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91.发明授权Method of fabricating an implantable medical device with biaxially oriented polymers 有权用双轴取向聚合物制造可植入医疗器械的方法公开(公告)号：US08715564B2
公开(公告)日：2014-05-06
申请号：US13463562
申请日：2012-05-03
Applicant: Bin Huang , Stephen Schaible , Richard Kaufman , Jim Kennedy , David C. Gale , Suresh Amin , John Guardiano
Inventor： Bin Huang , Stephen Schaible , Richard Kaufman , Jim Kennedy , David C. Gale , Suresh Amin , John Guardiano
IPC: B29C49/04
CPC classification number: A61F2/82 , A61F2/91 , A61F2002/825 , A61L31/148 , B23K2103/42 , B23K2103/50 , B29C47/0023 , B29C47/0057 , B29C47/24 , B29C49/786 , B29L2031/7534
Abstract: Methods and systems for manufacturing an implantable medical device, such as a stent, from a tube with desirable mechanical properties, such as improved circumferential strength and rigidity, are described herein. Improved circumferential strength and rigidity may be obtained by inducing molecular orientation in materials for use in manufacturing an implantable medical device. Methods of inducing circumferential molecular orientation by inducing circumferential flow in a molten polymer are disclosed.
Abstract translation: 本文描述了用于制造可植入医疗装置（例如支架）的方法和系统，其具有期望的机械性质（例如改善的周向强度和刚度）的管。 可以通过在用于制造可植入医疗装置的材料中诱导分子取向来获得改善的周向强度和刚性。 公开了通过在熔融聚合物中引起圆周流动而导致圆周分子取向的方法。
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92.发明授权Stent locking element and a method of securing a stent on a delivery system 有权支架锁定元件和将支架固定在输送系统上的方法公开(公告)号：US08568469B1
公开(公告)日：2013-10-29
申请号：US10879328
申请日：2004-06-28
Applicant: David C. Gale , Klaus Kleine , Anthony J. Abbate , Bin Huang , Svava Maria Atladottir
Inventor： David C. Gale , Klaus Kleine , Anthony J. Abbate , Bin Huang , Svava Maria Atladottir
IPC: A61F2/06
CPC classification number: A61F2/82 , A61F2/91 , A61F2/958 , A61F2002/91558 , A61F2002/91583 , A61F2002/91591 , A61F2002/9505 , A61F2220/0033
Abstract: A stent with a stent locking element and a method of securing a stent on a delivery implement, such as a catheter are disclosed. The locking element can include coupling elements capable of being releasably coupled to one another. The coupling elements may be adapted to inhibit shifting of the stent on the delivery implement. In some embodiments, the releasably coupled elements may secure the stent on the delivery implement.
Abstract translation: 公开了具有支架锁定元件的支架和将支架固定在诸如导管的递送工具上的方法。 锁定元件可以包括能够可释放地彼此联接的联接元件。 联接元件可适于阻止支架在输送工具上的移动。 在一些实施例中，可释放地联接的元件可将支架固定在输送工具上。
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公开(公告)号：US08486135B2
公开(公告)日：2013-07-16
申请号：US11784886
申请日：2007-04-09
Applicant: Yunbing Wang , David C. Gale , Bin Huang , Mikael O. Trollsas , Thierry Glauser , Florian Ludwig
Inventor： Yunbing Wang , David C. Gale , Bin Huang , Mikael O. Trollsas , Thierry Glauser , Florian Ludwig
IPC: A61F2/06
Abstract: This invention relates to implantable medical devices, such as stents, fabricated from hyperbranched-like polymers, comb-like polymers, star polymers, dendrimer-like star polymers, dendrimers, and mixtures thereof.
