公开(公告)号：US12078473B2

公开(公告)日：2024-09-03

申请号：US17841514

申请日：2022-06-15

Applicant: Universität Stuttgart

Inventor： Patrick Foltyn ,  Bernhard Weigand ,  Norbert Roth

IPC: G01B11/22 ,  G01F15/00

CPC classification number: G01B11/22 ,  G01F15/001

Abstract: The present invention relates to a measuring device (10) and a method for determining a depth of field of an optical structure (100). In this case, the measuring device comprises a device body (12) with a measuring axis (14), the device body (12) being formed such that, in a measuring position, it can be placed in a stationary manner on a deposit plane of the optical structure such that the measuring axis (14) of the device body (12) coincides with an optical axis of the optical structure, wherein the device body (12) has a measurement scale (18) arranged along a scale line (16) such that the scale line (16) encloses with the direction of the measuring axis (14) a scale angle φ greater than 0° and less than 90° and the measurement scale (18) can be optically detected in the measuring position of the device body (12) by the optical structure (100) for determining the depth of field.

公开(公告)号：US20230152218A1

公开(公告)日：2023-05-18

申请号：US18050334

申请日：2022-10-27

Applicant: Universität Stuttgart

Inventor： Tobias Haist ,  Robin Hahn ,  Kristina Michel

IPC: G01N21/31 ,  G02B27/42 ,  G02B13/22 ,  G02B5/18 ,  H04N5/225

CPC classification number: G01N21/31 ,  G02B27/4205 ,  G02B13/22 ,  G02B5/1866 ,  H04N5/2258

Abstract: An imaging device (110) and a method for imaging at least one object (112), specifically for multispectral imaging or hyperspectral imaging, are disclosed. The imaging device (110) comprises



I. at least one image sensor (114) located in at least one image plane (116) of the imaging device (110), the image sensor (114) comprising a plurality of photosensitive elements (118);
II. at least one first imaging system (120) configured for generating at least one intermediate image (122) of the object (112) in at least one intermediate image plane (124);
III. at least one second imaging system (132) configured for generating at least one image (134) of the intermediate image (122) on the image sensor (114) in the image plane (116);
IV. at least one diffractive optical element (142) arranged in the intermediate image plane (124); and
V. at least one aperture (144) arranged in a beam path (146) of the second imaging system (132) between the intermediate image plane (124) and the image sensor (114),

wherein the diffractive optical element (142), the second imaging system (132) and the aperture (144) are arranged such that at least two different images for at least two different wavelengths of the intermediate image (122) are generated on at least two different groups of the photosensitive elements (118).

公开(公告)号：US20220396635A1

公开(公告)日：2022-12-15

申请号：US17762626

申请日：2020-09-25

Applicant: UNIVERSITÄT STUTTGART

Inventor： Roland KONTERMANN ,  Oliver SEIFERT ,  Nadine ASCHMONEIT

IPC: C07K16/32 ,  C07K16/28

Abstract: The present invention relates to a trivalent binding molecule comprising a first polypeptide comprising two binding domains and a second polypeptide comprising a third binding domain. The present invention further relates to the trivalent binding molecule for use in medicine and in particular in the prophylaxis, treatment or diagnosis of a disorder or disease.

公开(公告)号：US11334690B2

公开(公告)日：2022-05-17

申请号：US16104186

申请日：2018-08-17

Applicant: Universität Stuttgart

Inventor： Steffen Reichert ,  Long Nguyen ,  Achim Menges

IPC: G06F30/00 ,  G06T17/20 ,  G06T19/20 ,  G06F30/15

Abstract: A method of determining a modified shape of a computer-aided design model of an object or a partition thereof is described. With the method, at least two reference landmarks are placed at a reference position with respect to the shape of the object or to the partition. An adjustment landmark is placed at the reference position of the corresponding reference landmark. The adjustment landmarks are displaced from the reference position to a modified position, and a displacement between the modified position and the reference position is obtained. The modified shape of the object or the partition is generated by modifying the shape of the object or the partition by applying a homogeneous function of the displacement to the computer-aided design model of the shape of the object or the partition.

