公开(公告)号：US20190167918A1

公开(公告)日：2019-06-06

申请号：US16178940

申请日：2018-11-02

Applicant: ABLATIVE SOLUTIONS, INC.

Inventor： David R. Fischell ,  Tim A. Fischell

IPC: A61M5/46 ,  A61M25/00 ,  A61M25/06

Abstract: A catheter-based/intravascular fluid injection system with application to renal denervation includes a multiplicity of needles which expand open around a central axis to engage the wall of a blood vessel, or the wall of the left atrium, allowing the injection of a cytotoxic and/or neurotoxic solution for ablating conducting tissue, or nerve fibers around the ostium of the pulmonary vein, or circumferentially in or just beyond the outer layer of the renal artery. The expandable delivery system includes expandable components that facilitate positioning of a multiplicity of injection needles against the inside wall of a blood vessel from where they can be advanced. The system also includes means to limit and/or adjust the depth of penetration of the ablative fluid into the tissue of the wall of the targeted blood vessel.

公开(公告)号：US10022059B2

公开(公告)日：2018-07-17

申请号：US15663409

申请日：2017-07-28

Applicant: Ablative Solutions, Inc.

Inventor： David R. Fischell ,  Tim A. Fischell ,  Vartan Ghazarossian ,  Steven Almany ,  Michael Sasha John

IPC: A61B3/02 ,  A61B5/04 ,  A61M31/00 ,  A61B5/00 ,  A61B18/14 ,  A61B17/32 ,  A61B90/00 ,  A61B18/04 ,  A61B17/00 ,  A61B18/02 ,  A61B18/00 ,  A61B18/12 ,  A61M25/00 ,  A61B18/18 ,  A61B5/20

Abstract: An intravascular catheter for nerve activity ablation and/or sensing includes one or more needles advanced through supported guide tubes (needle guiding elements) which expand to contact the interior surface of the wall of the renal artery or other vessel of a human body allowing the needles to be advanced though the vessel wall into the extra-luminal tissue including the media, adventitia and periadvential space. The catheter also includes structures which provide radial and lateral support to the guide tubes so that the guide tubes open uniformly and maintain their position against the interior surface of the vessel wall as the sharpened needles are advanced to penetrate into the vessel wall. Electrodes near the distal ends of the needles allow sensing of nerve activity before and after attempted renal denervation. In a combination embodiment ablative energy or fluid is delivered from the needles in or near the adventitia to ablate nerves outside of the media while sparing nerves within the media.

公开(公告)号：US20170304594A1

公开(公告)日：2017-10-26

申请号：US15383528

申请日：2016-12-19

Applicant: Ablative Solutions, Inc.

Inventor： David R. Fischell ,  Tim A. Fischell ,  Robert Ryan Ragland ,  Darrin James Kent ,  Andy Edward Denison ,  Eric Thomas Johnson ,  Jeff Alan Burke ,  Christopher Scott Hayden ,  Robert E. Fischell

IPC: A61M25/10 ,  A61M25/06 ,  A61M5/158 ,  A61B18/00

CPC classification number: A61M25/10 ,  A61B18/00 ,  A61B18/04 ,  A61B2018/00011 ,  A61B2018/00279 ,  A61B2018/00404 ,  A61B2018/00517 ,  A61B2018/00577 ,  A61B2018/046 ,  A61B2090/3966 ,  A61B2218/002 ,  A61M5/158 ,  A61M25/0084 ,  A61M25/0662 ,  A61M2005/1585 ,  A61M2025/0087

Abstract: An intravascular catheter for peri-vascular and/or peri-urethral tissue ablation includes multiple needles advanced through supported guide tubes which expand around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, and/or nerve fibers in the outer layer or deep to the outer layer of the vessel, or in prostatic tissue. The system may also include a means to limit and/or adjust the depth of penetration of the ablative fluid into and beyond the tissue of the vessel wall. The catheter may also include structures which provide radial and/or lateral support to the guide tubes so that the guide tubes expand uniformly and maintain their position against the interior surface of the vessel wall as the sharpened injection needles are advanced to penetrate into the vessel wall.