Abstract translation: 本发明涉及由超支化聚合物，梳状聚合物，星形聚合物，树枝状大分子星形聚合物，树枝状大分子及其混合物制成的可植入医疗装置，例如支架。
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94.发明授权Methods of treatment with drug delivery after biodegradation of the stent scaffolding 有权在支架支架生物降解后用药物递送治疗的方法公开(公告)号：US08469968B2
公开(公告)日：2013-06-25
申请号：US13185370
申请日：2011-07-18
Applicant: David C. Gale , Bin Huang
Inventor： David C. Gale , Bin Huang
CPC classification number: A61L31/14 , A61F2/82 , A61L31/146 , A61L31/148 , A61L31/16 , A61L2300/41 , A61L2300/416 , A61L2300/604
Abstract: Disclosed is a stent comprising a bioabsorbable polymeric scaffolding; and a plurality of depots in at least a portion of the scaffolding, wherein the plurality of depots comprise a bioabsorbable material, wherein the degradation rate of all or substantially all of the bioabsorbable polymer of the scaffolding is faster than the degradation rate of all or substantially all of the bioabsorbable material of the depots.
Abstract translation: 公开了一种支架，其包括生物可吸收聚合物支架; 以及在所述脚手架的至少一部分中的多个仓库，其中所述多个仓库包含生物可吸收材料，其中所述脚手架的所有或基本上全部所述生物可吸收聚合物的降解速度比全部或基本上 所有生物可吸收材料的仓库。
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95.发明授权公开(公告)号：US08431060B2
公开(公告)日：2013-04-30
申请号：US12559404
申请日：2009-09-14
Applicant: Bin Huang , David C. Gale
Inventor： Bin Huang , David C. Gale
CPC classification number: A61L31/00 , A61F2/82 , A61F2210/0004 , A61F2240/001 , A61F2250/0067 , B29C47/0026 , B29C47/8835 , B29C47/887 , B29C47/8895
Abstract: The invention provides a method of manufacturing a polymeric implantable medical device using gel extrusion of high molecular weight polymers or charge-induced orientation to avoid heat degradation of the polymer that might occur during conventional heat extrusion.
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Patent Agency Ranking
公开(公告)号：US08309022B2
公开(公告)日：2012-11-13
申请号：US13179473
申请日：2011-07-08
Applicant: Bin Huang , Abigail Freeman , Daniel Castro , David C. Gale
Inventor： Bin Huang , Abigail Freeman , Daniel Castro , David C. Gale
CPC classification number: A61L2/08 , A61L2/081 , A61L2/082 , A61L2/085 , A61L2/087 , A61L2/10 , A61L2202/23 , A61L2202/24 , B65B55/00 , B65B55/16
Abstract: Methods and systems for reduced temperature radiation sterilization of stents are disclosed.
Abstract translation: 公开了用于降低放射线灭菌的支架的方法和系统。
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公开(公告)号：US20120283814A1
公开(公告)日：2012-11-08
申请号：US13551538
申请日：2012-07-17
Applicant: Bin Huang , David C. Gale , Daniel Castro
Inventor： Bin Huang , David C. Gale , Daniel Castro
CPC classification number: A61F2/958 , A61F2002/9505 , A61F2002/9522 , A61F2002/9583 , A61F2002/9586 , B23P11/005 , Y10T29/49863 , Y10T29/49913 , Y10T29/49925 , Y10T29/49927 , Y10T29/53065 , Y10T29/53987
Abstract: A method of crimping a stent on a balloon of a catheter assembly is provided. A polymeric stent is disposed over a balloon in an inflated configuration. The stent is crimped over the inflated balloon to a reduced crimped configuration so that the stent is secured onto the balloon. The balloon wall membrane is wedged or pinched between the strut elements of the stent for increasing the retention of the stent on the balloon.