公开(公告)号：US11142558B2

公开(公告)日：2021-10-12

申请号：US16500849

申请日：2018-04-05

Applicant: UNIVERSITÄT STUTTGART

Inventor： Roman Fischer ,  Roland Kontermann ,  Klaus Pfizenmaier ,  Martin Siegemund

IPC: C07K14/525 ,  A61K38/00

Abstract: The present invention relates to a tumor necrosis factor receptor (TNFR) binding protein complex comprising 12 or more protein ligands (PLs) that specifically bind to the extracellular part of the same TNFR. Preferably, the TNFR binding protein complex binds to the extracellular part of TNFR2. Preferably, the TNFR binding protein complex of the present invention further comprises two or more polymerization domains (PD).

公开(公告)号：US20210174263A1

公开(公告)日：2021-06-10

申请号：US17113198

申请日：2020-12-07

Applicant: UNIVERSITÄT STUTTGART

Inventor： Michael Weyrich ,  Christof Ebert

IPC: G06N20/10 ,  G06K9/62

Abstract: A method and a device for testing, the device including a learning arrangement adapted to provide scenarios for test cases and principles to be tested, in particular comprising a digital representation of one or more of a law, an accident report, a log, or human expertise or a combination thereof, wherein the learning arrangement is adapted to determine at least one rule for test case generation from the scenarios and the principles, and wherein a modelling arrangement is adapted to determine, store and/or output a model for test case generation depending on the at least one rule.

公开(公告)号：US10910088B2

公开(公告)日：2021-02-02

申请号：US15756156

申请日：2016-09-08

Applicant: FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V. ,  UNIVERSITÄT STUTTGART ,  MEDIZINISCHE UNIVERSITÄT WIEN ,  UNIVERSITÄT WIEN

Inventor： Kai Sohn ,  Silke Grumaz ,  Philip Stevens ,  Arndt Von Haeseler

IPC: C12Q1/68 ,  G16B40/00 ,  G16B50/00 ,  C12Q1/6869

Abstract: The present invention relates to a method and a device for a nucleic acid based diagnostic approach including the determination of a deviant condition of a sample, wherein the deviant condition is preferably a health condition and/or a pathogenic condition.

公开(公告)号：US20190350442A1

公开(公告)日：2019-11-21

申请号：US16400357

申请日：2019-05-01

Applicant: Karl Storz SE & Co. KG ,  Universität Stuttgart

Inventor： Harald Gießen ,  Alois Herkommer ,  Simon Thiele ,  Klaus Irion ,  Werner Göbel ,  Benjamin Häsler

IPC: A61B1/00 ,  G02B23/24

Abstract: An endoscope includes a shaft having a distal end, an optical imaging device at the distal end of the shaft for producing a real image of an object observed by means of the endoscope and at least one of an image transfer device for transmitting the real image and an image sensor for capturing the real image. The imaging device has curved light-refracting interfaces, which are tilted in relation to one another.

公开(公告)号：US10152806B2

公开(公告)日：2018-12-11

申请号：US15183189

申请日：2016-06-15

Applicant: Universität Stuttgart

Inventor： Sven Simon ,  Steffen Kieβ ,  Jürgen Hillebrand ,  Jajnabalkya Guhathakurta

IPC: G06K9/00 ,  G06T11/00

Abstract: The present invention relates to a method and a computer program product for generating an artifact-reduced voxel data record of an object. The artifact-reduced voxel data record of the object is generated with the aid of a computed tomography scanner. In some aspects of the present disclosure, a first image data record and a second image data record is generated by acquiring computed tomography images of the object. In still other aspects of the present disclosure, the artifact-reduced voxel data record of the object is generated with the aid of an image data reconstruction algorithm.

公开(公告)号：US20180066983A1

公开(公告)日：2018-03-08

申请号：US15558750

申请日：2016-03-16

Applicant: Universität Stuttgart

Inventor： Stefan PIEHLER ,  Benjamin DANNECKER ,  Jan Philipp NEGEL

IPC: G01J1/04 ,  H01S3/00 ,  H01S3/067

CPC classification number: G01J1/0411 ,  G01J1/0407 ,  G01J1/0414 ,  G01J1/4257 ,  H01S3/0014 ,  H01S3/067 ,  H01S3/1305 ,  H01S2301/085

Abstract: The present disclosure provides a method and to a device for quantitatively sensing the power fraction of a radiation background of a pulsed laser. The disclosure further relates to the use of a saturable element. The method includes modulating a measurement beam, which is emitted by the laser, by means of a saturable element in accordance with the fluence of the measurement beam, detecting, by means of a modulation beam power detector, the power of the measurement beam modulated by the saturable element, and determining the power fraction of the radiation background of the pulsed laser on the basis of the detected power of the measurement beam modulated by means of the saturable element.