公开(公告)号：US09777273B2

公开(公告)日：2017-10-03

申请号：US15322878

申请日：2015-08-05

Applicant: Industrial Technology Research Institute ,  Academia Sinica

Inventor： Yen-Ju Lin ,  Jui-Wen Huang ,  Fu-Tong Liu ,  Huan-Yuan Chen ,  Wei-Chen Hsieh

IPC: C12N15/11 ,  C12N15/113

CPC classification number: C12N15/113 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3521

Abstract: A small interfering RNA is provided. The small interfering RNA consists of a passenger strand and a guide strand, wherein the sequence of the passenger strand comprises the sequence of SEQ ID NO. 7, and the sequence of the guide strand comprises the sequence of SEQ ID NO. 8, wherein the small interfering RNA is capable of inhibiting galectin-12 expression.

公开(公告)号：US09763431B2

公开(公告)日：2017-09-19

申请号：US14920497

申请日：2015-10-22

Applicant: ACADEMIA SINICA ,  Yu-Ho Lin

Inventor： Yu-Ho Lin ,  Jyh-Yih Chen

IPC: A01K67/027 ,  C12N15/85 ,  C07K14/46

CPC classification number: A01K67/0275 ,  A01K2217/052 ,  A01K2217/206 ,  A01K2227/40 ,  A01K2267/02 ,  A01K2267/0393 ,  C07K14/461 ,  C12N15/8509 ,  C12N2830/008

Abstract: The preset invention relates to a promoter to target a fluorescent protein to the muscles of fish, such as A. nigrofasciatus, for ornamental purposes, which is a Mlc3 (myosin, light polypeptide 3, skeletal muscle) promoter. The Mlc3 promoter has the nucleotides of tilapia (Oreochromis niloticus) myosin light chain 3 (Mlc3) promoter region, which is potential to be a tilapia Mlc3 promoter to enhance protein expression in muscle of fish, particularly for the generation of ornamental fish.

公开(公告)号：US09718891B2

公开(公告)日：2017-08-01

申请号：US14775204

申请日：2014-03-12

Applicant: Academia Sinica

Inventor： Tse Wen Chang ,  Chien-Jen Lin ,  Chien-Sheng Lu

IPC: A61K39/395 ,  C07K16/42 ,  C07K7/04

CPC classification number: C07K16/4291 ,  C07K7/04 ,  C07K2317/34 ,  C07K2317/52 ,  C07K2317/73

Abstract: The present disclosure relates to anti-IgE antibodies that bind to novel antigenic epitopes of the CsmX domain, e.g., SVPHPRCHCGAGRA (SEQ ID NO: 4) and the uses thereof in treating IgE-mediated diseases.

公开(公告)号：US20170211067A1

公开(公告)日：2017-07-27

申请号：US15500345

申请日：2015-07-31

Applicant: Academia Sinica ,  National Taiwan University ,  Taipei Medical University

Inventor： Konan Peck ,  Pan-Chyr Yang ,  Yi-Chung Chang ,  Bo-Tsang Huang ,  Shauh-Der Yeh

IPC: C12N15/115 ,  A61K9/00 ,  A61K31/713

Abstract: Aptamers that bind to and inhibit CTLA-4 and uses thereof in enhancing immune activities, and treating cancer and HIV infection are provided.

公开(公告)号：US20170183660A1

公开(公告)日：2017-06-29

申请号：US15312667

申请日：2015-05-29

Applicant: Academia Sinica

Inventor： Chung-Hsuan CHEN ,  Bai-Ling LIN ,  Chin-Yu WANG

IPC: C12N15/115

CPC classification number: C12N15/115 ,  A61K47/55 ,  C12N2310/16 ,  C12N2310/315 ,  C12N2310/3517 ,  C12N2320/13 ,  C12N2320/31 ,  C12N2320/32

Abstract: Disclosed herein is an aptamer targeting a MHC-presented peptide and its uses thereof. The MHC-presented peptide is expressed in various cancer cells; therefor, the aptamer of the disclosure is useful as a bio-tool to label and/or treat peptide-presenting cancer cells. Also disclosed herein is a pharmaceutical composition containing the aptamer.

公开(公告)号：US09662324B2

公开(公告)日：2017-05-30

申请号：US14787885

申请日：2014-05-01

Applicant: Academia Sinica

Inventor： Che-Kun James Shen ,  Yu-Chi Chou ,  Tsann-Long Su

IPC: A61K31/473 ,  A61K9/00 ,  A61K45/06 ,  G01N33/50 ,  C07D221/14

CPC classification number: A61K31/473 ,  A61K9/0053 ,  A61K45/06 ,  C07D221/14 ,  G01N33/5044 ,  G01N2333/805 ,  G01N2800/52 ,  A61K2300/00

Abstract: Compounds, pharmaceutical compositions, and methods for treating anemia (β-thalassemia anemia or sickle cell anemia.

公开(公告)号：US09598738B2

公开(公告)日：2017-03-21

申请号：US15027032

申请日：2014-10-01

Applicant: Academia Sinica

Inventor： Ting-Fang Wang

IPC: C12N1/15 ,  C12Q1/68 ,  C12N1/14

CPC classification number: C12Q1/6895 ,  C12N1/14

Abstract: The present invention relates to a technology to provide segmental aneuploidy progeny strains of Trichoderma reesei. In particular, the present invention relates to a method to produce segmental aneuploidy progeny strains of Trichoderma reesei via sexual crossing of two parent haploid strains with chromosome heterozygosity (e.g. one having scaffold M and scaffold 33, the other having scaffold F and scaffold X), preferably at least one of which includes a non-homologous end joining (NHEJ) gene. The present invention also relates to stable, segmental aneuploidy progeny strains of richoderma reesei thus produced which particularly exhibit enhanced gene expression or activities of carbohydrate-active enzymes (CAZymes) and more particularly prevent returning to euploidy for an extended period of time.

