公开(公告)号：US08121685B2

公开(公告)日：2012-02-21

申请号：US12622602

申请日：2009-11-20

Applicant: Jiang Ding ,  Yinghong Yu ,  Milton M. Morris

Inventor： Jiang Ding ,  Yinghong Yu ,  Milton M. Morris

IPC: A61N1/00

CPC classification number: A61N1/36585 ,  A61N1/3627 ,  A61N1/3682 ,  A61N1/3684

Abstract: A pacing system computes optimal cardiac resynchronization pacing parameters using intrinsic conduction intervals. In various embodiments, values for atrio-ventricular delay intervals are each computed as a function of an intrinsic atrio-ventricular interval and a parameter reflective of an interventricular conduction delay. Examples of the parameter reflective of the interventricular conduction delay include QRS width and interval between right and left ventricular senses.

Abstract translation: 起搏系统使用内在导电间隔计算最佳心脏再同步起搏参数。 在各种实施例中，心室间隔延迟间隔的值各自被计算为内在房室间隔和反映室间传导延迟的参数的函数。 反映室间传导延迟的参数的示例包括QRS宽度和右心室感觉和左心室感觉之间的间隔。

公开(公告)号：US08103345B2

公开(公告)日：2012-01-24

申请号：US12955218

申请日：2010-11-29

Applicant: Jiang Ding ,  Yinghong Yu ,  Andrew P. Kramer ,  Julio C. Spinelli

Inventor： Jiang Ding ,  Yinghong Yu ,  Andrew P. Kramer ,  Julio C. Spinelli

IPC: A61N1/365

CPC classification number: E21B17/01 ,  A61N1/3627 ,  A61N1/3682 ,  E21B43/36

Abstract: A pacing system for providing optimal hemodynamic cardiac function for parameters such as contractility (peak left ventricle pressure change during systole or LV+dp/dt), or stroke volume (aortic pulse pressure) using system for calculating atrio-ventricular delays for optimal timing of a ventricular pacing pulse. The system providing an option for near optimal pacing of multiple hemodynamic parameters. The system deriving the proper timing using electrical or mechanical events having a predictable relationship with an optimal ventricular pacing timing signal.

Abstract translation: 一种起搏系统，用于为诸如收缩性（收缩期峰值左心室压力变化或LV + dp / dt）之间的参数或行程体积（主动脉脉压）提供最佳血液动力学心脏功能，使用用于计算心室延迟的系统以获得最佳时机 心室起搏脉搏。 该系统为多个血液动力学参数的近似最佳起搏提供了选择。 该系统使用与最佳心室起搏定时信号具有可预测关系的电或机械事件导出适当的定时。

公开(公告)号：US08041426B2

公开(公告)日：2011-10-18

申请号：US12565344

申请日：2009-09-23

Applicant: Richard Fogoros ,  Jiang Ding ,  Yinghong Yu

Inventor： Richard Fogoros ,  Jiang Ding ,  Yinghong Yu

IPC: A61N1/365

CPC classification number: A61N1/3627 ,  A61N1/36564 ,  A61N1/3682 ,  A61N1/3684

Abstract: A method and system for calculating an atrio-ventricular delay interval based upon an inter-atrial delay exhibited by a patient's heart. The aforementioned atrio-ventricular delay interval may optimize the stroke volume exhibited by a patient's heart. The aforementioned atrio-ventricular delay interval may be blended with another atrio-ventricular delay interval that may optimize another performance characteristic, such as left ventricular contractility. Such blending may include finding an arithmetic mean, geometric mean, or weighted mean of two or more proposed atrio-ventricular delay intervals.

Abstract translation: 一种用于根据患者心脏表现的心房间延迟来计算心房延迟间隔的方法和系统。 上述的心室延迟间隔可以优化患者心脏展示的搏动量。 上述房室延迟间隔可以与可以优化另一性能特征（例如左心室收缩力）的另一心房延迟间隔混合。 这种混合可以包括找到两个或更多个提出的心房延迟间隔的算术平均值，几何平均值或加权平均值。

公开(公告)号：US08032214B2

公开(公告)日：2011-10-04

申请号：US12424136

申请日：2009-04-15

Applicant: Yinghong Yu ,  Jiang Ding ,  Julio C. Spinelli ,  Andrew P. Kramer

Inventor： Yinghong Yu ,  Jiang Ding ,  Julio C. Spinelli ,  Andrew P. Kramer

IPC: A61N1/362

CPC classification number: A61N1/3627 ,  A61N1/056 ,  A61N1/36564 ,  A61N1/368 ,  A61N1/3682

Abstract: A pacing system for providing optimal hemodynamic cardiac function for parameters such as ventricular synchrony or contractility (peak left ventricle pressure change during systole or LV+dp/dt), or stroke volume (aortic pulse pressure) using system for calculating atrio-ventricular delays for optimal timing of a ventricular pacing pulse. The system providing an option for near optimal pacing of multiple hemodynamic parameters. The system deriving the proper timing using electrical or mechanical events having a predictable relationship with an optimal ventricular pacing timing signal.

