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公开(公告)号：US20220133680A1
公开(公告)日：2022-05-05
申请号：US17342117
申请日：2021-06-08
Inventor： Michael Wargovich
IPC: A61K31/343 , A61K47/44 , A61K31/355 , A61K36/58 , A61K47/02 , A61P35/00 , A61K47/36 , A61K36/185 , A61K47/46 , A61K9/00 , A61K35/04 , A61K47/22 , A61K9/48
Abstract: The disclosure relates to compositions and methods of treating cancer in a subject. The method comprises administering to a patient in need of treatment an effective amount of supercritical CO2 neem extract.
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公开(公告)号：US20220120537A1
公开(公告)日：2022-04-21
申请号：US17602974
申请日：2020-04-13
Inventor： Gold Darr Hood , Rachael Lynn Anderson
Abstract: The disclosed self defense devices include devices configured to look like everyday clothing or accessories, but which allow a user to respond to potential danger or attack.
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公开(公告)号：US20220111249A1
公开(公告)日：2022-04-14
申请号：US17498986
申请日：2021-10-12
Inventor： David A. Brown , Chih-Ying Li , Mansoo Ko , Shengting Cao , Xuefeng Wang , Fei Hu , Yu Gan , Liang Zhang
Abstract: The present disclosure presents improved treadmill control systems and methods. One such method comprises initiating a recording a video sequence of a walking exercise by a subject on a treadmill device; extracting intra-gait phases of the subject from the recorded video sequence using a video temporal alignment with a neural network; generating a series of treadmill belt control settings for the treadmill device corresponding to each phase of the gait pattern of the subject; and signaling the series of treadmill belt control settings to a motor controller of the treadmill device. Other methods and systems are also provided.
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94.发明授权公开(公告)号：US11294652B2
公开(公告)日：2022-04-05
申请号：US16385118
申请日：2019-04-16
Inventor： Tongping Liu , Mohammad Mejbah ul Alam , Abdullah Al Muzahid
Abstract: The techniques described herein may provide techniques to detect, categorize, and diagnose synchronization issues that provide improved performance and issue resolution. For example, in an embodiment, a method may comprise detecting occurrence of synchronization performance problems in software code, when at least some detected synchronization performance problems occur when a contention rate for software locks is low, determining a cause of the synchronization performance problems, and modifying the software code to remedy the cause of the synchronization performance problems so as to improve synchronization performance of the software code.
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公开(公告)号：US11285190B2
公开(公告)日：2022-03-29
申请号：US15567762
申请日：2016-04-18
Inventor： Sean Morrison , Rui Yue
Abstract: The present disclosure describes the C-type lectin CLEC11a as a bone growth factor. Clec11a-deficient mice showed reduced bone volume and mineralization, while bone resorption remained unchanged. Administration of recombinant Clec11a systemically promoted bone formation in mice at risk for osteoporosis.
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Patent Agency Ranking
公开(公告)号：US11274282B2
公开(公告)日：2022-03-15
申请号：US16875056
申请日：2020-05-15
Inventor： Sergio E. Rodriguez , Robert W. Cross , Chad E. Mire , Thomas W. Geisbert
IPC: A61K39/00 , A61K39/12 , A61K39/23 , C12N15/00 , C12N15/74 , C12N7/00 , C07K14/005 , A61K39/205 , C12N15/86 , G01N33/569 , A61P31/14
Abstract: Certain embodiments are directed generally to compositions and methods related to recombinant vesicular stomatitis virus vectors (ΔGrVSV) encoding Crimean-Congo Hemorrhagic Fever glycoprotein precursor (CCHFV-GPC) and forming a recombinant vesicular stomatitis virus vector encoding Crimean-Congo Hemorrhagic Fever glycoprotein precursor (ΔGrVSV-CCHFV-GPC).
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公开(公告)号：US20220056124A1
公开(公告)日：2022-02-24
申请号：US17273538
申请日：2019-09-05
Inventor： Ningyan ZHANG , Dawei BU , Zhiqiang AN , Hui DENG , Philipp E. SCHERER
Abstract: Aspects of the present invention relate to methods and reagents for increasing chemosensitivity to platinum-based chemotherapy. In one aspect, a method of increasing chemosensitivity to platinum-based chemotherapy is provided, comprising administering to a patient in need thereof an effective amount of an endotrophin-neutralizing agent. The agent can be a monoclonal antibody, or fragment thereof, capable of binding to the C5 domain of the alphas chain of collagen VI. In some embodiments, the method can further include administering an effective amount of thiazolidinedione to said patient.
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公开(公告)号：US11249092B2
公开(公告)日：2022-02-15
申请号：US15981449
申请日：2018-05-16
Inventor： Claudio Soto-Jara , Russell M. Lebovitz , Benedikt K. Vollrath , Mohammad Shahnawaz , Nicolas Mendez Dinamarca
IPC: G01N33/68
Abstract: Methods and kits are provided for amplifying and detecting misfolded tau protein from samples, for example, from patients having tauopathies such as Alzheimer's Disease, Progressive Supranuclear Palsy, and the like.
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公开(公告)号：US20220000899A1
公开(公告)日：2022-01-06
申请号：US17180469
申请日：2021-02-19
Inventor： William S. Korinek , James D. Lechleiter , Theodore E. Liston
IPC: A61K31/7076 , A61K31/52
Abstract: The present invention relates to compounds and methods of use thereof for treatment of certain disorders and conditions, for example brain injuries such as stroke or traumatic brain injuries.
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公开(公告)号：US20210380695A1
公开(公告)日：2021-12-09
申请号：US17322827
申请日：2021-05-17
Inventor： Zhijian CHEN , Lijun SUN
IPC: C07K16/28 , A61K31/7084 , A61K47/68 , A61P35/00
Abstract: The disclosure provides, among other things, methods and uses for treating a disease or disorder, particularly a cancer, in a patient, comprising conjointly administering a CTLA4 inhibitor (e.g., an anti-CTLA4 antibody) and a STING agonist to the patient, wherein the CTLA4 inhibitor is administered intratumorally to the patient. The STING agonist can be administered intratumorally, orally or systemically (e.g., intravenously, intramuscularly, or subcutaneously) to the patient.
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