公开(公告)号：US07423156B2

公开(公告)日：2008-09-09

申请号：US11341197

申请日：2006-01-27

Applicant: Roger Smith ,  Ann-Marie Campbell ,  Philip Coish ,  Miao Dai ,  Susan Jenkins ,  Derek Lowe ,  Stephen O'Connor ,  Ning Su ,  Gan Wang ,  Mingbao Zhang ,  Lei Zhu

Inventor： Roger Smith ,  Ann-Marie Campbell ,  Philip Coish ,  Miao Dai ,  Susan Jenkins ,  Derek Lowe ,  Stephen O'Connor ,  Ning Su ,  Gan Wang ,  Mingbao Zhang ,  Lei Zhu

IPC: C07D277/42 ,  C07D277/62 ,  C07D263/34 ,  C07D263/58

CPC classification number: C07D263/58 ,  C07D235/30 ,  C07D263/60 ,  C07D277/42 ,  C07D277/58 ,  C07D277/82 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12

Abstract: This invention relates to certain aryl alkyl acid compounds, compositions, and methods for treating or preventing obesity and related diseases.

Abstract translation: 本发明涉及某些芳基烷基酸化合物，组合物和治疗或预防肥胖症和相关疾病的方法。

公开(公告)号：US07384639B2

公开(公告)日：2008-06-10

申请号：US11220224

申请日：2005-09-06

Applicant: Andrew S. Kende ,  Barbara H. Iglewski ,  Roger Smith ,  Richard P. Phipps ,  James P. Pearson

Inventor： Andrew S. Kende ,  Barbara H. Iglewski ,  Roger Smith ,  Richard P. Phipps ,  James P. Pearson

IPC: A61K39/385 ,  A61K39/02 ,  A61K39/108 ,  A61K39/106 ,  A61K39/00

CPC classification number: C07D207/273 ,  A61K39/385 ,  A61K2039/505 ,  A61K2039/6081 ,  C07D263/26 ,  C07D307/33 ,  C07D333/36 ,  C07K16/1203 ,  C07K16/1214 ,  G01N33/56911 ,  Y10S435/975 ,  Y10S436/80 ,  Y10S436/804 ,  Y10S530/806 ,  Y10S530/808

Abstract: The present invention relates to an immunogenic conjugate comprising a carrier molecule coupled to an autoinducer of a Gram negative bacteria The immunogenic conjugate, when combined with a pharmaceutically acceptable carrier, forms a suitable vaccine for mammals to prevent infection by the Gram negative bacteria The immunogenic conjugate is also used to raise and subsequently isolate antibodies or binding portions thereof which are capable of recognizing and binding to the autoinducer. The antibodies or binding portions thereof are utilized in a method of treating infections, a method of inhibiting autoinducer activity, and in diagnostic assays which detect the presence of autoinducers or autoinducer antagonists in fluid or tissue samples.

Abstract translation: 本发明涉及包含与革兰氏阴性细菌的自身诱导剂偶联的载体分子的免疫原性缀合物。当与药学上可接受的载体组合时，免疫原性缀合物形成用于哺乳动物以防止革兰氏阴性细菌感染的合适疫苗。免疫原性缀合物 也用于提高和随后分离能够识别和结合自动诱导剂的抗体或其结合部分。 抗体或其结合部分用于治疗感染的方法，抑制自身诱导剂活性的方法，以及用于检测流体或组织样品中自身诱导剂或自身诱导剂拮抗剂的存在的诊断测定。

公开(公告)号：US20080132497A1

公开(公告)日：2008-06-05

申请号：US11665313

申请日：2005-10-14

Applicant: Chengzhi Zhang ,  Roger Smith ,  Jason Duquette ,  Qian Zhao ,  Jacques Dumas ,  Georgiy Bondar ,  Yingfu Li ,  Dongping Fan

Inventor： Chengzhi Zhang ,  Roger Smith ,  Jason Duquette ,  Qian Zhao ,  Jacques Dumas ,  Georgiy Bondar ,  Yingfu Li ,  Dongping Fan

IPC: A61K31/541 ,  C07D239/70 ,  C07D295/00 ,  A61K31/519 ,  A61P35/00 ,  A61K31/5377 ,  A61K31/496

CPC classification number: C07D495/04

Abstract: This invention relates to novel compounds and processes for their preparation, methods of treating diseases, particularly hyperproliferative diseases such as cancer, comprising administering said compounds, and methods of making pharmaceutical compositions for the treatment or prevention of disorders, particularly hyperproliferative diseases such as cancer.

