant: Nanopath Inc.

Inventor： Alison Burklund ,  Amogha Tadimety ,  David Wolf ,  Doug Sabin ,  Travis Colosi

IPC: G01N21/25 ,  G01N33/53

CPC classification number: G01N21/255 ,  G01N33/5308 ,  G01N2021/258 ,  G01N2201/021 ,  G01N2201/0636

Abstract: Provided herein is an apparatus for the detection of analytes. In some embodiments, the analyte to be detected consists of nucleotide sequences. In some embodiments, the analytes are detected in liquid solutions. In some embodiments, the apparatus comprises a stage, a light source, a spectrometer, and a lens assembly.

公开(公告)号：US20240248029A1

公开(公告)日：2024-07-25

申请号：US18597384

申请日：2024-03-06

Applicant: Calumino Pty Ltd.

Inventor： Marek Steffanson ,  Gabrielle de Wit

IPC: G01N21/35

CPC classification number: G01N21/35 ,  G01N2201/0636

Abstract: A radiation imaging apparatus includes an imaging surface; a light source; and an array of micro mirrors that rotate via radiation absorbed in the micro mirrors and reflect light from the light source to generate a distribution of reflected light on the imaging surface. The array first micro mirrors and second micro mirrors. The first micro mirrors have a first structure and the second micro mirrors have a second structure different than the first structure. The second structure is configured to correct for one or more environmental influences on the radiation imaging apparatus. A photodetector captures an image of the distribution of reflected light on the imaging surface. A processor is coupled to the photodetector. A communication interface is coupled with the processor; and a computing device is located separately from the radiation imaging apparatus and in communication with the communication interface.

公开(公告)号：US20240230530A9

公开(公告)日：2024-07-11

申请号：US17972339

申请日：2022-10-24

Applicant: Applied Materials Israel Ltd.

Inventor： Benny Kirshner ,  Boris Golberg

IPC: G01N21/47 ,  G01N21/95

CPC classification number: G01N21/47 ,  G01N21/9501 ,  G01N2201/0636

Abstract: A method for phase retrieval, the method may include (a) obtaining multiple out-of-focus intensity images of one or more point spread function targets; wherein the out-of-focus intensity images are generated by based on residual collected light signals obtained by a residual collection channel of an optical unit having a numerical aperture that exceeds 0.8; and (b) calculating phase information, based on the multiple out-of-focus intensity images and on a vectorial model of the point spread function.