公开(公告)号：US20110059945A1

公开(公告)日：2011-03-10

申请号：US12945572

申请日：2010-11-12

Applicant: Ashis K. Saha ,  Nili Schutz ,  Xiang Yu ,  Dilara McCauley ,  Mercedes Lobera ,  Yael Marantz ,  Jian Lin ,  Srinivasa Cheruku ,  Pini Orbach ,  Anurag Sharadendu ,  Robert Christian Penland ,  Kimberley Gannon ,  Sharon Shacham ,  Silvia Noiman ,  Oren Becker

Inventor： Ashis K. Saha ,  Nili Schutz ,  Xiang Yu ,  Dilara McCauley ,  Mercedes Lobera ,  Yael Marantz ,  Jian Lin ,  Srinivasa Cheruku ,  Pini Orbach ,  Anurag Sharadendu ,  Robert Christian Penland ,  Kimberley Gannon ,  Sharon Shacham ,  Silvia Noiman ,  Oren Becker

IPC: A61K31/397 ,  A61P37/06 ,  A61P35/00 ,  A61P19/00 ,  A61P3/10 ,  A61P35/04 ,  A61P11/06 ,  A61P9/10 ,  A61P13/12 ,  A61P1/16 ,  A61K31/4525 ,  A61K31/4725 ,  A61K31/5377 ,  A61K31/343

CPC classification number: C07D405/10 ,  C07D307/80 ,  C07D307/81 ,  C07D405/04 ,  C07D405/14 ,  C07D409/14 ,  C07D413/10 ,  C07D417/14

Abstract: The present invention relates to compounds of the general formula (I) that have activity as S1P receptor modulating agents and the use of such compounds to treat diseases associated with inappropriate S1P receptor activity. The compounds may be used as immunomodulators, e.g., for treating or preventing diseases such as autoimmune and related immune disorders including systemic lupus erythematosus, inflammatory bowel diseases such as Crohn's disease and ulcerative colitis, type I diabetes, uveitis, psoriasis, myasthenia gravis, rheumatoid arthritis, non-glomerular nephrosis, hepatitis, Behçet's disease, glomerulonephritis, chronic thrombocytopenic purpura, hemolytic anemia, hepatitis and Wegner's granuloma; and for treating other conditions.

Abstract translation: 本发明涉及具有作为S1P受体调节剂的活性的通式（I）的化合物，以及这些化合物用于治疗与不适当的S1P受体活性有关的疾病的用途。 这些化合物可用作免疫调节剂，例如用于治疗或预防诸如自身免疫性疾病和相关免疫疾病（包括系统性红斑狼疮），炎症性肠病如克罗恩病和溃疡性结肠炎，I型糖尿病，葡萄膜炎，牛皮癣，重症肌无力，类风湿 关节炎，非肾小球性肾病，肝炎，白塞病，肾小球性肾炎，慢性血小板减少性紫癜，溶血性贫血，肝炎和韦格纳肉芽肿; 并处理其他条件。

公开(公告)号：US20110034293A1

公开(公告)日：2011-02-10

申请号：US12744459

申请日：2008-12-04

Applicant: Jiafeng Yang ,  Bill Lakis ,  Andrew Nowacki ,  Sarah Wykes ,  Chris Reis ,  John Stokes ,  Frank Bauer ,  Jian Lin

Inventor： Jiafeng Yang ,  Bill Lakis ,  Andrew Nowacki ,  Sarah Wykes ,  Chris Reis ,  John Stokes ,  Frank Bauer ,  Jian Lin

IPC: F16H3/44

CPC classification number: F16H3/663 ,  F16H2200/0052 ,  F16H2200/2007 ,  F16H2200/2023 ,  F16H2200/2046 ,  F16H2200/2097

Abstract: A transmission includes an input shaft (IP), an output shaft (OP), a single planetary gearset (SP), a compound planetary gearset (CP), shifting elements. The single planetary gearset is arranged before the compound planetary gearset, and the shifting elements comprise at least two brakes (B1,B2), the first clutch (C1), the second clutch (C2), the third clutch (C3), and all the shifting elements are positioned between the single planetary gearset and the compound planetary gearset, which has compact arrangements, and can reduce the power transmission length. The transmission also includes an one-way clutch (OWC) acted on the compound planetary gearset. When the transmission shifts to the first speed stage, the first clutch (C1) and the one-way clutch are operated, and the power is transferred from the input shaft to the output shaft via the single planetary gearset and the compound planetary gearset, and when the first speed stage is shifted to the second speed stage, only the first brake (B1) should be operated to engage, thereby it can reduce the frequency of operating the shifting elements and the shifting time in low speed stage.