公开(公告)号：US09526827B2

公开(公告)日：2016-12-27

申请号：US14266726

申请日：2014-04-30

Applicant: Ablative Solutions, Inc.

Inventor： David R. Fischell ,  Tim A. Fischell ,  Robert Ryan Ragland ,  Darrin James Kent ,  Andy Edward Denison ,  Eric Thomas Johnson ,  Jeff Alan Burke ,  Christopher Scott Hayden ,  Robert E. Fischell

IPC: A61M5/158 ,  A61M25/00 ,  A61B18/00 ,  A61B18/04 ,  A61M25/06 ,  A61M25/10

CPC classification number: A61M25/10 ,  A61B18/00 ,  A61B18/04 ,  A61B2018/00011 ,  A61B2018/00279 ,  A61B2018/00404 ,  A61B2018/00517 ,  A61B2018/00577 ,  A61B2018/046 ,  A61B2090/3966 ,  A61B2218/002 ,  A61M5/158 ,  A61M25/0084 ,  A61M25/0662 ,  A61M2005/1585 ,  A61M2025/0087

Abstract: An intravascular catheter for peri-vascular or peri-urethral tissue ablation includes multiple needles advanced through supported guide tubes which expand around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, such as nerve fibers in the outer layer or deep to the outer layer of the vessel, or in prostatic tissue. The system may also include a controls the depth of penetration of the ablative fluid into and beyond the tissue of the vessel wall. The catheter may also include structures which provide radial and/or lateral support to the guide tubes so that the guide tubes expand uniformly and maintain their position against the interior surface of the vessel wall as the sharpened injection needles are advanced to penetrate into the vessel wall.

Abstract translation: 用于周围血管或尿道周围组织消融的血管内导管包括穿过支撑的导管的多个针，所述导管围绕中心轴线膨胀以接合肾动脉壁或其他容器的内表面，允许注射 用于烧蚀组织的消融液，例如外层中的神经纤维或深层至血管外层，或前列腺组织。 该系统还可以包括控制烧蚀流体渗透到血管壁的组织内和超出血管壁的组织的深度。 导管还可以包括向引导管提供径向和/或侧向支撑的结构，使得引导管均匀地膨胀并且当尖锐的注射针被推入以穿透血管壁时将其位置保持抵靠血管壁的内表面 。

公开(公告)号：US20160242661A1

公开(公告)日：2016-08-25

申请号：US14963179

申请日：2015-12-08

Applicant: Ablative Solutions, Inc.

Inventor： David R. Fischell ,  Tim A. Fischell ,  Vartan Ghazarossian ,  Steven Almany ,  Michael Sasha John

IPC: A61B5/04 ,  A61B18/14 ,  A61B5/00

CPC classification number: A61B5/04001 ,  A61B5/201 ,  A61B5/4035 ,  A61B5/6848 ,  A61B5/6852 ,  A61B17/320068 ,  A61B18/0218 ,  A61B18/1233 ,  A61B18/1477 ,  A61B18/1492 ,  A61B18/1815 ,  A61B2017/00039 ,  A61B2018/00214 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00541 ,  A61B2018/00577 ,  A61B2018/00642 ,  A61B2018/00666 ,  A61B2018/00738 ,  A61B2018/00779 ,  A61B2018/00815 ,  A61B2018/00821 ,  A61B2018/00827 ,  A61B2018/00839 ,  A61B2018/00875 ,  A61B2018/00892 ,  A61B2018/00898 ,  A61B2018/00916 ,  A61B2018/0212 ,  A61B2018/046 ,  A61B2018/048 ,  A61B2018/1425 ,  A61B2018/143 ,  A61B2018/1432 ,  A61B2018/1467 ,  A61B2018/1475 ,  A61B2090/376 ,  A61B2090/3966 ,  A61M2025/0095

