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公开(公告)号：US09737336B2
公开(公告)日：2017-08-22
申请号：US14580247
申请日：2014-12-23
Applicant: Aalto University Foundation
Inventor： Jan Erik Lindahl , Jari Salo , Jukka Tuomi , Roy Björkstrand , Mika Salmi , Eero Huotilainen , Mikko Roiha
CPC classification number: A61B17/62 , A61B5/103 , A61B5/1116 , A61B5/1121 , A61B5/1124 , A61B5/4528 , A61B5/4595 , A61B5/6878 , A61B17/6425
Abstract: The invention concerns an anatomically personalized and mobilizing external support configured to be arranged to support a physical joint between a first and a second bone group, which support comprises at least one first external auxiliary frame, which is configured to be attached to the first bone group using invasive attachment means, at least one second external auxiliary frame, which is configured to be attached to the second bone group using invasive attachment means, and at least one external auxiliary joint, which is fitted between the first and the second auxiliary frame. The external support is configured to permit a rotation of the second external auxiliary frame relative to the first external auxiliary frame about a rotational axis, sliding of the rotational axis relative to the first external auxiliary frame in a first direction, and sliding of the rotational axis or at least a portion of the second external auxiliary frame relative to the first external auxiliary frame in a second direction, which differs from the first direction.
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92.发明申请Topographically Functionalized NFC Film as an Immunoassay Platform for Rapid Diagnostics 审中-公开地形功能化NFC膜作为快速诊断的免疫测定平台公开(公告)号：US20150203594A1
公开(公告)日：2015-07-23
申请号：US14410409
申请日：2013-06-28
Applicant: Aalto University Foundation
Inventor： Hannes Orelma , Ilari Filpponen , Janne Laine
IPC: C08B3/00 , C07K16/18 , C07K14/765
CPC classification number: C08B3/00 , C07K14/765 , C07K16/18 , C08J5/18 , C08J2301/02
Abstract: The present invention concerns a method for functionalization, via topographical modification, of the surfaces of nanofibrillated (NFC) cellulose films into non-porous, water-resistant platforms, usable in diagnostic applications. The method includes a carboxylation of the NFC-film via TEMPO-mediated oxidation, and optionally an activation via EDS/NHS chemistry and, finally, the reactivity of the film can be tested using anti-human IgG. The invention also concerns the thus prepared functionalized NFC films, as well as the use thereof as platforms for diagnostical assays.
Abstract translation: 本发明涉及通过拓扑修饰将纳米纤维化（NFC）纤维素膜的表面官能化成无孔，防水平台的方法，其可用于诊断应用。 该方法包括通过TEMPO介导的氧化对NFC膜的羧化，以及任选地通过EDS / NHS化学的活化，最后可以使用抗人IgG测试膜的反应性。 本发明还涉及如此制备的功能化NFC膜，以及其作为诊断测定平台的用途。
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公开(公告)号：US12286522B2
公开(公告)日：2025-04-29
申请号：US16647744
申请日：2018-09-26
Inventor： Matti Toivonen , Olli Ikkala , Silvia Vignolini , Olimpia Domitilla Onelli
Abstract: The present invention concerns a material, based on fibrillar, elongated, or disk-like colloidal particles, that has a high scattering efficiency, a method that is suitable for preparing such a material, and the use of such a material. The material can be used as, or as a part of, a pigment, paint or protective coating in various industries, but due to its high scattering, and due to the fact that the material appears white even as a thin membrane, it is an interesting option also in the paper and pulp, cosmetic and medical industries.
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公开(公告)号：US20250116591A1
公开(公告)日：2025-04-10
申请号：US18865650
申请日：2023-05-12
Applicant: AALTO UNIVERSITY FOUNDATION SR
Inventor： Mikael MIETTINEN , Tuomas TIAINEN , Valtteri VAINIO , Raine VIITALA
Abstract: A device for measuring porosity and/or gas permeability of a sheet of material (9) comprises a measurement head comprising a body part (1) having a measurement face to be set towards the sheet of material, the body part comprising, on its measurement face, a first indentation defining a control volume (3) and a sealing arrangement (2, 5, 6, 7, 8) surrounding the first indentation to seal the control volume, and a control flow channel (11) forming a flow connection between the control volume and the outside of the body part for controlling the pressure in the control volume to create a pressure difference across the sheet of material to be measured. The sealing arrangement comprises a first aerostatic bearing for forming a contactless sealing between the body part (1) and the sheet of material (9) to be measured.
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公开(公告)号：US12226839B2
公开(公告)日：2025-02-18
申请号：US17606142
申请日：2020-04-24
Applicant: Aalto University Foundation sr
Inventor： Petri Kuosmanen , Raine Viitala , Valtteri Vainio
Abstract: Fastening an object onto a lathe, such that the location of the centre of rotation of the object may be adjusted relative to the centre of the lathe axis, wherein the centre of rotation of the object relative to the centre of the lathe may be displaced steplessly and biaxially, according to a predetermined calculation, without removing the object from the chuck.