Abstract translation: 变速器包括输入轴（IP），输出轴（OP），单个行星齿轮组（SP），复合行星齿轮组（CP），变速元件。 单个行星齿轮组布置在复合行星齿轮组之前，变速元件包括至少两个制动器（B1，B2），第一离合器（C1），第二离合器（C2），第三离合器（C3）和所有 移动元件位于单个行星齿轮组和复合行星齿轮组之间，其具有紧凑的布置，并且可以降低动力传递长度。 变速器还包括作用在复合行星齿轮组上的单向离合器（OWC）。 当变速器移动到第一速度档时，第一离合器（C1）和单向离合器被操作，并且动力通过单个行星齿轮组和复合行星齿轮组从输入轴传递到输出轴，并且 当第一速度档位移动到第二速度档时，只有第一制动器（B1）应该被操作以啮合，从而可以降低在低速档中操作变速元件的频率和移动时间。

公开(公告)号：US07729322B2

公开(公告)日：2010-06-01

申请号：US10086576

申请日：2002-02-28

Applicant: Nischal Abrol ,  Jian Lin ,  Hanfang Pan ,  Simon Turner

Inventor： Nischal Abrol ,  Jian Lin ,  Hanfang Pan ,  Simon Turner

IPC: H04W4/00

CPC classification number: H04L69/08 ,  H04L69/16 ,  H04L69/168 ,  H04L69/324

Abstract: An HDLC accelerator includes a deframer and framer to respectively accelerate the deframing and framing processes for PPP packets. The deframer includes an input interface unit, a detection unit, a conversion unit, and an output interface unit. The input interface unit receives a packet of data to be deframed. The detection unit evaluates each data byte to detect for special bytes (e.g., flag, escape, and invalid bytes). The conversion unit deframes the received data by removing flag and escape bytes, “un-escaping” the data byte following each escape byte, providing a header word for each flag byte, and checking each deframed packet based on a frame check sequence (FCS) value associated with the packet. The output interface unit provides deframed data and may further perform byte alignment in providing the deframed data. A state control unit provides control signals indicative of specific tasks to be performed for deframing.

Abstract translation: HDLC加速器包括一个除帧和帧分频器，以分别加速PPP报文的去帧和成帧过程。 除法器包括输入接口单元，检测单元，转换单元和输出接口单元。 输入接口单元接收要解帧的数据包。 检测单元评估每个数据字节以检测特殊字节（例如，标志，转义和无效字节）。 转换单元通过删除标志和转义字节来去除所接收的数据，“去除”每个转义字节之后的数据字节，为每个标志字节提供标题字，并且基于帧校验序列（FCS）检查每个失真的分组， 值与数据包相关联。 输出接口单元提供去数据，并且可以在提供失真数据时进一步执行字节对齐。 状态控制单元提供指示要执行的特定任务的控制信号。

公开(公告)号：US07653164B2

公开(公告)日：2010-01-26

申请号：US10942248

申请日：2004-09-15

Applicant: Jian Lin ,  Ernest Tsui

Inventor： Jian Lin ,  Ernest Tsui

IPC: H04B1/10

CPC classification number: H04B1/30 ,  H04B1/28

Abstract: Embodiments of an adaptive in-phase (I) and/or quadrature-phase (Q) imbalance correction for multicarrier wireless communication systems is generally described.

Abstract translation: 通常描述多载波无线通信系统的自适应同相（I）和/或正交相（Q）不平衡校正的实施例。

公开(公告)号：US20090143351A1

公开(公告)日：2009-06-04

申请号：US12359490

申请日：2009-01-26

Applicant: Thomas Bannister ,  Cassandra Celatka ,  Nizal S. Chandrakumar ,  Hongfeng Deng ,  Zihong Guo ,  Lei Jin ,  Tsvetelina Lazarova ,  Jian Lin ,  Scott T. Moe ,  Pamela Nagafuji ,  Manuel Navia ,  Amy Ripka ,  Michael J. Rynkiewicz ,  Kerry L. Spear ,  James E. Stickler ,  Roger Xie

Inventor： Thomas Bannister ,  Cassandra Celatka ,  Nizal S. Chandrakumar ,  Hongfeng Deng ,  Zihong Guo ,  Lei Jin ,  Tsvetelina Lazarova ,  Jian Lin ,  Scott T. Moe ,  Pamela Nagafuji ,  Manuel Navia ,  Amy Ripka ,  Michael J. Rynkiewicz ,  Kerry L. Spear ,  James E. Stickler ,  Roger Xie

IPC: A61K31/397 ,  C07D401/06 ,  C07D205/08 ,  A61P7/00 ,  C07D401/04 ,  A61K31/4427

CPC classification number: C07D405/06 ,  C07D205/08 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D405/14

Abstract: Compounds are provided which have the structure Wherein A, B, C, D, m, Y, Ra, Rc, Rd, and Rd′ are as described herein, and which are useful as inhibitors of tryptase, thrombin, trypsin, Factor Xa, Factor VIIa, Factor XIa, and urokinase-type plasminogen activator and may be employed in preventing and/or treating asthma, chronic asthma, allergic rhinitis, and thrombotic disorders.

