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公开(公告)号：US20210380650A1
公开(公告)日：2021-12-09
申请号：US17392137
申请日：2021-08-02
Inventor： Eric N. OLSON , Rhonda S. BASSEL-DUBY , Catherine A. MAKAREWICH , Benjamin R. NELSON
Abstract: The present disclosure describes a new native peptide designated herein as Dwarf Open Reading Frame, or DWORF. This peptide enhances the apparent activity of the SERCA pump, is positively inotropic and lusitropic, and therefore is provided as a therapeutic agent for disorders characterized by cytosolic calcium overload.
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公开(公告)号：US20210371508A1
公开(公告)日：2021-12-02
申请号：US17332790
申请日：2021-05-27
Inventor： Ningyan ZHANG , Zhiqiang AN , Zhiqiang KU , Yihong WAN , Jing KRZESZINSKI
IPC: C07K16/18 , A61K45/06 , G01N33/574 , A61K47/68
Abstract: Provided herein are methods for treating cancer, such as breast cancer, by administering an inhibitor of NMES1. Further provided herein are NMES1 monoclonal antibodies which may be used to detect or treat cancer.
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公开(公告)号：US11162063B2
公开(公告)日：2021-11-02
申请号：US16855831
申请日：2020-04-22
Inventor： Charles S. Cox, Jr. , Brijesh S. Gill , Kevin Aroom , Pamela Wenzel
Abstract: A bioreactor system for conditioning of pluripotent cells or cell media is provided. In further aspects, conditioned pluripotent cells and methods for making such cells are provided.
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公开(公告)号：US20210275266A1
公开(公告)日：2021-09-09
申请号：US17325446
申请日：2021-05-20
Inventor： Daniel H. KIM , Dong Suk SHIN , Taeho JANG , Yong Man PARK , Jeihan LEE , Hongmin KIM , Kihoon NAM , Seokyung HAN
IPC: A61B34/00 , A61B34/30 , A61B17/295 , A61B17/32
Abstract: The disclosure provides a surgical apparatus comprising: a steerable member that is bendable and comprises a plurality of bending segments with channels therein; and a plurality of bending actuation wires that are arranged to pass through the steerable member and cause the steerable member to bend, the steerable member comprising at least one outwardly opening lumen through which the bending actuation wires pass.
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公开(公告)号：US11111278B2
公开(公告)日：2021-09-07
申请号：US16743831
申请日：2020-01-15
Inventor： Eric N. Olson , Rhonda S. Bassel-Duby , Catherine A. Makarewich , Benjamin R. Nelson
Abstract: The present disclosure describes a new native peptide designated herein as Dwarf Open Reading Frame, or DWORF. This peptide enhances the apparent activity of the SERCA pump, is positively inotropic and lusitropic, and therefore is provided as a therapeutic agent for disorders characterized by cytosolic calcium overload.
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Patent Agency Ranking
公开(公告)号：US20210267702A1
公开(公告)日：2021-09-02
申请号：US17325495
申请日：2021-05-20
Inventor： Daniel H. KIM , Dong Suk SHIN , Taeho JANG , Yong Man PARK , Jeihan LEE , Hongmin KIM , Kihoon NAM , Seokyung HAN
IPC: A61B34/00 , A61B34/30 , A61B17/295 , A61B17/32
Abstract: The disclosure provides a surgical apparatus comprising: a steerable member that is bendable and comprises a plurality of bending segments with channels therein; and a plurality of bending actuation wires that are arranged to pass through the steerable member and cause the steerable member to bend, the steerable member comprising at least one outwardly opening lumen through which the bending actuation wires pass.
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公开(公告)号：US11093787B2
公开(公告)日：2021-08-17
申请号：US16312983
申请日：2017-06-30
Inventor： Darin T Okuda , Braeden D Newton
Abstract: Methods, apparatuses, systems, and implementations for creating 3-dimensional (3D) representations exhibiting geometric and surface characteristics of brain lesions are disclosed. 2D and/or 3D MRI images of the brain may be acquired. Brain lesions and other abnormalities may be identified and isolated with each lesion serving as a region of interest (ROI). Saved ROI may be converted into stereolithography format, maximum intensity projection (MIP) images, and/or orthographic projection images. Data corresponding to these resulting 3D brain lesion images may be used to create 3D printed models of the isolated brain lesions using 3D printing technology. Analysis of the 3D brain lesion images and the 3D printed brain lesion models may enable a more efficient and accurate way of determining brain lesion etiologies.
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公开(公告)号：US20210238564A1
公开(公告)日：2021-08-05
申请号：US17273880
申请日：2019-09-03
Inventor： Jerry W. SHAY , Enzo TEDONE , Mohammed E. SAYED
Abstract: The present disclosure describes purified telomerase holoenzyme and its delivery to cells, such as T cells, for increasing telomere length, increasing cell proliferation, and impeding cell senescence.
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公开(公告)号：US20210236018A1
公开(公告)日：2021-08-05
申请号：US17051770
申请日：2019-04-30
Inventor： Daniel T. DeArmond , Lucas M. Holt , Andrew P. Wang
Abstract: The present invention relates to systems and methods for monitoring impedance from a sensor in the chest of a subject to determine the status of lung inflation or presence of pneumothorax in the subject, the presence of pulmonary edema, the status of regional lung ventilation, and the status of cardiac contractility.
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公开(公告)号：US20210208166A1
公开(公告)日：2021-07-08
申请号：US17209125
申请日：2021-03-22
Inventor： Claudio Soto Jara , Mohammad Shahnawaz , Russell M. Lebovitz , Benedikt K. Vollrath
IPC: G01N33/68
Abstract: Methods and kits are provided for amplifying and detecting αS proteins from samples, for example, from patients having Parkinson's Disease. For example, a method for determining a presence of a soluble, misfolded αS protein may include: contacting the sample with a monomeric, folded αS protein to form an incubation mixture; conducting an incubation cycle two or more times on the incubation mixture effective to form an amplified portion of misfolded αS protein; incubating the incubation mixture effective to cause misfolding and/or aggregation of at least a portion of the monomeric, folded αS protein in the presence of the soluble, misfolded αS protein; physically disrupting the incubation mixture effective to at least partly de-aggregate at least a portion of a misfolded αS aggregate present; and determining the presence of the soluble, misfolded αS protein in the sample by detecting at least a portion of the soluble, misfolded αS protein.
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