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Patent Agency Ranking
96.发明公开公开(公告)号：US20240264156A1
公开(公告)日：2024-08-08
申请号：US18290827
申请日：2022-12-21
Applicant: Aalto University Foundation sr
Inventor： Jacky Loo , Yike Huang , Minh-Kha Nguyen , Susanna Hällsten , Anton Kuzyk , Tim Liedl
IPC: G01N33/543 , G01N21/552
CPC classification number: G01N33/54346 , G01N21/554 , G01N33/54386
Abstract: The present invention is directed to a nanoscaled construct, said construct comprising or essentially consisting of a nucleic acid structure with reconfigurable or switchable features, and at least two separate metallic nanoparticles coupled with said nucleic acid structure, wherein said two separate nanoparticles are at an interchangeable angle to each other, wherein said nanoparticles provide high chirality and/or optical activity within the visible and near-infrared (NIR) spectrum from 400 to 800 nm generating a color for the construct, and wherein said construct has an absorption dissymmetry factor (g-factor) of over 10%. There is also provided a method for detecting an analyte in a sample, the method comprising steps of contacting a nanoscaled construct of the present disclosure specific to said analyte with a sample in a test assay, and detecting said analyte in said sample by optical means or by naked eye, wherein the presence of the analyte in said sample changes the color of said nanoscaled structure and the change of color in said assay confirms the presence of the analyte in said sample.
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公开(公告)号：US20240102906A1
公开(公告)日：2024-03-28
申请号：US18267782
申请日：2022-01-04
Applicant: Aalto University Foundation sr
Inventor： Juho Pokki-Riikonen
CPC classification number: G01N11/10 , G01N3/08 , G01N2011/0086
Abstract: There is provided a microscope comprising a micromanipulator, comprising a first electromagnet comprising a first magnetic core; a second electromagnet comprising a second magnetic core, wherein the first magnetic core and the second magnetic core are configured to generate a magnetic force on magnetic probes arranged within a biological matrix arranged in between the first magnetic core and the second magnetic core; and wherein the microscope comprises imaging means configured to capture images of the biological matrix comprising the magnetic probes for detection of displacements of the magnetic probes caused by the magnetic force.
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公开(公告)号：US20230220193A1
公开(公告)日：2023-07-13
申请号：US17927938
申请日：2021-05-28
Applicant: Aalto University Foundation sr
Inventor： Nina Forsman , Monika Österberg , Alexander Henn
IPC: C08L63/00 , C08H7/00 , C08L97/00 , C08J3/00 , C09D163/00 , C09D197/00 , C09D5/02 , C09D7/20 , C09D7/80 , C09J163/00 , C09J197/00 , C09J5/06
CPC classification number: C08L63/00 , C08H6/00 , C08J3/005 , C08L97/005 , C09D5/02 , C09D7/20 , C09D7/80 , C09D163/00 , C09D197/005 , C09J5/06 , C09J163/00 , C09J197/005 , C08J2363/00 , C08J2397/00 , C08J2463/00 , C08J2497/00 , C08L2201/50 , C08L2205/06 , C08L2205/18
Abstract: According to an example aspect of the present invention, there is provided a composition comprising colloidal lignin particles and an epoxy compound.
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公开(公告)号：US11656309B2
公开(公告)日：2023-05-23
申请号：US17436627
申请日：2020-03-04
Applicant: Aalto University Foundation sr
Inventor： Cornelis Zevenhoven , Antti Mäkinen , Risto Ilmoniemi
CPC classification number: G01R33/445 , G01R33/32 , G01R33/4808 , G01R35/00
Abstract: According to an example aspect of the present invention, there is provided generating, Low-Field-Magnetic Resonance Imaging, LF-MRI, or Ultra-Low-Field Magnetic Resonance Imaging, ULF-MRI, data with respect to an image frame, determining a sensorwise agreement of the data with determined sensitivity profiles, and determining a mapping between the image frame and a sensor frame, such that the sensorwise agreement has been fulfilled.
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公开(公告)号：US20220412812A1
公开(公告)日：2022-12-29
申请号：US17847204
申请日：2022-06-23
Applicant: Aalto University Foundation sr
Inventor： Jukka Pekola , Yu-Cheng Chang , Bayan Karimi , Joonas Peltonen
Abstract: According to an example aspect of the present invention, there is provided a Coulomb blockade thermometer, comprising a Coulomb blockade thermometer sensor element, a radio-frequency generator configured to feed a radio-frequency signal to a first port of the Coulomb blockade thermometer, and a radio-frequency sensor configured to measure a response of the Coulomb blockade thermometer to the radio-frequency signal from a second port of the Coulomb blockade thermometer to perform a conductance measurement of the Coulomb blockade thermometer, and a bias voltage generator configured to sweep through a bias voltage range during the conductance measurement, performed using the radio-frequency generator, of the Coulomb blockade thermometer.
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