Abstract translation: 提供了一种将支架卷曲在导管组件的球囊上的方法。 将聚合物支架设置在膨胀构型的气球上。 将支架卷曲在膨胀的气囊上以减小卷曲构造，使得支架固定在气球上。 球囊壁膜被楔入或夹在支架的支柱元件之间，以增加支架在气囊上的保留。
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公开(公告)号：US08172897B2
公开(公告)日：2012-05-08
申请号：US10880025
申请日：2004-06-28
Applicant: David C. Gale , Bin Huang , John M Capek , John Y. Yan , Houdin Dehnad
Inventor： David C. Gale , Bin Huang , John M Capek , John Y. Yan , Houdin Dehnad
IPC: A61F2/06
CPC classification number: A61L31/148 , A61F2/0077 , A61F2/82 , A61F2/91 , A61F2/915 , A61F2/92 , A61F2002/91533 , A61F2002/91566 , A61F2002/91583 , A61F2210/0004 , A61F2210/0076 , A61F2250/003 , A61F2250/0067 , A61L31/022 , A61L31/028 , A61L31/10 , A61L31/146 , A61L31/16 , A61L2300/416 , A61L2300/45 , A61L2300/604 , A61L2300/606 , A61L2400/12 , Y10T29/49982
Abstract: A device and a method of manufacturing an implantable medical device, such as a stent, are described herein. The device includes a metallic region composed of a bioerodable metal and a polymer region composed of a biodegradable polymer contacting the metallic region. The metallic region may erode at a different rate when exposed to bodily fluids than the polymer region when exposed to bodily fluids. In certain embodiments, the polymer region is an outer layer and the metallic region is an inner layer of the device. A further aspect of the invention includes device and a method of manufacturing the device that includes a mixture of a biodegradable polymer and bioerodable metallic particles. The mixture may be used to fabricate an implantable medical device or to coat an implantable medical device. In some embodiments, the metallic particles are metallic nanoparticles.
Abstract translation: 这里描述了一种制造植入式医疗装置（例如支架）的装置和方法。 该装置包括由生物侵蚀金属组成的金属区域和由与金属区域接触的可生物降解的聚合物组成的聚合物区域。 当暴露于体液时，当暴露于体液时，金属区域可能以不同于聚合物区域的速度侵蚀。 在某些实施方案中，聚合物区域是外层，金属区域是该装置的内层。 本发明的另一方面包括装置和制造该装置的方法，该装置包括可生物降解的聚合物和可生物侵蚀的金属颗粒的混合物。 混合物可用于制造可植入医疗装置或涂覆可植入医疗装置。 在一些实施方案中，金属颗粒是金属纳米颗粒。
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公开(公告)号：US20110270382A1
公开(公告)日：2011-11-03
申请号：US13185370
申请日：2011-07-18
Applicant: David C. Gale , Bin Huang
Inventor： David C. Gale , Bin Huang
IPC: A61F2/82
CPC classification number: A61L31/14 , A61F2/82 , A61L31/146 , A61L31/148 , A61L31/16 , A61L2300/41 , A61L2300/416 , A61L2300/604
Abstract: Disclosed is a stent comprising a bioabsorbable polymeric scaffolding; and a plurality of depots in at least a portion of the scaffolding, wherein the plurality of depots comprise a bioabsorbable material, wherein the degradation rate of all or substantially all of the bioabsorbable polymer of the scaffolding is faster than the degradation rate of all or substantially all of the bioabsorbable material of the depots.
Abstract translation: 公开了一种支架，其包括生物可吸收聚合物支架; 以及在所述脚手架的至少一部分中的多个仓库，其中所述多个仓库包含生物可吸收材料，其中所述脚手架的所有或基本上全部所述生物可吸收聚合物的降解速度比全部或基本上 所有生物可吸收材料的仓库。
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公开(公告)号：US07998404B2
公开(公告)日：2011-08-16
申请号：US11486690
申请日：2006-07-13
Applicant: Bin Huang , Abigail Freeman , Daniel Castro , David C. Gale
Inventor： Bin Huang , Abigail Freeman , Daniel Castro , David C. Gale
CPC classification number: A61L2/08 , A61L2/081 , A61L2/082 , A61L2/085 , A61L2/087 , A61L2/10 , A61L2202/23 , A61L2202/24 , B65B55/00 , B65B55/16
Abstract: Methods and systems for reduced temperature radiation sterilization of stents are disclosed.
Abstract translation: 公开了用于降低放射线灭菌的支架的方法和系统。
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