Abstract translation: 提供具有其中A，B，C，D，m，Y，Ra，Rc，Rd和Rd'如本文所述的结构的化合物，其可用作类胰蛋白酶，凝血酶，胰蛋白酶，因子Xa， 因子VIIa，因子XIa和尿激酶型纤溶酶原激活剂，可用于预防和/或治疗哮喘，慢性哮喘，过敏性鼻炎和血栓形成障碍。

公开(公告)号：US07450959B2

公开(公告)日：2008-11-11

申请号：US10841739

申请日：2004-05-06

Applicant: Jian Lin ,  Nicholas K. Yu

Inventor： Jian Lin ,  Nicholas K. Yu

IPC: H04M1/00

CPC classification number: G06F21/554 ,  G06F21/577 ,  H04M1/72527

Abstract: Wireless mobile communication device includes unified memory portion; processing units coupled with, and communicating through, unified memory; fault inhibitor coupled with unified memory inhibiting operational fault from nocent informon. Memory, fault inhibitor, and processing units fabricated on monolithic integrated circuit as system-on-chip disposed in wireless mobile personal host. Multiprocessor module includes fault inhibitor and applications and communications processing units and buses, coupled with unified memory. Integrated functional constituent can include coprocessor, accelerator, operational control unit, interprocessor controller, memory controller, bus management unit, bridge, arbiters, and transceiver. Method inhibits operational fault from nocent informon, setting device in operational or fallback state.

Abstract translation: 无线移动通信设备包括统一存储器部分; 处理单元加上并通过统一记忆进行通信; 故障抑制器加上统一的记忆功能，禁止无效信息的操作故障。 存储器，故障抑制器和单片集成电路上制造的处理单元，作为芯片上系统布置在无线移动个人主机中。 多处理器模块包括故障抑制器和应用以及通信处理单元和总线，以及统一存储器。 集成功能组件可以包括协处理器，加速器，操作控制单元，处理器间控制器，存储器控制器，总线管理单元，桥接器，仲裁器和收发器。 方法禁止无效信号的操作故障，将设备设置为运行或后备状态。

公开(公告)号：US20080264791A1

公开(公告)日：2008-10-30

申请号：US12167290

申请日：2008-07-03

Applicant: Richard J. Paolini ,  David Miller ,  Barrett Comiskey ,  Joseph M. Jacobson ,  Bin Wu ,  Charles Howie Honeyman ,  Jian Lin

Inventor： Richard J. Paolini ,  David Miller ,  Barrett Comiskey ,  Joseph M. Jacobson ,  Bin Wu ,  Charles Howie Honeyman ,  Jian Lin

IPC: C07K1/26

CPC classification number: G02F1/167

Abstract: A two-phase electrophoretic medium comprises a continuous phase and a discontinuous phase. The discontinuous phase comprises a plurality of droplets, each of which comprises a suspending fluid and at least one particle disposed within the suspending fluid and capable of moving through the fluid upon application of an electric field to the electrophoretic medium. The continuous phase surrounds and encapsulates the discontinuous phase. To reduce the humidity sensitivity of the medium, a non-ionizable or crystalline polymer may be used as the continuous phase.

Abstract translation: 两相电泳介质包括连续相和不连续相。 不连续相包括多个液滴，每个液滴包括悬浮流体和设置在悬浮流体内的至少一个颗粒，并且在向电泳介质施加电场时能够移动通过流体。 连续相围绕并封装不连续相。 为了降低介质的湿度敏感性，可以使用不可离子化或结晶的聚合物作为连续相。

公开(公告)号：US20080229806A1

公开(公告)日：2008-09-25

申请号：US11853124

申请日：2007-09-11

Applicant: Anthony E. Cubr ,  Craig M. Sawdon ,  Wajdi B. Hamama ,  Karl T. Kiebel ,  Robert J. Horner ,  Marilyn L. Kindermann ,  Jian Lin ,  Trenton W. Haines ,  Eric Ferch ,  Hamid M. Esfahan ,  James T. Kurnik ,  Weixin Yan

Inventor： Anthony E. Cubr ,  Craig M. Sawdon ,  Wajdi B. Hamama ,  Karl T. Kiebel ,  Robert J. Horner ,  Marilyn L. Kindermann ,  Jian Lin ,  Trenton W. Haines ,  Eric Ferch ,  Hamid M. Esfahan ,  James T. Kurnik ,  Weixin Yan

IPC: G01L23/22

CPC classification number: G01L23/225 ,  F02P5/152

Abstract: A knock detection module for an engine comprises a statistics storage module and a processing module. The statistics storage module stores M times N vibration profiles corresponding to M zones of operation of the engine and N cylinders of the engine, wherein M and N are integers greater than one. The processing module determines in which one of the M zones the engine is operating and determines whether knock has occurred for one of the N cylinders by comparing measured vibration data with a selected one of the vibration profiles corresponding to the one of the M zones and the one of the N cylinders.