Abstract: An intravascular catheter for nerve activity ablation and/or sensing includes one or more needles advanced through supported guide tubes (needle guiding elements) which expand to contact the interior surface of the wall of the renal artery or other vessel of a human body allowing the needles to be advanced though the vessel wall into the extra-luminal tissue including the media, adventitia and periadvential space. The catheter also includes structures which provide radial and lateral support to the guide tubes so that the guide tubes open uniformly and maintain their position against the interior surface of the vessel wall as the sharpened needles are advanced to penetrate into the vessel wall. Electrodes near the distal ends of the needles allow sensing of nerve activity before and after attempted renal denervation. In a combination embodiment ablative energy or fluid is delivered from the needles in or near the adventitia to ablate nerves outside of the media while sparing nerves within the media.

Abstract translation: 用于神经活动消融和/或感测的血管内导管包括穿过支撑的导管（针引导元件）前进的一个或多个针，其膨胀以接触肾动脉的壁的内表面或人体的其他容器，允许针 通过血管壁进入包括介质，外膜和周围空间的腔内组织。 导管还包括向引导管提供径向和横向支撑的结构，使得引导管均匀地打开并且当尖锐的针被推进以穿透到血管壁时，它们保持其抵靠血管壁的内表面的位置。 针头末端附近的电极可以在尝试肾去神经支配前后感测神经活动。 在组合实施例中，消融能量或流体从外膜中或附近的针递送到消融介质外部的神经，同时将神经保持在介质内。

公开(公告)号：US20150245863A1

公开(公告)日：2015-09-03

申请号：US14712861

申请日：2015-05-14

Applicant: Ablative Solutions, Inc.

Inventor： David R. Fischell ,  Tim A. Fischell ,  Robert Ryan Ragland ,  Darrin James Kent ,  Andy Edward Denison ,  Eric Thomas Johnson ,  Jeff Alan Burke ,  Christopher Scott Hayden ,  Robert E. Fischell

IPC: A61B18/06

CPC classification number: A61B18/1492 ,  A61B5/0071 ,  A61B18/00 ,  A61B2018/00166 ,  A61B2018/00279 ,  A61B2018/00285 ,  A61B2018/00345 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/00982 ,  A61B2018/143 ,  A61B2018/1475 ,  A61B2090/3966 ,  A61B2218/002 ,  A61M5/158 ,  A61M25/0084 ,  A61M25/10 ,  A61M2005/1585 ,  A61M2025/0087

Abstract: An intravascular catheter for peri-vascular and/or peri-urethral tissue ablation includes multiple needles advanced through supported guide tubes which expand around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, and/or nerve fibers in the outer layer or deep to the outer layer of the vessel. A method of treating hypertension involves injecting an ablative fluid such as ethanol deep into zones in the wall of the renal artery such that the zones of fluid merge to form a circumferential ablation ring at a depth which ablates sympathetic nerves while minimizing injury to interior layers of the vessel wall.

Abstract translation: 用于周围血管和/或尿道周围组织消融的血管内导管包括穿过支撑的导管的多个针，所述导管围绕中心轴线膨胀以接合肾动脉或其他人体容器的壁的内表面，允许 注射用于烧蚀组织的消融液，和/或外层中的神经纤维或深层到容器的外层。 一种治疗高血压的方法包括将消融液体如乙醇深入注射到肾动脉壁中的区域中，使得流体区域合并以在消融交感神经的深度处形成圆周消融环，同时最小化内部层的损伤 血管壁。

公开(公告)号：US20150119674A1

公开(公告)日：2015-04-30

申请号：US14063907

申请日：2013-10-25

Applicant: Ablative Solutions, Inc.