Abstract translation: 本发明涉及新化合物及其制备方法，治疗疾病，特别是过度增殖性疾病如癌症的方法，包括给药所述化合物，以及制备用于治疗或预防病症，特别是过度增殖性疾病如癌症的药物组合物的方法。

公开(公告)号：US20070299066A1

公开(公告)日：2007-12-27

申请号：US11666362

申请日：2005-10-26

Applicant: Chengzhi Zhang ,  Roger Smith ,  Gan Wang ,  Sharad Verma ,  Qingming Zhu

Inventor： Chengzhi Zhang ,  Roger Smith ,  Gan Wang ,  Sharad Verma ,  Qingming Zhu

IPC: A61K31/381 ,  A61K31/5377 ,  A61P35/00 ,  C07D239/28 ,  C07D413/14

CPC classification number: C07D495/14

Abstract: The invention relates to novel pyrimidothienoindazoles of formula (I) processes for their preparation and their use for preparing medicaments for the treatment or prophylaxis of disorders, especially of hyperproliferative disorders.

Abstract translation: 本发明涉及式（I）的新型嘧啶并噻吩并唑，其制备方法及其用于制备用于治疗或预防病症，特别是过度增殖性疾病的药物的用途。

公开(公告)号：US20070193194A1

公开(公告)日：2007-08-23

申请号：US11627728

申请日：2007-01-26

Applicant: Roger Smith

Inventor： Roger Smith

IPC: E04B1/38

CPC classification number: E04B5/12 ,  E04B1/2612

Abstract: Width enlargement means is described, which is adapted to be attached to a joist end to adapt the latter for use with a joist hanger having a joist receiving socket with diverging side cheeks therein. When attached, the cross section shape of the end of the joist becomes trapezoidal so as to form a wedge. The inclined faces engage the diverging side cheeks of the socket thereby to provide lateral support for the joist end when fitted in the joist receiving socket. One form of enlargement means for a conventional rectangular cross section joist comprises triangular cross section fillets, which are adapted to be fitted to the opposite faces of the end of a the joist. Alternatively it may comprise a wedge shaped member having a central slot into which the end of the joist is fitted. Where the joist has an I-beam cross section, fillets are secured to opposite faces of the central web of the I-beam, or the end of the latter is fitted into a slot in a slotted wedge. Alternatively at least one metal structure is adapted to be fitted to one end of the joist, and the outer faces of the metal structure or structures are spaced by a greater distance in the region of the upper edge of the I-beam section than they are in the region of the lower edge thereof. Where the joist has an I-beam cross section the metal structure(s) may be attached to the web or the upper or lower rails, or all three. However formed the included angle between the inclined faces of the enlargement means whether formed by fillets or a wedge shaped member, or one or more metal structures, is substantially the same as, but not greater, than that between the diverging cheeks of the joist hanger socket in which the joist is to be received in use.