Abstract translation: 用于发动机的爆震检测模块包括统计存储模块和处理模块。 统计存储模块存储对应于发动机和发动机的N个气缸的M个操作区域的M次N次振动轮廓，其中M和N是大于1的整数。 处理模块确定发动机正在操作的M个区域中的哪一个，并且通过将测量的振动数据与对应于M个区域中的一个的振动曲线中选择的一个进行比较来确定是否已经对N个气缸之一发生了爆震 其中一个N缸。

公开(公告)号：US20080196833A1

公开(公告)日：2008-08-21

申请号：US12049650

申请日：2008-03-17

Applicant: Hung Chih Chen ,  Steven M. Zuniga ,  Charles C. Garretson ,  Douglas R. McAllister ,  Jian Lin ,  Stacy Meyer ,  Sidney P. Huey ,  Jeonghoon Oh ,  Trung T. Doan ,  Jeffrey Schmidt ,  Martin S. Wohlert ,  Kerry F. Hughes ,  James C. Wang ,  Danny Cam Toan Lu ,  Romain Beau De Lamenie ,  Venkata R. Balagani ,  Aden Martin Allen ,  Michael Jon Fong

Inventor： Hung Chih Chen ,  Steven M. Zuniga ,  Charles C. Garretson ,  Douglas R. McAllister ,  Jian Lin ,  Stacy Meyer ,  Sidney P. Huey ,  Jeonghoon Oh ,  Trung T. Doan ,  Jeffrey Schmidt ,  Martin S. Wohlert ,  Kerry F. Hughes ,  James C. Wang ,  Danny Cam Toan Lu ,  Romain Beau De Lamenie ,  Venkata R. Balagani ,  Aden Martin Allen ,  Michael Jon Fong

IPC: H01L21/306 ,  B24B1/00

CPC classification number: B24B37/32 ,  Y10T29/49815

Abstract: A retaining ring can be shaped by machining or lapping the bottom surface of the ring to form a shaped profile in the bottom surface. The bottom surface of the retaining ring can include flat, sloped and curved portions. The lapping can be performed using a machine that dedicated for use in lapping the bottom surface of retaining rings. During the lapping the ring can be permitted to rotate freely about an axis of the ring. The bottom surface of the retaining ring can have curved or flat portions.

Abstract translation: 保持环可以通过机械加工或研磨环的底部表面而在底面形成成形轮廓。 保持环的底面可以包括平坦的，倾斜的和弯曲的部分。 可以使用专用于研磨保持环底面的机器进行研磨。 在研磨期间，可以允许环围绕环的轴线自由旋转。 保持环的底面可以具有弯曲或平坦的部分。

公开(公告)号：US07411719B2

公开(公告)日：2008-08-12

申请号：US11160364

申请日：2005-06-21

Applicant: Richard J. Paolini, Jr. ,  David Miller ,  Barrett Comiskey ,  Joseph M. Jacobson ,  Bin Wu ,  Charles Howie Honeyman ,  Jian Lin

Inventor： Richard J. Paolini, Jr. ,  David Miller ,  Barrett Comiskey ,  Joseph M. Jacobson ,  Bin Wu ,  Charles Howie Honeyman ,  Jian Lin

IPC: G02B26/00 ,  G09G3/34 ,  G03G13/04

CPC classification number: G02F1/167

Abstract: A two-phase electrophoretic medium comprises a continuous phase and a discontinuous phase. The discontinuous phase comprises a plurality of droplets, each of which comprises a suspending fluid and at least one particle disposed within the suspending fluid and capable of moving through the fluid upon application of an electric field to the electrophoretic medium. The continuous phase surrounds and encapsulates the discontinuous phase. To reduce the humidity sensitivity of the medium, a non-ionizable or crystalline polymer may be used as the continuous phase.

Abstract translation: 两相电泳介质包括连续相和不连续相。 不连续相包括多个液滴，每个液滴包括悬浮流体和设置在悬浮流体内的至少一个颗粒，并且在向电泳介质施加电场时能够移动通过流体。 连续相围绕并封装不连续相。 为了降低介质的湿度敏感性，可以使用不可离子化或结晶的聚合物作为连续相。