Inventor： David R. Fischell ,  Tim A. Fischell ,  Vartan Ghazarossian ,  Steven Almany

IPC: A61B5/04 ,  A61B18/14 ,  A61B5/00

CPC classification number: A61B5/04001 ,  A61B5/201 ,  A61B5/4035 ,  A61B5/6848 ,  A61B5/6852 ,  A61B17/320068 ,  A61B18/1477 ,  A61B18/1492 ,  A61B18/1815 ,  A61B2018/00214 ,  A61B2018/00434 ,  A61B2018/00577 ,  A61B2018/00642 ,  A61B2018/00839 ,  A61B2018/0212 ,  A61B2018/046 ,  A61B2018/1425 ,  A61B2090/3966 ,  A61M2025/0095

Abstract: An intravascular catheter for peri-vascular nerve activity sensing or measurement includes multiple needles advanced through supported guide tubes (needle guiding elements) which expand with open ends around a central axis to contact the interior surface of the wall of the renal artery or other vessel of a human body allowing the needles to be advanced though the vessel wall into the perivascular space. The system also may include means to limit and/or adjust the depth of penetration of the needles. The catheter also includes structures which provide radial and lateral support to the guide tubes so that the guide tubes open uniformly and maintain their position against the interior surface of the vessel wall as the sharpened needles are advanced to penetrate into the vessel wall. The addition of an injection lumen at the proximal end of the catheter and openings in the needles adds the functionality of ablative fluid injection into the perivascular space for an integrated nerve sending and ablation capability.

Abstract translation: 用于周围血管神经活动感测或测量的血管内导管包括通过支撑的导管（针引导元件）前进的多个针，其以围绕中心轴线的开口端膨胀，以接触肾动脉或其他血管的壁的内表面 人体允许针通过血管壁进入血管周围空间。 该系统还可以包括限制和/或调整针的穿透深度的装置。 导管还包括向引导管提供径向和横向支撑的结构，使得引导管均匀地打开并且当尖锐的针被推进以穿透到血管壁时，它们保持其抵靠血管壁的内表面的位置。 在导管的近端添加注射腔和针中的开口，将烧蚀液注入到血管周围空间中的功能可用于整合的神经发生和消融能力。

公开(公告)号：US08740849B1

公开(公告)日：2014-06-03

申请号：US13752062

申请日：2013-01-28

Applicant: Ablative Solutions, Inc.

Inventor： David R. Fischell ,  Tim A. Fischell ,  Robert Ryan Ragland ,  Darrin James Kent ,  Andy Edward Denison ,  Eric Thomas Johnson ,  Jeff Alan Burke ,  Christopher Scott Hayden ,  Robert E. Fischell

IPC: A61M5/178 ,  A61M5/00

CPC classification number: A61M25/0084 ,  A61B18/1477 ,  A61B18/1492 ,  A61B90/37 ,  A61B2018/00285 ,  A61B2018/00434 ,  A61B2018/00577 ,  A61B2018/046 ,  A61B2090/376 ,  A61B2090/3966 ,  A61M2025/0087

Abstract: An intravascular catheter for peri-vascular and/or peri-urethral tissue ablation includes multiple needles advanced through supported guide tubes which expand with open ends around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, and/or nerve fibers in the outer layer or deep to the outer layer of the vessel, or in prostatic tissue. The system also includes means to limit and/or adjust the depth of penetration of the ablative fluid into and beyond the tissue of the vessel wall. The preferred embodiment of the catheter includes structures which provide radial and lateral support to the guide tubes so that the guide tubes open uniformly and maintain their position against the interior surface of the vessel wall as the sharpened injection needles are advanced to penetrate into the vessel wall.

Abstract translation: 用于周围血管和/或尿道周围组织消融的血管内导管包括穿过支撑的导管的多个针，所述导管围绕中心轴线以开口端膨胀，以接合肾动脉壁或人的其他血管的内表面 允许注射用于烧蚀组织的消融液体，和/或外层中的神经纤维或深层到血管的外层，或在前列腺组织中。 该系统还包括限制和/或调节烧蚀液体渗透到血管壁组织内和/或超过血管壁组织的深度的手段。 导管的优选实施例包括向引导管提供径向和侧向支撑的结构，使得引导管均匀地打开并且当尖锐的注射针推进以穿透血管壁时将其位置保持抵靠血管壁的内表面 。