Abstract translation: 用于为诸如心室同步或收缩性（收缩期左心室压力峰值或LV + dp / dt）之间的参数提供最佳血液动力学心脏功能或行程体积（主动脉脉压）的起搏系统，用于计算心室间期延迟 心室起搏脉冲的最佳时机。 该系统为多个血液动力学参数的近似最佳起搏提供了选择。 该系统使用与最佳心室起搏定时信号具有可预测关系的电或机械事件导出适当的定时。

公开(公告)号：US20110137366A1

公开(公告)日：2011-06-09

申请号：US13026917

申请日：2011-02-14

Applicant: Jiang Ding ,  Julio C. Spinelli ,  Andrew P. Kramer

Inventor： Jiang Ding ,  Julio C. Spinelli ,  Andrew P. Kramer

IPC: A61N1/365

CPC classification number: A61N1/3684 ,  A61N1/3627 ,  A61N1/36514 ,  A61N1/368

Abstract: A cardiac rhythm management system selects one of multiple electrodes associated with a particular heart chamber based on a relative timing between detection of a depolarization fiducial point at the multiple electrodes, or based on a delay between detection of a depolarization fiducial point at the multiple electrodes and detection of a reference depolarization fiducial point at another electrode associated with the same or a different heart chamber. Subsequent contraction-evoking stimulation therapy is delivered from the selected electrode.

Abstract translation: 心脏节律管理系统基于在多个电极处的去极化基准点的检测之间的相对定时或基于在多个电极之间的去极化基准点的检测之间的延迟来选择与特定心室相关联的多个电极中的一个，以及 在与相同或不同的心室相关联的另一电极处检测参考去极化基准点。 随后的收缩诱导刺激疗法从所选择的电极递送。

公开(公告)号：US07890169B2

公开(公告)日：2011-02-15

申请号：US11742655

申请日：2007-05-01

Applicant: Jiang Ding ,  Julio C. Spinelli ,  Andrew P. Kramer

Inventor： Jiang Ding ,  Julio C. Spinelli ,  Andrew P. Kramer

IPC: A61N1/362

CPC classification number: A61N1/3684 ,  A61N1/3627 ,  A61N1/36514 ,  A61N1/368

Abstract: A cardiac rhythm management system selects one of multiple electrodes associated with a particular heart chamber based on a relative timing between detection of a depolarization fiducial point at the multiple electrodes, or based on a delay between detection of a depolarization fiducial point at the multiple electrodes and detection of a reference depolarization fiducial point at another electrode associated with the same or a different heart chamber. Subsequent contraction-evoking stimulation therapy is delivered from the selected electrode.

Abstract translation: 心脏节律管理系统基于在多个电极处的去极化基准点的检测之间的相对定时或基于在多个电极之间的去极化基准点的检测之间的延迟来选择与特定心室相关联的多个电极中的一个，以及 在与相同或不同的心室相关联的另一电极处检测参考去极化基准点。 随后的收缩诱导刺激疗法从所选择的电极递送。

公开(公告)号：US07844330B2

公开(公告)日：2010-11-30

申请号：US11689646

申请日：2007-03-22

Applicant: Yinghong Yu ,  Jiang Ding ,  Joseph M. Pastore

Inventor： Yinghong Yu ,  Jiang Ding ,  Joseph M. Pastore

IPC: A61N1/362

CPC classification number: A61N1/365

Abstract: A cardiac rhythm management system includes an implantable device executing a dynamic pacing algorithm after an myocardial infarction (MI) event. The dynamic pacing algorithm dynamically adjusts one or more pacing parameters based on a person's gross physical activity level. Examples of the one or more pacing parameters include atrioventricular pacing delays and pacing channels/sites. The dynamic pacing algorithm provides for improved hemodynamic performance when a person's metabolic need is high, and post MI remodeling control when the person's metabolic need is low.