Abstract translation: 描述了宽度扩大装置，其适于附接到托梁端部，以使后者适用于具有在其中具有发散侧面的托梁接收插座的托梁吊架。 当安装时，托梁的端部的横截面形状变成梯形以形成楔形件。 倾斜面接合插座的发散侧面，从而当装配在托梁接收插座中时，为托梁端提供横向支撑。 用于常规矩形截面托梁的一种形式的放大装置包括三角形横截面圆角，其适于装配到托梁的端部的相对面。 或者，它可以包括具有中心狭槽的楔形构件，托梁的端部装配在该中空狭槽中。 在托梁具有工字梁横截面的情况下，圆角固定在工字梁的中心腹板的相对面上，或者后端的端部装配在开槽楔形件的槽中。 或者，至少一个金属结构适于装配到托梁的一端，并且金属结构或结构的外表面在I形梁部分的上边缘的区域中间隔更大的距离，而不是它们 在其下边缘的区域中。 在托梁具有工字梁横截面的情况下，金属结构可以附接到腹板或上部或下部导轨上，或者全部三个。 然而，形成的放大装置的倾斜面之间的夹角是由鱼片还是楔形构件形成的或一个或多个金属结构，与托梁悬挂器的发散的脸颊之间的夹角大致相同但不大 托架在其中被接收在使用中的插座。

公开(公告)号：US20070122692A1

公开(公告)日：2007-05-31

申请号：US11699695

申请日：2007-01-30

Applicant: Roger Smith ,  Xiao Liu

Inventor： Roger Smith ,  Xiao Liu

IPC: H01M2/12 ,  H02J7/00

CPC classification number: H01M10/46 ,  H01M2/0202 ,  H01M2/022 ,  H01M6/42 ,  H01M10/613 ,  H01M10/6235 ,  H01M10/643 ,  H01M10/653 ,  H01M10/6551 ,  H01M10/6557 ,  H01M10/6563 ,  H01M10/6566

Abstract: A battery venting system that is useful for cordless power tools. The system can include a cell that may have a sleeve with a plurality of apertures surrounding a peripheral side face of the cell to enhance heat dissipation from the cell. A plurality of cells may be electrically connected to form a cell pack. A carrier includes an upper carrier and a lower carrier to sandwich a plurality of cells that are aligned parallel to each other. The carriers include at least one vent hole that are aligned with a gap formed from adjacent cells to define an elongated fluid flow path. A charger may be provided to receive a housing containing the carrier and may be provided with a fan to direct a flow into the fluid flow path.

Abstract translation: 用于无绳电动工具的电池排气系统。 该系统可以包括可以具有套筒的电池，其具有围绕电池的外围侧面的多个孔，以增强从电池的散热。 多个电池可以电连接以形成电池组。 载体包括上部载体和下部载体，以夹持彼此平行排列的多个单元。 载体包括至少一个通气孔，其与由相邻电池形成的间隙对准以限定细长的流体流动路径。 可以提供充电器以接收容纳载体的壳体，并且可以设置有风扇以将流引导到流体流动路径中。

公开(公告)号：US20070078458A1

公开(公告)日：2007-04-05

申请号：US11529798

申请日：2006-09-29

Applicant: Patrick Dumbauld ,  Paul Guerra ,  Roger Smith ,  Scott DePierro

Inventor： Patrick Dumbauld ,  Paul Guerra ,  Roger Smith ,  Scott DePierro

IPC: A61B18/14

CPC classification number: A61B18/1442 ,  A61B18/1445 ,  A61B2017/2945 ,  A61B2018/00083 ,  A61B2018/0063 ,  A61B2018/1412 ,  A61B2018/1432 ,  A61B2018/1455 ,  A61B2018/1475 ,  A61B2090/034

Abstract: Either an endoscopic or open bipolar forceps includes a flexible, generally tubular insulating boot for insulating patient tissue, while not impeding motion of the jaw members. The jaw members are movable from an open to a closed position and the jaw members are connected to a source of electrosurgical energy such that the jaw members are capable of conducting energy through tissue held therebetween to effect a tissue seal. A knife assembly may be included that allows a user to selectively divide tissue upon actuation thereof. The insulating boot may be made from a viscoelastic, elastomeric or flexible material suitable for use with a sterilization process including ethylene oxide.