公开(公告)号：US20170056523A1

公开(公告)日：2017-03-02

申请号：US15123243

申请日：2015-03-02

Applicant: ACADEMIA SINICA ,  KAOHSIUNG MEDICAL UNIVERSITY

Inventor： STEVEN R ROFFLER ,  TIAN-LU CHENG ,  CHIEN-HAN KAO ,  BING-MAE CHEN ,  YU-CHENG SU ,  HSIN-YI TUNG ,  Kuo-Hsiang Chuang

IPC: A61K47/48 ,  A61K49/00 ,  C07K16/28 ,  C07K16/32 ,  C07K16/44 ,  C07K16/30

CPC classification number: A61K47/6879 ,  A61K47/6897 ,  A61K49/0002 ,  C07K16/2803 ,  C07K16/2863 ,  C07K16/2887 ,  C07K16/30 ,  C07K16/3061 ,  C07K16/32 ,  C07K16/44 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/35 ,  C07K2317/622 ,  C07K2317/624 ,  C07K2317/73

Abstract: Disclosed herein is a bi-specific antibody that specifically directs a therapeutic agent to a cancer cell by targeting a tumor antigen of the cancer cell, and thereby suppresses the growth of the cancer or blocking the invasion or metastasis of the cancer. The bi-specific antibody of the present disclosure includes a first antigen binding site that binds to polyethylene glycol (PEG); and a second antigen binding site that binds to a target ligand, such as a tumor antigen.

Abstract translation: 本文公开了通过靶向癌细胞的肿瘤抗原来特异性地将治疗剂引导至癌细胞的双特异性抗体，从而抑制癌症的生长或阻断癌症的侵袭或转移。 本公开的双特异性抗体包括结合聚乙二醇（PEG）的第一抗原结合位点; 以及结合靶配体例如肿瘤抗原的第二抗原结合位点。

公开(公告)号：US20170016011A1

公开(公告)日：2017-01-19

申请号：US15210445

申请日：2016-07-14

Applicant: ACADEMIA SINICA

Inventor： Hsou-Min Li ,  Chiung-Chih Chu

IPC: C12N15/82

CPC classification number: C12N15/8214 ,  C12N15/8221

Abstract: The present invention provides a recombinant DNA molecule encoding a fusion protein, comprising a first DNA sequence encoding a high-efficiency transit peptide operably linked to a second DNA sequence encoding a passenger protein, wherein the high-efficiency transit peptide is selected from the group consisting of transit peptides of the precursors of translocon at the inner envelope membrane of chloroplasts 40 kD (prTic40), chaperonin 10-2 (prCpn10-2), Fibrillin 1B (prFibrillin), ATP sulfurylase 1 (prAPS1), ATP sulfurylase 3 (prAPS3), 5′-adenylylsulfate reductase 3 (prAPR3), stromal ascorbate peroxidase (prsAPX), prTic40-E2A (a prTic40 variant), prCpn10-1-ΔC7C37S (a chaperonin 10-1 variant), a functional fragment of any of the transit peptides and an equivalent thereof. And the present invention also provides a method of high efficiency delivery of a protein into plastids using the high-efficiency transit peptides.

Abstract translation: 本发明提供了编码融合蛋白的重组DNA分子，其包含编码与编码乘客蛋白质的第二DNA序列可操作地连接的高效转运肽的第一DNA序列，其中所述高效转运肽选自 叶绿体内包膜40kD（prTic40），伴侣蛋白10-2（prCpn10-2），纤维蛋白1A（prFibrillin），ATP硫化酶1（prAPS1），ATP硫化酶3（prAPS3））的转运蛋白前体的转运肽， ，5'-腺苷酸还原酶3（prAPR3），基质抗坏血酸过氧化物酶（prsAPX），prTic40-E2A（prTic40变体），prCpn10-1-ΔC7C37S（伴侣蛋白10-1变体），任何转运肽的功能片段 及其等同物。 并且本发明还提供了使用高效转运肽将蛋白质高效递送到质体中的方法。

公开(公告)号：US09494500B2

公开(公告)日：2016-11-15

申请号：US14065265

申请日：2013-10-28

Applicant: Academia Sinica

Inventor： Ying-Chih Chang ,  Chia-Hsien Hsu

IPC: C12M1/00 ,  G01N1/40 ,  B01L3/00 ,  B01D61/18 ,  B01D63/08

CPC classification number: G01N1/405 ,  B01D61/18 ,  B01D63/088 ,  B01L3/502715 ,  B01L3/502753 ,  B01L2200/027 ,  B01L2300/0681 ,  B01L2300/163

Abstract: A system and method thereof for collecting and concentrating a biologic substance of interest is provided. The biologic of interest obtained from a biologic sample present at an initial low concentration (or low number counts) can be captured and released through a collection device of the system to an intermediate second concentration, and further recovered through a concentration device of the system to a third concentration, thereby facilitating subsequent detection, characterization, enumeration, immunostaining, inspection, imaging, culturing, molecular analysis, and/or other assays.

Abstract translation: 提供了一种用于收集和浓缩感兴趣的生物物质的系统及其方法。 从初始低浓度（或低数量计数）存在的生物样品获得的感兴趣的生物学物质可以通过系统的收集装置捕获并释放到中间第二浓度，并通过系统的浓度装置进一步回收至 从而促进随后的检测，表征，计数，免疫染色，检查，成像，培养，分子分析和/或其他测定。