Abstract translation: 心律管理系统包括在心肌梗死（MI）事件之后执行动态起搏算法的可植入装置。 动态起搏算法根据人的总身体活动水平动态调整一个或多个起搏参数。 一个或多个起搏参数的示例包括房室起搏延迟和起搏通道/部位。 当人的代谢需求高时，动态起搏算法提供改善的血液动力学性能，并且当人的代谢需求低时，进行MI重建控制。

公开(公告)号：US20100131026A1

公开(公告)日：2010-05-27

申请号：US12694124

申请日：2010-01-26

Applicant: Joseph M. Pastore ,  Rodney W. Salo ,  Gerrard M. Carlson ,  Andrew P. Kramer ,  Jiang Ding ,  Yinghong Yu

Inventor： Joseph M. Pastore ,  Rodney W. Salo ,  Gerrard M. Carlson ,  Andrew P. Kramer ,  Jiang Ding ,  Yinghong Yu

IPC: A61N1/365

CPC classification number: A61N1/365 ,  A61N1/36592

Abstract: A cardiac rhythm management system modulates the delivery of pacing and/or autonomic neurostimulation pulses based on heart rate variability (HRV). An HRV parameter being a measure of the HRV is produced to indicate a patient's cardiac condition, based on which the delivery of pacing and/or autonomic neurostimulation pulses is started, stopped, adjusted, or optimized. In one embodiment, the HRV parameter is used as a safety check to stop an electrical therapy when it is believed to be potentially harmful to continue the therapy.

Abstract translation: 心律管理系统基于心率变异性（HRV）调节起搏和/或自主神经刺激脉冲的传递。 产生作为HRV的量度的HRV参数以指示患者的心脏状况，基于该HRV参数开始，停止，调整或优化起搏和/或自主神经刺激脉冲的递送。 在一个实施例中，当HRV参数被认为对继续治疗有潜在危害时，将HRV参数用作安全检查以停止电疗法。

公开(公告)号：US20100087889A1

公开(公告)日：2010-04-08

申请号：US12570167

申请日：2009-09-30

Applicant: Barun Maskara ,  Jiang Ding

Inventor： Barun Maskara ,  Jiang Ding

IPC: A61N1/365

CPC classification number: A61N1/3682 ,  A61N1/3627 ,  A61N1/36507 ,  A61N1/368 ,  A61N1/3684

Abstract: Systems and methods for pacing the heart using resynchronization pacing delays that achieve improvement of cardiac function are described. An early activation pacing interval is calculated based on an optimal AV delay and an atrial to early ventricular activation interval between an atrial event and early activation of a ventricular depolarization. The early activation pacing interval for the ventricle is calculated by subtracting the measured AVEA from the calculated optimal AV delay. The early activation pacing interval is initiated responsive to sensing early activation of the ventricle and pacing is delivered relative to expiration of the early activation pacing interval.

Abstract translation: 描述了实现心脏功能改善的再同步起搏延迟来起搏心脏的系统和方法。 基于最佳AV延迟和心房事件与心室去极化的早期激活之间的早期心室激活间隔来计算早期激活起搏间隔。 通过从计算的最佳AV延迟中减去测量的AVEA来计算心室的早期激活起搏间隔。 响应于感测心室的早期激活而启动早期激活起搏间隔，并且相对于早期激活起搏间隔的期满而递送起搏。

公开(公告)号：US07632882B2

公开(公告)日：2009-12-15

申请号：US11330933

申请日：2006-01-12

Applicant: Christian Peter Lenges ,  Yanhui Niu ,  Yu-Ling Hsiao ,  Jiang Ding ,  Robert John Barsotti ,  Renee J. Kelly ,  Robert James Butera ,  Young H. Kim

Inventor： Christian Peter Lenges ,  Yanhui Niu ,  Yu-Ling Hsiao ,  Jiang Ding ,  Robert John Barsotti ,  Renee J. Kelly ,  Robert James Butera ,  Young H. Kim

IPC: C08K5/16 ,  C08G73/00

CPC classification number: C08G18/3228 ,  C08G18/3271 ,  C08G18/3829 ,  C08G18/71 ,  C08G18/73 ,  C08G18/78 ,  C08K5/20 ,  C08K5/21 ,  C09D7/43 ,  C09D175/04

Abstract: The present invention is directed to a rheology control agent for coating compositions. The rheology control agent includes a compound having the Formula (I) including isomers or mixtures of isomers thereof: wherein p is 0, 1, 2, or 3; and R2, R3, R4, X and Y groups are described in the specification. The solvent-borne coating compositions containing the rheology control agent have improved rheology control on application and are useful for OEM, refinishing or repainting the exterior of automobile and truck bodies and parts thereof.

Abstract translation: 本发明涉及用于涂料组合物的流变控制剂。 流变控制剂包括具有式（I）的化合物，其包含异构体或其异构体的混合物：其中p为0,1,2或3; 在说明书中描述了R2，R3，R4，X和Y基团。 含有流变控制剂的溶剂型涂料组合物在应用上具有改进的流变学控制，并且可用于OEM，修补或重新涂漆汽车和卡车车身及其部件的外部。