Abstract translation: 内窥镜或开放式双极镊子包括用于绝缘患者组织的柔性的，通常为管状的绝缘护套，同时不阻碍钳口构件的运动。 钳口构件可以从打开位置移动到关闭位置，并且钳口构件连接到电外科能量源，使得钳口构件能够通过保持在其间的组织传导能量来实现组织密封。 可以包括刀组件，其允许使用者在其致动时选择性地分割组织。 绝缘靴可以由适用于包括环氧乙烷在内的灭菌方法使用的粘弹性，弹性或柔性材料制成。

公开(公告)号：US20070062361A1

公开(公告)日：2007-03-22

申请号：US11228148

申请日：2005-09-16

Applicant: Wei Xiong ,  Haijun Zhou ,  Chin Lo ,  Andrew Eyre ,  Roger Smith

Inventor： Wei Xiong ,  Haijun Zhou ,  Chin Lo ,  Andrew Eyre ,  Roger Smith

IPC: B23D55/00

CPC classification number: B27B17/14 ,  Y10T83/7226

Abstract: A chainsaw tensioner that includes set of bevel gears. The input gear is connected to a knob to be operated to the user. Torque from the input knob is transferred to an output bevel gear that is connected to a threaded rod. A plate travels about the threaded rod and is mated with the chain guide bar. When the rod is rotated, the plate and the chain guide bar translate linearly to either tighten or loosen the chain around the periphery of the chain guide bar depending on the direction of rotation of the knob.

Abstract translation: 包括一组锥齿轮的链锯张紧器。 输入齿轮连接到用于操作的旋钮。 输入旋钮的扭矩传递到连接到螺纹杆的输出锥齿轮。 板绕着螺杆行进并与链条导杆配合。 当杆旋转时，板和链条导杆线性地平移，以根据旋钮的旋转方向将链条围绕链条导杆的周边拧紧或松开。

公开(公告)号：US20070007374A1

公开(公告)日：2007-01-11

申请号：US11175632

申请日：2005-07-05

Applicant: Roger Smith ,  Jason Gerard

Inventor： Roger Smith ,  Jason Gerard

IPC: B02C19/00

CPC classification number: B02C21/026 ,  B02C1/14

Abstract: A vehicle for breaking material is disclosed. The vehicle includes: an elongate vehicle frame; a feeder having a feed end portion and a discharge end portion, wherein the feeder is configured to convey the material from the feed end portion to the discharge end portion; and a material breaker supported via the vehicle frame with a feed end portion that is downstream from the discharge end portion of the feeder. The material breaker includes: a platform configured to support the material received from the feeder, at least one breaker element configured to move towards the platform and contact at least a portion of the material received from the feeder and supported by the platform, wherein movement of the at least one breaker element towards the platform is assisted, at least in part, by gravitational forces, and a lifting mechanism configured to move the at least one breaker element away from the platform.

公开(公告)号：US20060213784A1

公开(公告)日：2006-09-28

申请号：US11086016

申请日：2005-03-22

Applicant: Michael Tokarski ,  James Peck ,  Edward Dzwill ,  George Brock ,  Roger Smith ,  Michael Ulrich ,  Raymond Sander

Inventor： Michael Tokarski ,  James Peck ,  Edward Dzwill ,  George Brock ,  Roger Smith ,  Michael Ulrich ,  Raymond Sander

IPC: A45C11/04

CPC classification number: B65D81/22 ,  B65D2585/545

Abstract: An ophthalmic lens package comprises a shell having an internal cavity accessible through an opening in the shell and a drainage member that divides the internal chamber into an upper chamber and a lower chamber. The drainage member is permeable to aqueous liquids and is arranged to allow drainage of liquid from the upper chamber to the lower chamber. This arrangement of the ophthalmic lens package allows the consumer to retrieve the lens from the upper chamber without handling any significant amount of saline solution.

Abstract translation: 一种眼科镜包装，包括具有通过外壳中的开口可接近的内腔的外壳和将内腔分成上腔室和下室的排液构件。 排水构件对水性液体是可渗透的，并且被布置成允许液体从上腔排出到下室。 眼镜镜片包装的这种布置允许消费者从上腔取出镜片，而不用处理任何明显的盐溶液。